{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:57:47Z","timestamp":1762160267207},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6036","license":[{"start":{"date-parts":[[1985,10,1]],"date-time":"1985-10-01T00:00:00Z","timestamp":496972800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1985,10]]},"DOI":"10.1038\/317449a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T03:40:51Z","timestamp":1100749251000},"page":"449-451","source":"Crossref","is-referenced-by-count":90,"title":["Identification of talin as a major cytoplasmic protein implicated in platelet activation"],"prefix":"10.1038","volume":"317","author":[{"given":"Theresa","family":"O'Halloran","sequence":"first","affiliation":[]},{"given":"Mary C.","family":"Beckerle","sequence":"additional","affiliation":[]},{"given":"Keith","family":"Burridge","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF317449a0_CR1","first-page":"261","volume":"20","author":"VT Nachmias","year":"1983","unstructured":"Nachmias, V. T. Semin. Hemat. 20, 261\u2013281 (1983).","journal-title":"Semin. Hemat."},{"key":"BF317449a0_CR2","first-page":"243","volume":"20","author":"JEB Fox","year":"1983","unstructured":"Fox, J. E. B. & Phillips, D. R. Semin. Hemat. 20, 243\u2013260 (1983).","journal-title":"Semin. Hemat."},{"key":"BF317449a0_CR3","first-page":"207","volume":"110","author":"TC Detwiler","year":"1978","unstructured":"Detwiler, T. C., Charo, I. F. & Feinman, R. D. Thromb. Haem. 110, 207\u2013211 (1978).","journal-title":"Thromb. Haem."},{"key":"BF317449a0_CR4","first-page":"135","volume":"77","author":"JG White","year":"1974","unstructured":"White, J. G., Rao, F. H. R. & Gerrard, J. M. Am. J. Path. 77, 135\u2013149 (1974).","journal-title":"Am. J. Path."},{"key":"BF317449a0_CR5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0021-9258(20)71208-1","volume":"260","author":"JEB Fox","year":"1985","unstructured":"Fox, J. E. B., Goll, D. E., Reynolds, C. C. & Phillips, D. R. J. biol. Chem. 260, 1060\u20131066 (1985).","journal-title":"J. biol. Chem."},{"key":"BF317449a0_CR6","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1016\/S0021-9258(18)34520-4","volume":"257","author":"NC Collier","year":"1982","unstructured":"Collier, N. C. & Wang, K. J. biol. Chem. 257, 6937\u20136943 (1982).","journal-title":"J. biol. Chem."},{"key":"BF317449a0_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0014-5793(82)80099-9","volume":"143","author":"NC Collier","year":"1982","unstructured":"Collier, N. C. & Wang, K. FEBS Lett. 143, 205\u2013210 (1982).","journal-title":"FEBS Lett."},{"key":"BF317449a0_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1098\/rstb.1982.0133","volume":"299","author":"K Burridge","year":"1982","unstructured":"Burridge, K., Kelly, T. & Connell, L. Phil. Trans. R. Soc. B299, 291\u2013299 (1982).","journal-title":"Phil. Trans. R. Soc."},{"key":"BF317449a0_CR9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1083\/jcb.97.2.359","volume":"97","author":"K Burridge","year":"1983","unstructured":"Burridge, K. & Connell, L. J. Cell Biol. 97, 359\u2013367 (1983).","journal-title":"J. Cell Biol."},{"key":"BF317449a0_CR10","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/308744a0","volume":"308","author":"K Burridge","year":"1984","unstructured":"Burridge, K. & Mangeat, P. Nature 308, 744\u2013746 (1984).","journal-title":"Nature"},{"key":"BF317449a0_CR11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0092-8674(79)90368-4","volume":"18","author":"B Geiger","year":"1979","unstructured":"Geiger, B. Cell 18, 193\u2013205 (1979).","journal-title":"Cell"},{"key":"BF317449a0_CR12","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0092-8674(80)80035-3","volume":"19","author":"K Burridge","year":"1980","unstructured":"Burridge, K. & Feramisco, J. R. Cell 19, 587\u2013595 (1980).","journal-title":"Cell"},{"key":"BF317449a0_CR13","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1083\/jcb.97.4.1283","volume":"97","author":"J Otto","year":"1983","unstructured":"Otto, J. J. Cell Biol. 97, 1283\u20131287 (1983).","journal-title":"J. Cell Biol."