{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:54:23Z","timestamp":1770702863169,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6197","license":[{"start":{"date-parts":[[1988,11,1]],"date-time":"1988-11-01T00:00:00Z","timestamp":594345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1988,11]]},"DOI":"10.1038\/336388a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T22:02:39Z","timestamp":1055455359000},"page":"388-390","source":"Crossref","is-referenced-by-count":108,"title":["Deletion of self-reactive T cells before entry into the thymus medulla"],"prefix":"10.1038","volume":"336","author":[{"given":"Hans","family":"Hengartner","sequence":"first","affiliation":[]},{"given":"Bernhard","family":"Odermat","sequence":"additional","affiliation":[]},{"given":"Reto","family":"Schneider","sequence":"additional","affiliation":[]},{"given":"Magali","family":"Schreyer","sequence":"additional","affiliation":[]},{"given":"Gaby","family":"W\u00e4lle","sequence":"additional","affiliation":[]},{"given":"H. Robson","family":"MacDonald","sequence":"additional","affiliation":[]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF336388a0_CR1","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.137.10.3195","volume":"137","author":"RC Howe","year":"1986","unstructured":"Howe, R. C., Lowenthal, J. W. & MacDonald, H. R. J. Immun. 137, 3195\u20133200 (1986).","journal-title":"J. Immun."},{"key":"BF336388a0_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/j.1460-2075.1987.tb04723.x","volume":"6","author":"R Palacios","year":"1987","unstructured":"Palacios, R., Sideras, P. & von Boehmer, H. EMBO J. 6, 91\u201395 (1987).","journal-title":"EMBO J."},{"key":"BF336388a0_CR3","first-page":"1417","volume":"5","author":"AL Goldstein","year":"1983","unstructured":"Goldstein, A. L. & Low, T. L. K. Prog. Immun. 5, 1417\u20131427 (1983).","journal-title":"Prog. Immun."},{"key":"BF336388a0_CR4","first-page":"1563","volume":"5","author":"JF Bach","year":"1983","unstructured":"Bach, J. F. Prog. Immun. 5, 1563\u20131579 (1983).","journal-title":"Prog. Immun."},{"key":"BF336388a0_CR5","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1084\/jem.151.4.925","volume":"151","author":"H Wekerle","year":"1980","unstructured":"Wekerle, H., Ketelsen, U. P. & Ernst, M. J. exp. Med. 151, 925\u2013944 (1980).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/287044a0","volume":"287","author":"DL Longo","year":"1980","unstructured":"Longo, D. L. & Schwartz, R. H. Nature 287, 44\u201345 (1980).","journal-title":"Nature"},{"key":"BF336388a0_CR7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1084\/jem.163.2.231","volume":"163","author":"BA Kyewski","year":"1986","unstructured":"Kyewski, B. A., Fathman, C. G. & Rouse, R. V. J. exp. Med. 163, 231\u2013246 (1986).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/308196a0","volume":"308","author":"BA Kyewski","year":"1984","unstructured":"Kyewski, B. A., Fathman, C. G. & Kaplan, H. S. Nature 308, 196\u2013199 (1984).","journal-title":"Nature"},{"key":"BF336388a0_CR9","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/317811a0","volume":"317","author":"R Kingston","year":"1985","unstructured":"Kingston, R., Jenkinson, E. J. & Owen, J. J. T. Nature 317, 811\u2013813 (1985).","journal-title":"Nature"},{"key":"BF336388a0_CR10","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/0092-8674(85)90183-7","volume":"43","author":"AG Farr","year":"1985","unstructured":"Farr, A. G., Anderson, S. K., Marrack, P. & Kappler, J. W. Cell 43, 543\u2013550 (1985).","journal-title":"Cell"},{"key":"BF336388a0_CR11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1084\/jem.126.2.291","volume":"126","author":"IL Weissman","year":"1967","unstructured":"Weissman, I. L. J. exp. Med. 126, 291\u2013304 (1967).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR12","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1084\/jem.166.2.577","volume":"166","author":"RC Budd","year":"1987","unstructured":"Budd, R. C. et al. J. exp. Med. 166, 577\u2013582 (1987).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1600-065X.1988.tb00731.x","volume":"101","author":"H von Boehmer","year":"1988","unstructured":"von Boehmer, H., Karjalainen, K., Pelkonen, J., Borgulya, P. & Rammensee, H. G. Immunol. Rev. 101, 21\u201337 (1988).","journal-title":"Immunol. Rev."},{"key":"BF336388a0_CR14","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1084\/jem.161.5.1048","volume":"161","author":"JP Lugo","year":"1985","unstructured":"Lugo, J. P. et al. J. exp. Med. 161, 1048\u20131062 (1985).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR15","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.137.8.2579","volume":"137","author":"JW Lowenthal","year":"1986","unstructured":"Lowenthal, J. W., Howe, R. C., Ceredig, R. & MacDonald, H. R. J. Immun. 137, 2579\u20132584 (1986).","journal-title":"J. Immun."