{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:57:35Z","timestamp":1791320255913,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6777","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1038\/35006670","type":"journal-article","created":{"date-parts":[[2002,9,13]],"date-time":"2002-09-13T16:33:56Z","timestamp":1031934836000},"page":"510-514","source":"Crossref","is-referenced-by-count":459,"title":["DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation"],"prefix":"10.1038","volume":"404","author":[{"given":"Michael J.","family":"Difilippantonio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua Tang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Meffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel C.","family":"Nussenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Max","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Nussenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35006670_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/386761a0","volume":"386","author":"KW Kinzler","year":"1997","unstructured":"Kinzler, K. W. & Vogelstein, B. Gatekeepers and caretakers.  Nature 386, 761\u2013763 ( 1997).","journal-title":"Nature"},{"key":"BF35006670_CR2","doi-asserted-by":"publisher","first-page":"10770","DOI":"10.1073\/pnas.96.19.10770","volume":"96","author":"H Vogel","year":"1999","unstructured":"Vogel, H., Lim, D. S., Karsenty, G., Finegold, M. & Hasty, P. Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl Acad. Sci. USA 96, 10770 \u201310775 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35006670_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/382551a0","volume":"382","author":"A Nussenzweig","year":"1996","unstructured":"Nussenzweig, A.  et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382, 551\u2013555 (1996).","journal-title":"Nature"},{"key":"BF35006670_CR4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0092-8674(00)80111-7","volume":"86","author":"C Zhu","year":"1996","unstructured":"Zhu, C., Bogue, M. A., Lim, D. S., Hasty, P. & Roth, D. B. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates.  Cell 86, 379\u2013389 ( 1996).","journal-title":"Cell"},{"key":"BF35006670_CR5","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1084\/jem.186.6.921","volume":"186","author":"H Ouyang","year":"1997","unstructured":"Ouyang, H. et al. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo. J. Exp. Med. 186 , 921\u2013929 (1997).","journal-title":"J. Exp. Med."},{"key":"BF35006670_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S1074-7613(00)80386-6","volume":"7","author":"Y Gu","year":"1997","unstructured":"Gu, Y. et al. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 367\u2013376 (1997).","journal-title":"Immunity"},{"key":"BF35006670_CR7","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0092-8674(00)81714-6","volume":"95","author":"Y Gao","year":"1998","unstructured":"Gao, Y. et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95, 891\u2013 902 (1998).","journal-title":"Cell"},{"key":"BF35006670_CR8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/24172","volume":"396","author":"KM Frank","year":"1998","unstructured":"Frank, K. M.  et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173\u2013177 (1998).","journal-title":"Nature"},{"key":"BF35006670_CR9","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/S0960-9822(98)00021-9","volume":"8","author":"DE Barnes","year":"1998","unstructured":"Barnes, D. E., Stamp, G., Rosewell, I., Denzel, A. & Lindahl, T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol.  8, 1395\u20131398 (1998).","journal-title":"Curr. Biol."},{"key":"BF35006670_CR10","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","volume":"88","author":"AJ Levine","year":"1997","unstructured":"Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell  88, 323\u2013331 (1997).","journal-title":"Cell"},{"key":"BF35006670_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","volume":"4","author":"T Jacks","year":"1994","unstructured":"Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1\u20137 ( 1994).","journal-title":"Curr. Biol."},{"key":"BF35006670_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/ng1196-312","volume":"14","author":"M Liyanage","year":"1996","unstructured":"Liyanage, M.  et al. Multicolour spectral karyotyping of mouse chromosomes.  Nature Genet. 14, 312\u2013315 (1996).","journal-title":"Nature Genet."},{"key":"BF35006670_CR13","doi-asserted-by":"publisher","first-page":"7837","DOI":"10.1073\/pnas.79.24.7837","volume":"79","author":"R Taub","year":"1982","unstructured":"Taub, R. et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc. Natl Acad. Sci. USA 79, 7837\u2013 7841 (1982).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35006670_CR14","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1172\/JCI6658","volume":"103","author":"GJ Vanasse","year":"1999","unstructured":"Vanasse, G. J.  et al. Genetic pathway to recurrent chromsome translocations in murine lymphoma involves V(D)J recombinase. J. Clin. Invest.  103, 1669\u20131675 (1999).","journal-title":"J. Clin. Invest."},{"key":"BF35006670_CR15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S1074-7613(00)80619-6","volume":"9","author":"Y Gao","year":"1998","unstructured":"Gao, Y. et al. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9, 367\u2013376 (1998).","journal-title":"Immunity"},{"key":"BF35006670_CR16","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/25292","volume":"396","author":"C Lengauer","year":"1998","unstructured":"Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers.  Nature 396, 643\u2013649 ( 1998).","journal-title":"Nature"},{"key":"BF35006670_CR17","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/S0960-9822(00)80123-2","volume":"9","author":"ZE Karanjawala","year":"1999","unstructured":"Karanjawala, Z. E., Grawunder, U., Hsieh, C. L. & Lieber, M. R. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr. Biol. 9, 1501 \u20131504 (1999).","journal-title":"Curr. Biol."},{"key":"BF35006670_CR18","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1126\/science.271.5256.1744","volume":"271","author":"K Fukasawa","year":"1996","unstructured":"Fukasawa, K., Choi, T., Kuriyama, R., Rulong, S. & Vande Woude, G. F. Abnormal centrosome amplification in the absence of p53. Science 271, 1744\u2013 1747 (1996).","journal-title":"Science"},{"key":"BF35006670_CR19","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S1097-2765(00)80466-9","volume":"3","author":"X Xu","year":"1999","unstructured":"Xu, X. et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.  Mol. Cell 3, 389\u2013395 ( 1999).","journal-title":"Mol. Cell"},{"key":"BF35006670_CR20","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/29457","volume":"394","author":"A Agrawal","year":"1998","unstructured":"Agrawal, A., Eastman, Q. M. & Schatz, D. G. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394, 744\u2013751 (1998).","journal-title":"Nature"},{"key":"BF35006670_CR21","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0092-8674(00)81587-1","volume":"94","author":"K Hiom","year":"1998","unstructured":"Hiom, K., Melek, M. & Gellert, M. DNA transposition by the Rag1 and Rag2 proteins: a possible source of oncogenic translocations. Cell 94, 463\u2013470 (1998).","journal-title":"Cell"},{"key":"BF35006670_CR22","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/emboj\/17.2.609","volume":"17","author":"DA Ramsden","year":"1998","unstructured":"Ramsden, D. A. & Gellert, M. Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J 17, 609 \u2013614 (1998).","journal-title":"EMBO J"},{"key":"BF35006670_CR23","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1101\/gad.13.8.916","volume":"13","author":"GCM Smith","year":"1999","unstructured":"Smith, G. C. M. & Jackson, S. P. The DNA-dependent protein kinase. Genes Dev. 13, 916\u2013 934 (1999).","journal-title":"Genes Dev."},{"key":"BF35006670_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S1097-2765(00)80109-4","volume":"2","author":"C Chen","year":"1998","unstructured":"Chen, C., Umezu, K. & Kolodner, R. D. Chromosomal rearrangements occur in S. cerevisiae  rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol. Cell 2, 9\u2013 22 (1998).","journal-title":"Mol. Cell"},{"key":"BF35006670_CR25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S1097-2765(00)80202-6","volume":"4","author":"ME Moynahan","year":"1999","unstructured":"Moynahan, M. E., Chiu, J. W., Koller, B. H. & Jasin, M. Brca1 controls homology-directed DNA repair. Mol. Cell  4, 511\u2013518 (1999).","journal-title":"Mol. Cell"},{"key":"BF35006670_CR26","first-page":"397","volume":"401","author":"RD Johnson","year":"1999","unstructured":"Johnson, R. D., Liu, N. & Jasin, M. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature 401, 397\u2013 399 (1999).","journal-title":"Nature"},{"key":"BF35006670_CR27","first-page":"462","volume":"17","author":"TL Timme","year":"1994","unstructured":"Timme, T. L. & Thompson, T. C. Rapid allelotype analysis of p53 knockout mice. Biotechniques 17, 462 \u2013463 (1994).","journal-title":"Biotechniques"},{"key":"BF35006670_CR28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/356215a0","volume":"356","author":"LA Donehower","year":"1992","unstructured":"Donehower, L. A.  et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215\u2013 221 (1992).","journal-title":"Nature"},{"key":"BF35006670_CR29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P","volume":"27","author":"BM Ghadimi","year":"2000","unstructured":"Ghadimi, B. M.  et al. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer  27, 183\u2013190 ( 2000).","journal-title":"Genes Chromosomes Cancer"},{"key":"BF35006670_CR30","doi-asserted-by":"publisher","first-page":"6978","DOI":"10.1073\/pnas.89.15.6978","volume":"89","author":"CC Chu","year":"1992","unstructured":"Chu, C. C., Paul, W. E. & Max, E. E. Quantitation of immunoglobulin \u00b5-\u03b31 heavy chain switch region recombination by a digestion\u2013circularization polymerase chain reaction method. Proc. Natl Acad. Sci. USA 89 , 6978\u20136982 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35006670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35006670","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35006670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:52:48Z","timestamp":1684288368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35006670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":30,"journal-issue":{"issue":"6777","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["BF35006670"],"URL":"https:\/\/doi.org\/10.1038\/35006670","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}