{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:50:33Z","timestamp":1780098633872,"version":"3.54.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6265","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,3]]},"DOI":"10.1038\/344395a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T22:45:32Z","timestamp":1055457932000},"page":"395-400","source":"Crossref","is-referenced-by-count":535,"title":["Signal transduction in bacteria"],"prefix":"10.1038","volume":"344","author":[{"given":"Jeffry B.","family":"Stock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Mottonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF344395a0_CR1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/339330b0","volume":"339","author":"M Kroger","year":"1989","unstructured":"Kroger, M. Nature 339, 330 (1989).","journal-title":"Nature"},{"key":"BF344395a0_CR2","first-page":"7","volume-title":"Escherichia coli and Salmonella typhimurium","author":"H Nikaido","year":"1987","unstructured":"Nikaido, H. & Vaara, M. in Escherichia coli and Salmonella typhimurium Vol. 1 (eds Neidhart, F. C. et al.) 7\u201322 (Am. Soc. Microbiol., Washington DC, 1987)."},{"key":"BF344395a0_CR3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1128\/MMBR.53.1.121-147.1989","volume":"53","author":"LN Csonka","year":"1989","unstructured":"Csonka, L. N. Microbiol. Rev. 53, 121\u2013147 (1989).","journal-title":"Microbiol. Rev."},{"key":"BF344395a0_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev.cb.04.110188.000321","volume":"4","author":"S Forst","year":"1988","unstructured":"Forst, S. & Inouye, M. A. Rev. Cell Biol. 4, 21\u201342 (1988).","journal-title":"A. Rev. Cell Biol."},{"key":"BF344395a0_CR5","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1101\/gad.3.5.598","volume":"3","author":"MM Igo","year":"1989","unstructured":"Igo, M. M., Ninfa, A. J. & Silhavy, T. J. Genes Dev. 3, 598\u2013605 (1989).","journal-title":"Genes Dev."},{"key":"BF344395a0_CR6","doi-asserted-by":"crossref","first-page":"8563","DOI":"10.1016\/S0021-9258(18)81828-2","volume":"264","author":"H Aiba","year":"1989","unstructured":"Aiba, H., Mizuno, T. & Mizushima, S. J. biol. Chem. 264, 8563\u20138567 (1989).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR7","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1101\/gad.3.11.1725","volume":"3","author":"MM Igo","year":"1989","unstructured":"Igo, M. M., Ninfa, A. J., Stock, J. B. & Silhavy, T. J. Genes Dev. 3, 1725\u20131734 (1989).","journal-title":"J. Genes Dev."},{"key":"BF344395a0_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/oxfordjournals.jbchem.a122817","volume":"106","author":"H Aiba","year":"1989","unstructured":"Aiba, H., Nakasai, F., Mizushima, S. & Mizuno, T. J. Biochem. (Tokyo) 106, 5\u20137 (1989).","journal-title":"J. Biochem. (Tokyo)"},{"key":"BF344395a0_CR9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0022-2836(89)90330-6","volume":"210","author":"JM Slauch","year":"1989","unstructured":"Slauch, J. M. & Silhavy, T. J. J. molec. Biol. 210, 281\u2013292 (1989).","journal-title":"J. molec. Biol."},{"key":"BF344395a0_CR10","first-page":"302","volume-title":"Escherichia coli and Salmonella typhimurium","author":"LJ Reitzer","year":"1987","unstructured":"Reitzer, L. J. & Magasanik, B. in Escherichia coli and Salmonella typhimurium Vol. 1 (eds Neidhart, F. C. et al.) 302\u2013320 (Am. Soc. Microbiol., Washington DC, 1987)."},{"key":"BF344395a0_CR11","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/0092-8674(87)90170-X","volume":"50","author":"AJ Ninfa","year":"1987","unstructured":"Ninfa, A. J., Reitzer, L. J. & Magasanik, B. Cell 50, 1039\u20131046 (1987).","journal-title":"Cell"},{"key":"BF344395a0_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-152827-0.50008-6","volume":"27","author":"PB Chock","year":"1985","unstructured":"Chock, P. B., Shatter, E., Jurgensen, S. R. & Rhee, S. G. Curr. Top. Cell Regul. 