{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:43:57Z","timestamp":1777700637640,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6050","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1986,1]]},"DOI":"10.1038\/319199a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T03:56:06Z","timestamp":1100750166000},"page":"199-203","source":"Crossref","is-referenced-by-count":1605,"title":["Solvation energy in protein folding and binding"],"prefix":"10.1038","volume":"319","author":[{"given":"David","family":"Eisenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF319199a0_CR1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0022-2836(84)90049-4","volume":"177","author":"J Novotn\u00fd","year":"1984","unstructured":"Novotn\u00fd, J., Bruccoleri, R. & Karplus, M. J. molec. Biol. 177, 787\u2013818 (1984).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60608-7","volume":"14","author":"W Kauzmann","year":"1959","unstructured":"Kauzmann, W. Adv. Protein Chem. 14, 1\u201363 (1959).","journal-title":"Adv. Protein Chem."},{"key":"BF319199a0_CR3","volume-title":"Proteins","author":"TE Creighton","year":"1984","unstructured":"Creighton, T. E. Proteins (Freeman, San Francisco, 1984)."},{"key":"BF319199a0_CR4","volume-title":"The Hydrophobic Effect","author":"C Tanford","year":"1980","unstructured":"Tanford, C. The Hydrophobic Effect 2nd edn (Wiley, New York, 1980)."},{"key":"BF319199a0_CR5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.bi.52.070183.001403","volume":"52","author":"M Karplus","year":"1983","unstructured":"Karplus, M. & McCammon, A. A. Rev. Biochem. 52, 263\u2013300 (1983).","journal-title":"Rev. Biochem."},{"key":"BF319199a0_CR6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S0033583500002936","volume":"10","author":"G Nemethy","year":"1977","unstructured":"Nemethy, G. & Scheraga, H. A. Q. Rev. Biophys. 10, 239\u2013352 (1977).","journal-title":"Q. Rev. Biophys."},{"key":"BF319199a0_CR7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/253694a0","volume":"253","author":"M Levitt","year":"1975","unstructured":"Levitt, M. & Warshel, A. Nature 253, 694\u2013698 (1975).","journal-title":"Nature"},{"key":"BF319199a0_CR8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.4023714","volume":"229","author":"GD Rose","year":"1985","unstructured":"Rose, G. D., Geselowitz, A. R., Lesser, G. J., Lee, R. H. & Zehfus, M. H. Science 229, 834\u2013838 (1985).","journal-title":"Science"},{"key":"BF319199a0_CR9","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/S0021-9258(19)77210-X","volume":"246","author":"Y Nozaki","year":"1971","unstructured":"Nozaki, Y. & Tanford, C. J. biol. Chem. 246, 2211\u20132217 (1971).","journal-title":"J. biol. Chem."},{"key":"BF319199a0_CR10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/277491a0","volume":"277","author":"J Janin","year":"1979","unstructured":"Janin, J. Nature 277, 491\u2013492 (1979).","journal-title":"Nature"},{"key":"BF319199a0_CR11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/bi00507a030","volume":"20","author":"R Wolfenden","year":"1981","unstructured":"Wolfenden, R., Anderson, L., Cullis, P. M. & Southgate, C. C. B. Biochemistry 20, 849\u2013855 (1981).","journal-title":"Biochemistry"},{"key":"BF319199a0_CR12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/fs9821700109","volume":"17","author":"D Eisenberg","year":"1982","unstructured":"Eisenberg, D., Weiss, R. M., Terwilliger, T. C. & Wilcox, W. Faraday Symp. chem. Soc. 17, 109\u2013120 (1982).","journal-title":"Faraday Symp. chem. Soc."},{"key":"BF319199a0_CR13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0006-3495(85)83877-7","volume":"47","author":"HR Guy","year":"1985","unstructured":"Guy, H. R. Biophys. J. 47, 61\u201370 (1985).","journal-title":"Biophys. J."