{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:19:22Z","timestamp":1776899962437,"version":"3.51.2"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6674","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1038\/32831","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:37:13Z","timestamp":1027672633000},"page":"353-358","source":"Crossref","is-referenced-by-count":897,"title":["The complete genome of the hyperthermophilic bacterium Aquifex aeolicus"],"prefix":"10.1038","volume":"392","author":[{"given":"Gerard","family":"Deckert","sequence":"first","affiliation":[]},{"given":"Patrick V.","family":"Warren","sequence":"additional","affiliation":[]},{"given":"Terry","family":"Gaasterland","sequence":"additional","affiliation":[]},{"given":"William G.","family":"Young","sequence":"additional","affiliation":[]},{"given":"Anna L.","family":"Lenox","sequence":"additional","affiliation":[]},{"given":"David E.","family":"Graham","sequence":"additional","affiliation":[]},{"given":"Ross","family":"Overbeek","sequence":"additional","affiliation":[]},{"given":"Marjory A.","family":"Snead","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Keller","sequence":"additional","affiliation":[]},{"given":"Monette","family":"Aujay","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Huber","sequence":"additional","affiliation":[]},{"given":"Robert A.","family":"Feldman","sequence":"additional","affiliation":[]},{"given":"Jay M.","family":"Short","sequence":"additional","affiliation":[]},{"given":"Gary J.","family":"Olsen","sequence":"additional","affiliation":[]},{"given":"Ronald V.","family":"Swanson","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF32831_CR1","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1126\/science.273.5278.1058","volume":"273","author":"C Bult","year":"1996","unstructured":"Bult, C. et al. Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii . Science 273, 1058\u2013 1073 (1996).","journal-title":"Science"},{"key":"BF32831_CR2","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1126\/science.7542800","volume":"269","author":"RD Fleischmann","year":"1995","unstructured":"Fleischmann, R. D. et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269, 496\u2013 511 (1995).","journal-title":"Science"},{"key":"BF32831_CR3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1126\/science.270.5235.397","volume":"270","author":"CM Fraser","year":"1995","unstructured":"Fraser, C. M. et al. The minimal gene complement of Mycoplasma genitalium. Science 270, 397\u2013403 (1995).","journal-title":"Science"},{"key":"BF32831_CR4","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/41483","volume":"388","author":"J-F Tomb","year":"1997","unstructured":"Tomb, J.-F. et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539\u2013 547 (1997).","journal-title":"Nature"},{"key":"BF32831_CR5","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1093\/nar\/24.22.4420","volume":"24","author":"R Himmelreich","year":"1996","unstructured":"Himmelreich, R. et al . Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res. 24, 4420\u20134449 (1996).","journal-title":"Nucleic Acids Res."},{"key":"BF32831_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/dnares\/3.3.109","volume":"3","author":"T Kaneko","year":"1996","unstructured":"Kaneko, T. et al. Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC7803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res. 3, 109\u2013136 ( 1996).","journal-title":"DNA Res."