27, 3\u201312 (1985).","journal-title":"Curr. Top. Cell Regul."},{"key":"BF344395a0_CR13","doi-asserted-by":"publisher","first-page":"5909","DOI":"10.1073\/pnas.83.16.5909","volume":"83","author":"AJ Ninfa","year":"1986","unstructured":"Ninfa, A. J. & Magasanik, B. Proc. natn. Acad. Sci. U.S.A. 83, 5909\u20135913 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR14","doi-asserted-by":"publisher","first-page":"4976","DOI":"10.1073\/pnas.85.14.4976","volume":"85","author":"J Keener","year":"1988","unstructured":"Keener, J. & Kustu, S. Proc. natn. Acad. Sci. U.S.A. 85, 4976\u20134980 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/323304a0","volume":"323","author":"RJ Almassy","year":"1986","unstructured":"Almassy, R. J., Janson, C. A., Hamlin, R., Xuong, N.-H. & Eisenberg, D. Nature 323, 304\u2013309 (1986).","journal-title":"Nature"},{"key":"BF344395a0_CR16","doi-asserted-by":"publisher","first-page":"8919","DOI":"10.1073\/pnas.85.23.8919","volume":"85","author":"V Weiss","year":"1988","unstructured":"Weiss, V. & Magasanik, B. Proc. natn. Acad. Sci. U.S.A. 85, 8919\u20138923 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR17","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1073\/pnas.80.13.4030","volume":"80","author":"V Sundaresan","year":"1983","unstructured":"Sundaresan, V., Ow, D. & Ausubel, F. M. Proc. natn. Acad. Sci. U.S.A. 80, 4030\u20134034 (1983).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR18","first-page":"732","volume-title":"Escherichia coli and Salmonella typhimurium","author":"RM Macnab","year":"1987","unstructured":"Macnab, R. M. in Escherichia coli and Salmonella typhimurium Vol. 1 (eds Neidhart, F. C. et al.) 732\u2013759 (Am. Soc. Microbiol., Washington, DC, 1987)."},{"key":"BF344395a0_CR19","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1073\/pnas.85.5.1403","volume":"85","author":"A Stock","year":"1988","unstructured":"Stock, A., Chen, T., Welsh, D. & Stock, J. Proc. natn. Acad. Sci. U.S.A. 85, 1403\u20131407 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR20","doi-asserted-by":"publisher","first-page":"5829","DOI":"10.1021\/bi00416a001","volume":"27","author":"DE Koshland Jr","year":"1988","unstructured":"Koshland, D. E., Jr Biochemistry 27, 5829\u20135832 (1988).","journal-title":"Biochemistry"},{"key":"BF344395a0_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1101\/SQB.1988.053.01.010","volume":"53","author":"P Ames","year":"1988","unstructured":"Ames, P., Chen, J., Wolff, C. & Parkinson, J. S. Cold Spring Harbor Symp. quant. Biol. 53, 59\u201365 (1988).","journal-title":"Cold Spring Harbor Symp. quant. Biol."},{"key":"BF344395a0_CR22","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1073\/pnas.86.4.1208","volume":"86","author":"KA Borkovich","year":"1989","unstructured":"Borkovich, K. A., Kaplan, N., Hess, J. F. & Simon, M. I. Proc. natn. Acad. Sci. U.S.A. 86, 1208\u20131212 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR23","doi-asserted-by":"publisher","first-page":"7989","DOI":"10.1073\/pnas.82.23.7989","volume":"82","author":"AM Stock","year":"1985","unstructured":"Stock, A. M., Koshland, D. E., Jr & Stock, J. B. Proc. natn. Acad. Sci. U.S.A. 82, 7989\u20137993 (1985).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0021-9258(19)75814-1","volume":"262","author":"A Stock","year":"1987","unstructured":"Stock, A., Mottonen, J., Chen, T. & Stock, J. J. biol. Chem. 262, 535\u2013537 (1987).