{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:12:16Z","timestamp":1780103536533,"version":"3.54.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6284","license":[{"start":{"date-parts":[[1990,8,9]],"date-time":"1990-08-09T00:00:00Z","timestamp":650160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1990,8,9]],"date-time":"1990-08-09T00:00:00Z","timestamp":650160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,8,9]]},"DOI":"10.1038\/346561a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T18:48:27Z","timestamp":1055443707000},"page":"561-564","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4038,"title":["Structure of a cannabinoid receptor and functional expression of the cloned cDNA"],"prefix":"10.1038","volume":"346","author":[{"given":"Lisa A.","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Lolait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Brownstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom I.","family":"Bonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1990,8,9]]},"reference":[{"key":"BF346561a0_CR1","first-page":"1","volume":"38","author":"LE Hollister","year":"1986","unstructured":"Hollister, L. E. Pharmac. Rev. 38, 1\u201320 (1986).","journal-title":"Pharmac. Rev."},{"key":"BF346561a0_CR2","first-page":"45","volume":"38","author":"BR Martin","year":"1986","unstructured":"Martin, B. R. Pharmac. Rev. 38, 45\u201374 (1986).","journal-title":"Pharmac. Rev."},{"key":"BF346561a0_CR3","first-page":"151","volume":"38","author":"WL Dewey","year":"1986","unstructured":"Dewey, W. L. Pharmac. Rev. 38, 151\u2013178 (1986).","journal-title":"Pharmac. Rev."},{"key":"BF346561a0_CR4","first-page":"429","volume":"27","author":"AC Howlett","year":"1985","unstructured":"Howlett, A. C. Molec. Pharmacol. 27, 429\u2013436 (1985).","journal-title":"Molec. Pharmacol."},{"key":"BF346561a0_CR5","first-page":"532","volume":"26","author":"AC Howlett","year":"1984","unstructured":"Howlett, A. C. & Fleming, R. M. Molec. Pharmacol. 26, 532\u2013538 (1984).","journal-title":"Molec. Pharmacol."},{"key":"BF346561a0_CR6","first-page":"307","volume":"29","author":"AC Howlett","year":"1986","unstructured":"Howlett, A. C., Qualy, J. M. & Khachatrian, L. L. Molec. Pharmacol. 29, 307\u2013313 (1986).","journal-title":"Molec. Pharmacol."},{"key":"BF346561a0_CR7","first-page":"605","volume":"34","author":"WA Devane","year":"1988","unstructured":"Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. Molec. Pharmacol. 34, 605\u2013613 (1988).","journal-title":"Molec. Pharmacol."},{"key":"BF346561a0_CR8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/0028-3908(87)90035-9","volume":"26","author":"AC Howlett","year":"1987","unstructured":"Howlett, A. C. Neuropharmacology 26, 507\u2013512 (1987).","journal-title":"Neuropharmacology"},{"key":"BF346561a0_CR9","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1126\/science.3037705","volume":"237","author":"TI Bonner","year":"1987","unstructured":"Bonner, T. I., Buckley, N. J., Young, A. C. & Brann, M. R. Science 237, 527\u2013532 (1987).","journal-title":"Science"},{"key":"BF346561a0_CR10","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1126\/science.6314503","volume":"222","author":"M Nirenburg","year":"1983","unstructured":"Nirenburg, M. et al. Science 222, 794\u2013799 (1983).","journal-title":"Science"},{"key":"BF346561a0_CR11","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1111\/j.1471-4159.1986.tb08515.x","volume":"46","author":"WA Devane","year":"1986","unstructured":"Devane, W. A., Spain, J. W., Coscia, C. J. & Howlett, A. C. J. Neurochem. 46, 1925\u20131935 (1986).","journal-title":"J. Neurochem."},{"key":"BF346561a0_CR12","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","volume":"87","author":"M Herkenham","year":"1990","unstructured":"Herkenham, M. et al. Proc. natn. Acad. Scl. U.S.A. 87, 1932\u20131936 (1990).","journal-title":"Proc. natn. Acad. Scl. U.S.A."},{"key":"BF346561a0_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1471-4159.1990.tb08815.x","volume":"55","author":"M Bidaut-Russell","year":"1990","unstructured":"Bidaut-Russell, M., Devane, W. A. & Howlett, A. C. J. Neurochem. 55, 21\u201326 (1990).","journal-title":"J. Neurochem."},{"key":"BF346561a0_CR14","first-page":"297","volume":"33","author":"AC Howlett","year":"1988","unstructured":"Howlett, A. C., Johnson, M. R., Melvin, L. S. & Milne, G. M. Molec. Pharmacol. 33, 297\u2013302 (1988).","journal-title":"Molec. Pharmacol."},{"key":"BF346561a0_CR15","first-page":"75","volume":"38","author":"RK Razdan","year":"1986","unstructured":"Razdan, R. K. Pharmac. Rev. 38, 75\u2013149 (1986).","journal-title":"Pharmac. Rev."