{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:41:37Z","timestamp":1772811697960,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"6177","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1988,7]]},"DOI":"10.1038\/334031a0","type":"journal-article","created":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T21:33:38Z","timestamp":1060637618000},"page":"31-36","source":"Crossref","is-referenced-by-count":264,"title":["The human oestrogen receptor functions in yeast"],"prefix":"10.1038","volume":"334","author":[{"given":"D.","family":"Metzger","sequence":"first","affiliation":[]},{"given":"J. H.","family":"White","sequence":"additional","affiliation":[]},{"given":"P.","family":"Chambon","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF334031a0_CR1","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/322697a0","volume":"322","author":"M Ptashne","year":"1986","unstructured":"Ptashne, M. Nature 322, 697\u2013701 (1986).","journal-title":"Nature"},{"key":"BF334031a0_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0092-8674(88)80020-5","volume":"52","author":"L Guarente","year":"1988","unstructured":"Guarente, L. Cell 52, 303\u2013305 (1988).","journal-title":"Cell"},{"key":"BF334031a0_CR3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0092-8674(87)90277-7","volume":"49","author":"K Struhl","year":"1987","unstructured":"Struhl, K. Cell 49, 295\u2013297 (1987).","journal-title":"Cell"},{"key":"BF334031a0_CR4","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev.ge.21.120187.002233","volume":"21","author":"L Guarente","year":"1987","unstructured":"Guarente, L. A. Rev. Genet. 21, 425\u2013452 (1987).","journal-title":"A. Rev. Genet."},{"key":"BF334031a0_CR5","unstructured":"Wasylyk, B. CRC Critical Rev. (in the press)."},{"key":"BF334031a0_CR6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/MMBR.51.4.458-476.1987","volume":"51","author":"M Johnston","year":"1987","unstructured":"Johnston, M. Microbiol. Rev. 51, 458\u2013476 (1987).","journal-title":"Microbiol. Rev."},{"key":"BF334031a0_CR7","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/0092-8674(86)90070-X","volume":"46","author":"IA Hope","year":"1986","unstructured":"Hope, I. A. & Struhl, K. Cell 46, 885\u2013894 (1986).","journal-title":"Cell"},{"key":"BF334031a0_CR8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/319264a0","volume":"319","author":"JM Berg","year":"1986","unstructured":"Berg, J. M. Nature 319, 264\u2013265 (1986).","journal-title":"Nature"},{"key":"BF334031a0_CR9","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1126\/science.3080805","volume":"231","author":"L Keegan","year":"1986","unstructured":"Keegan, L., Gill, G. & Ptashne, M. Science 231, 699\u2013704 (1986).","journal-title":"Science"},{"key":"BF334031a0_CR10","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/0092-8674(87)90081-X","volume":"48","author":"J Ma","year":"1987","unstructured":"Ma, J. & Ptashne, M. Cell 48, 847\u2013853 (1987).","journal-title":"Cell"},{"key":"BF334031a0_CR11","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0092-8674(85)90246-6","volume":"43","author":"R Brent","year":"1985","unstructured":"Brent, R. & Ptashne, M. Cell 43, 729\u2013736 (1985).","journal-title":"Cell"},{"key":"BF334031a0_CR12","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/330444a0","volume":"330","author":"M Petkovich","year":"1987","unstructured":"Petkovich, M., Brand, N. J., Krust, A. & Chambon, P. Nature 330, 444\u2013450 (1987).","journal-title":"Nature"},{"key":"BF334031a0_CR13","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/332850a0","volume":"332","author":"N Brand","year":"1988","unstructured":"Brand, N. et al. Nature 332, 850\u2013853 (1988).","journal-title":"Nature"},{"key":"BF334031a0_CR14","first-page":"8","volume-title":"Growth Factors and Oncogenes in Breast Cancer","author":"S Green","year":"1987","unstructured":"Green, S., Gronemeyer, H. & Chambon, P. in Growth Factors and Oncogenes in Breast Cancer (ed. Sluyser, M.) 8\u201328 (Horwood, New York, 1987)."