{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:06:40Z","timestamp":1783555600858,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6098","license":[{"start":{"date-parts":[[1986,12,1]],"date-time":"1986-12-01T00:00:00Z","timestamp":533779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1986,12]]},"DOI":"10.1038\/324641a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T06:06:40Z","timestamp":1100758000000},"page":"641-646","source":"Crossref","is-referenced-by-count":1083,"title":["The c-erb-A gene encodes a thyroid hormone receptor"],"prefix":"10.1038","volume":"324","author":[{"given":"Cary","family":"Weinberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelita S.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Lebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Gruol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF324641a0_CR1","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1126\/science.2581314","volume":"228","author":"C Weinberger","year":"1985","unstructured":"Weinberger, C. et al. Science 228, 740\u2013742 (1985).","journal-title":"Science"},{"key":"BF324641a0_CR2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/318635a0","volume":"318","author":"SM Hollenberg","year":"1985","unstructured":"Hollenberg, S. M. et al. Nature 318, 635\u2013641 (1985).","journal-title":"Nature"},{"key":"BF324641a0_CR3","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/0092-8674(86)90339-9","volume":"46","author":"V Giguere","year":"1986","unstructured":"Giguere, V., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Cell 46, 645\u2013642 (1986).","journal-title":"Cell"},{"key":"BF324641a0_CR4","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/318670a0","volume":"318","author":"C Weinberger","year":"1985","unstructured":"Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Nature 318, 670\u2013672 (1985).","journal-title":"Nature"},{"key":"BF324641a0_CR5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/320134a0","volume":"320","author":"S Green","year":"1986","unstructured":"Green, S. et al. Nature 320, 134\u2013139 (1986).","journal-title":"Nature"},{"key":"BF324641a0_CR6","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1126\/science.3753802","volume":"231","author":"GL Greene","year":"1986","unstructured":"Greene, G. L. et al. Science 231, 1150\u20131154 (1986).","journal-title":"Science"},{"key":"BF324641a0_CR7","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1073\/pnas.83.15.5424","volume":"83","author":"JM Jeltsch","year":"1986","unstructured":"Jeltsch, J. M. Proc. natn. Acad. Sci. U.S.A. 83, 5424\u20135428 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR8","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1126\/science.2426779","volume":"233","author":"OM Conneely","year":"1986","unstructured":"Conneely, O. M. et al. Science 233, 767\u2013770 (1986).","journal-title":"Science"},{"key":"BF324641a0_CR9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/B978-0-12-452807-9.50015-2","volume-title":"Biochemical Actions of Hormones","author":"NL Eberhardt","year":"1980","unstructured":"Eberhardt, N. L., Apriletti, J. W. & Baxter, J. D. in Biochemical Actions of Hormones Vol. VII (ed. Litwack, G.) 311\u2013394 (Academic, New York, 1980)."},{"key":"BF324641a0_CR10","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1042\/bj0980604","volume":"98","author":"JR Tata","year":"1966","unstructured":"Tata, J. R. & Widnell, C. C. Biochem. J. 98, 604\u2013620 (1966).","journal-title":"Biochem. J."},{"key":"BF324641a0_CR11","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1210\/jcem-35-2-330","volume":"35","author":"JH Oppenheimer","year":"1972","unstructured":"Oppenheimer, J. H., Koerner, D., Schwartz, H. L. & Surks, M.I.J. Clin. Endocr. Metab. 35, 330\u2013333 (1972).","journal-title":"Clin. Endocr. Metab."},{"key":"BF324641a0_CR12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1126\/science.181.4106.1253","volume":"181","author":"HH Samuels","year":"1973","unstructured":"Samuels, H. H., Tsai, J. S. & Cintron, R. Science 181, 1253\u20131256 (1973).","journal-title":"Science"},{"key":"BF324641a0_CR13","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S0006-291X(74)80223-8","volume":"59","author":"JS Tsai","year":"1974","unstructured":"Tsai, J. S. & Samuels, H. H. Biochem. biophys. Res. Commun. 59, 420\u2013428 (1974).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF324641a0_CR14","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1073\/pnas.74.5.1816","volume":"74","author":"JA Martial","year":"1977","unstructured":"Martial, J. A., Baxter, J. D., Goodman, H. M. & Seeburg, P. H. Proc. natn. Acad. Sci. U.S.A. 74, 1816\u20131820 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR15","doi-asserted-by":"publisher","first-page":"7659","DOI":"10.1073\/pnas.79.24.7659","volume":"79","author":"RM Evans","year":"1982","unstructured":"Evans, R. M., Birnberg, N. C. & Rosenfeld, M. G. Proc. natn. Acad. Sci. U.S.A.. 79, 7659\u20137663 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR16","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1073\/pnas.73.10.3369","volume":"73","author":"HH Samuels","year":"1976","unstructured":"Samuels, H. H. & Shapiro, L. E. Proc. natn. Acad. Sci. U.S.A. 73, 3369\u20133373 (1976).