},{"key":"BF32831_CR7","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1126\/science.277.5331.1453","volume":"277","author":"FR Blattner","year":"1997","unstructured":"Blattner, F. R. et al . The complete genome sequence of Escherichia coli K-12. Science 277, 1453\u2013 1462 (1997).","journal-title":"Science"},{"key":"BF32831_CR8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1126\/science.274.5287.546","volume":"274","author":"A Goffeau","year":"1996","unstructured":"Goffeau, A. et al. Life with 6000 genes. Science 274, 546 (1996).","journal-title":"Science"},{"key":"BF32831_CR9","first-page":"340","volume":"15","author":"R Huber","year":"1992","unstructured":"Huber, R. et al. Aquifex pyrophilus gen. nov. sp. nov. represents a novel group of marine hyperthermophilic hydrogen oxidizing bacteria. Arch. Micrtobiol. 15, 340\u2013351 (1992).","journal-title":"Arch. Micrtobiol."},{"key":"BF32831_CR10","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1128\/AEM.60.6.2113-2119.1994","volume":"60","author":"L Reysenbach","year":"1994","unstructured":"Reysenbach, L., Wickham, G. S. & Pace, N. R. Phylogenetic analysis of the hyperthermophilic pink filament community in Octopus Spring, Yellowstone National Park. Appl. Environ. Microbiol. 60, 2113\u2013 2119 (1994).","journal-title":"Appl. Environ. Microbiol."},{"key":"BF32831_CR11","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1126\/science.17.441.934","volume":"17","author":"WA Setchell","year":"1903","unstructured":"Setchell, W. A. The upper temperature limits of life. Science 17, 934\u2013937 (1903).","journal-title":"Science"},{"key":"BF32831_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.mi.49.100195.000245","volume":"49","author":"TD Brock","year":"1995","unstructured":"Brock, T. D. The road to Yellowstone \u2014 and beyond. Annu. Rev. Microbiol. 49, 1\u201328 (1995 ).","journal-title":"Annu. Rev. Microbiol."},{"key":"BF32831_CR13","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0723-2020(11)80207-9","volume":"15","author":"S Burggraf","year":"1992","unstructured":"Burggraf, S., Olsen, G. J., Stetter, K. O. & Woese, C. R. Aphylogenetic analysis of Aquifex pyrophilus. Syst. Appl. Microbiol. 15, 353\u2013356 ( 1992).","journal-title":"Syst. Appl. Microbiol."},{"key":"BF32831_CR14","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1099\/00207713-44-4-620","volume":"44","author":"C Pitulle","year":"1994","unstructured":"Pitulle, C. et al. Phylogenetic position of the genus Hydrogenobacter. Int. J. Syst. Bacteriol. 44, 620\u2013626 (1994).","journal-title":"Int. J. Syst. Bacteriol."},{"key":"BF32831_CR15","doi-asserted-by":"publisher","first-page":"7749","DOI":"10.1073\/pnas.93.15.7749","volume":"93","author":"SL Baldauf","year":"1996","unstructured":"Baldauf, S. L., Palmer, J. D. & Doolittle, W. F. The root of the universal tree and the origin of eukaryotes based on elongation factor phylogeny. Proc. Natl Acad. Sci. USA 93, 7749\u20137754 ( 1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF32831_CR16","first-page":"139","volume-title":"Molecular Biology of the Archaea","author":"H-P Klenk","year":"1994","unstructured":"Klenk, H.-P., Palm, P. & Zillig, W. in Molecular Biology of the Archaea(eds Pfeifer, F., Palm, P. & Scleeifer, K. H.) 139\u2013147 (Vch Pub, (1994)."},{"key":"BF32831_CR17","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/BF00173160","volume":"41","author":"M Bocchetta","year":"1995","unstructured":"Bocchetta, M. et al . Arrangement and nucleotide sequence of the gene (fus ) encoding elongation factor G (EF-G) from the hyperthermophilic bacterium Aquifex pyrophilus : phylogenetic depth of hyperthermophilic bacteria inferred from analysis of the EF-G\/fus sequences. J. Mol. Evol. 41, 803\u2013812 ( 1995).","journal-title":"J. Mol. Evol."},{"key":"BF32831_CR18","doi-asserted-by":"crossref","first-page":"25928","DOI":"10.1016\/S0021-9258(18)47335-8","volume":"269","author":"JG Wetmur","year":"1994","unstructured":"Wetmur, J. G. et al . Cloning, sequencing, and expression of RecA proteins from three distantly related thermophilic eubacteria. J. Biol. Chem. 269, 25928\u201325935 ( 1994).","journal-title":"J. Biol. Chem."