{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:16:47Z","timestamp":1778894207464,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2000,4,7]],"date-time":"2000-04-07T00:00:00Z","timestamp":955065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1038\/35010579","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:46:14Z","timestamp":1027673174000},"page":"302-309","source":"Crossref","is-referenced-by-count":476,"title":["PDGF-C is a new protease-activated ligand for the PDGF \u03b1-receptor"],"prefix":"10.1038","volume":"2","author":[{"given":"Xuri","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annica","family":"Pont\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Aase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Abramsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Uutela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudrun","family":"B\u00e4ckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Bostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Betsholtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-Henrik","family":"Heldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Alitalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"\u00d6stman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,4,7]]},"reference":[{"key":"BFncb0500_302_CR1","unstructured":"Raines, E. W., Bowen-Pope, D. F. & Ross, R. in Handbook of Experimental Pharmacology: Peptide Growth Factors and their Receptors Vol. I (eds Sporn, M. B. & Roberts, A. B.) 173\u2013262 (Springer, New York, 1990)."},{"key":"BFncb0500_302_CR2","first-page":"F79","volume":"1378","author":"CH Heldin","year":"1998","unstructured":"Heldin, C. H., \u00d6stman, A. & R\u00f6nnstrand, L. Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378 , F79\u2013F113 (1998).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncb0500_302_CR3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0074-7696(08)62359-1","volume":"172","author":"P Ataliotis","year":"1997","unstructured":"Ataliotis, P. & Mercola, M. Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis. Int. Rev. Cytol. 172, 95\u2013127 (1997).","journal-title":"Int. Rev. Cytol."},{"key":"BFncb0500_302_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0092-8674(84)90452-5","volume":"39","author":"C Betsholtz","year":"1984","unstructured":"Betsholtz, C., Westermark, B., Ek, B. & Heldin, C.-H. Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation. Cell 39, 447\u2013457 (1984).","journal-title":"Cell"},{"key":"BFncb0500_302_CR5","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1126\/science.2829358","volume":"239","author":"MT Keating","year":"1988","unstructured":"Keating, M. T. & Williams, L. T. Autocrine stimulation of intracellular PDGF receptors in v-sis transformed cells. Science 239, 914\u2013916 (1988).","journal-title":"Science"},{"key":"BFncb0500_302_CR6","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1152\/physrev.1999.79.4.1283","volume":"79","author":"CH Heldin","year":"1999","unstructured":"Heldin, C. H. & Westermark, B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79, 1283\u20131316 (1999).","journal-title":"Physiol. Rev."},{"key":"BFncb0500_302_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00041552-199801000-00004","volume":"7","author":"P Lindahl","year":"1998","unstructured":"Lindahl, P. & Betsholtz, C. Not all myofibroblasts are alike: revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice. Curr. Opin. Nephrol. Hypertens. 7, 21\u2013 26 (1998).","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"BFncb0500_302_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-642-58456-5_4","volume":"93","author":"P Lindahl","year":"1999","unstructured":"Lindahl, P. et al. Role of platelet-derived growth factors in angiogenesis and alveogenesis. Curr. Top. Pathol. 93, 27\u2013 33 (1999).","journal-title":"Curr. Top. Pathol."},{"key":"BFncb0500_302_CR9","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","volume":"85","author":"H Bostr\u00f6m","year":"1996","unstructured":"Bostr\u00f6m, H. et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85, 863 \u2013873 (1996).","journal-title":"Cell"},{"key":"BFncb0500_302_CR10","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1242\/dev.126.12.2611","volume":"126","author":"L Karlsson","year":"1999","unstructured":"Karlsson, L., Bondjers, C. & Betsholtz, C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126, 2611\u20132621 (1999).","journal-title":"Development"},{"key":"BFncb0500_302_CR11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.126.3.457","volume":"126","author":"M Fruttiger","year":"1999","unstructured":"Fruttiger, M. et al. Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development 126, 457\u2013467 (1999).","journal-title":"Development"},{"key":"BFncb0500_302_CR12","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/dev.124.14.2691","volume":"124","author":"P Soriano","year":"1997","unstructured":"Soriano, P. The PDGF\u03b1 receptor is required for neural crest cell development and for normal patterning of the somites. Development 124 , 2691\u20132700 (1997).","journal-title":"Development"},{"key":"BFncb0500_302_CR13","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1101\/gad.8.16.1875","volume":"8","author":"P Lev\u00e9en","year":"1994","unstructured":"Lev\u00e9en, P . et al. