{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:21:57Z","timestamp":1775503317567,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6031","license":[{"start":{"date-parts":[[1985,8,1]],"date-time":"1985-08-01T00:00:00Z","timestamp":491702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1985,8]]},"DOI":"10.1038\/316820a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T04:57:47Z","timestamp":1100753867000},"page":"820-823","source":"Crossref","is-referenced-by-count":676,"title":["Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies"],"prefix":"10.1038","volume":"316","author":[{"given":"Norbert","family":"Kartner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna","family":"Evernden-Porelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF316820a0_CR1","first-page":"1","volume-title":"Drug Resistance and Neoplasia","author":"V Ling","year":"1982","unstructured":"Ling, V. in Drug Resistance and Neoplasia Vol. 1 (eds Bruchovsky, N. & Goldie, J. H.) 1\u201319 (CRC Press, Florida, 1982)."},{"key":"BF316820a0_CR2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/BF01806390","volume":"4","author":"V Ling","year":"1984","unstructured":"Ling, V., Gerlach, J. & Kartner, N. Breast Cancer Res. Treat. 4, 89\u201394 (1984).","journal-title":"Breast Cancer Res. Treat."},{"key":"BF316820a0_CR3","first-page":"87","volume":"68","author":"GA Curt","year":"1984","unstructured":"Curt, G. A., Clendeninn, N. J. & Chabner, B. A. Cancer Treat. Rep. 68, 87\u201399 (1984).","journal-title":"Cancer Treat. Rep."},{"key":"BF316820a0_CR4","unstructured":"Riordan, J. R. & Ling, V. in The International Encyclopedia of Pharmacology and Therapeutics (ed. Goldman, I. D.) (Pergamon, New York, in the press)."},{"key":"BF316820a0_CR5","first-page":"453","volume-title":"Molecular Actions and Targets for Cancer Chemotherapeutic Agents","author":"JL Biedler","year":"1981","unstructured":"Biedler, J. L. & Peterson, R. H. F. in Molecular Actions and Targets for Cancer Chemotherapeutic Agents (eds Sartorelli, A. C., Lazo, J. S. & Bertino, J. R.) 453\u2013482 (Academic, New York, 1981)."},{"key":"BF316820a0_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/BF00434344","volume":"14","author":"S Kaye","year":"1985","unstructured":"Kaye, S. & Merry, S. Cancer Chemother. Pharmac. 14, 96\u2013103 (1985).","journal-title":"Cancer Chemother. Pharmac."},{"key":"BF316820a0_CR7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0065-2571(84)90015-3","volume":"22","author":"WT Beck","year":"1984","unstructured":"Beck, W. T. Adv. Enzyme Regul. 22, 207\u2013227 (1984).","journal-title":"Adv. Enzyme Regul."},{"key":"BF316820a0_CR8","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","volume":"455","author":"RL Juliano","year":"1976","unstructured":"Juliano, R. L. & Ling, V. Biochim. biophys. Acta 455, 152\u2013162 (1976).","journal-title":"Biochim. biophys. Acta"},{"key":"BF316820a0_CR9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/jss.400040412","volume":"4","author":"R Juliano","year":"1976","unstructured":"Juliano, R., Ling, V. & Graves, J. J. supramolec. Struct. 4, 521\u2013526 (1976).","journal-title":"J. supramolec. Struct."},{"key":"BF316820a0_CR10","doi-asserted-by":"crossref","first-page":"12701","DOI":"10.1016\/S0021-9258(19)86370-6","volume":"254","author":"JR Riordan","year":"1979","unstructured":"Riordan, J. R. & Ling, V. J. biol. Chem. 254, 12701\u201312705 (1979).","journal-title":"J. biol. Chem."},{"key":"BF316820a0_CR11","first-page":"4413","volume":"43","author":"N Kartner","year":"1983","unstructured":"Kartner, N., Shales, M., Riordan, J. R. & Ling, V. Cancer Res. 43, 4413\u20134419 (1983).","journal-title":"Cancer Res."},{"key":"BF316820a0_CR12","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1126\/science.6137059","volume":"221","author":"N Kartner","year":"1983","unstructured":"Kartner, N., Riordan, J. R. & Ling, V. Science 221, 1285\u20131288 (1983).","journal-title":"Science"},{"key":"BF316820a0_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/BF00257134","volume":"13","author":"R Giavazzi","year":"1984","unstructured":"Giavazzi, R., Kartner, N. & Hart, I. R. Cancer Chemother. Pharmac. 