},{"key":"BF32831_CR19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1099\/00207713-34-1-5","volume":"34","author":"T Kawasumi","year":"1984","unstructured":"Kawasumi, T., Igarashi, Y., Kodama, T. & Minoda, Y. Hydrogenobacter thermophilus gen. nov., sp. nov. an extremely thermophilic, aerobic, hydrogen-oxidizing bacterium. Int. J. Syst. Bacteriol. 34, 5\u201310 (1984).","journal-title":"Int. J. Syst. Bacteriol."},{"key":"BF32831_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/BF00446971","volume":"140","author":"J Kristjannson","year":"1985","unstructured":"Kristjannson, J., Ingason, A. & Alfredsson, G. A. Isolation of thermophilic obligately autotrophic hydrogen-oxidizing bacteria, similar to Hydrogenobacter thermophilus, from Icelandic hotsprings. Arch. Microbiol. 140, 321\u2013325 (1985).","journal-title":"Arch. Microbiol."},{"key":"BF32831_CR21","first-page":"611","volume":"52","author":"VR Kryukov","year":"1983","unstructured":"Kryukov, V. R., Savel'eva, N. D. & Pusheva, M. A. Calderobacterium hydrogenophilum gen. nov., sp. nov. an extreme thermophilic bacterium and its hydrogenase activity. Microbiology (Engl. Trans. Mikrobiologiya) 52, 611\u2013618 (1983).","journal-title":"Microbiology (Engl. Trans. Mikrobiologiya)"},{"key":"BF32831_CR22","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1128\/MR.57.4.862-952.1993","volume":"57","author":"M Riley","year":"1993","unstructured":"Riley, M. Functions of the gene products of Escherichia coli. Microbiol. Rev. 57, 862\u2013952 ( 1993).","journal-title":"Microbiol. Rev."},{"key":"BF32831_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0723-2020(89)80051-7","volume":"11","author":"WG Weisburg","year":"1989","unstructured":"Weisburg, W. G., Giovannoni, S. J. & Woese, C. R. The Deinococcus-Thermus phylum and the effect of rRNA composition on phylogenetic tree construction. Syst. Appl. Microbiol. 11, 128\u2013134 ( 1989).","journal-title":"Syst. Appl. Microbiol."},{"key":"BF32831_CR24","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/BF00292082","volume":"160","author":"M Beh","year":"1993","unstructured":"Beh, M., Strauss, G., Huber, R., Stetter, K. O. & Fuchs, G. Enzymes of the reductive citric acid cycle in the autotrophic eubacterium Aquifex pyrophilus and in the archaebacterium Thermoproteus neutrophilus. Arch. Microbiol. 160, 306\u2013311 (1993).","journal-title":"Arch. Microbiol."},{"key":"BF32831_CR25","first-page":"365","volume-title":"Autotrophic Bacteria","author":"G Fuchs","year":"1987","unstructured":"Fuchs, G. in Autotrophic Bacteria(eds Schegel, H. G & Bowein, B.) 365\u2013 382 (Springer, New York, (1987)."},{"key":"BF32831_CR26","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.1128\/jb.178.20.5890-5896.1996","volume":"178","author":"X Mai","year":"1996","unstructured":"Mai, X. & Adams, M. W. Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis. J. Bacteriol. 178, 5890\u20135896 (1996).","journal-title":"J. Bacteriol."},{"key":"BF32831_CR27","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S0014-5793(97)00262-7","volume":"406","author":"JH Lim","year":"1997","unstructured":"Lim, J. H. et al. Cloning and expression of superoxide dismutase from Aquifex pyrophilus, a hyperthermophilic bacterium. FEBS Lett. 406, 142\u2013146 (1997).","journal-title":"FEBS Lett."},{"key":"BF32831_CR28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev.bi.60.070191.002153","volume":"60","author":"RB Bourret","year":"1991","unstructured":"Bourret, R. B., Borkovich, K. A. & Simon, M. I. Signal transduction pathways involving protein phosphorylation in prokaryotes. Annu. Rev. Biochem. 60, 401\u2013441 (1991).","journal-title":"Annu. Rev. Biochem."