{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:38:50Z","timestamp":1775151530620,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6181","license":[{"start":{"date-parts":[[1988,8,1]],"date-time":"1988-08-01T00:00:00Z","timestamp":586396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1988,8]]},"DOI":"10.1038\/334440a0","type":"journal-article","created":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T21:35:28Z","timestamp":1060637728000},"page":"440-444","source":"Crossref","is-referenced-by-count":307,"title":["Extensive variation of human immunodeficiency virus type-1 in vivo"],"prefix":"10.1038","volume":"334","author":[{"given":"Michael S.","family":"Saag","sequence":"first","affiliation":[]},{"given":"Beatrice H.","family":"Hahn","sequence":"additional","affiliation":[]},{"given":"Joseph","family":"Gibbons","sequence":"additional","affiliation":[]},{"given":"Yuexia","family":"Li","sequence":"additional","affiliation":[]},{"given":"Elizabeth S.","family":"Parks","sequence":"additional","affiliation":[]},{"given":"Wade P.","family":"Parks","sequence":"additional","affiliation":[]},{"given":"George M.","family":"Shaw","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[1988,8,1]]},"reference":[{"key":"BF334440a0_CR1","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1126\/science.6095449","volume":"226","author":"GM Shaw","year":"1984","unstructured":"Shaw, G. M. et al. Science 226, 1165\u20131171 (1984).","journal-title":"Science"},{"key":"BF334440a0_CR2","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1126\/science.2992084","volume":"229","author":"F Wong-Staal","year":"1985","unstructured":"Wong-Staal, F. et al. Science 229, 759\u2013762 (1985).","journal-title":"Science"},{"key":"BF334440a0_CR3","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1126\/science.2997922","volume":"230","author":"S Benn","year":"1985","unstructured":"Benn, S. et al. Science 230, 949\u2013951 (1985).","journal-title":"Science"},{"key":"BF334440a0_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0092-8674(86)90860-3","volume":"46","author":"M Alizon","year":"1986","unstructured":"Alizon, M., Wain-Hobson, S., Montagnier, L. & Sonigo, P. Cell 46, 63\u201374 (1986).","journal-title":"Cell"},{"key":"BF334440a0_CR5","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/0092-8674(86)90778-6","volume":"45","author":"B Starcich","year":"1986","unstructured":"Starcich, B. et al. Cell 45, 637\u2013648 (1986).","journal-title":"Cell"},{"key":"BF334440a0_CR6","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1073\/pnas.83.14.5038","volume":"83","author":"RL Willey","year":"1986","unstructured":"Willey, R. L. et al. Proc. natn. Acad. Sci. U.S.A. 83, 5038\u20135042 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334440a0_CR7","doi-asserted-by":"publisher","first-page":"8380","DOI":"10.1073\/pnas.83.21.8380","volume":"83","author":"SM Desai","year":"1986","unstructured":"Desai, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 83, 8380\u20138384 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334440a0_CR8","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1126\/science.3012778","volume":"232","author":"B Hahn","year":"1986","unstructured":"Hahn, B. et al. Science 232, 1548\u20131553 (1986).","journal-title":"Science"},{"key":"BF334440a0_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0092-8674(86)90851-2","volume":"46","author":"JM Coffin","year":"1986","unstructured":"Coffin, J. M. Cell 46, 1\u20134 (1986).","journal-title":"Cell"},{"key":"BF334440a0_CR10","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1182\/blood.V69.6.1766.1766","volume":"69","author":"A Srinivasan","year":"1987","unstructured":"Srinivasan, A. et al. Blood 69, 1766\u20131770 (1987).","journal-title":"Blood"},{"key":"BF334440a0_CR11","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1128\/JVI.54.2.552-560.1985","volume":"54","author":"RC Desrosiers","year":"1985","unstructured":"Desrosiers, R. C. et al. J. Virol. 54, 552\u2013560 (1985).","journal-title":"J. Virol."},{"key":"BF334440a0_CR12","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/331619a0","volume":"331","author":"HW Kestler","year":"1988","unstructured":"Kestler, H. W. et al. Nature 331, 619\u2013621 (1988).","journal-title":"Nature"},{"key":"BF334440a0_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1128\/JVI.62.1.139-147.1988","volume":"62","author":"RL Willey","year":"1987","unstructured":"Willey, R. L. et al. J. Virol. 62, 139\u2013147 (1987).","journal-title":"J. Virol."},{"key":"BF334440a0_CR14","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1128\/JVI.61.4.1266-1270.1987","volume":"61","author":"S Payne","year":"1987","unstructured":"Payne, S., Salinovich, O., Nauman, S., Issel, C. & Montelaro, R. J. Virol. 61, 1266\u20131270 (1987).","journal-title":"J. Virol."},{"key":"BF334440a0_CR15","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0042-6822(87)90124-3","volume":"161","author":"S Payne","year":"1987","unstructured":"Payne, S. et al. Virology 161, 321\u2013331 (1987).","journal-title":"Virology"},{"key":"BF334440a0_CR16","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1126\/science.2893454","volume":"239","author":"J Overbaugh","year":"1988","unstructured":"Overbaugh, J., Donahue, P. R., Quackenbush, S. L., Hoover, E. A. & Mullins, J. I. Science 239, 906\u2013910 (1988).","journal-title":"Science"},{"key":"BF334440a0_CR17","doi-asserted-by":"crossref","first-page":"10539","DOI":"10.1016\/S0021-9258(18)90997-X","volume":"259","author":"RC Montelaro","year":"1984","unstructured":"Montelaro, R. C., Parekh, B., Orrego, A. & Issel, C. J. J. biol. Chem. 259, 10539\u201310544 (1984).","journal-title":"J. biol. Chem."},{"key":"BF334440a0_CR18","doi-asserted-by":"publisher","first-page":"4454","DOI":"10.1073\/pnas.77.8.4454","volume":"77","author":"JE Clements","year":"1980","unstructured":"Clements, J. E., Pedersen, F. S., Narayan, O. & Haseltine, W. A. Proc. natn. Acad. Sci. U.S.A. 77, 4454\u20134458 (1980).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF334440a0_CR19","first-page":"60","volume":"8","author":"O Narayan","year":"1987","unstructured":"Narayan, O., Clements, J., Kennedy-Stoskopf, S., Sheffer, D. & Royal, W. Contr. Microbiol. Immunol. 8, 60\u201376 (1987).","journal-title":"Contr. Microbiol. Immunol."},{"key":"BF334440a0_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.3014648","volume":"233","author":"S Gartner","year":"1986","unstructured":"Gartner, S., Markovits, P., Markovits, D. M., Betts, R. F. & Popovic, M. Science 233, 215\u2013219 (1986).","journal-title":"Science"},{"key":"BF334440a0_CR21","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1126\/science.3646751","volume":"236","author":"Y Koyanagi","year":"1987","unstructured":"Koyanagi, Y. et al. Science 236, 819\u2013822 (1987).","journal-title":"Science"},{"key":"BF334440a0_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.2832945","volume":"240","author":"C Cheng-Meyer","year":"1988","unstructured":"Cheng-Meyer, C., Seto, D., Tateno, M. & Levy, J. A. Science 240, 80\u201382 (1988).","journal-title":"Science"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/334440a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/334440a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/334440a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:43:07Z","timestamp":1684287787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/334440a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":22,"journal-issue":{"issue":"6181","published-print":{"date-parts":[[1988,8]]}},"alternative-id":["BF334440a0"],"URL":"https:\/\/doi.org\/10.1038\/334440a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8]]}}}