{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:48:03Z","timestamp":1784076483132,"version":"3.55.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6034","license":[{"start":{"date-parts":[[1985,9,1]],"date-time":"1985-09-01T00:00:00Z","timestamp":494380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1985,9]]},"DOI":"10.1038\/317267a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T03:40:05Z","timestamp":1100749205000},"page":"267-270","source":"Crossref","is-referenced-by-count":482,"title":["Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin"],"prefix":"10.1038","volume":"317","author":[{"given":"Jeffrey C.","family":"Edman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leland","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell W.","family":"Blacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF317267a0_CR1","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.1016\/S0021-9258(18)50469-5","volume":"254","author":"LW Bergman","year":"1979","unstructured":"Bergman, L. W. & Kuehl, W. M. J. biol. Chem. 254, 5690\u20135694 (1979).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR2","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1016\/S0021-9258(18)34207-8","volume":"257","author":"T Peters","year":"1982","unstructured":"Peters, T. & Davidson, L. K. J. biol. Chem. 257, 8847\u20138853 (1982).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR3","first-page":"167","volume-title":"The Enzymology of Post-Translational Modifications of Proteins","author":"RB Freedman","year":"1980","unstructured":"Freedman, R. B. & Hillson, D. A. in The Enzymology of Post-Translational Modifications of Proteins (eds Freeman, R. B. & Hawkins, H. C.) 167\u2013212 (Academic, New York, 1980)."},{"key":"BF317267a0_CR4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0065-3233(08)60413-1","volume":"29","author":"CB Anfinsen","year":"1975","unstructured":"Anfinsen, C. B. & Scheraga, H. A. Adv. Protein Chem. 29, 205\u2013300 (1975).","journal-title":"Adv. Protein Chem."},{"key":"BF317267a0_CR5","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0021-9258(18)81309-6","volume":"238","author":"RF Goldberger","year":"1963","unstructured":"Goldberger, R. F., Epstein, C. J. & Anfinsen, C. B. J. biol. Chem. 238, 628\u2013635 (1963).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0021-9258(18)93938-4","volume":"237","author":"H Tomizawa","year":"1962","unstructured":"Tomizawa, H. J. biol. Chem. 237, 428\u2013431 (1962).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR7","first-page":"271","volume":"11","author":"HM Katzen","year":"1962","unstructured":"Katzen, H. M. & Stetten, D. Diabetes 11, 271\u2013280 (1962).","journal-title":"Diabetes"},{"key":"BF317267a0_CR8","first-page":"778","volume":"2","author":"WC Duckworth","year":"1983","unstructured":"Duckworth, W. C. & Kitabchi, A. E. Endocrine Rev. 2, 778\u2013782 (1983).","journal-title":"Endocrine Rev."},{"key":"BF317267a0_CR9","doi-asserted-by":"crossref","unstructured":"Freedman, R. B. Trends biochem. Sci. 9, (1984).","DOI":"10.1016\/0968-0004(84)90152-X"},{"key":"BF317267a0_CR10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1432-1033.1968.tb00470.x","volume":"6","author":"A Holmgren","year":"1968","unstructured":"Holmgren, A. Eur. J. Biochem. 6, 475\u2013484 (1968).","journal-title":"Eur. J. Biochem."},{"key":"BF317267a0_CR11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1042\/bst0120929","volume":"12","author":"RB Freedman","year":"1984","unstructured":"Freedman, R. B., Brockway, B. E. & Lambert, N. Biochem. Soc. Trans. 12, 929\u2013932 (1984).","journal-title":"Biochem. Soc. Trans."},{"key":"BF317267a0_CR12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0022-2836(80)90205-3","volume":"142","author":"TE Creighton","year":"1980","unstructured":"Creighton, T. E., Hillson, D. A. & Freedman, R. B. J. molec. Biol. 142, 43\u201362 (1980).","journal-title":"J. molec. Biol."},{"key":"BF317267a0_CR13","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1021\/bi00526a012","volume":"20","author":"RA Roth","year":"1981","unstructured":"Roth, R. A. & Koshland, M. E. Biochemistry 20, 6594\u20136599 (1981).","journal-title":"Biochemistry"},{"key":"BF317267a0_CR14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4684-3282-4_3","volume-title":"Protein Crosslinking","author":"DB Wetlaufer","year":"1977","unstructured":"Wetlaufer, D. B., Saxena, V. P., Ahmed, A. K., Schaffer, S. W., Pick, P. W., Oh, K.