13, 145\u2013147 (1984).","journal-title":"Cancer Chemother. Pharmac."},{"key":"BF316820a0_CR14","first-page":"869","volume":"67","author":"V Ling","year":"1983","unstructured":"Ling, V., Kartner, N., Sudo, T., Siminovitch, L. & Riordan, J. R. Cancer Treat. Rep. 67, 869\u2013874 (1983).","journal-title":"Cancer Treat. Rep."},{"key":"BF316820a0_CR15","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1128\/MCB.2.8.881","volume":"2","author":"PG Debenham","year":"1982","unstructured":"Debenham, P. G., Kartner, N., Siminovitch, L., Riordan, J. R. & Ling, V. Molec. cell. Biol. 2, 881\u2013889 (1982).","journal-title":"Molec. cell. Biol."},{"key":"BF316820a0_CR16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1200\/JCO.1985.3.3.311","volume":"3","author":"DR Bell","year":"1985","unstructured":"Bell, D. R., Gerlach, J. H., Kartner, N., Buick, R. N. & Ling, V. J. clin. Oncol. 3, 311\u2013315 (1985).","journal-title":"J. clin. Oncol."},{"key":"BF316820a0_CR17","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/316817a0","volume":"316","author":"JR Riordan","year":"1985","unstructured":"Riordan, J. R. et al. Nature 316, 817\u2013819 (1985).","journal-title":"Nature"},{"key":"BF316820a0_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/311123a0","volume":"311","author":"E Westhof","year":"1984","unstructured":"Westhof, E. et al. Nature 311, 123\u2013126 (1984).","journal-title":"Nature"},{"key":"BF316820a0_CR19","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/312127a0","volume":"312","author":"JA Tainer","year":"1984","unstructured":"Tainer, J. A. et al. Nature 312, 127\u2013134 (1984).","journal-title":"Nature"},{"key":"BF316820a0_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev.iy.02.040184.000435","volume":"2","author":"DC Benjamin","year":"1984","unstructured":"Benjamin, D. C. et al. A. Rev. Immun. 2, 67\u2013101 (1984).","journal-title":"A. Rev. Immun."},{"key":"BF316820a0_CR21","first-page":"889","volume":"67","author":"T Tsuruo","year":"1983","unstructured":"Tsuruo, T. Cancer Chemother. Rep. 67, 889\u2013894 (1983).","journal-title":"Cancer Chemother. Rep."},{"key":"BF316820a0_CR22","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1126\/science.6372095","volume":"224","author":"AM Rogan","year":"1984","unstructured":"Rogan, A. M., Hamilton, T. C., Young, R. C., Klecker, R. W. & Ozols, R. F. Science 224, 994\u2013996 (1984).","journal-title":"Science"},{"key":"BF316820a0_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jcp.1040830114","volume":"83","author":"V Ling","year":"1974","unstructured":"Ling, V. & Thompson, L. H. J. cell. Physiol. 83, 103\u2013116 (1974).","journal-title":"J. cell. Physiol."},{"key":"BF316820a0_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/jcp.1040880104","volume":"88","author":"NT Bech-Hansen","year":"1979","unstructured":"Bech-Hansen, N. T., Till, J. E. & Ling, V. J. cell. Physiol. 88, 23\u201331 (1979).","journal-title":"J. cell. Physiol."},{"key":"BF316820a0_CR25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1139\/g75-064","volume":"17","author":"V Ling","year":"1975","unstructured":"Ling, V. Can. J. Genet. Cytol. 17, 503\u2013515 (1975).","journal-title":"Can. J. Genet. Cytol."},{"key":"BF316820a0_CR26","first-page":"53","volume-title":"Gene Amplification","author":"T Kuo","year":"1982","unstructured":"Kuo, T., Pathak, S., Ramagli, L., Rodriguez, L. & Hsu, T. C. in Gene Amplification (ed. Schimke, R. T.) 53\u201357 (Cold Spring Harbor Laboratory, New York, 1982)."},{"key":"BF316820a0_CR27","first-page":"1590","volume":"29","author":"R Simard","year":"1969","unstructured":"Simard, R. & Cassingena, R. Cancer Res. 29, 1590\u20131597 (1969).","journal-title":"Cancer Res."