},{"key":"BF346561a0_CR16","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0092-8674(84)90336-2","volume":"36","author":"AG Gilman","year":"1984","unstructured":"Gilman, A. G. Cell 36, 577\u2013579 (1984).","journal-title":"Cell"},{"key":"BF346561a0_CR17","first-page":"595","volume":"11","author":"DK Lawrence","year":"1975","unstructured":"Lawrence, D. K. & Gill, E. W. Molec. Pharmacol. 11, 595\u2013602 (1975).","journal-title":"Molec. Pharmacol."},{"key":"BF346561a0_CR18","first-page":"579","volume":"232","author":"CJ Hillard","year":"1985","unstructured":"Hillard, C. J., Harris, R. A. & Bloom, A. S. J. Pharmac. exp. Ther. 232, 579\u2013588 (1985).","journal-title":"J. Pharmac. exp. Ther."},{"key":"BF346561a0_CR19","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/329836a0","volume":"329","author":"Y Masu","year":"1987","unstructured":"Masu, Y. et al. Nature 329, 836\u2013838 (1987).","journal-title":"Nature"},{"key":"BF346561a0_CR20","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1126\/science.2502842","volume":"245","author":"KC McFarland","year":"1989","unstructured":"McFarland, K. C. et al. Science 245, 494\u2013499 (1989).","journal-title":"Science"},{"key":"BF346561a0_CR21","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1126\/science.2502844","volume":"245","author":"H Loosfelt","year":"1989","unstructured":"Loosfelt, H. et al. Science 245, 525\u2013528 (1989).","journal-title":"Science"},{"key":"BF346561a0_CR22","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/0092-8674(86)90785-3","volume":"45","author":"D Young","year":"1986","unstructured":"Young, D., Waitches, G., Birchmeier, C., Fasano, O. & Wigler, M. Cell 45, 711\u2013719 (1986).","journal-title":"Cell"},{"key":"BF346561a0_CR23","doi-asserted-by":"publisher","first-page":"8459","DOI":"10.1073\/pnas.85.22.8459","volume":"85","author":"SS Karnik","year":"1988","unstructured":"Karnik, S. S., Sakmar, T. P., Chen, H.-B. & Khorana, H. G. Proc. natn. Acad. Sci. U.S.A. 85, 8459\u20138463 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346561a0_CR24","first-page":"280","volume":"3","author":"H Okayama","year":"1983","unstructured":"Okayama, H. & Berg, P. Molec. cell. Biol. 3, 280\u2013289 (1983).","journal-title":"Molec. cell. Biol."},{"key":"BF346561a0_CR25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156\u2013159 (1987).","journal-title":"Analyt. Biochem."},{"key":"BF346561a0_CR26","doi-asserted-by":"publisher","first-page":"9827","DOI":"10.1073\/pnas.83.24.9827","volume":"83","author":"WS Young III","year":"1986","unstructured":"Young, W. S. III, Bonner, T. I. & Brann, M. R. Proc. natn. Acad. Sci. U.S.A. 83, 9827\u20139831 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF346561a0_CR27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1159\/000124858","volume":"46","author":"WS Young III","year":"1987","unstructured":"Young, W. S. III, Warden, M. & Mezey, E. Neuroendocrinology 46, 439\u2013444 (1987).","journal-title":"Neuroendocrinology"},{"key":"BF346561a0_CR28","first-page":"2745","volume":"7","author":"C Chen","year":"1987","unstructured":"Chen, C. & Okayama, H. Molec. cell. Biol. 7, 2745\u20132752 (1987).","journal-title":"Molec. cell. Biol."},{"key":"BF346561a0_CR29","first-page":"1","volume":"10","author":"G Brooker","year":"1979","unstructured":"Brooker, G., Harper, J. F., Terasaki, W. L. & Moylan, R. D. Adv. Cyclic Nucleotide Res. 10, 1\u201333 (1979).","journal-title":"Adv. Cyclic Nucleotide Res."},{"key":"BF346561a0_CR30","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/0024-3205(88)90196-8","volume":"43","author":"S Borst","year":"1988","unstructured":"Borst, S. & Conolly, M. Life Sci. 43, 1021\u20131030 (1988).","journal-title":"Life Sci."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/346561a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/346561a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/346561a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T18:38:14Z","timestamp":1704825494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/346561a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8,9]]},"references-count":30,"journal-issue":{"issue":"6284","published-print":{"date-parts":[[1990,8,9]]}},"alternative-id":["BF346561a0"],"URL":"https:\/\/doi.org\/10.1038\/346561a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,8,9]]},"assertion":[{"value":"24 April 1990","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 1990","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 1990","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}