{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:46:41Z","timestamp":1774532801256,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6295","license":[{"start":{"date-parts":[[1990,10,1]],"date-time":"1990-10-01T00:00:00Z","timestamp":654739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,10]]},"DOI":"10.1038\/347773a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T22:54:52Z","timestamp":1055458492000},"page":"773-776","source":"Crossref","is-referenced-by-count":225,"title":["Identification of the primary gene defect at the cytochrome P450 CYP2D locus"],"prefix":"10.1038","volume":"347","author":[{"given":"Alan C.","family":"Gough","sequence":"first","affiliation":[]},{"given":"John S.","family":"Miles","sequence":"additional","affiliation":[]},{"given":"Nigel K.","family":"Spurr","sequence":"additional","affiliation":[]},{"given":"Julie E.","family":"Moss","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Gaedigk","sequence":"additional","affiliation":[]},{"given":"Michel","family":"Eichelbaum","sequence":"additional","affiliation":[]},{"given":"C. Roland","family":"Wolf","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF347773a0_CR1","volume-title":"Phenotypic Variation in Populations, Relevance to Risk Assessment","author":"DW Nebert","year":"1988","unstructured":"Nebert, D. W. in Phenotypic Variation in Populations, Relevance to Risk Assessment (eds Woodhead, A. D., Bender, M. A. & Leonard, R. C.) (Plenum, New York, 1988)."},{"key":"BF347773a0_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0168-9525(86)90232-5","volume":"2","author":"CR Wolf","year":"1986","unstructured":"Wolf, C. R. Trends Genet. 2, 209\u2013214 (1986).","journal-title":"Trends Genet."},{"key":"BF347773a0_CR3","unstructured":"Guengerich, F. P. (ed.) Cytochrome P450, Vols I and II (CRC, Baton Roca, 1987)."},{"key":"BF347773a0_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/dna.1.1989.8.1","volume":"8","author":"DW Nebert","year":"1989","unstructured":"Nebert, D. W. et al. DNA 8, 1\u201314 (1989).","journal-title":"DNA"},{"key":"BF347773a0_CR5","first-page":"243","volume":"40","author":"FJ Gonzalez","year":"1989","unstructured":"Gonzalez, F. J. Pharmac. Rev. 40, 243\u2013287 (1989).","journal-title":"Pharmac. Rev."},{"key":"BF347773a0_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF00562059","volume":"16","author":"M Eichelbaum","year":"1979","unstructured":"Eichelbaum, M., Spannbrucker, N., Steinke, B. & Dengler, H. J. Eur. J. clin. Pharmacol. 16, 183\u2013187 (1979).","journal-title":"Eur. J. clin. Pharmacol."},{"key":"BF347773a0_CR7","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/S0140-6736(77)91430-1","volume":"ii","author":"A Mahgoub","year":"1977","unstructured":"Mahgoub, A. et al. Lancet ii, 584\u2013586 (1977).","journal-title":"Lancet"},{"key":"BF347773a0_CR8","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/S0140-6736(77)90527-X","volume":"ii","author":"GT Tucker","year":"1977","unstructured":"Tucker, G. T. et al. Lancet ii, 718 (1977).","journal-title":"Lancet"},{"key":"BF347773a0_CR9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3109\/00498258609050251","volume":"16","author":"UA Meyer","year":"1986","unstructured":"Meyer, U. A. et al. Xenobiotica 16, 449\u2013464 (1986).","journal-title":"Xenobiotica"},{"key":"BF347773a0_CR10","first-page":"243","volume":"2","author":"M Eichelbaum","year":"1988","unstructured":"Eichelbaum, M. ISI Atlas of Science-Pharmacology 2, 243\u2013251 (1988).","journal-title":"ISI Atlas of Science-Pharmacology"},{"key":"BF347773a0_CR11","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/331442a0","volume":"331","author":"FJ Gonzalez","year":"1988","unstructured":"Gonzalez, F. J. et al. Nature 331, 442\u2013446 (1988).","journal-title":"Nature"},{"key":"BF347773a0_CR12","first-page":"3","volume-title":"Metabolic Basis of Acquired Disease","author":"LM Forrester","year":"1990","unstructured":"Forrester, L. M. & Wolf, C. R. in Metabolic Basis of Acquired Disease (eds Cohen, R. D., Alberti, K. G. M. M., Lewis, B. & Denman, A. M.) 3\u201318 (Balliere Tindall, London, 1990)."},{"key":"BF347773a0_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/312169a0","volume":"312","author":"R Ayesh","year":"1984","unstructured":"Ayesh, R. et al. Nature 312, 169\u2013170 (1984).","journal-title":"Nature"},{"key":"BF347773a0_CR14","unstructured":"Cuporaso, N. et al. Proc. Soc. clin. Oncol. 