{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:30:23Z","timestamp":1769110223544,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6210","license":[{"start":{"date-parts":[[1989,3,1]],"date-time":"1989-03-01T00:00:00Z","timestamp":604713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1989,3]]},"DOI":"10.1038\/338076a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T22:11:05Z","timestamp":1055455865000},"page":"76-78","source":"Crossref","is-referenced-by-count":66,"title":["Positive selection of CD4-CD8+ T cells in the thymus of normal mice"],"prefix":"10.1038","volume":"338","author":[{"given":"Juan Carlos","family":"Zu\u00f1iga-Pflucker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan L.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada M.","family":"Kruisbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF338076a0_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/269417a0","volume":"269","author":"MJ Bevan","year":"1977","unstructured":"Bevan, M. J. Nature 269, 417\u2013419 (1977).","journal-title":"Nature"},{"key":"BF338076a0_CR2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1084\/jem.148.3.766","volume":"148","author":"P Fink","year":"1978","unstructured":"Fink, P. & Bevan, M. J. exp. Med. 148, 766\u2013775 (1978).","journal-title":"J. exp. Med."},{"key":"BF338076a0_CR3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/271251a0","volume":"271","author":"RM Zinkernagel","year":"1978","unstructured":"Zinkernagel, R. M., Callahan, G. N., Klein, J. & Dennert, G. Nature 271, 251\u2013253 (1978).","journal-title":"Nature"},{"key":"BF338076a0_CR4","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1084\/jem.147.3.882","volume":"147","author":"RM Zinkernagel","year":"1978","unstructured":"Zinkernagel, R. M. et al. J. exp. Med. 147, 882\u2013896 (1978).","journal-title":"J. exp. Med."},{"key":"BF338076a0_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1084\/jem.153.1.13","volume":"153","author":"AM Kruisbeek","year":"1981","unstructured":"Kruisbeek, A. M., Hodes, R. J. & Singer, A. J. exp. Med. 153, 13\u201329 (1981).","journal-title":"J. exp. Med."},{"key":"BF338076a0_CR6","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1084\/jem.153.5.1286","volume":"153","author":"A Singer","year":"1981","unstructured":"Singer, A., Hathcock, K. S. & Hodes, R. J. J. exp. Med. 153, 1286\u20131301 (1981).","journal-title":"J. exp. Med."},{"key":"BF338076a0_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0092-8674(87)90568-X","volume":"49","author":"JW Kappler","year":"1987","unstructured":"Kappler, J. W., Roehm, N. & Marrack, P. Cell 49, 273\u2013280 (1987).","journal-title":"Cell"},{"key":"BF338076a0_CR8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/332035a0","volume":"322","author":"JW Kappler","year":"1988","unstructured":"Kappler, J. W., Staerz, U., White, J. & Marrack, P. C. Nature 322, 35\u201340 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/332040a0","volume":"332","author":"HR MacDonald","year":"1988","unstructured":"MacDonald, H. R. et al. Nature 332, 40\u201345 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR10","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/333742a0","volume":"333","author":"P Kisielow","year":"1988","unstructured":"Kisielow, P. et al. Nature 333, 742\u2013746 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/334620a0","volume":"334","author":"BJ Fowlkes","year":"1988","unstructured":"Fowlkes, B. J., Schwartz, R. H. and Pardoll, D. M. Nature 334, 620\u2013623 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR12","first-page":"89","volume-title":"Recognition and Regulation in Cell-mediated Immunity","author":"H Von Boehmer","year":"1985","unstructured":"Von Boehmer, H., Teh, M. S., Bennink, J. R. & Haas, W. Recognition and Regulation in Cell-mediated Immunity (eds Watson, J. D. & Marbrook, J.) 89\u2013106 (Marcel Dekker Inc., New York and Basel, 1985)."},{"key":"BF338076a0_CR13","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.4049\/jimmunol.140.8.2481","volume":"140","author":"A Singer","year":"1988","unstructured":"Singer, A. J. Immun. 140, 2481\u20132483 (1988).","journal-title":"J. Immun."},{"key":"BF338076a0_CR14","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/333180a0","volume":"333","author":"S Marusic-Galesic","year":"1988","unstructured":"Marusic-Galesic, S., Stephany, D. A., Longo, D. L. & Kruisbeek, A. M. Nature 333, 180\u2013183 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0092-8674(87)90567-8","volume":"49","author":"JW Kappler","year":"1987","unstructured":"Kappler, J. W. et al. Cell 49, 263\u2013271 (1987).","journal-title":"Cell"},{"key":"BF338076a0_CR16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0092-8674(87)90551-4","volume":"49","author":"DH Raulet","year":"1987","unstructured":"Raulet, D. H. Cell 49, 153\u2013154 (1987).","journal-title":"Cell"},{"key":"BF338076a0_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00007890-198209000-00001","volume":"34","author":"K Ozato","year":"1982","unstructured":"Ozato, K., Mayer, N. & Sachs, D. H. Transplantation 34, 113\u2013118 (1982).","journal-title":"Transplantation"},{"key":"BF338076a0_CR18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4049\/jimmunol.124.2.533","volume":"124","author":"K Ozato","year":"1980","unstructured":"Ozato, K., Mayer, N. & Sachs, D. H. J. Immun. 