{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T16:13:47Z","timestamp":1773591227856,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6115","license":[{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1987,4,23]]},"DOI":"10.1038\/326760a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T21:23:05Z","timestamp":1055452985000},"page":"760-765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":322,"title":["Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region"],"prefix":"10.1038","volume":"326","author":[{"given":"C. Geoffrey","family":"Davis","sequence":"first","affiliation":[]},{"given":"Joseph L.","family":"Goldstein","sequence":"additional","affiliation":[]},{"given":"Thomas C.","family":"S\u00fcdhof","sequence":"additional","affiliation":[]},{"given":"Richard G. W.","family":"Anderson","sequence":"additional","affiliation":[]},{"given":"David W.","family":"Russell","sequence":"additional","affiliation":[]},{"given":"Michael S.","family":"Brown","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"BF326760a0_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/307558a0","volume":"307","author":"RF Doolittle","year":"1984","unstructured":"Doolittle, R. F., Feng, D.-F. & Johnson, M. S. Nature 307, 558\u2013566 (1984).","journal-title":"Nature"},{"key":"BF326760a0_CR2","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1126\/science.3873704","volume":"228","author":"TC S\u00fcdhof","year":"1985","unstructured":"S\u00fcdhof, T. C. et al. Science 228, 893\u2013895 (1985).","journal-title":"Science"},{"key":"BF326760a0_CR3","doi-asserted-by":"publisher","first-page":"8834","DOI":"10.1073\/pnas.83.23.8834","volume":"83","author":"RW Jackman","year":"1986","unstructured":"Jackman, R. W., Beeler, D. L., VanDeWater, L. & Rosenberg, R. D. Proc. natn. Acad. Sci. U.S.A. 83, 8834\u20138838 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF326760a0_CR4","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1073\/pnas.83.12.4199","volume":"83","author":"B Dahlback","year":"1986","unstructured":"Dahlback, B., Lundwall, A. & Stenflo, J. Proc. natn. Acad. Sci. U.S.A. 83, 4199\u20134203 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF326760a0_CR5","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/0092-8674(85)90229-6","volume":"43","author":"KA Wharton","year":"1985","unstructured":"Wharton, K. A., Johansen, K. M., Xu, T. & Artavanis-Tsakonas, S. Cell 43, 567\u2013581 (1985).","journal-title":"Cell"},{"key":"BF326760a0_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0092-8674(85)90230-2","volume":"43","author":"I Greenwald","year":"1985","unstructured":"Greenwald, I. Cell 43, 583\u2013590 (1985).","journal-title":"Cell"},{"key":"BF326760a0_CR7","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0968-0004(85)90140-9","volume":"10","author":"RF Doolittle","year":"1985","unstructured":"Doolittle, R. F. Trends biochem. Sci 10, 233\u2013237 (1985).","journal-title":"Trends biochem. Sci"},{"key":"BF326760a0_CR8","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1126\/science.2988123","volume":"228","author":"TC S\u00fcdhof","year":"1985","unstructured":"S\u00fcdhof, T. C., Goldstein, J. L., Brown, M. S. & Russell, D. W. Science 228, 815\u2013822 (1985).","journal-title":"Science"},{"key":"BF326760a0_CR9","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1016\/S0021-9258(17)35862-3","volume":"261","author":"CG Davis","year":"1986","unstructured":"Davis, C. G. et al. J. biol. Chem. 261, 2828\u20132838 (1986).","journal-title":"J. biol. Chem."},{"key":"BF326760a0_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.cb.01.110185.000245","volume":"1","author":"JL Goldstein","year":"1985","unstructured":"Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W. & Schneider, W. J. A. Rev. Cell Biol. 1, 1\u201339 (1985).","journal-title":"A. Rev. Cell Biol."},{"key":"BF326760a0_CR11","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/0092-8674(83)90052-1","volume":"32","author":"MS Brown","year":"1983","unstructured":"Brown, M. S., Anderson, R. G. W. & Goldstein, J. L. Cell 32, 663\u2013667 (1983).","journal-title":"Cell"},{"key":"BF326760a0_CR12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0968-0004(83)90350-X","volume":"8","author":"A Helenius","year":"1983","unstructured":"Helenius, A., Mellman, I., Wall, D. & Hubbard, A. Trends biochem. Sci. 8, 245\u2013250 (1983).","journal-title":"Trends biochem. Sci."