{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:24:36Z","timestamp":1791221076016,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6075","license":[{"start":{"date-parts":[[1986,7,1]],"date-time":"1986-07-01T00:00:00Z","timestamp":520560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1986,7]]},"DOI":"10.1038\/322192a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T04:31:59Z","timestamp":1100752319000},"page":"192-194","source":"Crossref","is-referenced-by-count":145,"title":["Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase"],"prefix":"10.1038","volume":"322","author":[{"given":"James B.","family":"Doherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie M.","family":"Ashe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence W.","family":"Argenbright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Bonney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert O.","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ellen","family":"Dahlgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Conrad P.","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Firestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Hagmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mumford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"O'Grady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Maycock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrenik K.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevan R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF322192a0_CR1","first-page":"S54","volume":"127","author":"JC Powers","year":"1983","unstructured":"Powers, J. C. Am. Rev. respir. Dis. 127, S54\u2013S58 (1983).","journal-title":"Am. Rev. respir. Dis."},{"key":"BF322192a0_CR2","doi-asserted-by":"crossref","first-page":"9848","DOI":"10.1016\/S0021-9258(18)43470-9","volume":"255","author":"M Zimmerman","year":"1980","unstructured":"Zimmerman, M. et al. J. biol Chem. 255, 9848\u20139851 (1980).","journal-title":"J. biol Chem."},{"key":"BF322192a0_CR3","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1016\/S0021-9258(19)68446-2","volume":"256","author":"BM Ashe","year":"1981","unstructured":"Ashe, B. M., Clark, R. L., Jones, H. & Zimmerman, M. J. biol. Chem. 256, 11603\u201311606 (1981).","journal-title":"J. biol. Chem."},{"key":"BF322192a0_CR4","doi-asserted-by":"publisher","first-page":"6785","DOI":"10.1021\/ja00388a053","volume":"104","author":"AR Moorman","year":"1982","unstructured":"Moorman, A. R. & Abeles, R. J. J. Am. chem. Soc. 104, 6785\u20136786 (1982).","journal-title":"J. Am. chem. Soc."},{"key":"BF322192a0_CR5","unstructured":"Mittman, C. (ed.) Pulmonary Emphysema and Proteolysis 1\u2013537 (Academic, New York, 1972)."},{"key":"BF322192a0_CR6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1128\/IAI.14.2.555-563.1976","volume":"14","author":"KJI Thorne","year":"1976","unstructured":"Thorne, K. J. I., Oliver, R. C. & Barrett, A. J. Infect. Immun. 14, 555\u2013563 (1976).","journal-title":"J. Infect. Immun."},{"key":"BF322192a0_CR7","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1172\/JCI108551","volume":"58","author":"J Blondin","year":"1976","unstructured":"Blondin, J. & Janoff, A. J. clin. Invest. 58, 971\u2013979 (1976).","journal-title":"J. clin. Invest."},{"key":"BF322192a0_CR8","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1042\/bj1550265","volume":"155","author":"PM Starkey","year":"1976","unstructured":"Starkey, P. M. & Barrett, A. Biochem. J. 155, 265\u2013271 (1976).","journal-title":"Biochem. J."},{"key":"BF322192a0_CR9","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1515\/bchm2.1974.355.2.1077","volume":"355","author":"W Schmidt","year":"1974","unstructured":"Schmidt, W. & Havemann, K. Hoppe-Seylers Z. physiol. Chem. 355, 1077\u20131082 (1974).","journal-title":"Hoppe-Seylers Z. physiol. Chem."},{"key":"BF322192a0_CR10","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.4049\/jimmunol.107.6.1547","volume":"107","author":"PM Henson","year":"1971","unstructured":"Henson, P. M. J. Immun. 107, 1547\u20131557 (1971).","journal-title":"J. Immun."},{"key":"BF322192a0_CR11","first-page":"1301","volume":"304","author":"CL Sprung","year":"1984","unstructured":"Sprung, C. L., Schultz, D. R. & Clerch, A. R. New Engl. J. Med. 304, 1301\u20131302 (1984).","journal-title":"New Engl. J. Med."},{"key":"BF322192a0_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF00541256","volume":"1","author":"M Velvart","year":"1981","unstructured":"Velvart, M. Rheumatol. Int. 1, 121\u2013130 (1981).","journal-title":"Rheumatol. Int."},{"key":"BF322192a0_CR13","first-page":"115","volume-title":"The Bacterial D-D Carboxypeptides\/transpeptidase Enzyme System","author":"J-M Ghuysen","year":"1976","unstructured":"Ghuysen, J.-M. in The Bacterial D-D Carboxypeptides\/transpeptidase Enzyme System, 115\u2013143 (University of Tokyo Press, 1976)."},{"key":"BF322192a0_CR14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0006-291X(67)80055-X","volume":"27","author":"I Schechter","year":"1967","unstructured":"Schechter, I. & Berger, A. Biochem. biophys. Res. Commun. 27, 157\u2013162 (1967).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF322192a0_CR15","first-page":"186","volume":"30","author":"M Zimmerman","year":"1979","unstructured":"Zimmerman, M. Colloquium Ges. biolog. Chem. 30, 186\u2013195 (1979).","journal-title":"Colloquium Ges. biolog. Chem."},{"key":"BF322192a0_CR16","doi-asserted-by":"publisher","first-page":"5833","DOI":"10.1021\/bi00319a024","volume":"23","author":"DG Brenner","year":"1984","unstructured":"Brenner, D. G. & Knowles, J. R. Biochemistry 23, 5833\u20135839 (1984).","journal-title":"Biochemistry"},{"key":"BF322192a0_CR17","doi-asserted-by":"publisher","first-page":"5839","DOI":"10.1021\/bi00319a025","volume":"23","author":"DG Brenner","year":"1984","unstructured":"Brenner, D. G. & Knowles, J. R. Biochemistry 23, 5839\u20135846 (1984).","journal-title":"Biochemistry"},{"key":"BF322192a0_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1084\/jem.94.4.347","volume":"94","author":"CA Stetson Jr","year":"1951","unstructured":"Stetson, C. A. Jr J. exp. Med. 94, 347\u2013358 (1951).","journal-title":"J. exp. Med."},{"key":"BF322192a0_CR19","first-page":"456","volume-title":"The Inflammatory Process","author":"L Thomas","year":"1965","unstructured":"Thomas, L. in The Inflammatory Process 456\u2013459 (Academic, New York, 1965)."},{"key":"BF322192a0_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1084\/jem.93.1.49","volume":"93","author":"CA Stetson","year":"1951","unstructured":"Stetson, C. A. & Good, R. A. J. exp. Med. 93, 49\u201364 (1951).","journal-title":"J. exp. Med."},{"key":"BF322192a0_CR21","first-page":"405","volume":"43","author":"LW Argenbright","year":"1984","unstructured":"Argenbright, L. W., Ashe, B. M., Zimmerman, M. & Bonney, R. J. Fedn Proc. 43, 405 (1984).","journal-title":"Fedn Proc."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/322192a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/322192a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/322192a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:28:22Z","timestamp":1684286902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/322192a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":21,"journal-issue":{"issue":"6075","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["BF322192a0"],"URL":"https:\/\/doi.org\/10.1038\/322192a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}