{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:26:14Z","timestamp":1774736774941,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5992","license":[{"start":{"date-parts":[[1984,11,1]],"date-time":"1984-11-01T00:00:00Z","timestamp":468115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1984,11]]},"DOI":"10.1038\/312337a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T02:00:36Z","timestamp":1100743236000},"page":"337-342","source":"Crossref","is-referenced-by-count":657,"title":["Structure of human factor VIII"],"prefix":"10.1038","volume":"312","author":[{"given":"Gordon A.","family":"Vehar","sequence":"first","affiliation":[]},{"given":"Bruce","family":"Keyt","sequence":"additional","affiliation":[]},{"given":"Dan","family":"Eaton","sequence":"additional","affiliation":[]},{"given":"Henry","family":"Rodriguez","sequence":"additional","affiliation":[]},{"given":"Donogh P.","family":"O'Brien","sequence":"additional","affiliation":[]},{"given":"Frances","family":"Rotblat","sequence":"additional","affiliation":[]},{"given":"Herman","family":"Oppermann","sequence":"additional","affiliation":[]},{"given":"Rodney","family":"Keck","sequence":"additional","affiliation":[]},{"given":"William I.","family":"Wood","sequence":"additional","affiliation":[]},{"given":"Richard N.","family":"Harkins","sequence":"additional","affiliation":[]},{"given":"Edward G. D.","family":"Tuddenham","sequence":"additional","affiliation":[]},{"given":"Richard M.","family":"Lawn","sequence":"additional","affiliation":[]},{"given":"Daniel J.","family":"Capon","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF312337a0_CR1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1146\/annurev.bi.49.070180.004001","volume":"49","author":"CM Jackson","year":"1980","unstructured":"Jackson, C. M. & Nemerson, Y. A. Rev. Biochem. 49, 765\u2013811 (1980).","journal-title":"A. Rev. Biochem."},{"key":"BF312337a0_CR2","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1021\/bi00899a022","volume":"3","author":"RL Lundblad","year":"1964","unstructured":"Lundblad, R. L. & Davie, E. W. Biochemistry 3, 1720\u20131725 (1964).","journal-title":"Biochemistry"},{"key":"BF312337a0_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1055\/s-0038-1655030","volume":"18","author":"C Hougie","year":"1967","unstructured":"Hougie, C., Denson, K. W. E. & Biggs, R. Thromb. Diath. haemorrh. 18, 211\u2013222 (1967).","journal-title":"Thromb. Diath. haemorrh."},{"key":"BF312337a0_CR4","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/2151201a0","volume":"215","author":"HC Hemker","year":"1967","unstructured":"Hemker, H. C. & Kahn, M. J. P. Nature 215, 1201\u20131202 (1967).","journal-title":"Nature"},{"key":"BF312337a0_CR5","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1038\/2151508a0","volume":"215","author":"PG Barton","year":"1967","unstructured":"Barton, P. G. Nature 215, 1508\u20131509 (1967).","journal-title":"Nature"},{"key":"BF312337a0_CR6","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1021\/bi00810a028","volume":"9","author":"B Osterud","year":"1970","unstructured":"Osterud, B. & Rapaport, S. I. Biochemistry 9, 1854\u20131861 (1970).","journal-title":"Biochemistry"},{"key":"BF312337a0_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0304-4165(72)90219-X","volume":"273","author":"TF Chuang","year":"1972","unstructured":"Chuang, T. F., Sargeant, R. B. & Hougie, C. Biochim. biophys. Acta 273, 287\u2013291 (1972).","journal-title":"Biochim. biophys. Acta"},{"key":"BF312337a0_CR8","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1172\/JCI106055","volume":"48","author":"OD Ratnoff","year":"1969","unstructured":"Ratnoff, O. D., Kass, L. & Lang, P. D. J. clin. Invest. 48, 957\u2013962 (1969).","journal-title":"J. clin. Invest."},{"key":"BF312337a0_CR9","first-page":"185","volume":"77","author":"EJ Hershgold","year":"1971","unstructured":"Hershgold, E. J., Silverman, L., Davison, A. & Janszen, M. E. J. Lab. clin. Med. 77, 185\u2013205 (1971).","journal-title":"J. Lab. clin. Med."},{"key":"BF312337a0_CR10","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1016\/S0021-9258(19)45457-4","volume":"247","author":"G Schmer","year":"1972","unstructured":"Schmer, G., Kirby, E. P., Teller, D. C. & Davie, E. W. J. biol. Chem. 247, 2512\u20132521 (1972).