{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:02:35Z","timestamp":1776322955202,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6179","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1988,7]]},"DOI":"10.1038\/334213a0","type":"journal-article","created":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T21:34:44Z","timestamp":1060637684000},"page":"213-218","source":"Crossref","is-referenced-by-count":290,"title":["Spliceosomal RNA U6 is remarkably conserved from yeast to mammals"],"prefix":"10.1038","volume":"334","author":[{"given":"David A.","family":"Brow","sequence":"first","affiliation":[]},{"given":"Christine","family":"Guthrie","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF334213a0_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/325673a0","volume":"325","author":"T Maniatis","year":"1987","unstructured":"Maniatis, T. & Reed, R. Nature 325, 673\u2013678 (1987).","journal-title":"Nature"},{"key":"BF334213a0_CR2","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1093\/nar\/12.7.3283","volume":"12","author":"C Hashimoto","year":"1984","unstructured":"Hashimoto, C. & Steitz, J. A. Nucleic Acids Res. 12, 3283\u20133293 (1984).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR3","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/j.1460-2075.1984.tb01977.x","volume":"3","author":"P Bringmann","year":"1984","unstructured":"Bringmann, P. et al. EMBO J. 3, 1357\u20131363 (1984).","journal-title":"EMBO J."},{"key":"BF334213a0_CR4","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1126\/science.2948278","volume":"235","author":"N Riedel","year":"1987","unstructured":"Riedel, N., Wolin, S. & Guthrie, C. Science 235, 328\u2013331 (1987).","journal-title":"Science"},{"key":"BF334213a0_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0092-8674(86)90365-X","volume":"47","author":"M Ares","year":"1986","unstructured":"Ares, M. Cell 47, 49\u201359 (1986).","journal-title":"Cell"},{"key":"BF334213a0_CR6","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/0092-8674(87)90537-X","volume":"49","author":"B Patterson","year":"1987","unstructured":"Patterson, B. & Guthrie, C. Cell 49, 613\u2013624 (1987).","journal-title":"Cell"},{"key":"BF334213a0_CR7","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/0092-8674(87)90032-8","volume":"50","author":"L Kretzner","year":"1987","unstructured":"Kretzner, L., Rymond, B. C. & Rosbash, M. Cell 50, 593\u2013602 (1987).","journal-title":"Cell"},{"key":"BF334213a0_CR8","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1126\/science.3306922","volume":"237","author":"PG Siliciano","year":"1987","unstructured":"Siliciano, P. G., Jones, M. H. & Guthrie, C. Science 237, 1484\u20131487 (1987).","journal-title":"Science"},{"key":"BF334213a0_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0092-8674(87)90031-6","volume":"50","author":"PG Siliciano","year":"1987","unstructured":"Siliciano, P. G., Brow, D. A., Roiha, H. & Guthrie, C. Cell 50, 585\u2013592 (1987).","journal-title":"Cell"},{"key":"BF334213a0_CR10","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1101\/gad.1.9.1014","volume":"1","author":"S-C Cheng","year":"1987","unstructured":"Cheng, S.-C. & Abelson, J. Genes Dev. 1, 1014\u20131027 (1987).","journal-title":"Genes Dev."},{"key":"BF334213a0_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1073\/pnas.85.2.411","volume":"85","author":"AI Lamond","year":"1988","unstructured":"Lamond, A. I., Konarska, M. M., Grabowski, P. J. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 85, 411\u2013415 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334213a0_CR12","doi-asserted-by":"publisher","first-page":"8575","DOI":"10.1073\/pnas.83.22.8575","volume":"83","author":"GR Kunkel","year":"1986","unstructured":"Kunkel, G. R., Maser, R. L., Calvet, J. P. & Pederson, T. Proc. natn. Acad. Sci. U.S.A. 83, 8575\u20138579 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334213a0_CR13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0021-9258(19)75890-6","volume":"262","author":"R Reddy","year":"1987","unstructured":"Reddy, R., Henning, D., Das, G., Harless, M. & Wright, D. J. biol. Chem. 262, 75\u201381 (1987).","journal-title":"J. biol. Chem."},{"key":"BF334213a0_CR14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1002\/j.1460-2075.1988.tb02838.x","volume":"7","author":"G Das","year":"1988","unstructured":"Das, G., Henning, D., Wright, D. & Reddy, R. EMBO J. 7, 503\u2013512 (1988).","journal-title":"EMBO J."