{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:12:18Z","timestamp":1776449538140,"version":"3.51.2"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6302","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1990,12]]},"DOI":"10.1038\/348651a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T22:59:15Z","timestamp":1055458755000},"page":"651-653","source":"Crossref","is-referenced-by-count":1649,"title":["A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies"],"prefix":"10.1038","volume":"348","author":[{"given":"Yu-ichi","family":"Goto","sequence":"first","affiliation":[]},{"given":"Ikuya","family":"Nonaka","sequence":"additional","affiliation":[]},{"given":"Satoshi","family":"Horai","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF348651a0_CR1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/ana.410170602","volume":"17","author":"S DiMauro","year":"1985","unstructured":"DiMauro, S., Bonulla, E., Zeviani, M., Nakagawa, M. & DeVivo, D. C. Ann. Neurol. 17, 521\u2013538 (1985).","journal-title":"Ann. Neurol."},{"key":"BF348651a0_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/ana.410160409","volume":"16","author":"SG Pavlakis","year":"1984","unstructured":"Pavlakis, S. G., Phillips, P. C., DiMauro, S., DeVivo, D. C. & Rowland, L. P. Ann. Neurol. 16, 481\u2013488 (1984).","journal-title":"Ann. Neurol."},{"key":"BF348651a0_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0022-510X(80)90031-3","volume":"47","author":"N Fukuhara","year":"1980","unstructured":"Fukuhara, N., Tokiguchi, S., Shirakawa, K. & Tsubaki, T. J. neurol. Sci. 47, 117\u2013133 (1980).","journal-title":"J. neurol. Sci."},{"key":"BF348651a0_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/archopht.1958.00940080296016","volume":"60","author":"TP Kearns","year":"1967","unstructured":"Kearns, T. P. & Sayre, G. P. Arch. Ophthalmol. 60, 280\u2013289 (1967).","journal-title":"Arch. Ophthalmol."},{"key":"BF348651a0_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0002-9343(67)90015-0","volume":"42","author":"GH Shy","year":"1967","unstructured":"Shy, G. H., Silberberg, D. H., Appel, S. H., Mishkin, M. M. & Godfrey, E. H. Am. J. Med. 42, 163\u2013178 (1967).","journal-title":"Am. J. Med."},{"key":"BF348651a0_CR6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/331717a0","volume":"331","author":"IJ Holt","year":"1988","unstructured":"Holt, I. J., Harding, A. E. & Morgan-Hughes, J. A. Nature 331, 717\u2013719 (1988).","journal-title":"Nature"},{"key":"BF348651a0_CR7","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1212\/WNL.38.9.1339","volume":"38","author":"M Zeviani","year":"1988","unstructured":"Zeviani, M. et al. Neurology 38, 1339\u20131346 (1988).","journal-title":"Neurology"},{"key":"BF348651a0_CR8","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1056\/NEJM198905183202001","volume":"320","author":"CT Moraes","year":"1989","unstructured":"Moraes, C. T. et al. N. Engl. J. Med. 320, 1293\u20131299 (1989).","journal-title":"N. Engl. J. Med."},{"key":"BF348651a0_CR9","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0092-8674(90)90059-N","volume":"61","author":"JM Shoffner","year":"1990","unstructured":"Shoffner, J. M. et al. Cell 61, 931\u2013937 (1990).","journal-title":"Cell"},{"key":"BF348651a0_CR10","first-page":"789","volume":"21","author":"M Yoneda","year":"1990","unstructured":"Yoneda, M. et al. Biochem. Int. 21, 789\u2013796 (1990).","journal-title":"Biochem. Int."},{"key":"BF348651a0_CR11","doi-asserted-by":"publisher","first-page":"9509","DOI":"10.1073\/pnas.86.23.9509","volume":"86","author":"S Mita","year":"1989","unstructured":"Mita, S. et al. Proc. natn. Acad. Sci. U.S.A. 86, 9509\u20139513 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF348651a0_CR12","first-page":"418","volume":"46","author":"H Nakase","year":"1990","unstructured":"Nakase, H. et al. Am. J. hum. Genet. 46, 418\u2013427 (1990).","journal-title":"Am. J. hum. Genet."},{"key":"BF348651a0_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0092-8674(90)90238-A","volume":"62","author":"EA Shoubridge","year":"1990","unstructured":"Shoubridge, E. A., Karpati, G. & Hastings, K. E. H. Cell 62, 43\u201349 (1990).","journal-title":"Cell"},{"key":"BF348651a0_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/290457a0","volume":"290","author":"S Anderson","year":"1981","unstructured":"Anderson, S. et al. Nature 290, 457\u2013465 (1981).","journal-title":"Nature"},{"key":"BF348651a0_CR15","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/0022-2836(82)90137-1","volume":"156","author":"S Anderson","year":"1982","unstructured":"Anderson, S. et al. J. molec. Biol. 156, 683\u2013717 (1982).","journal-title":"J. molec. Biol."