},{"key":"BF319199a0_CR14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-5193(84)80209-X","volume":"111","author":"C Frommel","year":"1984","unstructured":"Frommel, C. J. theor. Biol. 111, 247\u2013260 (1984).","journal-title":"J. theor. Biol."},{"key":"BF319199a0_CR15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/248338a0","volume":"248","author":"C Chothia","year":"1974","unstructured":"Chothia, C. Nature 248, 338\u2013339 (1974).","journal-title":"Nature"},{"key":"BF319199a0_CR16","first-page":"48","volume":"3","author":"I Langmuir","year":"1925","unstructured":"Langmuir, I. Colloid Symp. Monogr. 3, 48\u201375 (1925).","journal-title":"Colloid Symp. Monogr."},{"key":"BF319199a0_CR17","volume-title":"Proteins, Amino Acids and Peptides as Ions and Dipolar Ions","author":"EJ Cohn","year":"1943","unstructured":"Cohn, E. J. & Edsall, J. T. in Proteins, Amino Acids and Peptides as Ions and Dipolar Ions, Ch. 9 (ACS Monograph Series, Reinhold, New York, 1943)."},{"key":"BF319199a0_CR18","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1021\/ja00881a009","volume":"84","author":"C Tanford","year":"1962","unstructured":"Tanford, C. J. Am. chem. Soc. 84, 4240\u20134247 (1962).","journal-title":"J. Am. chem. Soc."},{"key":"BF319199a0_CR19","volume-title":"Substitution Constants for Correlation Analysis in Chemistry and Biology","author":"C Hansch","year":"1979","unstructured":"Hansch, C. & Leo, A. in Substitution Constants for Correlation Analysis in Chemistry and Biology (Wiley, New York, 1979)."},{"key":"BF319199a0_CR20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0022-2836(71)90324-X","volume":"55","author":"B Lee","year":"1971","unstructured":"Lee, B. & Richards, F. M. J. molec. Biol. 55, 379\u2013400 (1971).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0022-2836(73)90011-9","volume":"79","author":"A Shrake","year":"1973","unstructured":"Shrake, A. & Rupley, J. A. J. molec. Biol. 79, 351\u2013371 (1973).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0022-2836(78)90201-2","volume":"119","author":"TJ Richmond","year":"1978","unstructured":"Richmond, T. J. & Richards, F. M. J. molec. Biol. 119, 537\u2013555 (1978).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0022-2836(84)90231-6","volume":"178","author":"TJ Richmond","year":"1984","unstructured":"Richmond, T. J. J. molec. Biol. 178, 63\u201389 (1984).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.bb.06.060177.001055","volume":"6","author":"FMA Richards","year":"1977","unstructured":"Richards, F. M. A. Rev. Biophys. Bioengng 6, 151\u2013176 (1977).","journal-title":"Rev. Biophys. Bioengng"},{"key":"BF319199a0_CR25","first-page":"369","volume":"18","author":"J-L Fauchere","year":"1983","unstructured":"Fauchere, J.-L. & Pliska, V. Eur. J. med. Chem.-Chim. ther. 18, 369\u2013375 (1983).","journal-title":"Eur. J. med. Chem.-Chim. ther."},{"key":"BF319199a0_CR26","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1107\/S0567740882004087","volume":"38","author":"RE Stenkamp","year":"1978","unstructured":"Stenkamp, R. E., Sicker, L. C. & Jensen, L. H. Acta crystallogr. B38, 784\u2013792 (1978).","journal-title":"Acta crystallogr."},{"key":"BF319199a0_CR27","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1073\/pnas.71.11.4298","volume":"71","author":"DM Segal","year":"1974","unstructured":"Segal, D. M. et al. Proc. natn. Acad. Sci. U.S.A. 71, 4298\u20134302 (1974).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF319199a0_CR28","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/j100663a023","volume":"76","author":"RB Hermann","year":"1972","unstructured":"Hermann, R. B. J. phys. Chem. 76, 2754\u20132759 (1972).","journal-title":"J. phys. Chem."},{"key":"BF319199a0_CR29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1399-3011.1976.tb02501.x","volume":"8","author":"PK Nandi","year":"1976","unstructured":"Nandi, P. K. Int. J. Peptide Protein Res. 8, 253\u2013264 (1976).","journal-title":"Int. J. Peptide Protein Res."