-J. & Peterson, J. D. in Protein Crosslinking Pt A (ed. Friedman, M.) 43\u201350 (Plenum, New York, 1977)."},{"key":"BF317267a0_CR15","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1016\/S0021-9258(17)33244-1","volume":"251","author":"JM Teale","year":"1976","unstructured":"Teale, J. M. & Benjamin, D. C. J. biol. Chem. 251, 4603\u20134608 (1976).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR16","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1126\/science.6356359","volume":"222","author":"RA Young","year":"1983","unstructured":"Young, R. A. & Davis, R. W. Science 222, 778\u2013782 (1983).","journal-title":"Science"},{"key":"BF317267a0_CR17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0167-4838(84)90261-9","volume":"788","author":"RA Roth","year":"1984","unstructured":"Roth, R. A. & Mesirow, M. L. Biochim. biophys. Acta 788, 189\u2013192 (1984).","journal-title":"Biochim. biophys. Acta"},{"key":"BF317267a0_CR18","unstructured":"Hyunh, T., Young, R. & Davis, R. W. in Practical Approaches in Biochemistry (ed. Glover, D.) (IRL, Oxford, in the press)."},{"key":"BF317267a0_CR19","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1073\/pnas.74.10.4370","volume":"74","author":"BM Paterson","year":"1977","unstructured":"Paterson, B. M., Roberts, B. E. & Kuff, E. L. Proc. natn. Acad. Sci. U.S.A. 74, 4370\u20134374 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317267a0_CR20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0092-8674(84)90549-X","volume":"38","author":"GA Reynolds","year":"1984","unstructured":"Reynolds, G. A. et al. Cell 38, 275\u2013285 (1984).","journal-title":"Cell"},{"key":"BF317267a0_CR21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1042\/bj2130225","volume":"213","author":"H Ohba","year":"1983","unstructured":"Ohba, H., Harano, T. & Omura, T. J. Biochem., Tokyo 213, 225\u2013234 (1983).","journal-title":"J. Biochem., Tokyo"},{"key":"BF317267a0_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.92.1.1","volume":"92","author":"DD Sabatini","year":"1982","unstructured":"Sabatini, D. D., Kreibich, G., Morimoto, T. & Adesnik, M. J. Cell Biol. 92, 1\u201322 (1982).","journal-title":"J. Cell Biol."},{"key":"BF317267a0_CR23","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1432-1033.1982.tb05894.x","volume":"122","author":"Y Okada","year":"1982","unstructured":"Okada, Y. et al. Eur. J. Biochem. 122, 393\u2013402 (1982).","journal-title":"Eur. J. Biochem."},{"key":"BF317267a0_CR24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0014-5793(73)80468-5","volume":"37","author":"S Ansorge","year":"1973","unstructured":"Ansorge, S. et al. FEBS Lett. 37, 238\u2013240 (1973).","journal-title":"FEBS Lett."},{"key":"BF317267a0_CR25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/bj2130245","volume":"213","author":"ENC Mills","year":"1983","unstructured":"Mills, E. N. C., Lambert, N. & Freedman, R. B. Biochem. J. 213, 245\u2013248 (1983).","journal-title":"Biochem. J."},{"key":"BF317267a0_CR26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bst0070573","volume":"7","author":"DA Hillson","year":"1979","unstructured":"Hillson, D. A. & Freedman, R. B. Biochem. Soc. Trans. 7, 573\u2013574 (1979).","journal-title":"Biochem. Soc. Trans."},{"key":"BF317267a0_CR27","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1016\/S0021-9258(19)86902-8","volume":"254","author":"DF Carmichael","year":"1979","unstructured":"Carmichael, D. F., Keefe, M., Pace, M. & Dixon, J. E. J. biol. Chem. 254, 8386\u20138390 (1979).