},{"key":"BF316820a0_CR28","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1432-0436.1974.tb00360.x","volume":"2","author":"Y Langelier","year":"1974","unstructured":"Langelier, Y., Simard, R. & Brailovsky, C. Differentiation 2, 261\u2013267 (1974).","journal-title":"Differentiation"},{"key":"BF316820a0_CR29","first-page":"2216","volume":"43","author":"R Giavazzi","year":"1983","unstructured":"Giavazzi, R., Scholar, E. & Hart, I. R. Cancer Res. 43, 2216\u20132222 (1983).","journal-title":"Cancer Res."},{"key":"BF316820a0_CR30","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/0277-5379(83)90039-1","volume":"19","author":"JM Siegfried","year":"1983","unstructured":"Siegfried, J. M., Tritton, T. R. & Sartirelli, A. C. Eur. J. Cancer din. Oncol. 19, 1133\u20131141 (1983).","journal-title":"Eur. J. Cancer din. Oncol."},{"key":"BF316820a0_CR31","first-page":"2070","volume":"39","author":"WT Beck","year":"1979","unstructured":"Beck, W. T., Mueller, T. J. & Tanzer, L. R. Cancer Res. 39, 2070\u20132076 (1979).","journal-title":"Cancer Res."},{"key":"BF316820a0_CR32","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/0003-2697(77)90043-4","volume":"83","author":"GL Peterson","year":"1977","unstructured":"Peterson, G. L. Analyt. Biochem. 83, 346\u2013356 (1977).","journal-title":"Analyt. Biochem."},{"key":"BF316820a0_CR33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. J. biol Chem. 193, 265\u2013275 (1951).","journal-title":"J. biol Chem."},{"key":"BF316820a0_CR34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/BF01551818","volume":"3","author":"ML Gefter","year":"1977","unstructured":"Gefter, M. L., Margulies, D. H. & Scharff, M. D. Somat. Cell Genet. 3, 231\u2013235 (1977).","journal-title":"Somat. Cell Genet."},{"key":"BF316820a0_CR35","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/276269a0","volume":"276","author":"M Shulman","year":"1978","unstructured":"Shulman, M., Wilden, C. D. & K\u00f6hler, G. Nature 276, 269\u2013270 (1978).","journal-title":"Nature"},{"key":"BF316820a0_CR36","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"H Towbin","year":"1979","unstructured":"Towbin, H., Staehelin, T. & Gordon, J. Proc. natn. Acad. Sci. U.S.A. 76, 4350\u20134354 (1979).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF316820a0_CR37","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/0161-5890(78)90070-6","volume":"15","author":"PL Ey","year":"1978","unstructured":"Ey, P. L., Prowse, S. J. & Jenkin, C. R. Immunochemistry 15, 429\u2013436 (1978).","journal-title":"Immunochemistry"},{"key":"BF316820a0_CR38","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1042\/bj0890114","volume":"89","author":"FC Greenwood","year":"1963","unstructured":"Greenwood, F. C., Hunter, W. M. & Glover, J. S. Biochem. J. 89, 114\u2013123 (1963).","journal-title":"Biochem. J."},{"key":"BF316820a0_CR39","first-page":"859","volume":"67","author":"FM Davis","year":"1983","unstructured":"Davis, F. M., Tsao, T. Y., Meyers, M. B., Peterson, R. H. F. & Spengler, B. A. Cancer Treat. Rep. 67, 859\u2013867 (1983).","journal-title":"Cancer Treat. Rep."},{"key":"BF316820a0_CR40","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1021\/bi00789a030","volume":"10","author":"G Fairbanks","year":"1971","unstructured":"Fairbanks, G., Steck, T. L. & Wallach, D. F. H. Biochemistry 10, 2606\u20132616 (1971).","journal-title":"Biochemistry"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/316820a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/316820a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/316820a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:57:22Z","timestamp":1684285042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/316820a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,8]]},"references-count":40,"journal-issue":{"issue":"6031","published-print":{"date-parts":[[1985,8]]}},"alternative-id":["BF316820a0"],"URL":"https:\/\/doi.org\/10.1038\/316820a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,8]]}}}