{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:46:35Z","timestamp":1790196395784,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6155","license":[{"start":{"date-parts":[[1988,2,1]],"date-time":"1988-02-01T00:00:00Z","timestamp":570672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1988,2]]},"DOI":"10.1038\/331446a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T21:54:39Z","timestamp":1055454879000},"page":"446-449","source":"Crossref","is-referenced-by-count":122,"title":["A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours"],"prefix":"10.1038","volume":"331","author":[{"given":"C. G.","family":"Humphries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Kuziel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Capra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. R.","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF331446a0_CR1","first-page":"89.1","volume-title":"Genetics and Molecular Immunology","author":"R Riblet","year":"1986","unstructured":"Riblet, R. & Brodeur, P. H. in Genetics and Molecular Immunology (eds. Herzenberg, L. A., Blackwell, C. & Herzenberg, L. A.) 89.1\u201389.6 (Blackwell, Oxford, 1986)."},{"key":"BF331446a0_CR2","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/311727a0","volume":"311","author":"GD Yancopoulos","year":"1984","unstructured":"Yancopoulos, G. D. et al. Nature 311, 727\u2013733 (1984).","journal-title":"Nature"},{"key":"BF331446a0_CR3","volume-title":"Sequences of Proteins of Immunological Interest","author":"EA Kabat","year":"1987","unstructured":"Kabat, E. A. et al. Sequences of Proteins of Immunological Interest Vol. 4 (U.S. Dept. of Health and Human Services, 1987)."},{"key":"BF331446a0_CR4","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0022-2836(86)90239-1","volume":"190","author":"M Kodaira","year":"1986","unstructured":"Kodaira, M. et al. J. molec Biol 190, 529\u2013541 (1986).","journal-title":"J. molec Biol"},{"key":"BF331446a0_CR5","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1073\/pnas.80.3.855","volume":"80","author":"G Rechavi","year":"1983","unstructured":"Rechavi, G. et al. Proc. natn. Acad. Sci. U.S.A. 80, 855\u2013859 (1983).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR6","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1073\/pnas.79.14.4405","volume":"79","author":"G Rechavi","year":"1982","unstructured":"Rechavi, G. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4405\u20134409 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR7","doi-asserted-by":"publisher","first-page":"6561","DOI":"10.1073\/pnas.77.11.6561","volume":"77","author":"G Matthyssens","year":"1980","unstructured":"Matthyssens, G. & Rabbitts, T. H. Proc. natn. Acad. Sci. U.S.A. 77, 6561\u20136565 (1980).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/0022-2836(87)90482-7","volume":"195","author":"KH Lee","year":"1987","unstructured":"Lee, K. H., Matsuda, F., Kinashi, T., Kodaira, M. & Honjo, T. J. Molec. Biol. 195, 761\u2013768 (1987).","journal-title":"Molec. Biol."},{"key":"BF331446a0_CR9","doi-asserted-by":"publisher","first-page":"554","DOI":"10.7326\/0003-4819-84-5-554","volume":"84","author":"W Blattner","year":"1976","unstructured":"Blattner, W. et al. Ann intern. Med. 84, 554\u2013557 (1976).","journal-title":"Ann intern. Med."},{"key":"BF331446a0_CR10","doi-asserted-by":"publisher","first-page":"8563","DOI":"10.1073\/pnas.84.23.8563","volume":"84","author":"A Shen","year":"1987","unstructured":"Shen, A., Humphries, C., Tucker, P. W. & Blattner, F. R. Proc. natn. Acad. Sci. U.S.A. 84, 8563\u20138567 (1987).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR11","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1073\/pnas.81.9.2650","volume":"81","author":"TG Parslow","year":"1984","unstructured":"Parslow, T. G., Blair, D. L., Murphy, N. J. & Granner, D. K. Proc. natn. Acad. Sci. U.S.A. 81, 2650\u20132654 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR12","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1002\/j.1460-2075.1987.tb02597.x","volume":"10","author":"GA Rathbun","year":"1987","unstructured":"Rathbun, G. A., Capra, J. D. & Tucker, P. W. EMBO J. 10, 2931\u20132937 (1987).","journal-title":"EMBO J."},{"key":"BF331446a0_CR13","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0092-8674(85)90141-2","volume":"40","author":"GD Yancopuolos","year":"1985","unstructured":"Yancopuolos, G. D. & Alt, F. W. Cell 40, 271\u2013281 (1985).","journal-title":"Cell"},{"key":"BF331446a0_CR14","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1002\/j.1460-2075.1986.tb04672.x","volume":"5","author":"GE Wu","year":"1986","unstructured":"Wu, G. E. & Paige, C. J. EMBO J. 5, 3475\u20133481 (1986).","journal-title":"EMBO J."