},{"key":"BF336388a0_CR16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-065X.1984.tb01118.x","volume":"82","author":"R Scollay","year":"1984","unstructured":"Scollay, R., Bartlett, P. & Shortman, K. Immunol. Rev. 82, 79\u2013103 (1984).","journal-title":"Immunol. Rev."},{"key":"BF336388a0_CR17","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/329336a0","volume":"329","author":"IN Crispe","year":"1987","unstructured":"Crispe, I. N., Moore, M. W., Husmann, L. A., Smith, L. & Bevan, M. J. Nature 329, 336\u2013339 (1987).","journal-title":"Nature"},{"key":"BF336388a0_CR18","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1084\/jem.147.3.882","volume":"147","author":"RM Zinkernagel","year":"1978","unstructured":"Zinkernagel, R. M. et al. J. exp. Med. 147, 882\u2013896 (1978).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR19","unstructured":"Payne, J. et al. Proc. natn. Acad. Sci. U.S.A. (in the press)."},{"key":"BF336388a0_CR20","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/332040a0","volume":"332","author":"HR MacDonald","year":"1988","unstructured":"MacDonald, H. R. et al. Nature 332, 40\u201345 (1988).","journal-title":"Nature"},{"key":"BF336388a0_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/332035a0","volume":"332","author":"JW Kappler","year":"1988","unstructured":"Kappler, J. W., Staerz, U. D., White, J. & Marrack, P. Nature 332, 35\u201340 (1988).","journal-title":"Nature"},{"key":"BF336388a0_CR22","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1084\/jem.157.4.1149","volume":"157","author":"K Haskins","year":"1984","unstructured":"Haskins, K. et al. J. exp. Med. 157, 1149\u20131169 (1984).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1084\/jem.165.1.257","volume":"165","author":"MA Behlke","year":"1987","unstructured":"Behlke, M. A. et al. J. exp. Med. 165, 257\u2013262 (1987).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR24","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1002\/j.1460-2075.1986.tb04577.x","volume":"5","author":"A Cristanti","year":"1986","unstructured":"Cristanti, A., Colantoni, A., Snodgrass, R. & von Boehmer, H. EMBO J. 5, 2837\u20132843 (1986).","journal-title":"EMBO J."},{"key":"BF336388a0_CR25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0092-8674(85)80104-5","volume":"42","author":"GK Sim","year":"1985","unstructured":"Sim, G. K. & Augustin, A. A. Cell 42, 89\u201392 (1985).","journal-title":"Cell"},{"key":"BF336388a0_CR26","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1084\/jem.153.6.1666","volume":"153","author":"AN Barclay","year":"1981","unstructured":"Barclay, A. N. & Mayrhofer, G. J. exp. Med. 153, 1666\u20131671 (1981).","journal-title":"J. exp. Med."},{"key":"BF336388a0_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1600-065X.1988.tb00737.x","volume":"101","author":"J Sprent","year":"1988","unstructured":"Sprent, J., Lo, D., Gao, K. E. & Ron, Y. Immunol. Rev. 101, 173\u2013190 (1988).","journal-title":"Immunol. Rev."},{"key":"BF336388a0_CR28","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/eji.1830170711","volume":"17","author":"BA Kyewski","year":"1987","unstructured":"Kyewski, B. A., Momburg, F. & Schirrmacher, V. Eur. J. Immun. 17, 961\u2013967 (1987).","journal-title":"Eur. J. Immun."},{"key":"BF336388a0_CR29","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/335174a0","volume":"335","author":"HR MacDonald","year":"1988","unstructured":"MacDonald, H. R., Hengartner, H. & Pedrazzini, T. Nature 335, 174\u2013176 (1988).","journal-title":"Nature"},{"key":"BF336388a0_CR30","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/334620a0","volume":"334","author":"BJ Fowlkes","year":"1988","unstructured":"Fowlkes, B. J., Schwartz, R. H. & Pardoll, D. N. Nature 334, 620\u2013623 (1988).","journal-title":"Nature"},{"key":"BF336388a0_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0167-5699(86)90152-0","volume":"7","author":"E Duvall","year":"1986","unstructured":"Duvall, E. & Wyllie, A. H. Immun. Today 7, 115\u2013119 (1986).","journal-title":"Immun. Today"},{"key":"BF336388a0_CR32","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.4049\/jimmunol.136.12.4337","volume":"136","author":"HR MacDonald","year":"1986","unstructured":"MacDonald, H. R., Blanc, C., Lees, R. L. & Sordat, B. J. Immun. 136, 4337\u20134339 (1986).","journal-title":"J. Immun."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/336388a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/336388a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/336388a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:56:34Z","timestamp":1684288594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/336388a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11]]},"references-count":32,"journal-issue":{"issue":"6197","published-print":{"date-parts":[[1988,11]]}},"alternative-id":["BF336388a0"],"URL":"https:\/\/doi.org\/10.1038\/336388a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,11]]}}}