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR17","doi-asserted-by":"crossref","first-page":"11627","DOI":"10.1016\/S0021-9258(18)33808-0","volume":"257","author":"BJ Spindler","year":"1982","unstructured":"Spindler, B. J., Mellon, S. H. & Baxter, J. D. J. biol. Chem. 257, 11627\u201311632 (1982).","journal-title":"J. biol. Chem."},{"key":"BF324641a0_CR18","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1016\/S0021-9258(20)82138-3","volume":"259","author":"BM Yaffe","year":"1984","unstructured":"Yaffe, B. M. & Samuels, H. H. J. biol. Chem. 259, 6284\u20136291 (1984).","journal-title":"J. biol. Chem."},{"key":"BF324641a0_CR19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/JVI.36.2.575-585.1980","volume":"36","author":"B Vennstrom","year":"1980","unstructured":"Vennstrom, B., Fanshier, L., Moscovici, C. & Bishop, J. M. J. Virol. 36, 575\u2013585 (1980).","journal-title":"J. Virol."},{"key":"BF324641a0_CR20","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/263211a0","volume":"263","author":"NJ Proudfoot","year":"1976","unstructured":"Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211\u2013214 (1976).","journal-title":"Nature"},{"key":"BF324641a0_CR21","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.6328658","volume":"224","author":"B Debuire","year":"1984","unstructured":"Debuire, B. et al. Science 224, 1456\u20131459 (1984).","journal-title":"Science"},{"key":"BF324641a0_CR22","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/j.1460-2075.1983.tb01463.x","volume":"2","author":"M Jansson","year":"1983","unstructured":"Jansson, M., Philipson, L. & Vennstrom, B. EMBO J. 2, 561\u2013565 (1983).","journal-title":"EMBO J."},{"key":"BF324641a0_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/j.1460-2075.1984.tb01777.x","volume":"3","author":"NK Spurr","year":"1984","unstructured":"Spurr, N. K. et al. EMBO J. 3, 159\u2013163 (1984).","journal-title":"EMBO J."},{"key":"BF324641a0_CR24","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1073\/pnas.81.14.4495","volume":"81","author":"AI Dayton","year":"1984","unstructured":"Dayton, A. I. Proc. natn. Acad. Sci. U.S.A. 81, 4495\u20134499 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1126\/science.6587566","volume":"225","author":"R Lebo","year":"1984","unstructured":"Lebo, R. et al. Science 225, 57\u201359 (1984).","journal-title":"Science"},{"key":"BF324641a0_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/322070a0","volume":"322","author":"A Dejean","year":"1986","unstructured":"Dejean, A., Bougueleret, L., Grzeschik, K.-H. & Tiollais, P. Nature 322, 70\u201372 (1986).","journal-title":"Nature"},{"key":"BF324641a0_CR27","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. Nature 227, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"BF324641a0_CR28","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/j.1460-2075.1986.tb04300.x","volume":"5","author":"A Krust","year":"1986","unstructured":"Krust, A. et al. EMBO J. 5, 891\u2013897 (1986).","journal-title":"EMBO J."},{"key":"BF324641a0_CR29","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1172\/JCI107825","volume":"54","author":"HH Samuels","year":"1974","unstructured":"Samuels, H. H., Tsai, J. S., Casanova, J. & Stanley, F. J. clin. Invest. 54, 853\u2013865 (1974).","journal-title":"J. clin. Invest."},{"key":"BF324641a0_CR30","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI109418","volume":"63","author":"HH Samuels","year":"1979","unstructured":"Samuels, H. H., Stanley, F. & Casanova, J. J clin. Invest. 63, 1229\u20131240 (1979).","journal-title":"J clin. Invest."},{"key":"BF324641a0_CR31","doi-asserted-by":"crossref","first-page":"7388","DOI":"10.1016\/S0021-9258(17)32861-2","volume":"251","author":"KR Latham","year":"1976","unstructured":"Latham, K. R., Ring, J. C. & Baxter, J. D. J. biol. Chem. 251, 7388\u20137397 (1976).","journal-title":"J. biol. Chem."},{"key":"BF324641a0_CR32","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1073\/pnas.79.14.4260","volume":"79","author":"J Carlstedt-Duke","year":"1982","unstructured":"Carlstedt-Duke, J., Okret, S., Wrange, O. & Gustafsson, J.-A. Proc. natn. Acad. Sci. U.S.A. 79, 4260\u20134264 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR33","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/j.1460-2075.1982.tb01161.x","volume":"1","author":"H-G Dellweg","year":"1982","unstructured":"Dellweg, H.-G., Hotz, A., Mugele, K. & Gehring, U. EMBO J. 1, 285\u2013289 (1982).","journal-title":"EMBO J."},{"key":"BF324641a0_CR34","doi-asserted-by":"publisher","first-page":"5376","DOI":"10.1021\/bi00317a042","volume":"23","author":"ME Reichman","year":"1984","unstructured":"Reichman, M. E. et al. Biochemistry 23, 5376\u20135384 (1984).","journal-title":"Biochemistry"},{"key":"BF324641a0_CR35","first-page":"167","volume":"37","author":"MR Sherman","year":"1978","unstructured":"Sherman, M. R., Pickering, L. A., Rollwagen, F. M. & Miller, L. K. Fedn Proc. 37, 167\u201373 (1978).","journal-title":"Fedn Proc."