},{"key":"BF334031a0_CR15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.ge.19.120185.001233","volume":"19","author":"KR Yamamoto","year":"1985","unstructured":"Yamamoto, K. R. A. Rev. Genet. 19, 209\u2013252 (1985).","journal-title":"A. Rev. Genet."},{"key":"BF334031a0_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/325075a0","volume":"325","author":"S Green","year":"1987","unstructured":"Green, S. & Chambon, P. Nature 325, 75\u201378 (1987).","journal-title":"Nature"},{"key":"BF334031a0_CR17","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/0092-8674(87)90581-2","volume":"51","author":"V Kumar","year":"1987","unstructured":"Kumar, V. et al. Cell 51, 941\u2013951 (1987).","journal-title":"Cell"},{"key":"BF334031a0_CR18","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1002\/j.1460-2075.1987.tb02706.x","volume":"6","author":"E Martinez","year":"1987","unstructured":"Martinez, E., Givel, F. & Wahli, W. EMBO J. 6, 3719\u20133727 (1987).","journal-title":"EMBO J."},{"key":"BF334031a0_CR19","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1002\/j.1460-2075.1986.tb04489.x","volume":"5","author":"V Kumar","year":"1986","unstructured":"Kumar, V., Green, S., Staub, A. & Chambon, P. EMBO J. 5, 2231\u20132236 (1986).","journal-title":"EMBO J."},{"key":"BF334031a0_CR20","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1002\/j.1460-2075.1987.tb02741.x","volume":"6","author":"H Gronemeyer","year":"1987","unstructured":"Gronemeyer, H. et al. EMBO J. 6, 3985\u20133994 (1987).","journal-title":"EMBO J."},{"key":"BF334031a0_CR21","unstructured":"Webster, N., Green, S., Jin, J. R. & Chambon, P. Cell (in the press)."},{"key":"BF334031a0_CR22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0092-8674(88)90505-3","volume":"52","author":"N Webster","year":"1988","unstructured":"Webster, N., Jin, J. R., Green, S., Hollis, M. & Chambon, P. Cell 52, 169\u2013178 (1988).","journal-title":"Cell"},{"key":"BF334031a0_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0092-8674(88)90504-1","volume":"52","author":"H Kakidani","year":"1988","unstructured":"Kakidani, H. & Ptashne, M. Cell 52, 161\u2013167 (1988).","journal-title":"Cell"},{"key":"BF334031a0_CR24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/320134a0","volume":"320","author":"S Green","year":"1986","unstructured":"Green, S. et al. Nature 320, 134\u2013139 (1986).","journal-title":"Nature"},{"key":"BF334031a0_CR25","doi-asserted-by":"publisher","first-page":"7791","DOI":"10.1093\/nar\/10.23.7791","volume":"10","author":"RA Hitzeman","year":"1982","unstructured":"Hitzeman, R. A. et al. Nucleic Acids Res. 10, 7791\u20137808 (1982).","journal-title":"Nucleic Acids Res."},{"key":"BF334031a0_CR26","doi-asserted-by":"publisher","first-page":"4900","DOI":"10.1021\/bi00616a007","volume":"17","author":"MJ Holland","year":"1978","unstructured":"Holland, M. J. & Holland, J. P. Biochemistry 17, 4900\u20134907 (1978).","journal-title":"Biochemistry"},{"key":"BF334031a0_CR27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0022-4731(84)90188-2","volume":"20","author":"GL Greene","year":"1984","unstructured":"Greene, G. L., Sobel, N. B., King, W. J. & Jensen, E. V. J. Steroid Biochem. 20, 51\u201356 (1984).","journal-title":"J. Steroid Biochem."},{"key":"BF334031a0_CR28","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1016\/S0021-9258(17)43114-0","volume":"259","author":"A Burshell","year":"1984","unstructured":"Burshell, A., Stathis, P. A., Do, Y., Miller, S. C. & Feldman, D. J. biol. Chem. 259, 3450\u20133456 (1984).","journal-title":"J. biol. Chem."},{"key":"BF334031a0_CR29","first-page":"1055","volume":"41","author":"L Klein-Hitpass","year":"1986","unstructured":"Klein-Hitpass, L., Schorpp, M., Wagner, U. & Ryffel, G. U. Cell 41, 1055\u20131061 (1986).","journal-title":"Cell"},{"key":"BF334031a0_CR30","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1093\/nar\/16.2.647","volume":"16","author":"L Klein-Hitpass","year":"1988","unstructured":"Klein-Hitpass, L., Ryffel, G. U., Heitlinger, E. & Cato, A. C. B. Nucleic Acids Res. 16, 644\u2013663 (1988).","journal-title":"Nucleic Acids Res."