},{"key":"BF319199a0_CR30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0005-2795(78)90392-6","volume":"533","author":"J Gelles","year":"1978","unstructured":"Gelles, J. & Klapper, M. H. Biochim. biophys. Acta 533, 465\u2013477 (1978).","journal-title":"Biochim. biophys. Acta"},{"key":"BF319199a0_CR31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0022-2836(79)90279-1","volume":"129","author":"TE Creighton","year":"1979","unstructured":"Creighton, T. E. J. molec. Biol. 129, 235\u2013264 (1979).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/299371a0","volume":"299","author":"D Eisenberg","year":"1982","unstructured":"Eisenberg, D., Weiss, R. M. & Terwilliger, T. C. Nature 299, 371\u2013374 (1982).","journal-title":"Nature"},{"key":"BF319199a0_CR33","unstructured":"Eisenberg, D., Wilcox, W. & McLachlan, A. D. Proc. UCLA Symp. Protein Structure, Folding and Design (in the press)."},{"key":"BF319199a0_CR34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-2836(84)90309-7","volume":"179","author":"D Eisenberg","year":"1984","unstructured":"Eisenberg, D., Schwarz, E., Komaromy, M. & Wall, R. J. molec. Biol. 179, 125\u2013142 (1984).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-5793(83)80408-6","volume":"159","author":"HJ Pownall","year":"1983","unstructured":"Pownall, H. J., Knapp, R. D., Gotto, A. M. Jr & Massey, J. B. FEBS Lett. 159,17\u201323 (1983).","journal-title":"FEBS Lett."},{"key":"BF319199a0_CR36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1073\/pnas.81.1.140","volume":"81","author":"D Eisenberg","year":"1984","unstructured":"Eisenberg, D., Weiss, R. M. & Terwilliger, T. C. Proc. natn. Acad. Sci. U.S.A. 81, 140\u2013144 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF319199a0_CR37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1073\/pnas.81.1.155","volume":"81","author":"J Finer-Moore","year":"1984","unstructured":"Finer-Moore, J. & Stroud, R.M. Proc. natn. Acad. Sci. U.S.A. 81, 155\u2013159 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF319199a0_CR38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0033583500005333","volume":"17","author":"A Warshel","year":"1984","unstructured":"Warshel, A. & Russell, S. T. Q. Rev. Biophys. 17, 283\u2013422 (1984).","journal-title":"Q. Rev. Biophys."},{"key":"BF319199a0_CR39","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0022-2836(74)90598-1","volume":"82","author":"R Diamond","year":"1974","unstructured":"Diamond, R. J. molec. Biol. 82, 371\u2013391 (1974).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR40","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1107\/S0567739477001958","volume":"33","author":"JL Susman","year":"1977","unstructured":"Susman, J. L., Holbrook, S. R., Church, G. M. & Kirn, S.-H. Acta crystallogr. A33, 800\u2013804 (1977).","journal-title":"Acta crystallogr."},{"key":"BF319199a0_CR41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0022-2836(74)90599-3","volume":"82","author":"M Levitt","year":"1974","unstructured":"Levitt, M. J. molec. Biol. 82, 393\u2013420 (1974).","journal-title":"J. molec. Biol."},{"key":"BF319199a0_CR42","first-page":"614","volume":"32","author":"JH Konnen","year":"1976","unstructured":"Konnen, J. H. Acta crystallogr. A32, 614\u2013617 (1976).","journal-title":"Acta crystallogr."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/319199a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/319199a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/319199a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:10:33Z","timestamp":1684285833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/319199a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":42,"journal-issue":{"issue":"6050","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["BF319199a0"],"URL":"https:\/\/doi.org\/10.1038\/319199a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}