{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:56:25Z","timestamp":1774677385058,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6281","license":[{"start":{"date-parts":[[1990,7,1]],"date-time":"1990-07-01T00:00:00Z","timestamp":646790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,7]]},"DOI":"10.1038\/346277a0","type":"journal-article","created":{"date-parts":[[2003,8,11]],"date-time":"2003-08-11T22:49:06Z","timestamp":1060642146000},"page":"277-279","source":"Crossref","is-referenced-by-count":137,"title":["HIV requires multiple gp120 molecules for CD4-mediated infection"],"prefix":"10.1038","volume":"346","author":[{"given":"Scott P.","family":"Layne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Merges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah","family":"Dembo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Spouge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L.","family":"Nara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF346277a0_CR1","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/312763a0","volume":"312","author":"AG Dalgleish","year":"1984","unstructured":"Dalgleish, A. G. et al. Nature 312, 763\u2013767 (1984).","journal-title":"Nature"},{"key":"BF346277a0_CR2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/312767a0","volume":"312","author":"D Klatzmann","year":"1984","unstructured":"Klatzmann, D. et al. Nature 312, 767\u2013768 (1984).","journal-title":"Nature"},{"key":"BF346277a0_CR3","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1126\/science.3001934","volume":"231","author":"JS McDougal","year":"1986","unstructured":"McDougal, J. S. et al. Science 231, 382\u2013385 (1986).","journal-title":"Science"},{"key":"BF346277a0_CR4","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1126\/science.3629244","volume":"237","author":"M Kowalski","year":"1987","unstructured":"Kowalski, M. et al. Science 237, 1351\u20131355 (1987).","journal-title":"Science"},{"key":"BF346277a0_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/334162a0","volume":"334","author":"P Bedinger","year":"1988","unstructured":"Bedinger, P. et al. Nature 334, 162\u2013165 (1988).","journal-title":"Nature"},{"key":"BF346277a0_CR6","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/0092-8674(87)90524-1","volume":"50","author":"LA Lasky","year":"1987","unstructured":"Lasky, L. A. et al. Cell 50, 975\u2013985 (1987).","journal-title":"Cell"},{"key":"BF346277a0_CR7","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1126\/science.3500514","volume":"238","author":"DH Smith","year":"1987","unstructured":"Smith, D. H. et al. Science 238, 1704\u20131707 (1987).","journal-title":"Science"},{"key":"BF346277a0_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/331076a0","volume":"331","author":"RA Fisher","year":"1988","unstructured":"Fisher, R. A. et al. Nature 331, 76\u201378 (1988).","journal-title":"Nature"},{"key":"BF346277a0_CR9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/331078a0","volume":"331","author":"RE Hussey","year":"1988","unstructured":"Hussey, R. E. et al. Nature 331, 78\u201381 (1988).","journal-title":"Nature"},{"key":"BF346277a0_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/331082a0","volume":"331","author":"KC Deen","year":"1988","unstructured":"Deen, K. C. et al. Nature 331, 82\u201384 (1988).","journal-title":"Nature"},{"key":"BF346277a0_CR11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/331084a0","volume":"331","author":"A Traunecker","year":"1988","unstructured":"Traunecker, A., L\u00fcke, W. & Karjalainen, K. Nature 331, 84\u201386 (1988).","journal-title":"Nature"},{"key":"BF346277a0_CR12","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/337368a0","volume":"337","author":"PR Clapham","year":"1989","unstructured":"Clapham, P. R. et al. Nature 337, 368\u2013370 (1989).","journal-title":"Nature"},{"key":"BF346277a0_CR13","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/337525a0","volume":"337","author":"DJ Capon","year":"1989","unstructured":"Capon, D. J. et al. Nature 337, 525\u2013531 (1989).","journal-title":"Nature"},{"key":"BF346277a0_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/339068a0","volume":"339","author":"A Traunecker","year":"1989","unstructured":"Traunecker, A., Schneider, J., Kiefer, H. & Karjalainen, K. Nature 339, 68\u201370 (1989).","journal-title":"Nature"},{"key":"BF346277a0_CR15","doi-asserted-by":"publisher","first-page":"7139","DOI":"10.1073\/pnas.86.18.7139","volume":"86","author":"PL Nara","year":"1989","unstructured":"Nara, P. L., Hwang, K. M., Rausch, D. M., Lifson, J. D. & Eiden, L. E. Proc. natn. Acad. Sci. U.S.A. 86, 7139\u20137143 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346277a0_CR16","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1128\/JVI.63.9.3579-3585.1989","volume":"63","author":"N-C Sun","year":"1989","unstructured":"Sun, N.-C. et al. J. Virology 63, 3579\u20133585 (1989).","journal-title":"J. Virology"},{"key":"BF346277a0_CR17","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1128\/JVI.63.10.4370-4375.1989","volume":"63","author":"RA Byrn","year":"1989","unstructured":"Byrn, R. A. et al. J. Virology 63, 4370\u20134375 (1989).","journal-title":"J. Virology"},{"key":"BF346277a0_CR18","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/337267a0","volume":"337","author":"M Watanabe","year":"1989","unstructured":"Watanabe, M. et al. Nature 337, 267\u2013270 (1989).","journal-title":"Nature"},{"key":"BF346277a0_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.7326\/0003-4819-112-4-247","volume":"112","author":"RT Schooley","year":"1990","unstructured":"Schooley, R. T. et al. Ann. intern. Med. 112, 247\u2013253 (1990).","journal-title":"Ann. intern. Med."},{"key":"BF346277a0_CR20","doi-asserted-by":"publisher","first-page":"254","DOI":"10.7326\/0003-4819-112-4-","volume":"112","author":"JO Kahn","year":"1990","unstructured":"Kahn, J. O. et al. Ann. intern. Med. 112, 254\u2013261 (1990).","journal-title":"Ann. intern. Med."},{"key":"BF346277a0_CR21","doi-asserted-by":"publisher","first-page":"4644","DOI":"10.1073\/pnas.86.12.4644","volume":"86","author":"SP Layne","year":"1989","unstructured":"Layne, S. P., Spouge, J. L. & Dembo, M. Proc. natn. Acad. Sci. U.S.A. 86, 4644\u20134648 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346277a0_CR22","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/BF02459657","volume":"51","author":"JL Spouge","year":"1989","unstructured":"Spouge, J. L., Layne, S. P. & Dembo, M. Bull. math. Biol. 51, 715\u2013730 (1989).","journal-title":"Bull. math. Biol."},{"key":"BF346277a0_CR23","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1089\/aid.1987.3.283","volume":"3","author":"PL Nara","year":"1987","unstructured":"Nara, P. L. et al. AIDS Res. hum. Retroviruses 3, 283\u2013302 (1987).","journal-title":"AIDS Res. hum. Retroviruses"},{"key":"BF346277a0_CR24","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/332469a0","volume":"332","author":"PL Nara","year":"1988","unstructured":"Nara, P. L. & Fischinger, P. J. Nature 332, 469\u2013470 (1988).","journal-title":"Nature"},{"key":"BF346277a0_CR25","unstructured":"Sweet, R. et al. Fifth Int. Conf. AIDS Abstr. W.C.O. 12 (1989)."},{"key":"BF346277a0_CR26","first-page":"9","volume-title":"Human Retroviruses and AIDS","author":"G Myers","year":"1990","unstructured":"Myers, G. et al. Human Retroviruses and AIDS Section III, 9\u201312 (Los Alamos National Laboratory, New Mexico, 1990)."},{"key":"BF346277a0_CR27","first-page":"137","volume-title":"Vaccines 89","author":"PL Nara","year":"1989","unstructured":"Nara, P. L. in Vaccines 89 (eds Lerner, R. A., Ginsberg, H., Chanock, R. M. & Brown, F.) 137\u2013144 (Cold Spring Harbor Laboratory, New York, 1989)."