{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:56:30Z","timestamp":1761486990898},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6279","license":[{"start":{"date-parts":[[1990,7,1]],"date-time":"1990-07-01T00:00:00Z","timestamp":646790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,7]]},"DOI":"10.1038\/346069a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T22:46:27Z","timestamp":1055457987000},"page":"69-71","source":"Crossref","is-referenced-by-count":301,"title":["Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium"],"prefix":"10.1038","volume":"346","author":[{"given":"M.","family":"Tare","sequence":"first","affiliation":[]},{"given":"H. C.","family":"Parkington","sequence":"additional","affiliation":[]},{"given":"H. A.","family":"Coleman","sequence":"additional","affiliation":[]},{"given":"T. O.","family":"Neild","sequence":"additional","affiliation":[]},{"given":"G. J.","family":"Dusting","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF346069a0_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/288373a0","volume":"288","author":"RF Furchgott","year":"1980","unstructured":"Furchgott, R. F. & Zawadzki, J. V. Nature 288, 373\u2013376 (1980).","journal-title":"Nature"},{"key":"BF346069a0_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1476-5381.1978.tb17310.x","volume":"64","author":"H Kuriyama","year":"1978","unstructured":"Kuriyama, H. & Suzuki, H. Br. J. Pharmac. 64, 493\u2013501 (1978).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR3","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1113\/jphysiol.1984.sp015262","volume":"351","author":"TB Bolton","year":"1984","unstructured":"Bolton, T. B., Lang, R. J. & Takewaki, T. J. Physiol., Lond. 351, 549\u2013572 (1984).","journal-title":"J. Physiol., Lond."},{"key":"BF346069a0_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1476-5381.1987.tb11369.x","volume":"92","author":"K Komori","year":"1987","unstructured":"Komori, K. & Suzuki, H. Br. J. Pharmac. 92, 657\u2013664 (1987).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR5","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/j.1476-5381.1988.tb11752.x","volume":"95","author":"G Chen","year":"1988","unstructured":"Chen, G., Suzuki, H. & Weston, A. H. Br. J. Pharmac. 95, 1165\u20131174 (1988).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR6","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1476-5381.1988.tb10306.x","volume":"93","author":"M Feletou","year":"1988","unstructured":"Feletou, M. & Vanhoutte, P. M. Br. J. Pharmac. 93, 515\u2013524 (1988).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR7","first-page":"H207","volume":"255","author":"K Komori","year":"1988","unstructured":"Komori, K., Lorenz, R. R. & Vanhoutte, P. M. Am. J. Physiol. 255, H207\u2013212 (1988).","journal-title":"Am. J. Physiol."},{"key":"BF346069a0_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1113\/jphysiol.1989.sp017522","volume":"410","author":"G Chen","year":"1989","unstructured":"Chen, G. & Suzuki, H. J. Physiol., Lond. 410, 91\u2013106 (1989).","journal-title":"J. Physiol., Lond."},{"key":"BF346069a0_CR9","first-page":"17P","volume":"20","author":"HC Parkington","year":"1989","unstructured":"Parkington, H. C. et al. Proc. Aust. Physiol. Pharmac. Soc. 20, 17P (1989).","journal-title":"Proc. Aust. Physiol. Pharmac. Soc."},{"key":"BF346069a0_CR10","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/327524a0","volume":"327","author":"RMJ Palmer","year":"1987","unstructured":"Palmer, R. M. J., Ferrige, A. G. & Moncada, S. Nature 327, 524\u2013526 (1987).","journal-title":"Nature"},{"key":"BF346069a0_CR11","doi-asserted-by":"publisher","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","volume":"84","author":"LJ Ignarro","year":"1987","unstructured":"Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E. & Chaudhuri, G. Proc. natn. Acad. Sci. U.S.A. 84, 9265\u20139269 (1987).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346069a0_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1440-1681.1988.tb01049.x","volume":"15","author":"GJ Dusting","year":"1988","unstructured":"Dusting, G. J., Read, M. A. & Stewart, A. G. Clin. exp. Pharmac. Physiol. 15, 83\u201392 (1988).","journal-title":"Clin. exp. Pharmac. Physiol."},{"key":"BF346069a0_CR13","first-page":"708","volume":"232","author":"W Martin","year":"1985","unstructured":"Martin, W., Villani, G. M., Jothianandan, D. & Furchgott, R. F. J. Pharmac. exp. Ther. 232, 708\u2013716 (1985).","journal-title":"J. Pharmac. exp. Ther."},{"key":"BF346069a0_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev.pa.25.040185.001131","volume":"25","author":"LJ Ignarro","year":"1985","unstructured":"Ignarro, L. J. & Kadowitz, P. J. A. Rev. Pharmac. Tox. 25, 171\u2013191 (1985).","journal-title":"A. Rev. Pharmac. Tox."