},{"key":"BF326760a0_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0092-8674(84)90188-0","volume":"39","author":"T Yamamoto","year":"1984","unstructured":"Yamamoto, T. et al. Cell 39, 27\u201338 (1984).","journal-title":"Cell"},{"key":"BF326760a0_CR14","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1089\/dna.1.1984.3.479","volume":"3","author":"MJ Zoller","year":"1984","unstructured":"Zoller, M. J. & Smith, M. DNA 3, 479\u2013488 (1984).","journal-title":"DNA"},{"key":"BF326760a0_CR15","doi-asserted-by":"publisher","first-page":"5454","DOI":"10.1073\/pnas.81.17.5454","volume":"81","author":"DM Kingsley","year":"1984","unstructured":"Kingsley, D. M. & Kreiger, M. Proc. natn. Acad. Sci. U.S.A. 81, 5454\u20135458 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF326760a0_CR16","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/0092-8674(83)90079-X","volume":"32","author":"H Tolleshaug","year":"1983","unstructured":"Tolleshaug, H., Hobgood, K. K., Brown, M. S. & Goldstein, J. L. Cell 32, 941\u2013951 (1983).","journal-title":"Cell"},{"key":"BF326760a0_CR17","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1016\/S0021-9258(18)32666-8","volume":"258","author":"TO Daniel","year":"1983","unstructured":"Daniel, T. O., Schneider, W. J., Goldstein, J. L. & Brown, M. S. J. biol. Chem. 258, 4606\u20134611 (1983).","journal-title":"J. biol. Chem."},{"key":"BF326760a0_CR18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1172\/JCI111044","volume":"72","author":"MS Brown","year":"1983","unstructured":"Brown, M. S. & Goldstein, J. L. J clin. Invest. 72, 743\u2013747 (1983).","journal-title":"J clin. Invest."},{"key":"BF326760a0_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0304-4157(83)90001-1","volume":"737","author":"RW Mahley","year":"1983","unstructured":"Mahley, R. W. & Innerarity, T. L. Biochim. biophys. Acta 737, 197\u2013222 (1983).","journal-title":"Biochim. biophys. Acta"},{"key":"BF326760a0_CR20","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/S0021-9258(18)34975-5","volume":"257","author":"WJ Schneider","year":"1982","unstructured":"Schneider, W. J., Beisiegel, U., Goldstein, J. L. & Brown, M. S. J. biol. Chem. 257, 2664\u20132673 (1982).","journal-title":"J. biol. Chem."},{"key":"BF326760a0_CR21","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/0092-8674(86)90076-0","volume":"46","author":"M-J Gething","year":"1986","unstructured":"Gething, M.-J., McCammon, K. & Sambrook, J. Cell 46, 939\u2013950 (1986).","journal-title":"Cell"},{"key":"BF326760a0_CR22","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1126\/science.3010466","volume":"232","author":"T Yamamoto","year":"1986","unstructured":"Yamamoto, T., Bishop, R. W., Brown, M. S., Goldstein, J. L. & Russell, D. W. Science 232, 1230\u20131237 (1986).","journal-title":"Science"},{"key":"BF326760a0_CR23","doi-asserted-by":"crossref","first-page":"13114","DOI":"10.1016\/S0021-9258(18)69278-6","volume":"261","author":"HH Hobbs","year":"1986","unstructured":"Hobbs, H. H., Brown, M. S., Goldstein, J. L. & Russell, D. W. J. biol. Chem. 261, 13114\u201313120 (1986).","journal-title":"J. biol. Chem."},{"key":"BF326760a0_CR24","first-page":"1","volume-title":"Molecular Cloning, a Laboratory Manual","author":"T Maniatis","year":"1982","unstructured":"Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning, a Laboratory Manual, 1\u2013545 (Cold Spring Harbor Laboratory Press, New York, 1982)."},{"key":"BF326760a0_CR25","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1172\/JCI111469","volume":"74","author":"M Huettinger","year":"1984","unstructured":"Huettinger, M., Schneider, W. J., Ho, Y. K., Goldstein, J. L. & Brown, M. S. J. clin. Invest. 74, 1017\u20131026 (1984).","journal-title":"J. clin. Invest."},{"key":"BF326760a0_CR26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0076-6879(83)98152-1","volume":"98","author":"JL Goldstein","year":"1983","unstructured":"Goldstein, J. L., Basu, S. K. & Brown, M. S. Meth. Enzym. 98, 241\u2013260 (1983).","journal-title":"Meth. Enzym."},{"key":"BF326760a0_CR27","doi-asserted-by":"crossref","first-page":"11923","DOI":"10.1016\/S0021-9258(19)68494-2","volume":"256","author":"U Beisiegel","year":"1981","unstructured":"Beisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G. W. & Brown, M. S. J. biol. Chem. 256, 11923\u201311931 (1981).","journal-title":"J. biol. Chem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/326760a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/326760a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/326760a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:05:31Z","timestamp":1684861531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/326760a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4,1]]},"references-count":27,"journal-issue":{"issue":"6115","published-print":{"date-parts":[[1987,4,23]]}},"alternative-id":["BF326760a0"],"URL":"https:\/\/doi.org\/10.1038\/326760a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4,1]]},"assertion":[{"value":"12 March 1987","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 1987","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 1987","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}