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR25","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1128\/jb.169.5.1878-1885.1987","volume":"169","author":"AJ Wolfe","year":"1987","unstructured":"Wolfe, A. J., Conley, M. P., Kramer, T. J. & Berg, H. C. J. Bact. 169, 1878\u20131885 (1987).","journal-title":"J. Bact."},{"key":"BF344395a0_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1101\/SQB.1988.053.01.009","volume":"53","author":"AM Stock","year":"1988","unstructured":"Stock, A. M. et al. Cold Spring Harbor Symp. quant. Biol. 53, 49\u201357 (1988).","journal-title":"Cold Spring Harbor Symp. quant. Biol."},{"key":"BF344395a0_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/336139a0","volume":"336","author":"JF Hess","year":"1988","unstructured":"Hess, J. F., Bourret, R. B. & Simon, M. I. Nature 336, 139\u2013143 (1988).","journal-title":"Nature"},{"key":"BF344395a0_CR28","doi-asserted-by":"crossref","first-page":"21770","DOI":"10.1016\/S0021-9258(20)88250-7","volume":"264","author":"DA Sanders","year":"1989","unstructured":"Sanders, D. A., Gilleve-Castro, B. L., Stock, A. M., Burlingame, A. L. & Koshland, D. E. Jr J. biol. Chem. 264, 21770\u201321778 (1989).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0092-8674(88)90489-8","volume":"53","author":"JF Hess","year":"1988","unstructured":"Hess, J. F., Oosawa, K., Kaplan, N. & Simon, M. I. Cell 53, 79\u201387 (1988).","journal-title":"Cell"},{"key":"BF344395a0_CR30","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/280279a0","volume":"280","author":"MS Springer","year":"1979","unstructured":"Springer, M. S., Goy, M. F. & Adler, J. Nature 280, 279\u2013284 (1979).","journal-title":"Nature"},{"key":"BF344395a0_CR31","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0968-0004(87)90172-1","volume":"12","author":"J Stock","year":"1987","unstructured":"Stock, J. & Stock, A. Trends Biochem. Sci. 12, 371\u2013375 (1987).","journal-title":"Trends Biochem. Sci."},{"key":"BF344395a0_CR32","doi-asserted-by":"crossref","first-page":"17337","DOI":"10.1016\/S0021-9258(18)71497-X","volume":"264","author":"AN Lupas","year":"1989","unstructured":"Lupas, A. N. & Stock, J. B. J. biol. Chem. 264, 17337\u201317342 (1989).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR33","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1016\/S0021-9258(17)39227-X","volume":"260","author":"SA Simms","year":"1985","unstructured":"Simms, S. A., Keane, M. G. & Stock, J. J. biol. Chem. 260, 10161\u201310168 (1985).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR34","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1128\/jb.170.12.5728-5738.1988","volume":"170","author":"RC Stewart","year":"1988","unstructured":"Stewart, R. C. & Dahlquist, F. W. J. Bact. 170, 5728\u20135738 (1988).","journal-title":"J. Bact."},{"key":"BF344395a0_CR35","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1073\/pnas.86.5.1448","volume":"86","author":"GL Hazelbauer","year":"1989","unstructured":"Hazelbauer, G. L., Park, C. & Nowlin, D. M. Proc. natn. Acad. Sci. U.S.A. 86, 1448\u20131452 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR36","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.1073\/pnas.85.15.5492","volume":"85","author":"AJ Ninfa","year":"1988","unstructured":"Ninfa, A. J. et al. Proc. natn. Acad. Sci. U.S.A. 85, 5492\u20135496 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR37","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/337745a0","volume":"337","author":"AM Stock","year":"1989","unstructured":"Stock, A. M., Mottonen, J. M., Stock, J. B. & Schutt, C. E. Nature 337, 745\u2013749 (1989).","journal-title":"Nature"},{"key":"BF344395a0_CR38","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1017\/S0033583500001712","volume":"13","author":"C-I Branden","year":"1980","unstructured":"Branden, C.