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Immun. 132, 2199\u20132209 (1984). 5. Guimezanes, A. & Schmitt\u2013Verhulst, A.\u2013M. Eur. J. Immun. 15, 1187\u20131191 (1985). 6. Sprent, J. & Schaefer, M. \/. exp. Med. 162, 2068\u20132088 (1985). 7. Sprent, J., Schaefer, M., Lo, D. & Korngold, R. \/. exp. Med. 163, 998\u20131011 (1986). 8. Dialynas, D. P. et al. J. Immun. 131, 2445\u20132451 (1983). 9. Dialynas, D. P. et al. Immun. Rev. 74, 29\u201356 (1983). 10. Wofsy, D., Mayes, D. C., Woodcock, J. & Seaman, W. E. \/ Immun. 135, 1698\u20131701 (1985). 11. Coulie, P. G., Coutelier, J\u2013P., Uyttenhove, C., Lambotte, P. & Van Snick, J. Eur. J. Immun. 15,638\u2013640(1985). 12. Titus, R. G., Ceredig, R., Cerottini, J\u2013C. & Louis, J. A. J. Immun. 135, 2108\u20132114 (1985). 13. Waldor, M. K. et al. Science 227, 415\u2013417 (1985). 14. Wofsy, D. & Seaman, W. E. J. exp. Med. 161, 378\u2013391 (1985). 15. Fenner, F. Aust. J. exp. Biol. med. Sci. 25, 275\u2013282 (1947). 16. Alien, A. M., Clarke, G. L., Ganaway, J. R., Lock, A. & Werner, R. M. Lab. Anim. Sci. 31, 599\u2013608 (1981). 17. Wallace, G. D. & Buller, R. M. L. Lab. Anim. Sci. 35, 41\u201346 (1985). 18. O'Neill, H. C. & Blanden, R. V. Infect. Immun. 41, 1391\u20131394 (1983). 19. Blanden, R. V. \/. exp. Med. 132, 1035\u20131054 (1970). 20. Blanden,, R. V. \/. exp. Med. 133, 1074\u20131089 (1971). 21. Gardner, I., Bowera, N. A. & Blanden, R. V. Eur. J. Immun. 4, 63\u201367 (1974). 22. Gardner, I., Bowern, N. A. & Blanden, R. V. Eur. J. Immun. 4, 68\u201372 (1974). 23. O'Neill, H. C., Blanden, R. V. & O'Neill, T. J. Immunogenetics 18, 255\u2013265 (1983). 24. Widmer, M. B. & Bach, F. H. Nature 294, 750\u2013752 (1981). 25. Von Boehmer, H. & Turton, K. Eur. J. Immun. 13, 176\u2013179 (1983). 26. Von Boehmer, H., Kisielow, S., Leiserson W. & Haas, W. J. Immun. 133, 59\u201364 (1984). 27. Moldwin, R. L., Lancki, D. W., Herold, K. C. & Fitch, F. W. \/. exp. Med. 163, 1566\u20131582 (1986). 28. Sprent, J., Schaefer, M., Lo, D. & Korngold, R. Immun. Rev. 91, 195\u2013218 (1986). 29. Morse, H. C. Ill et al. J. Immun. 122, 443\u2013454 (1979). 30. Yeh, C.\u2013J. G., Hsi, B.\u2013L. & Faulk, W. P. J. Immun. Meth. 43, 269\u201327'5 (1981). 31. Mishell, R. I. & Dutton, R. W. \/. exp. Med. 126, 423\u2013442 (1967). 32. Buller, R. M. L. & Wallace, G. D. Lab. Anim. 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