},{"key":"BF32831_CR29","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1002\/j.1460-2075.1995.tb00099.x","volume":"14","author":"J Rudolph","year":"1995","unstructured":"Rudolph, J., Tolliday, N., Schmitt, C., Schuster, S. C. & Oesterhelt, D. Phosphorylation in halobacterial signal transduction. EMBO J. 14, 4249\u2013 4257 (1995).","journal-title":"EMBO J."},{"key":"BF32831_CR30","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1128\/jb.178.17.5057-5064.1996","volume":"178","author":"KF Jarrell","year":"1996","unstructured":"Jarrell, K. F., Bayley, D. P. & Kostyukova, A. S. The archaeal flagellum: a unique motility structure. J. Bacteriol. 178, 5057\u2013 5064 (1996).","journal-title":"J. Bacteriol."},{"key":"BF32831_CR31","doi-asserted-by":"publisher","first-page":"10470","DOI":"10.1021\/bi00200a031","volume":"33","author":"M Welch","year":"1994","unstructured":"Welch, M., Oosawa, K., Aizawa, S. I. & Eisenbach, M. Effects of phosphorylation, Mg2+, and conformation of the chemotaxis protein CheY on its binding to the flagellar switch protein FliM. Biochemistry 33, 10470\u201310467 (1994).","journal-title":"Biochemistry"},{"key":"BF32831_CR32","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1128\/jb.174.3.793-806.1992","volume":"174","author":"H Sockett","year":"1992","unstructured":"Sockett, H., Yamaguchi, S., Kihara, M., Irikura, V. M. & Macnab, R. M. Molecular analysis of the flagellar switch protein FliM of Salmonella typhimurium. J. Bacteriol. 174, 793\u2013806 ( 1992).","journal-title":"J. Bacteriol."},{"key":"BF32831_CR33","first-page":"2385","volume":"54","author":"H Motoshima","year":"1990","unstructured":"Motoshima, H. et al . Molecular cloning and nucleotide sequence of the aminopeptidase T gene of Thermus aquaticus YT-1 and its high-level expression in Escherichia coli. Agric. Biol. Chem. 54, 2385\u20132392 (1990).","journal-title":"Agric. Biol. Chem."},{"key":"BF32831_CR34","doi-asserted-by":"publisher","first-page":"11819","DOI":"10.1073\/pnas.94.22.11819","volume":"94","author":"AW Curnow","year":"1997","unstructured":"Curnow, A. W. et al . Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. Proc. Natl Acad. Sci. USA 94, 11819\u2013 11826 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF32831_CR35","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/382589b0","volume":"382","author":"AW Curnow","year":"1996","unstructured":"Curnow, A. W., Ibba, M. & S\u00f6ll, D. tRNA-dependent asparagine formation. Nature 382, 589\u2013590 ( 1996).","journal-title":"Nature"},{"key":"BF32831_CR36","doi-asserted-by":"publisher","first-page":"9322","DOI":"10.1074\/jbc.270.16.9322","volume":"270","author":"GF Tu","year":"1995","unstructured":"Tu, G. F., Reid, G. E., Zhang, J. G., Moritz, R. L. & Simpson, R. J. C-terminal extension of truncated proteins in Escherichia coli with a 10Sa decapeptide. J. Biol. Chem. 270, 9322\u20139326 (1995).","journal-title":"J. Biol. Chem."},{"key":"BF32831_CR37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1399-3011.1994.tb00380.x","volume":"43","author":"G B\u00f6hm","year":"1994","unstructured":"B\u00f6hm, G. & Jaenicke, R. Relevance of sequence statistics for the properties of extremophilic proteins. Int. J. Pept. Protein Res. 43, 97\u2013106 ( 1994).","journal-title":"Int. J. Pept. Protein Res."},{"key":"BF32831_CR38","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s007920050025","volume":"1","author":"I-G Choi","year":"1997","unstructured":"Choi, I.-G. et al. Random sequence analysis of genomic DNA of a hyperthermophile: Aquifex pyrophilus. Extremophiles 1, 125\u2013134 (1997).","journal-title":"Extremophiles"},{"key":"BF32831_CR39","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0888-7543(88)90007-9","volume":"2","author":"ES Lander","year":"1988","unstructured":"Lander, E. S. & Waterman, M. S. Genomic mapping by fingerprinting random clones: a mathematical analysis. Genomics 2, 231\u2013239 (1988).","journal-title":"Genomics"},{"key":"BF32831_CR40","doi-asserted-by":"publisher","first-page":"7583","DOI":"10.1093\/nar\/16.15.7583","volume":"16","author":"JM Short","year":"1988","unstructured":"Short, J. M., Fernandez, J. M., Sorge, J. A. & Huse, W. D. Lambda ZAP: a bacteriophage lambda expression vector with in vivo excision properties. Nucleic Acids Res. 16, 7583\u2013 7600 (1988).","journal-title":"Nucleic Acids Res."