},{"key":"BF346069a0_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0014-2999(87)90493-6","volume":"139","author":"M Feelisch","year":"1987","unstructured":"Feelisch, M. & Noack, E. A. Eur. J. Pharmac. 139, 19\u201330 (1987).","journal-title":"Eur. J. Pharmac."},{"key":"BF346069a0_CR16","first-page":"163","volume":"39","author":"SA Waldman","year":"1987","unstructured":"Waldman, S. A. & Murad, F. Pharmac. Rev. 39, 163\u2013196 (1987).","journal-title":"Pharmac. Rev."},{"key":"BF346069a0_CR17","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/j.1476-5381.1988.tb11597.x","volume":"94","author":"SG Taylor","year":"1988","unstructured":"Taylor, S. G., Southerton, J. S., Weston, A. H. & Baker, J. R. J. Br. J. Pharmac. 94, 853\u2013863 (1988).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR18","first-page":"1022","volume":"207","author":"Y Itoh","year":"1978","unstructured":"Itoh, Y., Suzuki, H. & Kuriyama, H. J. Pharmac. exp. Ther. 207, 1022\u20131031 (1978).","journal-title":"J. Pharmac. exp. Ther."},{"key":"BF346069a0_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1476-5381.1985.tb09441.x","volume":"86","author":"DW Cheung","year":"1985","unstructured":"Cheung, D. W. & Mackay, M. J. Br. J. Pharmac. 86, 117\u2013124 (1985).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1476-5381.1980.tb07925.x","volume":"70","author":"Y Itoh","year":"1980","unstructured":"Itoh, Y., Kitamura, K. & Kuriyama, H. Br. J. Pharmac. 70, 197\u2013204 (1980).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR21","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/333664a0","volume":"333","author":"RMJ Palmer","year":"1988","unstructured":"Palmer, R. M. J., Ashton, D. S. & Moncada, S. Nature 333, 664\u2013666 (1988).","journal-title":"Nature"},{"key":"BF346069a0_CR22","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/S0006-291X(88)81362-7","volume":"153","author":"RMJ Palmer","year":"1988","unstructured":"Palmer, R. M. J., Rees, D. D., Ashton, D. S. & Moncada, S. Biochem. biophys. Res. Commun. 153, 1251\u20131256 (1988).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF346069a0_CR23","doi-asserted-by":"publisher","first-page":"8664","DOI":"10.1073\/pnas.85.22.8664","volume":"85","author":"I Sakuma","year":"1988","unstructured":"Sakuma, I., Stuehr, D. J., Gross, S. S., Nathan, C. & Levi, R. Proc. natn. Acad. Sci. U.S.A. 85, 8664\u20138667 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346069a0_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0006-291X(89)80219-0","volume":"158","author":"RMJ Palmer","year":"1989","unstructured":"Palmer, R. M. J. & Moncada, S. Biochem. biophys. Res. Commun. 158, 345\u2013352 (1989).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF346069a0_CR25","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/j.1476-5381.1989.tb11833.x","volume":"96","author":"DD Rees","year":"1989","unstructured":"Rees, D. D., Palmer, R. M., Hodson, H. F. & Moncada, S. Br. J. Pharmac. 96, 418\u2013424 (1989).","journal-title":"Br. J. Pharmac."},{"key":"BF346069a0_CR26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1113\/jphysiol.1980.sp013502","volume":"309","author":"Y Itoh","year":"1980","unstructured":"Itoh, Y., Kitamura, H. & Kuriyama, H. J. Physiol., Lond. 309, 171\u2013183 (1980).","journal-title":"J. Physiol., Lond."},{"key":"BF346069a0_CR27","first-page":"308","volume":"25","author":"JL Beny","year":"1988","unstructured":"Beny, J. L. & Burnet, P. C. Blood Vessels 25, 308\u2013311 (1988).","journal-title":"Blood Vessels"},{"key":"BF346069a0_CR28","first-page":"438","volume":"338","author":"AH Huang","year":"1988","unstructured":"Huang, A. H., Busse, R. & Bassenge, E. Naunyn-Schmeideberg, Archs Pharmac. 338, 438\u2013442 (1988).","journal-title":"Naunyn-Schmeideberg, Archs Pharmac."},{"key":"BF346069a0_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","volume":"41","author":"MJ Mulvany","year":"1977","unstructured":"Mulvany, M. J. & Halpern, W. Circulation Res. 41, 19\u201326 (1977).","journal-title":"Circulation Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/346069a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/346069a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/346069a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:08:48Z","timestamp":1684289328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/346069a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":29,"journal-issue":{"issue":"6279","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["BF346069a0"],"URL":"https:\/\/doi.org\/10.1038\/346069a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}