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR11","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1016\/S0021-9258(19)43824-6","volume":"248","author":"ME Legaz","year":"1973","unstructured":"Legaz, M. E., Schmer, G., Counts, R. B. & Davie, E. W. J. biol. Chem. 248, 3946\u20133955 (1973).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR12","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1172\/JCI107405","volume":"52","author":"GA Shapiro","year":"1973","unstructured":"Shapiro, G. A., Anderson, J. C., Pizzo, S. V. & McKee, P. A. J. clin. Invest. 52, 2198\u20132210 (1973).","journal-title":"J. clin. Invest."},{"key":"BF312337a0_CR13","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1021\/bi00544a001","volume":"19","author":"GA Vehar","year":"1980","unstructured":"Vehar, G. A. & Davie, E. W. Biochemistry 19, 401\u2013410 (1980).","journal-title":"Biochemistry"},{"key":"BF312337a0_CR14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1182\/blood.V59.3.594.594","volume":"59","author":"DN Fass","year":"1982","unstructured":"Fass, D. N., Knutson, G. J. & Katzman, J. A. Blood 59, 594\u2013600 (1982).","journal-title":"Blood"},{"key":"BF312337a0_CR15","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1073\/pnas.79.5.1648","volume":"79","author":"CA Fulcher","year":"1982","unstructured":"Fulcher, C. A. & Zimmerman, T. S. Proc. natn. Acad. Sci. U.S.A. 79, 1648\u20131652 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF312337a0_CR16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood.V59.3.615.615","volume":"59","author":"GJ Knutson","year":"1982","unstructured":"Knutson, G. J. & Fass, D. N. Blood 59, 615\u2013624 (1982).","journal-title":"Blood"},{"key":"BF312337a0_CR17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1182\/blood.V61.4.807.807","volume":"61","author":"CA Fulcher","year":"1983","unstructured":"Fulcher, C. A., Roberts, J. R. & Zimmerman, T. S. Blood 61, 807\u2013811 (1983).","journal-title":"Blood"},{"key":"BF312337a0_CR18","first-page":"108","volume":"50","author":"F Rotblat","year":"1983","unstructured":"Rotblat, F., O'Brien, D. P., Middleton, S. M. & Tuddenham, E. G. D. Thromb. Haemostasis 50, 108 (1983).","journal-title":"Thromb. Haemostasis"},{"key":"BF312337a0_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/312330a0","volume":"312","author":"WI Wood","year":"1984","unstructured":"Wood, W. I. et al. Nature 312, 330\u2013337 (1984).","journal-title":"Nature"},{"key":"BF312337a0_CR20","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/312326a0","volume":"312","author":"J Gitschier","year":"1984","unstructured":"Gitschier, J. et al. Nature 312, 326\u2013330 (1984).","journal-title":"Nature"},{"key":"BF312337a0_CR21","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S0022-2836(83)80341-6","volume":"167","author":"D Perlman","year":"1983","unstructured":"Perlman, D. & Halvorson, H. O. J. molec. Biol. 167, 394\u2013409 (1983).","journal-title":"J. molec. Biol."},{"key":"BF312337a0_CR22","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1073\/pnas.81.2.390","volume":"81","author":"N Takahashi","year":"1984","unstructured":"Takahashi, N., Ortel, T. L. & Putnam, F. W. Proc. natn. Acad. Sci. U.S.A. 81, 390\u2013394 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF312337a0_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1073\/pnas.80.1.115","volume":"80","author":"N Takahashi","year":"1983","unstructured":"Takahashi, N. et al. Proc. natn. Acad. Sci. U.S.A. 80, 115\u2013119 (1983).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF312337a0_CR24","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1073\/pnas.78.5.2805","volume":"78","author":"FE Dwulet","year":"1981","unstructured":"Dwulet, F. E. & Putnam, F. W. Proc. natn. Acad. Sci. U.S.A. 78, 2805\u20132809 (1981).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF312337a0_CR25","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0022-2836(81)90278-3","volume":"153","author":"Poole","year":"1981","unstructured":"Poole et al. J. molec. Biol. 153, 273\u2013289 (1981).","journal-title":"J. molec. Biol."