},{"key":"BF324641a0_CR36","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1002\/j.1460-2075.1985.tb03825.x","volume":"4","author":"J Miller","year":"1985","unstructured":"Miller, J., McLachlan, A. D. & Klug, A. EMBO J. 4, 1609\u20131614 (1985).","journal-title":"EMBO J."},{"key":"BF324641a0_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1126\/science.2421409","volume":"232","author":"J Berg","year":"1985","unstructured":"Berg, J. Science 232, 485\u2013487 (1985).","journal-title":"Science"},{"key":"BF324641a0_CR38","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1002\/j.1460-2075.1986.tb04489.x","volume":"5","author":"V Kumar","year":"1986","unstructured":"Kumar, V., Green, S., Staub, A. & Chambon, P. EMBO J. 5, 2231\u20132236 (1986).","journal-title":"EMBO J."},{"key":"BF324641a0_CR39","doi-asserted-by":"crossref","first-page":"9640","DOI":"10.1016\/S0021-9258(18)34120-6","volume":"257","author":"A Pascual","year":"1982","unstructured":"Pascual, A., Casanova, J. & Samuels, H. H. J. biol. Chem. 257, 9640\u20139647 (1982).","journal-title":"J. biol. Chem."},{"key":"BF324641a0_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0092-8674(83)90130-7","volume":"34","author":"T Graf","year":"1983","unstructured":"Graf, T. & Beug, H. Cell 34, 7\u20139 (1983).","journal-title":"Cell"},{"key":"BF324641a0_CR41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0092-8674(83)90513-5","volume":"32","author":"L Frykberg","year":"1983","unstructured":"Frykberg, L. et al. Cell 32, 227\u2013238 (1983).","journal-title":"Cell"},{"key":"BF324641a0_CR42","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0042-6822(83)90125-3","volume":"130","author":"L Sealy","year":"1983","unstructured":"Sealy, L., Privalsky, M. L., Moscovici, G., Moscovici, C. & Bishop, J. M. Virology 130, 155\u2013178 (1983).","journal-title":"Virology"},{"key":"BF324641a0_CR43","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0092-8674(86)90320-X","volume":"45","author":"P Kahn","year":"1986","unstructured":"Kahn, P. et al. Cell 45, 349\u2013356 (1986).","journal-title":"Cell"},{"key":"BF324641a0_CR44","first-page":"49","volume-title":"DNA Cloning, a Practical Approach","author":"TV Huynh","year":"1985","unstructured":"Huynh, T. V., Young, R. A. & Davis, R. W. in DNA Cloning, a Practical Approach Vol 1 (ed. Glover, D.) 49\u201378 (IRL Press, Oxford, 1985)."},{"key":"BF324641a0_CR45","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0022-2836(77)90052-3","volume":"113","author":"PWJ Rigby","year":"1977","unstructured":"Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237\u2013251 (1977).","journal-title":"J. molec. Biol."},{"key":"BF324641a0_CR46","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1073\/pnas.74.2.560","volume":"74","author":"A Maxam","year":"1977","unstructured":"Maxam, A. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560\u2013564 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF324641a0_CR47","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/BF02115583","volume":"23","author":"MS Johnson","year":"1986","unstructured":"Johnson, M. S. & Doolittle, R. F. J. molec. Evol. 23, 267\u2013278 (1986).","journal-title":"J. molec. Evol."},{"key":"BF324641a0_CR48","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"98","author":"EM Southern","year":"1975","unstructured":"Southern, E. M. J. molec. Biol. 98, 503\u2013517 (1975).","journal-title":"J. molec. Biol."},{"key":"BF324641a0_CR49","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.1073\/pnas.77.9.5201","volume":"77","author":"P Thomas","year":"1980","unstructured":"Thomas, P. Proc. natn. Acad. Sci U.S.A. 77, 5201\u20135205 (1980).","journal-title":"Proc. natn. Acad. Sci U.S.A."},{"key":"BF324641a0_CR50","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1021\/bi00591a005","volume":"18","author":"JM Chirgwin","year":"1979","unstructured":"Chirgwin, J. M., Przybyla, A. F., MacDonald, R. J. & Rutter, W. F. Biochemistry 18, 5294\u20135299 (1979).","journal-title":"Biochemistry"},{"key":"BF324641a0_CR51","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/0003-2697(80)90204-3","volume":"101","author":"DJ Gruol","year":"1980","unstructured":"Gruol, D. J. Analyt. Biochem. 101, 387\u2013393 (1980).","journal-title":"Analyt. Biochem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/324641a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/324641a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/324641a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:44:25Z","timestamp":1684287865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/324641a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":51,"journal-issue":{"issue":"6098","published-print":{"date-parts":[[1986,12]]}},"alternative-id":["BF324641a0"],"URL":"https:\/\/doi.org\/10.1038\/324641a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12]]}}}