{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:30:50Z","timestamp":1792150250688,"version":"4.4.0"},"reference-count":1,"publisher":"Springer Science and Business Media LLC","issue":"6146","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1987,11]]},"DOI":"10.1038\/330384a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T21:36:57Z","timestamp":1055453817000},"page":"384-386","source":"Crossref","is-referenced-by-count":365,"title":["Characterization of \u03b2-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA"],"prefix":"10.1038","volume":"330","author":[{"given":"Corinne","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E.","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall K.","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell G.","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry A.","family":"Erlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Haig H.","family":"Kazazian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF330384a0_CR1","unstructured":"1. Church, G. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 81, 1991-1995 (1984). 2. Saiki, R. K. et al Science 230, 1350-1354 (1985). 3. Scharf, S. J., Horn, G. T. & Erlich, H. A. Science 233, 1076-1078 (1986). 4. Saiki, R. K. et al. Nature 324, 163-166 (1986). 5. Mullis, K. B. & Faloona, F. Meth. Enzymol. (in the press). 6. Wong, C. et al. Proc. natn. Acad. Sci. U.S.A. 83, 6529-6532 (1986). 7. Wrischnick, L. A. et al. Nucleic Acids Res. 15, 529-542 (1987). 8. Orkin, S. H. et al Nature 296, 627-631 (1982). 9. Kazazian, H. H. Jr et al. Nature 310, 152-154 (1984). 10. Orkin, S. H. & Goff, S. C. \/. biol. Chem. 256, 9782-9784 (1981). 11. Baird, M. et al. Proc. natn. Acad. Sci. U.S.A. 78, 4218-4221 (1981). 12. Nevins, J. R. A. Rev. Biochem. 52, 441-466 (1983). 13. Shatkin, A. J. Cell 9, 645-653 (1976). 14. Kozak, M. Nucleic Acids Res. 12, 857-872 (1984). 15. Myers, R. M., Tilly, K. & Maniatis, T. Science 232, 613-618 (1986). 16. Tabor, S. & Richardson, C. C. Proc. natn. Acad. Sci. U.S.A. 84, 4767-4771 (1987). 17. Blatt, W. F., Robinson, S. M. & Bixter, J. H. Analyt. Biochem. 26, 151 (1968). 18. Sanger, R., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463-5467 (1977)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/330384a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/330384a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/330384a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:32:35Z","timestamp":1684287155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/330384a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":1,"journal-issue":{"issue":"6146","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["BF330384a0"],"URL":"https:\/\/doi.org\/10.1038\/330384a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}