},{"key":"BF331446a0_CR15","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1073\/pnas.83.8.2589","volume":"83","author":"SC Riley","year":"1986","unstructured":"Riley, S. C., Connors, S. J., Klinman, N. R. & Ogata, R. T. Proc. natn. Acad. Sci. U.S.A. 83, 2589\u20132592 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR16","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1126\/science.3975629","volume":"227","author":"RM Perlmutter","year":"1985","unstructured":"Perlmutter, R. M., Kearney, J. F., Chang, S. P. & Hood, L. G. Science 227, 1597\u20131601 (1985).","journal-title":"Science"},{"key":"BF331446a0_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0140-6736(77)90074-5","volume":"ii","author":"P Infante","year":"1977","unstructured":"Infante, P., Wagoner, J. & Rinskey, R. Lancet ii, 76\u201378 (1977).","journal-title":"Lancet"},{"key":"BF331446a0_CR18","doi-asserted-by":"publisher","first-page":"508","DOI":"10.2105\/AJPH.69.5.508","volume":"69","author":"A Blair","year":"1979","unstructured":"Blair, A., Decoufle, P. & Grauman, D. Am. J. Public Health 69, 508\u2013511 (1979).","journal-title":"Am. J. Public Health"},{"key":"BF331446a0_CR19","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1126\/science.2883731","volume":"236","author":"DL Mann","year":"1987","unstructured":"Mann, D. L. et al. Science 236, 1103\u20131106 (1987).","journal-title":"Science"},{"key":"BF331446a0_CR20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1084\/jem.152.1.229","volume":"152","author":"LH Boumsell","year":"1980","unstructured":"Boumsell, L. H. et al. J. exp. Med. 152, 229\u2013239 (1980).","journal-title":"J. exp. Med."},{"key":"BF331446a0_CR21","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1126\/science.3020687","volume":"234","author":"P Casali","year":"1986","unstructured":"Casali, P., Inghirami, G., Nakamura, M., Davies, T. F. & Notkins, A. L. Science 234, 476\u2013480 (1986).","journal-title":"Science"},{"key":"BF331446a0_CR22","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1084\/jem.157.1.202","volume":"157","author":"K Hayakawa","year":"1983","unstructured":"Hayakawa, K., Hardy, R. R., Parks, D. R. & Herzenberg, L. A. J. exp. Med. 157, 202\u2013207 (1983).","journal-title":"J. exp. Med."},{"key":"BF331446a0_CR23","doi-asserted-by":"publisher","first-page":"8293","DOI":"10.1073\/pnas.83.21.8293","volume":"83","author":"A Manheimer-Lory","year":"1986","unstructured":"Manheimer-Lory, A., Momestier, M., Bellan, B., Alt, F. & Bona, C. Proc. natn. Acad. Sci. U.S.A. 83, 8293\u20138297 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR24","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1084\/jem.137.2.331","volume":"137","author":"HG Kunkel","year":"1979","unstructured":"Kunkel, H. G., Agnello, V., Joslin, F. G., Winchester, R. J. & Capra, J. D. J. exp. Med. 137, 331\u2013342 (1979).","journal-title":"J. exp. Med."},{"key":"BF331446a0_CR25","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1073\/pnas.84.9.2916","volume":"84","author":"TJ Kipps","year":"1986","unstructured":"Kipps, T. J. et al. Proc. natn. Acad. Sci. U.S.A. 84, 2916\u20132920 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1600-065X.1979.tb00297.x","volume":"48","author":"SM Fu","year":"1979","unstructured":"Fu, S. M., Chiorazzi, N. & Kunkel, H. G. Immunol. Rev. 48, 23\u201335 (1979).","journal-title":"Immunol. Rev."},{"key":"BF331446a0_CR27","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1073\/pnas.81.8.2494","volume":"81","author":"K Hayakawa","year":"1984","unstructured":"Hayakawa, K. et al. Proc. natn. Acad. Sci. U.S.A. 81, 2494\u20132498 (1984).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF331446a0_CR28","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4049\/jimmunol.136.2.505","volume":"136","author":"JH Antin","year":"1986","unstructured":"Antin, J. H., Emerson, S. G., Martin, P., Gadol, N. & Ault, K. A. J. Immun. 136, 505\u2013510 (1986).","journal-title":"J. Immun."},{"key":"BF331446a0_CR29","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1093\/nar\/3.9.2303","volume":"3","author":"N Blin","year":"1976","unstructured":"Blin, N. & Stafford, D. W. Nucleic Acids Res. 3, 2303\u20132308 (1976).","journal-title":"Nucleic Acids Res."},{"key":"BF331446a0_CR30","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1126\/science.6774414","volume":"209","author":"C-P Liu","year":"1980","unstructured":"Liu, C.