8, Abstract 336 (1988)."},{"key":"BF347773a0_CR15","first-page":"3675","volume":"49","author":"N Cuporaso","year":"1989","unstructured":"Cuporaso, N. et al. Cancer Res. 49, 3675\u20133679 (1989).","journal-title":"Cancer Res."},{"key":"BF347773a0_CR16","first-page":"5488","volume":"47","author":"A Kaisary","year":"1987","unstructured":"Kaisary, A. et al. Cancer Res. 47, 5488\u20135493, (1987).","journal-title":"Cancer Res."},{"key":"BF347773a0_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF01774220","volume":"66","author":"L Roots","year":"1988","unstructured":"Roots, L. et al. Klin. Wochenschr. 66, Suppl. XI, 87\u201397 (1988).","journal-title":"Klin. Wochenschr."},{"key":"BF347773a0_CR18","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1365-2125.1990.tb03608.x","volume":"29","author":"CJ Spiers","year":"1989","unstructured":"Spiers, C. J. et al. Br. J. clin. Pharmac. 29, 101\u2013109 (1989).","journal-title":"Br. J. clin. Pharmac."},{"key":"BF347773a0_CR19","first-page":"889","volume":"45","author":"S Kimura","year":"1989","unstructured":"Kimura, S. et al. Am. J. hum. Genet. 45, 889\u2013904 (1989).","journal-title":"Am. J. hum. Genet."},{"key":"BF347773a0_CR20","doi-asserted-by":"publisher","first-page":"5240","DOI":"10.1073\/pnas.85.14.5240","volume":"85","author":"RC Skoda","year":"1988","unstructured":"Skoda, R. C., Gonzalez, F. J., Demierre, A. & Meyer, U. A. Proc. natn. Acad. Sci. U.S.A. 85, 5240\u20135243 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF347773a0_CR21","first-page":"R109","volume":"341","author":"A Gaedigk","year":"1990","unstructured":"Gaedigk, A., Blum, M., Meyer, U. A. & Eichelbaum, M. Naunyn-Schmiedeberg's Arch. Pharmac. 341, Suppl., R109 (1990).","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmac."},{"key":"BF347773a0_CR22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","volume":"136","author":"DP Feinberg","year":"1983","unstructured":"Feinberg, D. P. & Vogelstein, B. Analyt. Biochem. 136, 6\u201313 (1983).","journal-title":"Analyt. Biochem."},{"key":"BF347773a0_CR23","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1021\/bi00324a002","volume":"24","author":"SCM Kwok","year":"1985","unstructured":"Kwok, S. C. M. et al. Biochemistry 24, 556\u2013561 (1985).","journal-title":"Biochemistry"},{"key":"BF347773a0_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0022-2836(80)90196-5","volume":"143","author":"F Sanger","year":"1980","unstructured":"Sanger, F. et al. J. molec. Biol. 143, 161\u2013178 (1980).","journal-title":"J. molec. Biol."},{"key":"BF347773a0_CR25","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1073\/pnas.80.13.3963","volume":"80","author":"MD Biggin","year":"1983","unstructured":"Biggin, M. D., Gibson, T. J. & Hong, G. F. Proc. natn. Acad. Sci. U.S.A. 80, 3963\u20133965 (1983).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF347773a0_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/nar\/14.1.217","volume":"14","author":"R Staden","year":"1986","unstructured":"Staden, R. Nucleic Acids Res. 14, 217\u2013231 (1986).","journal-title":"Nucleic Acids Res."},{"key":"BF347773a0_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/0003-2697(87)90006-6","volume":"162","author":"T Kronbach","year":"1987","unstructured":"Kronbach, T. et al. Analyt. Biochem. 162, 24\u201332 (1987).","journal-title":"Analyt. Biochem."},{"key":"BF347773a0_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1126\/science.239.4839.487","volume":"239","author":"RK Saiki","year":"1988","unstructured":"Saiki, R. K. et al. Science 239, 487\u2013491 (1988).","journal-title":"Science"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/347773a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/347773a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/347773a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:36:09Z","timestamp":1684287369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/347773a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":28,"journal-issue":{"issue":"6295","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["BF347773a0"],"URL":"https:\/\/doi.org\/10.1038\/347773a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}