{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:18:56Z","timestamp":1779261536778,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6260","license":[{"start":{"date-parts":[[1990,2,1]],"date-time":"1990-02-01T00:00:00Z","timestamp":633830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,2]]},"DOI":"10.1038\/343714a0","type":"journal-article","created":{"date-parts":[[2003,8,13]],"date-time":"2003-08-13T15:20:12Z","timestamp":1060788012000},"page":"714-719","source":"Crossref","is-referenced-by-count":152,"title":["Self-reactive \u03b3\u03b4 T cells are eliminated in the thymus"],"prefix":"10.1038","volume":"343","author":[{"given":"Alexander L.","family":"Dent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Matis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Hooshmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Widacki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Bluestone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Hedrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF343714a0_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/326079a0","volume":"326","author":"DM Pardoll","year":"1987","unstructured":"Pardoll, D. M. et al. Nature 326, 79\u201381 (1987).","journal-title":"Nature"},{"key":"BF343714a0_CR2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/326082a0","volume":"326","author":"JA Bluestone","year":"1987","unstructured":"Bluestone, J. A., Pardoll, D., Sharrow, S. O. & Fowlkes, B. J. Nature 326, 82\u201384 (1987).","journal-title":"Nature"},{"key":"BF343714a0_CR3","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.4049\/jimmunol.141.4.1074","volume":"141","author":"R Cron","year":"1988","unstructured":"Cron, R. et al. J. Immun. 141, 1074\u20131082 (1988).","journal-title":"J. Immun."},{"key":"BF343714a0_CR4","first-page":"722","volume":"331","author":"JF Elliott","year":"1988","unstructured":"Elliott, J. F., Rock, E. P., Patten, P. A., Davis, M. M. & Chien, Y.-H. Nature 331, 722\u2013727 (1988).","journal-title":"Nature"},{"key":"BF343714a0_CR5","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1126\/science.3259726","volume":"250","author":"S Hata","year":"1988","unstructured":"Hata, S. et al. Science 250, 1541\u20131544 (1988).","journal-title":"Science"},{"key":"BF343714a0_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/322145a0","volume":"322","author":"MB Brenner","year":"1986","unstructured":"Brenner, M. B. et al. Nature 322, 145\u2013149 (1986).","journal-title":"Nature"},{"key":"BF343714a0_CR7","doi-asserted-by":"publisher","first-page":"6998","DOI":"10.1073\/pnas.83.18.6998","volume":"83","author":"A Weiss","year":"1986","unstructured":"Weiss, A., Newton, M. & Crommie, D. Proc. natn. Acad. Sci. U.S.A. 83, 6998\u20137002 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF343714a0_CR8","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1084\/jem.167.2.315","volume":"167","author":"JT Sowder","year":"1988","unstructured":"Sowder, J. T., Chen, C. H., Ager, L. L., Chan, M. M. & Cooper, M. D. J. exp. Med. 167, 315\u2013322 (1988).","journal-title":"J. exp. Med."},{"key":"BF343714a0_CR9","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1126\/science.3787252","volume":"234","author":"AM Lew","year":"1986","unstructured":"Lew, A. M. et al. Science 234, 1401\u20131405 (1986).","journal-title":"Science"},{"key":"BF343714a0_CR10","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1084\/jem.165.4.1076","volume":"165","author":"LL Lanier","year":"1987","unstructured":"Lanier, L. L. et al. J. exp. Med. 165, 1076\u20131094 (1987).","journal-title":"J. exp. Med."},{"key":"BF343714a0_CR11","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0065-2776(08)60644-6","volume":"44","author":"JR Parnes","year":"1989","unstructured":"Parnes, J. R. Adv. Immun. 44, 265\u2013311 (1989).","journal-title":"Adv. Immun."},{"key":"BF343714a0_CR12","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1073\/pnas.84.13.4586","volume":"84","author":"G Stingl","year":"1987","unstructured":"Stingl, G. et al. Proc. natn. Acad. Sci. U.S.A. 84, 4586\u20134690 (1987).