},{"key":"BF334031a0_CR31","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/329734a0","volume":"329","author":"G Klock","year":"1987","unstructured":"Klock, G., Str\u00e4hle, V. & Sch\u00fctz, G. Nature 329, 734\u2013736 (1987).","journal-title":"Nature"},{"key":"BF334031a0_CR32","doi-asserted-by":"publisher","first-page":"6505","DOI":"10.1093\/nar\/9.23.6505","volume":"9","author":"M Fried","year":"1981","unstructured":"Fried, M. & Crothers, D. M. Nucleic Acids Res. 9, 6505\u20136525 (1981).","journal-title":"Nucleic Acids Res."},{"key":"BF334031a0_CR33","first-page":"245","volume":"36","author":"VC Jordan","year":"1984","unstructured":"Jordan, V. C. Pharmac. Rev. 36, 245\u2013276 (1984).","journal-title":"Pharmac. Rev."},{"key":"BF334031a0_CR34","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1073\/pnas.82.10.3129","volume":"82","author":"W Hendrickson","year":"1985","unstructured":"Hendrickson, W. & Schleif, R. Proc. natn. Acad. Sci. U.S.A. 82, 3129\u20133133 (1985).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334031a0_CR35","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1128\/MCB.4.11.2467","volume":"4","author":"RW West Jr","year":"1984","unstructured":"West, R. W. Jr, Yocum, R. R. & Ptashne, M. Molec. Cell Biol. 4, 2467\u20132478 (1984).","journal-title":"Molec. Cell Biol."},{"key":"BF334031a0_CR36","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1073\/pnas.85.2.382","volume":"85","author":"E Giniger","year":"1988","unstructured":"Giniger, E. & Ptashne, M. Proc. natn. Sci. U.S.A. 85, 382\u2013386 (1988).","journal-title":"Proc. natn. Sci. U.S.A."},{"key":"BF334031a0_CR37","volume-title":"Current Protocols in Molecular Biology","author":"M Gilman","year":"1987","unstructured":"Gilman, M. in Current Protocols in Molecular Biology (eds Ausubel, F. M. et al.) section 4.7.1\u20134.7.3 (Greene Publishing and Wiley Interscience, New York, 1987)."},{"key":"BF334031a0_CR38","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/304749a0","volume":"304","author":"C Scheidereit","year":"1983","unstructured":"Scheidereit, C., Grisse, S., Westphal, H. M. & Beato, M. Nature 304, 749\u2013752 (1983).","journal-title":"Nature"},{"key":"BF334031a0_CR39","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/308850a0","volume":"308","author":"I Joab","year":"1984","unstructured":"Joab, I. et al. Nature 308, 850\u2013853 (1984).","journal-title":"Nature"},{"key":"BF334031a0_CR40","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1016\/S0021-9258(18)91077-X","volume":"259","author":"FW Farrelly","year":"1984","unstructured":"Farrelly, F. W. & Finkelstein, D. B. J. biol. Chem. 259, 5745\u20135751 (1984).","journal-title":"J. biol. Chem."},{"key":"BF334031a0_CR41","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1146\/annurev.bi.55.070186.005443","volume":"55","author":"S Lindquist","year":"1986","unstructured":"Lindquist, S. A. Rev. Biochem. 55, 1151\u20131191 (1986).","journal-title":"A. Rev. Biochem."},{"key":"BF334031a0_CR42","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0092-8674(88)90506-5","volume":"52","author":"K Lech","year":"1988","unstructured":"Lech, K., Anderson, K. & Brent, R. Cell 52, 179\u2013184 (1988).","journal-title":"Cell"},{"key":"BF334031a0_CR43","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/0092-8674(87)90511-3","volume":"50","author":"K Struhl","year":"1987","unstructured":"Struhl, K. Cell 50, 841\u2013846 (1987).","journal-title":"Cell"},{"key":"BF334031a0_CR44","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1126\/science.2825349","volume":"238","author":"D Bohmann","year":"1987","unstructured":"Bohmann, D. et al. Science 238, 1306\u20131392 (1987).","journal-title":"Science"},{"key":"BF334031a0_CR45","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/332166a0","volume":"332","author":"P Angel","year":"1988","unstructured":"Angel, P. et al. Nature 332, 166\u2013171 (1988).","journal-title":"Nature"},{"key":"BF334031a0_CR46","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0092-8674(88)80039-4","volume":"52","author":"FJ Rauscher","year":"1988","unstructured":"Rauscher, F. J., Sambucetti, L. C., Curran, T., Distel, R. J. & Spiegelman, B. M. Cell 52, 471\u2013480 (1988).","journal-title":"Cell"},{"key":"BF334031a0_CR47","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/319121a0","volume":"319","author":"K Takahashi","year":"1986","unstructured":"Takahashi, K. Nature 319, 121\u2013126 (1986).","journal-title":"Nature"},{"key":"BF334031a0_CR48","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1128\/MCB.8.1.321","volume":"8","author":"LA Allison","year":"1988","unstructured":"Allison, L. A., Wong, K.