-I. Q. Rev. Biophys. 13, 317\u2013338 (1980).","journal-title":"Q. Rev. Biophys."},{"key":"BF344395a0_CR39","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev.bi.57.070188.002303","volume":"57","author":"Y Yarden","year":"1988","unstructured":"Yarden, Y. & Ullrich, A. A. Rev. Biochem. 57, 443\u2013478 (1988).","journal-title":"A. Rev. Biochem."},{"key":"BF344395a0_CR40","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/336215a0","volume":"336","author":"SR Sprang","year":"1988","unstructured":"Sprang, S. R. et al. Nature 336, 215\u2013221 (1988).","journal-title":"Nature"},{"key":"BF344395a0_CR41","first-page":"75","volume":"51","author":"WP Jencks","year":"1980","unstructured":"Jencks, W. P. Adv. Enzym. 51, 75\u2013106 (1980).","journal-title":"Adv. Enzym."},{"key":"BF344395a0_CR42","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3109\/10409238409113603","volume":"17","author":"C Tanford","year":"1984","unstructured":"Tanford, C. CRC Crit. Rev. Biochem. 17, 123\u2013152 (1984).","journal-title":"CRC Crit. Rev. Biochem."},{"key":"BF344395a0_CR43","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.1016\/S0021-9258(19)41016-8","volume":"250","author":"Y Shizuta","year":"1975","unstructured":"Shizuta, Y., Beavo, J. A., Bechtel, P. J., Hofmann, F. & Krebs, E. G. J. biol. Chem. 250, 6891\u20136896 (1975).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR44","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1073\/pnas.80.7.1872","volume":"80","author":"Y Fukami","year":"1983","unstructured":"Fukami, Y. & Lipmann, F. Proc. natn. Acad. Sci. U.S.A. 80, 1872\u20131876 (1983).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF344395a0_CR45","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S0021-9258(18)94223-7","volume":"264","author":"L Hubler","year":"1989","unstructured":"Hubler, L., Gill, G. N. & Bertics, P. J. J. biol. Chem. 264, 1558\u20131564 (1989).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR46","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0006-291X(88)80365-6","volume":"151","author":"D Wylie","year":"1988","unstructured":"Wylie, D., Stock, A., Wong, C.-Y. & Stock, J. Biochem. biophys. Res. Commun. 151, 891\u2013896 (1988).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF344395a0_CR47","doi-asserted-by":"crossref","first-page":"14477","DOI":"10.1016\/S0021-9258(19)45405-7","volume":"257","author":"N Weigel","year":"1982","unstructured":"Weigel, N., Kukuruzinska, M. A., Nakazawa, A., Waygood, E. B. & Roseman, S. J. biol. Chem. 257, 14477\u201314491 (1982).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR48","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/S0021-9258(17)43455-7","volume":"259","author":"CM Pickart","year":"1984","unstructured":"Pickart, C. M. & Jencks, W. P. J. biol. Chem. 259, 1629\u20131643 (1984).","journal-title":"J. biol. Chem."},{"key":"BF344395a0_CR49","first-page":"J144","volume-title":"Handbook of Biochemistry","author":"WP Jencks","year":"1968","unstructured":"Jencks, W. P. in Handbook of Biochemistry (ed. Sober, H. A.) J144\u2013J149 (CRC, Cleveland, 1968)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/344395a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/344395a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/344395a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:59:10Z","timestamp":1684288750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/344395a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":49,"journal-issue":{"issue":"6265","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["BF344395a0"],"URL":"https:\/\/doi.org\/10.1038\/344395a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}