124, 533\u2013540 (1980).","journal-title":"J. Immun."},{"key":"BF338076a0_CR19","unstructured":"Marusic-Galesic, S., Longo, D. L. & Kruisbeek, A. M. J. exp. Med. (in the press)."},{"key":"BF338076a0_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/eji.1830080802","volume":"8","author":"T Springer","year":"1978","unstructured":"Springer, T., Galfre, G., Secher, D. S. & Milstein, C. Eur. J. Immun. 8, 539\u2013547 (1978).","journal-title":"Eur. J. Immun."},{"key":"BF338076a0_CR21","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.4049\/jimmunol.138.7.2013","volume":"138","author":"IN Crispe","year":"1987","unstructured":"Crispe, I. N. & Bevan, M. J. J. Immun. 138, 2013\u20132018 (1987).","journal-title":"J. Immun."},{"key":"BF338076a0_CR22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF02918806","volume":"4","author":"BJ Fowlkes","year":"1985","unstructured":"Fowlkes, B. J. & Mathieson, B. J. Surv. immunol. Res. 4, 96\u2013109 (1985).","journal-title":"Surv. immunol. Res."},{"key":"BF338076a0_CR23","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.4049\/jimmunol.140.8.2508","volume":"140","author":"P Marrack","year":"1988","unstructured":"Marrack, P., Kushnir, P., Born, W., McDuffie, M. & Kappler, J. J. Immun. 140, 2508\u20132514 (1988).","journal-title":"J. Immun."},{"key":"BF338076a0_CR24","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/335229a0","volume":"335","author":"HS Teh","year":"1988","unstructured":"Teh, H. S. et al. Nature 335, 229\u2013233 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR25","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/335730a0","volume":"335","author":"P Kisielow","year":"1988","unstructured":"Kisielow, P., Teh, H. S., Bluthmann, H. & von Boehmer, H. Nature 335, 730\u2013733 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR26","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/335271a0","volume":"335","author":"WC Sha","year":"1988","unstructured":"Sha, W. C. et al. Nature 335, 271\u2013274 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR27","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/335796a0","volume":"335","author":"AM Pullen","year":"1988","unstructured":"Pullen, A. M., Marrack, P. & Kappler, J. W. Nature 335, 796\u2013801 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR28","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/335830a0","volume":"335","author":"AM Fry","year":"1988","unstructured":"Fry, A. M. & Matis, L. A. Nature 335, 830\u2013832 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR29","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/335827a0","volume":"335","author":"R Abe","year":"1988","unstructured":"Abe, R., Vacchio, M. S., Fox, B. & Hodes, R. J. Nature 335, 827\u2013829 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR30","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/332840a0","volume":"332","author":"P Marrack","year":"1988","unstructured":"Marrack, P. & Kappler, J. W. Nature 332, 840\u2013842 (1988).","journal-title":"Nature"},{"key":"BF338076a0_CR31","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/0092-8674(88)90578-8","volume":"53","author":"P Marrack","year":"1988","unstructured":"Marrack, P. et al. Cell 53, 627\u2013634 (1988).","journal-title":"Cell"},{"key":"BF338076a0_CR32","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/326082a0","volume":"326","author":"JA Bluestone","year":"1987","unstructured":"Bluestone, J. A., Pardoll, D., Sharrow, S. O. & Fowlkes, B. J. Nature 326, 82\u201384 (1987).","journal-title":"Nature"},{"key":"BF338076a0_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-065X.1983.tb01083.x","volume":"74","author":"DP Dialynas","year":"1983","unstructured":"Dialynas, D. P. et al. Immunol. Rev. 74, 29\u201356 (1983).","journal-title":"Immunol. Rev."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/338076a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/338076a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/338076a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:06:02Z","timestamp":1684289162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/338076a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":33,"journal-issue":{"issue":"6210","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["BF338076a0"],"URL":"https:\/\/doi.org\/10.1038\/338076a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]}}}