-C. Z., Fitzpatrick, D., Moyle, M. & Ingles, C. J. J. molec. Cell Biol. 8, 321\u2013329 (1988).","journal-title":"J. molec. Cell Biol."},{"key":"BF334031a0_CR49","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1128\/MCB.8.1.330","volume":"8","author":"MS Bartholomei","year":"1988","unstructured":"Bartholomei, M. S., Halden, N. F., Cullen, C. R. & Corden, J. L. Molec. Cell Biol. 8, 330\u2013339 (1988).","journal-title":"Molec. Cell Biol."},{"key":"BF334031a0_CR50","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/334077a0","volume":"334","author":"B Cavallini","year":"1988","unstructured":"Cavallini, B. et al. Nature 334, 77\u201380 (1988).","journal-title":"Nature"},{"key":"BF334031a0_CR51","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0092-8674(87)90015-8","volume":"51","author":"J Ma","year":"1987","unstructured":"Ma, J. & Ptashne, M. Cell 51, 113\u2013119 (1987).","journal-title":"Cell"},{"key":"BF334031a0_CR52","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/330670a0","volume":"330","author":"E Giniger","year":"1987","unstructured":"Giniger, E. & Ptashne, M. Nature 330, 670\u2013672 (1987).","journal-title":"Nature"},{"key":"BF334031a0_CR53","first-page":"1","volume":"40","author":"P Chambon","year":"1984","unstructured":"Chambon, P. et al. Res. Prog. Hormone Res. 40, 1\u201342 (1984).","journal-title":"Res. Prog. Hormone Res."},{"key":"BF334031a0_CR54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/JB.153.1.163-168.1983","volume":"153","author":"H Ito","year":"1983","unstructured":"Ito, H., Fukuda, Y., Murata, K. & Kimura, A. J. Bacteriol. 153, 163\u2013168 (1983).","journal-title":"J. Bacteriol."},{"key":"BF334031a0_CR55","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1002\/j.1460-2075.1984.tb02269.x","volume":"3","author":"AG Wildeman","year":"1984","unstructured":"Wildeman, A. G., Sassone-Corsi, P., Grundstr\u00f6m, T., Zenke, M. & Chambon, P. EMBO J. 3, 3129\u20133133 (1984).","journal-title":"EMBO J."},{"key":"BF334031a0_CR56","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","volume":"65","author":"AM Maxam","year":"1980","unstructured":"Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499\u2013526 (1980).","journal-title":"Meth. Enzym."},{"key":"BF334031a0_CR57","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1016\/S0021-9258(18)32159-8","volume":"258","author":"M Geiser","year":"1983","unstructured":"Geiser, M., Mattaj, I. W., Wilks, A. F., Seldran, M. & Jost, J.-P. J. biol. Chem. 258, 9024\u20139030 (1983).","journal-title":"J. biol. Chem."},{"key":"BF334031a0_CR58","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/nar\/12.2.1117","volume":"12","author":"JBE Burch","year":"1983","unstructured":"Burch, J. B. E. Nucleic Acids Res. 12, 1117\u20131135 (1983).","journal-title":"Nucleic Acids Res."},{"key":"BF334031a0_CR59","first-page":"143","volume-title":"Methods in Yeast Genetics","author":"FG Sherman","year":"1986","unstructured":"Sherman, F. G., Fink, G. R. & Hicks, J. B. in Methods in Yeast Genetics (eds Sherman, Fink & Hicks) 143\u2013144 (Cold Spring Harbor Laboratory, New York, 1986)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/334031a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/334031a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/334031a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:40:01Z","timestamp":1684287601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/334031a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":59,"journal-issue":{"issue":"6177","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["BF334031a0"],"URL":"https:\/\/doi.org\/10.1038\/334031a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}