},{"key":"BF346277a0_CR28","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/0042-6822(83)90154-X","volume":"127","author":"J Icenogle","year":"1983","unstructured":"Icenogle, J. et al. Virology 127, 412\u2013425 (1983).","journal-title":"Virology"},{"key":"BF346277a0_CR29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/JVI.48.2.547-550.1983","volume":"48","author":"EA Emini","year":"1983","unstructured":"Emini, E. A., Ostapchuk, P. & Wimmer, E. J. Virology 48, 547\u2013550 (1983).","journal-title":"J. Virology"},{"key":"BF346277a0_CR30","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/0042-6822(87)90466-1","volume":"159","author":"HP Taylor","year":"1987","unstructured":"Taylor, H. P., Armstrong, S. J. & Dimmock, N. J. Virology 159, 288\u2013298 (1987).","journal-title":"Virology"},{"key":"BF346277a0_CR31","unstructured":"Goudsmit, J. et al. Proc. UCLA Symposia (in the press)."},{"key":"BF346277a0_CR32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1126\/science.3388046","volume":"241","author":"DJ Looney","year":"1988","unstructured":"Looney, D. J. et al. Science 241, 357\u2013359 (1988).","journal-title":"Science"},{"key":"BF346277a0_CR33","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/334440a0","volume":"334","author":"MS Saag","year":"1989","unstructured":"Saag, M. S. et al. Nature 334, 440\u2013444 (1989).","journal-title":"Nature"},{"key":"BF346277a0_CR34","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/340571a0","volume":"340","author":"A Cordonnier","year":"1989","unstructured":"Cordonnier, A., Montagnier, L. & Emerman, M. Nature 340, 571\u2013574 (1989).","journal-title":"Nature"},{"key":"BF346277a0_CR35","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/0140-6736(90)90707-C","volume":"l","author":"G Zwart","year":"1990","unstructured":"Zwart, G. et al. Lancet l, 474 (1990).","journal-title":"Lancet"},{"key":"BF346277a0_CR36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/BF01487688","volume":"100","author":"M \u00d6zel","year":"1988","unstructured":"\u00d6zel, M., Pauli, G. & Gelderblom, H. R. Arch. Virology 100, 255\u2013266 (1988).","journal-title":"Arch. Virology"},{"key":"BF346277a0_CR37","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1073\/pnas.87.2.648","volume":"87","author":"PL Earl","year":"1990","unstructured":"Earl, P. L., Doms, R. W. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 87, 648\u2013652 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346277a0_CR38","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1089\/aid.1987.3.387","volume":"3","author":"SW Pyle","year":"1987","unstructured":"Pyle, S. W. et al. AIDS Res. Hum. Retroviruses 3, 387\u2013400 (1987).","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"BF346277a0_CR39","volume-title":"The Advanced Theory of Statistics","author":"M Kendall","year":"1979","unstructured":"Kendall, M. & Stuart, A. The Advanced Theory of Statistics Vol. 2 (Griffin, London, 1979)."},{"key":"BF346277a0_CR40","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1214\/ss\/1177013815","volume":"1","author":"B Efron","year":"1986","unstructured":"Efron, B. & Tibshirani, R. Stat. Sci. 1, 54\u201377 (1986).","journal-title":"Stat. Sci."},{"key":"BF346277a0_CR41","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/00002030-199004000-00003","volume":"4","author":"JP Moore","year":"1990","unstructured":"Moore, J. P. AIDS 4, 297\u2013305 (1990).","journal-title":"AIDS"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/346277a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/346277a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/346277a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:10:10Z","timestamp":1684289410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/346277a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7]]},"references-count":41,"journal-issue":{"issue":"6281","published-print":{"date-parts":[[1990,7]]}},"alternative-id":["BF346277a0"],"URL":"https:\/\/doi.org\/10.1038\/346277a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,7]]}}}