},{"key":"BF317449a0_CR14","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/S0006-291X(83)80245-9","volume":"116","author":"JA Wilkins","year":"1983","unstructured":"Wilkins, J. A., Chen, K. Y. & Lin, S. Biochem. biophys. Res. Commun. 116, 1026\u20131032 (1983).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF317449a0_CR15","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1073\/pnas.78.5.3005","volume":"78","author":"BM Jockusch","year":"1981","unstructured":"Jockusch, B. M. & Isenberg, G. Proc. natn. Acad. Sci. U.S.A. 78, 3005\u20133009 (1981).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317449a0_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0092-8674(82)90377-4","volume":"28","author":"JA Wilkins","year":"1982","unstructured":"Wilkins, J. A. & Lin, S. Cell 28, 83\u201390 (1982).","journal-title":"Cell"},{"key":"BF317449a0_CR17","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1101\/SQB.1982.046.01.055","volume":"46","author":"K Burridge","year":"1982","unstructured":"Burridge, K. & Feramisco, J. R. Cold Spring Harb. Symp. quant. Biol. 46, 587\u2013597 (1982).","journal-title":"Cold Spring Harb. Symp. quant. Biol."},{"key":"BF317449a0_CR18","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1016\/S0021-9258(17)43184-X","volume":"259","author":"RR Evans","year":"1984","unstructured":"Evans, R. R., Robson, R. M. & Stromer, M. H. J. biol. Chem. 259, 3916\u20133925 (1984).","journal-title":"J. biol. Chem."},{"key":"BF317449a0_CR19","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1083\/jcb.100.3.669","volume":"100","author":"GC Rosenfeld","year":"1985","unstructured":"Rosenfeld, G. C., Hou, D. C., Dingus, J., Meza, I. & Bryan, J. J. Cell Biol. 100, 669\u2013676 (1985).","journal-title":"J. Cell Biol."},{"key":"BF317449a0_CR20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. Nature 227, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"BF317449a0_CR21","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1083\/jcb.95.2.478","volume":"95","author":"K Burridge","year":"1982","unstructured":"Burridge, K., Kelly, T. & Mangeat, P. J. Cell Biol. 95, 478\u2013486 (1982).","journal-title":"J. Cell Biol."},{"key":"BF317449a0_CR22","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1016\/S0021-9258(18)32244-0","volume":"258","author":"J Davis","year":"1983","unstructured":"Davis, J. & Bennett, V. J. biol. Chem. 258, 7757\u20137766 (1983).","journal-title":"J. biol. Chem."},{"key":"BF317449a0_CR23","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"H Towbin","year":"1979","unstructured":"Towbin, H. et al. Proc. natn. Acad. Sci. U.S.A. 76, 4350\u20134354 (1979).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF317449a0_CR24","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0022-1759(82)90089-8","volume":"55","author":"B Batteiger","year":"1982","unstructured":"Batteiger, B., Newhall, W. J. & Jones, R. B. J. immun. Meth. 55, 297\u2013307 (1982).","journal-title":"J. immun. Meth."},{"key":"BF317449a0_CR25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/194495a0","volume":"194","author":"WM Hunter","year":"1962","unstructured":"Hunter, W. M. & Greenwood, F. C. Nature 194, 495\u2013496 (1962).","journal-title":"Nature"},{"key":"BF317449a0_CR26","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/0167-4838(84)90048-7","volume":"788","author":"DE Croall","year":"1984","unstructured":"Croall, D. E. & DeMartino, G. N. Biochim. biophys. Acta 788, 348\u2013355 (1984).","journal-title":"Biochim. biophys. Acta"},{"key":"BF317449a0_CR27","unstructured":"Beckerle, M. C. et al. J. Cell Biochem (in the press)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/317449a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/317449a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/317449a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:00:37Z","timestamp":1684285237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/317449a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10]]},"references-count":27,"journal-issue":{"issue":"6036","published-print":{"date-parts":[[1985,10]]}},"alternative-id":["BF317449a0"],"URL":"https:\/\/doi.org\/10.1038\/317449a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,10]]}}}