},{"key":"BF312337a0_CR26","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1021\/bi00661a003","volume":"15","author":"L Ryden","year":"1976","unstructured":"Ryden, L. & Bjork, I. Biochemistry 15, 3411\u20133417 (1976).","journal-title":"Biochemistry"},{"key":"BF312337a0_CR27","doi-asserted-by":"publisher","first-page":"6767","DOI":"10.1073\/pnas.79.22.6767","volume":"79","author":"L Ryden","year":"1982","unstructured":"Ryden, L. Proc. natn. Acad. Sci. U.S.A. 79, 6767\u20136771 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF312337a0_CR28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1182\/blood.V21.2.221.221","volume":"21","author":"SI Rapaport","year":"1963","unstructured":"Rapaport, S. I., Schiffman, S., Patch, M. J. & Ames, S. B. Blood 21, 221\u2013236 (1963).","journal-title":"Blood"},{"key":"BF312337a0_CR29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0021-9673(00)81413-2","volume":"215","author":"L Ryden","year":"1981","unstructured":"Ryden, L. & Norder, H. J. Chromatogr. 215, 341\u2013350 (1981).","journal-title":"J. Chromatogr."},{"key":"BF312337a0_CR30","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1016\/S0021-9258(17)34775-0","volume":"253","author":"R Sperling","year":"1978","unstructured":"Sperling, R., Furie, B. C., Blumenstein, M., Keyt, B. & Furie, B. J. biol. Chem. 253, 3898\u20133906 (1978).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/B978-0-12-568402-6.50009-9","volume-title":"The Plasma Proteins","author":"MD Poulik","year":"1975","unstructured":"Poulik, M. D. & Weiss, M. L. in The Plasma Proteins Vol. 2 (ed. Putnam,. F. W.) 51\u2013108 (Academic, New York, 1975)."},{"key":"BF312337a0_CR32","first-page":"93","volume":"79","author":"E Frieden","year":"1980","unstructured":"Frieden, E. Ciba Fdn Symp. 79, 93\u2013124 (1980).","journal-title":"Ciba Fdn Symp."},{"key":"BF312337a0_CR33","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1016\/S0021-9258(18)50692-X","volume":"254","author":"IM Goldstein","year":"1979","unstructured":"Goldstein, I. M., Kaplan, H. B., Edelson, H. S. & Weissman, G. J. biol. Chem. 254, 4040\u20134045 (1979).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR34","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/S0021-9258(17)43279-0","volume":"259","author":"ME Nesheim","year":"1984","unstructured":"Nesheim, M. E., Foster, W. B., Hewick, R. & Mann, K. G. J. biol. Chem. 259, 3187\u20133196 (1984).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR35","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0021-9258(17)37898-5","volume":"254","author":"CT Esmon","year":"1979","unstructured":"Esmon, C. T. J. biol. Chem. 254, 964\u2013973 (1979).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR36","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1016\/S0021-9258(20)65178-X","volume":"257","author":"K Suzuki","year":"1982","unstructured":"Suzuki, K., Dahlback, B. & Stenflo, J. J. biol. Chem. 257, 6556\u20136564 (1982).","journal-title":"J. biol. Chem."},{"key":"BF312337a0_CR37","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. Nature 227, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"BF312337a0_CR38","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0003-2697(81)90783-1","volume":"117","author":"JH Morrissey","year":"1981","unstructured":"Morrissey, J. H. Analyt. Biochem. 117, 307\u2013310 (1981).","journal-title":"Analyt. Biochem."},{"key":"BF312337a0_CR39","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/0003-2697(82)90025-2","volume":"125","author":"MAK Markwell","year":"1982","unstructured":"Markwell, M. A. K. Analyt. Biochem. 125, 427\u2013432 (1982).","journal-title":"Analyt. Biochem."},{"key":"BF312337a0_CR40","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/0003-2697(84)90205-7","volume":"140","author":"H Rodriguez","year":"1984","unstructured":"Rodriguez, H., Kohr, W. J. & Harkins, R. N. Analyt. Biochem. 140, 538\u2013547 (1984).","journal-title":"Analyt. Biochem."},{"key":"BF312337a0_CR41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0076-6879(83)91019-4","volume":"91","author":"MW Hunkapiller","year":"1983","unstructured":"Hunkapiller, M. W., Lujan, E., Ostrander, F. & Hood, L. E. Meth. Enzym. 91, 227\u2013247 (1983).","journal-title":"Meth. Enzym."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/312337a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/312337a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/312337a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:04:21Z","timestamp":1684285461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/312337a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":41,"journal-issue":{"issue":"5992","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["BF312337a0"],"URL":"https:\/\/doi.org\/10.1038\/312337a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}