},{"key":"BF334213a0_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0092-8674(87)90011-0","volume":"51","author":"P Carbon","year":"1987","unstructured":"Carbon, P. et al. Cell 51, 71\u201379 (1987).","journal-title":"Cell"},{"key":"BF334213a0_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1101\/gad.2.2.196","volume":"2","author":"GR Kunkel","year":"1988","unstructured":"Kunkel, G. R. & Pederson, T. Genes Dev. 2, 196\u2013204 (1988).","journal-title":"Genes Dev."},{"key":"BF334213a0_CR17","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/328356a0","volume":"328","author":"C Bark","year":"1987","unstructured":"Bark, C., Weller, P., Zabielski, J., Janson, L. & Pettersson, U. Nature 328, 356\u2013359 (1987).","journal-title":"Nature"},{"key":"BF334213a0_CR18","doi-asserted-by":"crossref","first-page":"13959","DOI":"10.1016\/S0021-9258(18)47888-X","volume":"262","author":"DA Brow","year":"1987","unstructured":"Brow, D. A. J. biol. Chem. 262, 13959\u201313965 (1987).","journal-title":"J. biol. Chem."},{"key":"BF334213a0_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0092-8674(87)90012-2","volume":"51","author":"S Murphy","year":"1987","unstructured":"Murphy, S., DiLiegro, C. & Melli, M. Cell 51, 81\u201387 (1987).","journal-title":"Cell"},{"key":"BF334213a0_CR20","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0021-9258(19)75769-X","volume":"262","author":"G Das","year":"1987","unstructured":"Das, G., Henning, D. & Reddy, R. J. biol. Chem. 262, 1187\u20131193 (1987).","journal-title":"J. biol. Chem."},{"key":"BF334213a0_CR21","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1093\/nar\/15.6.2463","volume":"15","author":"A Krol","year":"1987","unstructured":"Krol, A., Carbon, P., Ebel, J.-P. & Appel, B. Nucleic Acids Res. 15, 2463\u20132478 (1987).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR22","doi-asserted-by":"publisher","first-page":"6354","DOI":"10.1073\/pnas.78.10.6354","volume":"78","author":"TL Orr-Weaver","year":"1981","unstructured":"Orr-Weaver, T. L., Szostak, J. W. & Rothstein, R. J. Proc. natn. Acad. Sci. U.S.A. 78, 6354\u20136358 (1981).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334213a0_CR23","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/0076-6879(87)54076-9","volume":"154","author":"JD Boeke","year":"1987","unstructured":"Boeke, J. D., Truehart, J., Natsoulis, G. & Fink, G. R. Meth. Enzym. 154, 164\u2013175 (1987).","journal-title":"Meth. Enzym."},{"key":"BF334213a0_CR24","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/0006-291X(80)91620-4","volume":"95","author":"F Harada","year":"1980","unstructured":"Harada, F., Kato, N. & Nishimura, S. Biochem. biophys. Res. Commun. 95, 1332\u20131340 (1980).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF334213a0_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0079-6603(08)60685-6","volume":"30","author":"R Reddy","year":"1983","unstructured":"Reddy, R. & Busch, H. Prog. Nucleic Acid Res. molec. Biol. 30, 127\u2013162 (1983).","journal-title":"Prog. Nucleic Acid Res. molec. Biol."},{"key":"BF334213a0_CR26","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/0022-2836(85)90057-9","volume":"185","author":"J Rinke","year":"1985","unstructured":"Rinke, J., Appel, B., Digweed, M. & L\u00fchrmann, R. J. molec. Biol. 185, 721\u2013731 (1985).","journal-title":"J. molec. Biol."},{"key":"BF334213a0_CR27","doi-asserted-by":"publisher","first-page":"9373","DOI":"10.1073\/pnas.83.24.9373","volume":"83","author":"SM Freier","year":"1986","unstructured":"Freier, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 83, 9373\u20139377 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334213a0_CR28","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1073\/pnas.83.8.2387","volume":"83","author":"S-C Cheng","year":"1986","unstructured":"Cheng, S.-C. & Abelson, J. Proc. natn. Acad. Sci. U.S.A. 83, 2387\u20132391 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334213a0_CR29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/324341a0","volume":"324","author":"CW Pikielny","year":"1986","unstructured":"Pikielny, C. W., Rymond, B. C. & Rosbash, M. Nature 324, 341\u2013345 (1986).","journal-title":"Nature"},{"key":"BF334213a0_CR30","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/0092-8674(86)90345-4","volume":"46","author":"DL Black","year":"1986","unstructured":"Black, D. L. & Steitz, J. A. Cell 46, 697\u2013704 (1986).","journal-title":"Cell"},{"key":"BF334213a0_CR31","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.1093\/nar\/9.19.5145","volume":"9","author":"Y Ohshima","year":"1981","unstructured":"Ohshima, Y., Okada, N., Tani, T., Itoh, Y. & Itoh, M. Nucleic Acids Res. 9, 5145\u20135158 (1981).