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF343714a0_CR13","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/333855a0","volume":"330","author":"T Goodman","year":"1988","unstructured":"Goodman, T. & Lefrancois, L. Nature 330, 855\u2013858 (1988).","journal-title":"Nature"},{"key":"BF343714a0_CR14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/340239a0","volume":"340","author":"A Augustin","year":"1989","unstructured":"Augustin, A., Kubo, R. T. & Sim, G. K. Nature 340, 239\u2013241 (1989).","journal-title":"Nature"},{"key":"BF343714a0_CR15","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.4049\/jimmunol.140.12.4091","volume":"140","author":"DM Pardoll","year":"1988","unstructured":"Pardoll, D. M. et al. J. Immun. 140, 4091\u20134096 (1988).","journal-title":"J. Immun."},{"key":"BF343714a0_CR16","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev.iy.06.040188.001521","volume":"6","author":"H von Boehmer","year":"1988","unstructured":"von Boehmer, H. A. Rev. Immun. 6, 309\u2013326 (1988).","journal-title":"A. Rev. Immun."},{"key":"BF343714a0_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0065-2776(08)60643-4","volume":"44","author":"BJ Fowlkes","year":"1989","unstructured":"Fowlkes, B. J., & Pardoll, D. M. Adv. Immun. 44, 207\u2013264 (1989).","journal-title":"Adv. Immun."},{"key":"BF343714a0_CR18","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1084\/jem.168.5.1899","volume":"168","author":"JA Bluestone","year":"1988","unstructured":"Bluestone, J. A., Cron, R., Cotterman, M., Houlden, B. A. & Matis, L. A. J. exp. Med. 168, 1899\u20131916 (1988).","journal-title":"J. exp. Med."},{"key":"BF343714a0_CR19","unstructured":"Houlden, B. A. et al. Cold Spring Harb. Symp. quant. Biol. Vol. 54 (in the press)."},{"key":"BF343714a0_CR20","volume-title":"Manipulating the Mouse Embryo","author":"B Hogan","year":"1986","unstructured":"Hogan, B., Constantini, F. & Lacy, E. in Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory, New York, 1986)."},{"key":"BF343714a0_CR21","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.4049\/jimmunol.142.8.2736","volume":"142","author":"RT Kubo","year":"1989","unstructured":"Kubo, R. T., Born, W., Kappler, J. K., Marrack, P. & Pigeon, M. J. Immun. 142, 2736\u20132742 (1989).","journal-title":"J. Immun."},{"key":"BF343714a0_CR22","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.4049\/jimmunol.133.3.1117","volume":"133","author":"P Kieselow","year":"1984","unstructured":"Kieselow, P., Leiserson, W. & von Boehmer, H. J. Immun. 133, 1117\u20131123 (1984).","journal-title":"J. Immun."},{"key":"BF343714a0_CR23","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/329336a0","volume":"329","author":"IN Crispe","year":"1987","unstructured":"Crispe, I. N. et al. Nature 329, 336\u2013339 (1987).","journal-title":"Nature"},{"key":"BF343714a0_CR24","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/329251a0","volume":"329","author":"BJ Fowlkes","year":"1987","unstructured":"Fowlkes, B. J. et al. Nature 329, 251\u2013254 (1987).","journal-title":"Nature"},{"key":"BF343714a0_CR25","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.4049\/jimmunol.140.6.1779","volume":"140","author":"GC Miescher","year":"1988","unstructured":"Miescher, G. C., Howe, R. C., Lees, R. K. & MacDonald, H. R. J. Immun. 140, 1779\u20131782 (1988).","journal-title":"J. Immun."},{"key":"BF343714a0_CR26","doi-asserted-by":"publisher","first-page":"5094","DOI":"10.1073\/pnas.86.13.5094","volume":"86","author":"S Itohara","year":"1989","unstructured":"Itohara, S., Nakanishi, N., Kanagawa, O., Kubo, R. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 86, 5094\u20135098 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF343714a0_CR27","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/333742a0","volume":"333","author":"P Kisielow","year":"1988","unstructured":"Kisielow, P., Bluthmann, H., Staerz, U. D., Steinmetz, M. D. & von Boehmer, H. Nature 333, 742\u2013746 (1988).","journal-title":"Nature"},{"key":"BF343714a0_CR28","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/336073a0","volume":"336","author":"WC Sha","year":"1988","unstructured":"Sha, W. C. et al. Nature 336, 73\u201376 (1988).","journal-title":"Nature"},{"key":"BF343714a0_CR29","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/341746a0","volume":"341","author":"J Kaye","year":"1989","unstructured":"Kaye, J., Jameson, S., Gascoigne, N. R. J. & Hedrick, S. M. Nature 341, 746\u2013749 (1989).","journal-title":"Nature"},{"key":"BF343714a0_CR30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/335229a0","volume":"335","author":"HS Teh","year":"1988","unstructured":"Teh, H. S. et al. Nature 335, 229\u2013233 (1988).","journal-title":"Nature"},{"key":"BF343714a0_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1146\/annurev.iy.07.040189.001135","volume":"7","author":"DH Raulet","year":"1989","unstructured":"Raulet, D. H. A. Rev. Immun. 7, 175\u2013207 (1989).","journal-title":"A. Rev. Immun."},{"key":"BF343714a0_CR32","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/338430a0","volume":"338","author":"A Winoto","year":"1989","unstructured":"Winoto, A. & Baltimore, D. Nature 338, 430\u2013432 (1989).","journal-title":"Nature"},{"key":"BF343714a0_CR33","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/335170a0","volume":"335","author":"J-P deVillartay","year":"1988","unstructured":"deVillartay, J.-P. et al. Nature 335, 170\u2013174 (1988).","journal-title":"Nature"},{"key":"BF343714a0_CR34","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/0092-8674(86)90787-7","volume":"45","author":"RD Garman","year":"1986","unstructured":"Garman, R. D., Doherty, P. J. & Raulet, D. H. Cell 45, 733\u2013742 (1986).","journal-title":"Cell"},{"key":"BF343714a0_CR35","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1073\/pnas.85.21.8161","volume":"85","author":"M Iwashima","year":"1988","unstructured":"Iwashima, M., Green, A., Davis, M. M. & Chien, Y.-H. Proc. natn. Acad. Sci. U.S.A. 85, 8161\u20138165 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF343714a0_CR36","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1084\/jem.165.2.279","volume":"165","author":"SB Sorger","year":"1987","unstructured":"Sorger, S. B., Hedrick, S. M., Fink, P. J., Bookman, M. A. & Matis, L. A. J. exp. Med. 165, 279\u2013301 (1987).","journal-title":"J. exp. Med."},{"key":"BF343714a0_CR37","volume-title":"Molecular Cloning: A Laboratory Manual","author":"T Maniatis","year":"1982","unstructured":"Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982)."},{"key":"BF343714a0_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0378-1119(89)90088-7","volume":"79","author":"GA Evans","year":"1989","unstructured":"Evans, G. A., Lewis, K. & Rothenberg, B. E. Gene 79, 9\u201320 (1989).","journal-title":"Gene"},{"key":"BF343714a0_CR39","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/327677a0","volume":"327","author":"Y-H Chien","year":"1987","unstructured":"Chien, Y.-H. et al. Nature 327, 677\u2013682 (1987).","journal-title":"Nature"},{"key":"BF343714a0_CR40","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1073\/pnas.84.5.1374","volume":"84","author":"O Leo","year":"1987","unstructured":"Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. & Bluestone, J. A. Proc. natn. Acad. Sci. U.S.A. 84, 1374\u20131378 (1987).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF343714a0_CR41","doi-asserted-by":"publisher","first-page":"4737","DOI":"10.1073\/pnas.79.15.4737","volume":"79","author":"GJ Hammerling","year":"1982","unstructured":"Hammerling, G. J., Rusch, E., Tada, N., Kimura, S. & Hammerling, U. Proc. natn. Acad. Sci. U.S.A. 79, 4737\u20134741 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/343714a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/343714a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/343714a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:16:44Z","timestamp":1704899804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/343714a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":41,"journal-issue":{"issue":"6260","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["BF343714a0"],"URL":"https:\/\/doi.org\/10.1038\/343714a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}