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR28","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1021\/bi00876a030","volume":"5","author":"F DeLorenzo","year":"1966","unstructured":"DeLorenzo, F., Fuchs, S. & Anfinsen, C. B. Biochemistry 5, 3961\u20133965 (1966).","journal-title":"Biochemistry"},{"key":"BF317267a0_CR29","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1073\/pnas.72.6.2305","volume":"72","author":"A Holmgren","year":"1975","unstructured":"Holmgren, A., Soderberg, B. O., Eklund, H. & Branden, C. I. Proc. natn. Acad. Sci. U.S.A. 72, 2305\u20132309 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317267a0_CR30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1073\/pnas.81.1.155","volume":"81","author":"J Finer-Moore","year":"1984","unstructured":"Finer-Moore, J. & Stroud, R. M. Proc. natn. Acad. Sci. U.S.A. 81, 155\u2013159 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317267a0_CR31","doi-asserted-by":"crossref","first-page":"9627","DOI":"10.1016\/S0021-9258(19)83562-7","volume":"254","author":"A Holmgren","year":"1979","unstructured":"Holmgren, A. J. biol. Chem. 254, 9627\u20139632 (1979).","journal-title":"J. biol. Chem."},{"key":"BF317267a0_CR32","volume-title":"Molecular Cloning, A Laboratory Manual","author":"T Maniatis","year":"1982","unstructured":"Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning, A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982)."},{"key":"BF317267a0_CR33","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1073\/pnas.69.6.1408","volume":"69","author":"H Aviv","year":"1972","unstructured":"Aviv, H. & Leder, P. Proc. natn. Acad. Sci. U.S.A. 69, 1408\u20131412 (1972).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317267a0_CR34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-1119(83)90230-5","volume":"25","author":"U Gubler","year":"1983","unstructured":"Gubler, U. & Hoffman, B. J. Gene 25, 263\u2013269 (1983).","journal-title":"Gene"},{"key":"BF317267a0_CR35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0022-2836(83)80284-8","volume":"166","author":"D Hanahan","year":"1983","unstructured":"Hanahan, D. J. molec. Biol. 166, 557\u2013580 (1983).","journal-title":"J. molec. Biol."},{"key":"BF317267a0_CR36","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","volume":"74","author":"F Sanger","year":"1977","unstructured":"Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463\u20135467 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317267a0_CR37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0076-6879(83)91038-8","volume":"91","author":"MW Hunkapiller","year":"1983","unstructured":"Hunkapiller, M. W., Hewich, R. M., Dreyer, W. J. & Hood, L. E. Meth. Enzym. 91, 399 (1983).","journal-title":"Meth. Enzym."},{"key":"BF317267a0_CR38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0003-2697(82)90351-7","volume":"120","author":"D Hawke","year":"1982","unstructured":"Hawke, D., Yuan, P. M. & Shively, J. E. Analyt. Biochem. 120, 302 (1982).","journal-title":"Analyt. Biochem."},{"key":"BF317267a0_CR39","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/JVI.50.2.657-661.1984","volume":"50","author":"CF Arias","year":"1984","unstructured":"Arias, C. F., Lopez, S., Bell, J. R. & Strauss, J. H. J. Virol. 50, 657\u2013661 (1984).","journal-title":"J. Virol."},{"key":"BF317267a0_CR40","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.115.6.1617","volume":"115","author":"SW Kessler","year":"1975","unstructured":"Kessler, S. W. J. Immun. 115, 1617\u20131624 (1975).","journal-title":"J. Immun."},{"key":"BF317267a0_CR41","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. Nature 227, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"BF317267a0_CR42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0076-6879(83)00060-9","volume":"100","author":"PS Thomas","year":"1983","unstructured":"Thomas, P. S. Meth. Enzym. 100, 255\u2013266 (1983).","journal-title":"Meth. Enzym."},{"key":"BF317267a0_CR43","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1021\/bi00591a005","volume":"18","author":"JM Chirgwin","year":"1979","unstructured":"Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294\u20135301 (1979).","journal-title":"Biochemistry"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/317267a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/317267a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/317267a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:59:01Z","timestamp":1684285141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/317267a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":43,"journal-issue":{"issue":"6034","published-print":{"date-parts":[[1985,9]]}},"alternative-id":["BF317267a0"],"URL":"https:\/\/doi.org\/10.1038\/317267a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}