},{"key":"BF348651a0_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0092-8674(81)90300-7","volume":"26","author":"M Bibb","year":"1981","unstructured":"Bibb, M., Van Etten, R. A., Wright, C. T., Walberg, M. W. & Clayton, D. A. Cell 26, 167\u2013180 (1981).","journal-title":"Cell"},{"key":"BF348651a0_CR17","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/BF02602930","volume":"28","author":"G Gadaleta","year":"1989","unstructured":"Gadaleta, G. et al. J. molec. Evol. 28, 497\u2013516 (1989).","journal-title":"J. molec. Evol."},{"key":"BF348651a0_CR18","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0022-2836(90)90225-B","volume":"212","author":"P Desjardins","year":"1990","unstructured":"Desjardins, P. & Morais, R. J. molec. Biol. 212, 599\u2013634 (1990).","journal-title":"J. molec. Biol."},{"key":"BF348651a0_CR19","first-page":"9757","volume":"260","author":"BA Roe","year":"1985","unstructured":"Roe, B. A., Ma, D.-P., Wilson, R. K. & Wong, J. F.-H. J. biol. Chem. 260, 9757\u20139774 (1985).","journal-title":"J. biol. Chem."},{"key":"BF348651a0_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/BF02099755","volume":"22","author":"DO Clary","year":"1985","unstructured":"Clary, D. O. & Wolstenholme, D. R. J. molec. Evol. 22, 252\u2013271 (1985).","journal-title":"J. molec. Evol."},{"key":"BF348651a0_CR21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/genetics\/118.4.649","volume":"118","author":"R Garesse","year":"1988","unstructured":"Garesse, R. Genetics 118, 649\u2013663 (1988).","journal-title":"Genetics"},{"key":"BF348651a0_CR22","doi-asserted-by":"crossref","first-page":"10965","DOI":"10.1016\/S0021-9258(18)60413-2","volume":"264","author":"P Cantatore","year":"1989","unstructured":"Cantatore, P., Roberti, M., Rainaldi, G., Gadeleta, M. N. & Saccone, C. J. biol. Chem. 264, 10965\u201310975 (1989).","journal-title":"J. biol. Chem."},{"key":"BF348651a0_CR23","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0022-2836(88)90452-4","volume":"202","author":"HT Jacobs","year":"1988","unstructured":"Jacobs, H. T., Elliott, D. J., Math, V. B. & Farquharson, A. J. molec. Biol. 202, 185\u2013217 (1988).","journal-title":"J. molec. Biol."},{"key":"BF348651a0_CR24","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1146\/annurev.bi.45.070176.004105","volume":"35","author":"A Rich","year":"1976","unstructured":"Rich, A. & RajBhandary, L. A. Rev. Biochem. 35, 805\u2013860 (1976).","journal-title":"A. Rev. Biochem."},{"key":"BF348651a0_CR25","first-page":"1266","volume":"28","author":"T Nishio","year":"1988","unstructured":"Nishio, T., Sunohara, N., Nonaka, I., Ono, R. & Hamaguchi, K. Clin. Neurol. 28, 1266\u20131273 (1988).","journal-title":"Clin. Neurol."},{"key":"BF348651a0_CR26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1126\/science.239.4839.487","volume":"239","author":"Saiki","year":"1988","unstructured":"Saiki, et al. Science 239, 487\u2013491 (1988).","journal-title":"Science"},{"key":"BF348651a0_CR27","doi-asserted-by":"publisher","first-page":"7652","DOI":"10.1073\/pnas.85.20.7652","volume":"85","author":"UB Gyllensten","year":"1988","unstructured":"Gyllensten, U. B. & Erlich, H. A. Proc. natn. Acad. Sci. U.S.A. 85, 7652\u20137656 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF348651a0_CR28","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","volume":"74","author":"F Sanger","year":"1977","unstructured":"Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463\u20135467 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/348651a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/348651a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/348651a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:40:03Z","timestamp":1684287603000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/348651a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":28,"journal-issue":{"issue":"6302","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["BF348651a0"],"URL":"https:\/\/doi.org\/10.1038\/348651a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}