-P., Tucker, P. W., Mushinski, J. F. & Blattner, F. R. Science 209, 1348\u20131352 (1980).","journal-title":"Science"},{"key":"BF331446a0_CR31","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0378-1119(83)90187-7","volume":"26","author":"W Loenen","year":"1983","unstructured":"Loenen, W. & Blattner, F. R. Gene 26, 171\u2013179 (1983).","journal-title":"Gene"},{"key":"BF331446a0_CR32","first-page":"86.1","volume-title":"Genetics and Molecular Immunology","author":"PW Tucker","year":"1986","unstructured":"Tucker, P. W. in Genetics and Molecular Immunology (eds Herzenberg, L. A., Blackwell, C. & Herzenberg, L. A.) 86.1\u201386.16 (Blackwell, Oxford, 1986)."},{"key":"BF331446a0_CR33","first-page":"771","volume":"19","author":"J Viera","year":"1982","unstructured":"Viera, J. & Messing J. Gene 19, 771\u2013780 (1982).","journal-title":"Gene"},{"key":"BF331446a0_CR34","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","volume":"65","author":"A Maxam","year":"1980","unstructured":"Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499\u2013560 (1980).","journal-title":"Meth. Enzym."},{"key":"BF331446a0_CR35","first-page":"4","volume":"2","author":"DA Bencini","year":"1984","unstructured":"Bencini, D. A., O'Donovan, G. A. & Wild, J. R. Biotechniques 2, 4\u201312 (1984).","journal-title":"Biotechniques"},{"key":"BF331446a0_CR36","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1093\/nar\/8.20.4613","volume":"8","author":"CM Rubin","year":"1980","unstructured":"Rubin, C. M. & Schmidt, C. W. Nucleic Acids Res. 8, 4613\u20134622 (1980).","journal-title":"Nucleic Acids Res."},{"key":"BF331446a0_CR37","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/ijc.2910230206","volume":"23","author":"R Hururitz","year":"1979","unstructured":"Hururitz, R. et al. Int. J. Cancer. 23, 174\u2013180 (1979).","journal-title":"Int. J. Cancer."},{"key":"BF331446a0_CR38","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/294536a0","volume":"24","author":"PA Hieter","year":"1981","unstructured":"Hieter, P. A., Hollis, G. F., Korsmeyer, S. J., Waldmann, T. A. & Leder, P. Nature 24, 536\u2013540 (1981).","journal-title":"Nature"},{"key":"BF331446a0_CR39","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0092-8674(84)90302-7","volume":"37","author":"LH Van der Ploeg","year":"1984","unstructured":"Van der Ploeg, L. H., Schwartz, D. C., Cantor, C. R. & Borst, P. Cell 37, 77\u201384 (1984).","journal-title":"Cell"},{"key":"BF331446a0_CR40","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1093\/nar\/12.14.5647","volume":"12","author":"GF Carle","year":"1984","unstructured":"Carle, G. F. & Olsen, M. V. Nucleic Acids Res. 12, 5647\u20135664 (1984).","journal-title":"Nucleic Acids Res."},{"key":"BF331446a0_CR41","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0092-8674(81)90400-1","volume":"27","author":"J Ravetch","year":"1981","unstructured":"Ravetch, J. et al. Cell 27, 583\u2013591 (1981).","journal-title":"Cell"},{"key":"BF331446a0_CR42","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1021\/bi00591a005","volume":"18","author":"JM Chirgwin","year":"1979","unstructured":"Chirgwin, J. M., Przybyla, A. S., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294\u20135304 (1979).","journal-title":"Biochemistry"},{"key":"BF331446a0_CR43","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.4049\/jimmunol.137.9.2998","volume":"137","author":"M Tutt","year":"1986","unstructured":"Tutt, M. et al. J. Immun. 137, 2998\u20133001 (1986).","journal-title":"J. Immun."},{"key":"BF331446a0_CR44","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.1093\/nar\/9.18.4509","volume":"9","author":"TH Rabbitts","year":"1981","unstructured":"Rabbitts, T. H., Forster, A. & Milstein, C. P. Nucleic Acids Res. 9, 4509\u20134525 (1981).","journal-title":"Nucleic Acids Res."},{"key":"BF331446a0_CR45","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1126\/science.3118465","volume":"238","author":"HW Schroeder","year":"1987","unstructured":"Schroeder, H. W., Hilson, J. L. & Pearlmutter, R. M. Science 238, 791\u2013793 (1987).","journal-title":"Science"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/331446a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/331446a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/331446a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:39:26Z","timestamp":1684287566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/331446a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":45,"journal-issue":{"issue":"6155","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["BF331446a0"],"URL":"https:\/\/doi.org\/10.1038\/331446a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]}}}