},{"key":"BF32831_CR41","doi-asserted-by":"publisher","first-page":"9494","DOI":"10.1093\/nar\/17.22.9494","volume":"17","author":"MA Alting-Mees","year":"1989","unstructured":"Alting-Mees, M. A. & Short, J. M. pBluescript II: gene mapping vectors. Nucleic Acids Res. 17, 9494 (1989).","journal-title":"Nucleic Acids Res."},{"key":"BF32831_CR42","doi-asserted-by":"publisher","first-page":"8794","DOI":"10.1073\/pnas.89.18.8794","volume":"89","author":"H Shizuya","year":"1992","unstructured":"Shizuya, H. et al. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl Acad. Sci. USA 89, 8794\u2013 8797 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF32831_CR43","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1093\/nar\/20.5.1083","volume":"20","author":"U-J Kim","year":"1992","unstructured":"Kim, U.-J., Shizuya, H., de Jong, P. J., Birren, B. & Simon, M. I. Stable propagation of cosmid sized human DNA inserts in an F factor based vector. Nucleic Acids Res. 20, 1083\u20131085 ( 1992).","journal-title":"Nucleic Acids Res."},{"key":"BF32831_CR44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul, S. F., Fish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403\u2013410 (1990).","journal-title":"J. Mol. Biol."},{"key":"BF32831_CR45","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1073\/pnas.85.8.2444","volume":"85","author":"WR Pearson","year":"1988","unstructured":"Pearson, W. R. & Lipman, D. J. Improved tools for biological sequence comparison. Proc. Natl Acad. Sci. USA 85, 2444\u20132448 (1988).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF32831_CR46","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/0168-9525(96)81406-5","volume":"12","author":"T Gaasterland","year":"1996","unstructured":"Gaasterland, T. & Sensen, C. W. MAGPIE: automated genome interpretation. Trends Genet. 12, 76\u201378 (1996).","journal-title":"Trends Genet."},{"key":"BF32831_CR47","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/0300-9084(96)84761-4","volume":"78","author":"T Gaasterland","year":"1996","unstructured":"Gaasterland, T. & Sensen, C. W. Fully automated genome analysis that reflects user needs and preferences. A detailed introduction to the MAGPIE system architecture. Biochimie 78, 302\u2013310 (1996).","journal-title":"Biochimie"},{"key":"BF32831_CR48","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/ng0393-266","volume":"3","author":"W Gish","year":"1993","unstructured":"Gish, W. & States, D. J. Identification of protein coding regions by database similarity search. Nature Genet. 3, 266\u2013272 (1993).","journal-title":"Nature Genet."},{"key":"BF32831_CR49","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1093\/nar\/25.5.955","volume":"25","author":"TM Lowe","year":"1997","unstructured":"Lowe, T. M. & Eddy, S. R. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. Nucleic Acids Res. 25, 955\u2013964 ( 1997).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/32831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/32831","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/32831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:17:46Z","timestamp":1684286266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/32831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":49,"journal-issue":{"issue":"6674","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["BF32831"],"URL":"https:\/\/doi.org\/10.1038\/32831","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}