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0076-6879(80)65011-3","volume":"65","author":"TE England","year":"1980","unstructured":"England, T. E., Bruce, A. G. & Uhlenbeck, O. C. Meth. Enzym. 65, 65\u201374 (1980).","journal-title":"Meth. Enzym."},{"key":"BF334213a0_CR33","doi-asserted-by":"crossref","first-page":"13953","DOI":"10.1016\/S0021-9258(18)47887-8","volume":"262","author":"DA Brow","year":"1987","unstructured":"Brow, D. A. & Geiduschek, E. P. J. biol Chem. 262, 13953\u201313958 (1987).","journal-title":"J. biol Chem."},{"key":"BF334213a0_CR34","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1093\/nar\/4.8.2527","volume":"4","author":"H Donis-Keller","year":"1977","unstructured":"Donis-Keller, H., Maxam, A. M. & Gilbert, W. Nucleic Acids Res. 4, 2527\u20132538 (1977).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/5.1.37","volume":"5","author":"RE Lockhard","year":"1978","unstructured":"Lockhard, R. E. et al. Nucleic Acids Res. 5, 37\u201356 (1978).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR36","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.1093\/nar\/14.14.5813","volume":"14","author":"D McPheeters","year":"1986","unstructured":"McPheeters, D. et al. Nucleic Acids Res. 14, 5813\u20135826 (1986).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR37","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0076-6879(83)01024-1","volume":"101","author":"JR Broach","year":"1983","unstructured":"Broach, J. R. Meth. Enzym. 101, 307\u2013325 (1983).","journal-title":"Meth. Enzym."},{"key":"BF334213a0_CR38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/JB.153.1.163-168.1983","volume":"153","author":"H Ito","year":"1983","unstructured":"Ito, H., Fukuda, Y., Murata, K. & Kimura, A. J. Bact. 153, 163\u2013168 (1983).","journal-title":"J. Bact."},{"key":"BF334213a0_CR39","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/0076-6879(87)52056-0","volume":"152","author":"MD Rose","year":"1987","unstructured":"Rose, M. D. Meth. Enzym. 152, 481\u2013504 (1987).","journal-title":"Meth. Enzym."},{"key":"BF334213a0_CR40","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/nar\/15.2.543","volume":"15","author":"T Kiss","year":"1987","unstructured":"Kiss, T., Antal, M. & Solymosy, F. Nucleic Acids Res. 15, 543\u2013560 (1987).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00798382","volume":"8","author":"Sri-Widada","year":"1981","unstructured":"Sri-Widada et al. Molec. Biol. Rep. 8, 29\u201336 (1981).","journal-title":"Molec. Biol. Rep."},{"key":"BF334213a0_CR42","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/nar\/15.1.371","volume":"15","author":"HB Skinner","year":"1987","unstructured":"Skinner, H. B. & Adams, D. S. Nucleic Acids Res. 15, 371 (1987).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR43","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1016\/S0021-9258(19)69641-9","volume":"256","author":"R Reddy","year":"1981","unstructured":"Reddy, R., Henning, D. & Busch, H. J. biol. Chem. 256, 3532\u20133538 (1981).","journal-title":"J. biol. Chem."},{"key":"BF334213a0_CR44","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/0006-291X(81)90785-3","volume":"99","author":"N Kato","year":"1981","unstructured":"Kato, N. & Harada, F. Biochem. biophys. Res. Commun. 99, 1477\u20131485 (1981).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF334213a0_CR45","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1093\/nar\/9.12.2699","volume":"9","author":"A Krol","year":"1981","unstructured":"Krol, A. et al. Nucleic Acids Res. 9, 2699\u20132716 (1981).","journal-title":"Nucleic Acids Res."},{"key":"BF334213a0_CR46","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","volume":"11","author":"JD Dignam","year":"1983","unstructured":"Dignam, J. D., Lebovitz, R. M. & Roeder, R. G. Nucleic Acids Res. 11, 1475\u20131489 (1983).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/334213a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/334213a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/334213a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:41:21Z","timestamp":1684287681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/334213a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":46,"journal-issue":{"issue":"6179","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["BF334213a0"],"URL":"https:\/\/doi.org\/10.1038\/334213a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}