{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:25:54Z","timestamp":1768465554739,"version":"3.49.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"6277","license":[{"start":{"date-parts":[[1990,6,21]],"date-time":"1990-06-21T00:00:00Z","timestamp":645926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1990,6,21]],"date-time":"1990-06-21T00:00:00Z","timestamp":645926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1990,6,21]],"date-time":"1990-06-21T00:00:00Z","timestamp":645926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1990,6,21]],"date-time":"1990-06-21T00:00:00Z","timestamp":645926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,6,21]]},"DOI":"10.1038\/345732a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:04:32Z","timestamp":1055459072000},"page":"732-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction"],"prefix":"10.1038","volume":"345","author":[{"given":"A. J. M.","family":"van den Eijnden-Van Raaij","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J. J.","family":"van Zoelent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"van Nimmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Koster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"Snoek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Durston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Huylebroeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF345732a0_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/326197a0","volume":"326","author":"JMW Slack","year":"1987","unstructured":"Slack, J. M. W., Darlington, B. G., Heath, J. K. & Godsave, S. F. Nature 326, 197\u2013200 (1987).","journal-title":"Nature"},{"key":"BF345732a0_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0045-6039(88)90010-3","volume":"22","author":"H Grunz","year":"1988","unstructured":"Grunz, H., McKeehan, W. L., Knochel, W., Tiedemann, H. & Tiedemann, H. Cell Diff. 22, 183\u2013190 (1988).","journal-title":"Cell Diff."},{"key":"BF345732a0_CR3","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/0092-8674(87)90110-3","volume":"51","author":"D Kimelman","year":"1987","unstructured":"Kimelman, D. & Kirschner, M. Cell 51, 869\u2013877 (1987).","journal-title":"Cell"},{"key":"BF345732a0_CR4","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1126\/science.3422517","volume":"239","author":"F Rosa","year":"1988","unstructured":"Rosa, F., Roberts, A. B., Danielpour, D., Dart, L. L., Sporn, M. B. & Dawid, I. B. Science 239, 783\u2013785 (1988).","journal-title":"Science"},{"key":"BF345732a0_CR5","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1242\/dev.105.4.665","volume":"105","author":"JC Smith","year":"1989","unstructured":"Smith, J. C. Development 105, 665\u2013677 (1989).","journal-title":"Development"},{"key":"BF345732a0_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.99.1.3","volume":"99","author":"JC Smith","year":"1987","unstructured":"Smith, J. C. Development 99, 3\u201314 (1987).","journal-title":"Development"},{"key":"BF345732a0_CR7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1242\/dev.103.3.591","volume":"103","author":"JC Smith","year":"1988","unstructured":"Smith, J. C., Yaqoob, M. & Symes, K. Development 103, 591\u2013600 (1988).","journal-title":"Development"},{"key":"BF345732a0_CR8","unstructured":"Snoek, G. T. et al. Expl. Cell Res. (in the press)."},{"key":"BF345732a0_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/BF00383771","volume":"198","author":"M Asashima","year":"1990","unstructured":"Asashima, M. et al. Roux's Arch. dev. Biol. 198, 330\u2013335 (1990).","journal-title":"Roux's Arch. dev. Biol."},{"key":"BF345732a0_CR10","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1073\/pnas.85.8.2434","volume":"85","author":"M Murata","year":"1988","unstructured":"Murata, M., Eto, Y., Shibai, H., Sakai, M. & Muramatsu, M. Proc. natn. Acad. Sci. U.S.A. 85, 2434\u20132438 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF345732a0_CR11","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/321776a0","volume":"321","author":"W Vale","year":"1986","unstructured":"Vale, W., Rivier, J., Vaughan, J., McClintock, R., Corrigan, A., Woo, W., Karr, D. & Spiess, J. Nature 321, 776\u2013779 (1986).","journal-title":"Nature"},{"key":"BF345732a0_CR12","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/321779a0","volume":"321","author":"N Ling","year":"1986","unstructured":"Ling, N. et al. Nature 321, 779\u2013782 (1986).","journal-title":"Nature"},{"key":"BF345732a0_CR13","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/345729a0","volume":"345","author":"JC Smith","year":"1990","unstructured":"Smith, J. C. Nature 345, 729\u2013731 (1990).","journal-title":"Nature"},{"key":"BF345732a0_CR14","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"U Laemmli","year":"1970","unstructured":"Laemmli, U. Nature 227, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"BF345732a0_CR15","volume-title":"Normal Table of Xenopus laevs (Daudin)","author":"PD Nieuwkoop","year":"1967","unstructured":"Nieuwkoop, P. D. & Faber, J. Normal Table of Xenopus laevs (Daudin) 2nd edn (North-Holland, Amsterdam, 1967."},{"key":"BF345732a0_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/jez.1401120306","volume":"112","author":"RA Flickinger","year":"1949","unstructured":"Flickinger, R. A. J. exp. Zool. 112, 165\u2013185 (1949).","journal-title":"J. exp. Zool."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/345732a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/345732a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/345732a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:12:01Z","timestamp":1684861921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/345732a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6,21]]},"references-count":16,"journal-issue":{"issue":"6277","published-print":{"date-parts":[[1990,6,21]]}},"alternative-id":["BF345732a0"],"URL":"https:\/\/doi.org\/10.1038\/345732a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6,21]]},"assertion":[{"value":"19 January 1990","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 1990","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}