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8, 1875\u20131887 (1994).","journal-title":"Genes Dev."},{"key":"BFncb0500_302_CR14","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1101\/gad.8.16.1888","volume":"8","author":"P Soriano","year":"1994","unstructured":"Soriano, P. Abnormal kidney development and hematological disorders in PDGF\u03b2-receptor mutant mice. Genes Dev. 8, 1888\u2013 1896 (1994).","journal-title":"Genes Dev."},{"key":"BFncb0500_302_CR15","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1242\/dev.125.17.3313","volume":"125","author":"P Lindahl","year":"1998","unstructured":"Lindahl, P. et al. Paracrine PDGF-B\/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development 125, 3313\u20133322 (1998).","journal-title":"Development"},{"key":"BFncb0500_302_CR16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.277.5323.242","volume":"277","author":"P Lindahl","year":"1997","unstructured":"Lindahl, P., Johansson, B. R., Lev\u00e9en, P. & Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277, 242\u2013245 (1997).","journal-title":"Science"},{"key":"BFncb0500_302_CR17","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0014-5793(91)80433-4","volume":"282","author":"P Bork","year":"1991","unstructured":"Bork, P. Complement components C1r\/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats. FEBS Lett. 282, 9\u201312 (1991).","journal-title":"FEBS Lett."},{"key":"BFncb0500_302_CR18","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3109\/08977198908998003","volume":"1","author":"A \u00d6stman","year":"1989","unstructured":"\u00d6stman, A. et al. Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. Growth Factors 1, 271\u2013281 (1989).","journal-title":"Growth Factors"},{"key":"BFncb0500_302_CR19","doi-asserted-by":"crossref","first-page":"24613","DOI":"10.1016\/S0021-9258(18)54273-3","volume":"266","author":"A Subramaniam","year":"1991","unstructured":"Subramaniam, A. et al. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266 , 24613\u201324620 (1991).","journal-title":"J. Biol. Chem."},{"key":"BFncb0500_302_CR20","unstructured":"Simm, A., Nestler, M. & Hoppe, V. Mitogenic effect of PDGF-AA on cardiac fibroblasts. Basic Res. Cardiol. 93, Suppl 3, 40\u201343 (1998)."},{"key":"BFncb0500_302_CR21","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/S0092-8674(00)80363-3","volume":"90","author":"S Vainio","year":"1997","unstructured":"Vainio, S. & Muller, U. Inductive tissue interactions, cell signaling, and the control of kidney organogenesis. Cell 90, 975\u2013978 (1997).","journal-title":"Cell"},{"key":"BFncb0500_302_CR22","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1002\/j.1460-2075.1992.tb05485.x","volume":"11","author":"C Oefner","year":"1992","unstructured":"Oefner, C., D\u2019Arcy, A., Winkler, F.K., Eggimann, B. & Hosang, M. Crystal structure of human platelet-derived growth factor BB. EMBO J. 11, 3921\u20133926 (1992).","journal-title":"EMBO J."},{"key":"BFncb0500_302_CR23","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1083\/jcb.118.3.509","volume":"118","author":"A \u00d6stman","year":"1992","unstructured":"\u00d6stman, A., Thyberg, J., Westermark, B. & Heldin, C.-H. PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly. J. Cell Biol. 118, 509\u2013519 (1992).","journal-title":"J. Cell Biol."},{"key":"BFncb0500_302_CR24","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/bj3270625","volume":"327","author":"K Nakayama","year":"1997","unstructured":"Nakayama, K. Furin: a mammalian subtilisin\/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem. J. 327, 625\u2013635 (1997).","journal-title":"Biochem. J."},{"key":"BFncb0500_302_CR25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1006\/jmbi.1993.1305","volume":"231","author":"P Bork","year":"1993","unstructured":"Bork, P. & Beckmann, G. The CUB domain. A widespread module in developmentally regulated proteins. J. Mol. Biol. 231, 539\u2013545 (1993).","journal-title":"J. Mol. Biol."},{"key":"BFncb0500_302_CR26","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.1074\/jbc.273.9.5235","volume":"273","author":"SK Moestrup","year":"1998","unstructured":"Moestrup, S. K. et al. The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J. Biol. Chem. 273, 5235\u20135242 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFncb0500_302_CR27","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/S0896-6273(00)80626-1","volume":"21","author":"F Nakamura","year":"1998","unstructured":"Nakamura, F., Tanaka, M., Takahashi, T., Kalb, R. G. & Strittmatter, S. M. Neuropilin-1 extracellular domains mediate semaphorin D\/III-induced growth cone collapse. Neuron 21, 1093\u20131100 (1998).","journal-title":"Neuron"},{"key":"BFncb0500_302_CR28","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/S0896-6273(00)80625-X","volume":"21","author":"RJ Giger","year":"1998","unstructured":"Giger, R.J. et al. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron 21, 1079\u20131092 (1998).","journal-title":"Neuron"},{"key":"BFncb0500_302_CR29","doi-asserted-by":"publisher","first-page":"20540","DOI":"10.1074\/jbc.274.29.20540","volume":"274","author":"M Kristiansen","year":"1999","unstructured":"Kristiansen, M. et al. Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding . J. Biol. Chem. 274, 20540\u2013 20544 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFncb0500_302_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0162-3109(99)00019-3","volume":"42","author":"NM Thielens","year":"1999","unstructured":"Thielens, N. M., Bersch, B., Hernandez, J. F. & Arlaud, G. J. Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex. Immunopharmacology 42, 3\u201313 (1999).","journal-title":"Immunopharmacology"},{"key":"BFncb0500_302_CR31","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0021-9258(17)42200-9","volume":"269","author":"M Andersson","year":"1994","unstructured":"Andersson, M., \u00d6stman, A., Westermark, B. & Heldin, C.-H. Characterization of the retention motif in the C-terminal part of the long splice form of platelet-derived growth factor A-chain. J. Biol. Chem. 269, 926\u2013 930 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFncb0500_302_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3109\/08977199409010981","volume":"10","author":"M Pekny","year":"1994","unstructured":"Pekny, M. et al. Differences in binding to the solid substratum and extracellular matrix may explain isoform-specific paracrine effects of platelet-derived growth factor. Growth Factors 10, 77\u2013 87 (1994).","journal-title":"Growth Factors"},{"key":"BFncb0500_302_CR33","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1091\/mbc.4.12.1317","volume":"4","author":"JE Park","year":"1993","unstructured":"Park, J. E., Keller, G. A. & Ferrara, N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell 4, 1317\u20131326 (1993).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0500_302_CR34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3109\/08977199308991586","volume":"9","author":"S Hauser","year":"1993","unstructured":"Hauser, S. & Weich, H. A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors 9, 259\u2013 268 (1993).","journal-title":"Growth Factors"},{"key":"BFncb0500_302_CR35","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1073\/pnas.93.6.2576","volume":"93","author":"B Olofsson","year":"1996","unstructured":"Olofsson, B. et al. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl Acad. Sci. USA 93, 2576\u20132581 (1996).","journal-title":"Proc. Natl Acad. Sci."},{"key":"BFncb0500_302_CR36","first-page":"41","volume":"237","author":"U Eriksson","year":"1999","unstructured":"Eriksson, U. & Alitalo, K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Curr. Top. Microbiol. Immunol. 237, 41\u201357 (1999).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFncb0500_302_CR37","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/nar\/16.1.369","volume":"16","author":"S Green","year":"1988","unstructured":"Green, S., Issemann, I. & Sheer, E. A versatile in vivo and in vitro eucaryotic expression vector for protein engineering. Nucleic Acid Res. 16, 369 (1988).","journal-title":"Nucleic Acid Res."},{"key":"BFncb0500_302_CR38","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1002\/j.1460-2075.1988.tb02955.x","volume":"7","author":"C-H Heldin","year":"1988","unstructured":"Heldin, C.-H. et al. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J. 7 , 1387\u20131393 (1988).","journal-title":"EMBO J."},{"key":"BFncb0500_302_CR39","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/j.1460-2075.1992.tb05085.x","volume":"11","author":"A Eriksson","year":"1992","unstructured":"Eriksson, A., Siegbahn, A., Westermark, B., Heldin, C.-H. & Claesson-Welsh, L. PDGF\u03b1- and \u03b2-receptors activate unique and common signal transduction pathways. EMBO J. 11, 543\u2013550 (1992).","journal-title":"EMBO J."},{"key":"BFncb0500_302_CR40","doi-asserted-by":"crossref","first-page":"21158","DOI":"10.1016\/S0021-9258(18)54834-1","volume":"266","author":"S Mori","year":"1991","unstructured":"Mori, S., Claesson-Welsh, L. & Heldin, C. H. Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis. J. Biol. Chem. 266 , 21158\u201321164 (1991).","journal-title":"J. Biol. Chem."},{"key":"BFncb0500_302_CR41","doi-asserted-by":"crossref","unstructured":"Evan, G. I., Lewis, G. K., Ramsay, G. & Bishop, J. M. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell Biol. 3610\u20133616 (1985).","DOI":"10.1128\/MCB.5.12.3610"},{"key":"BFncb0500_302_CR42","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski, P. & Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction . Anal. Biochem. 162, 156\u2013 159 (1987).","journal-title":"Anal. Biochem."},{"key":"BFncb0500_302_CR43","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/320695a0","volume":"320","author":"C Betsholtz","year":"1986","unstructured":"Betsholtz, C. et al. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320, 695\u2013699 (1986).","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1038\/35010508","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000}}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb0500_302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb0500_302","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb0500_302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:04:28Z","timestamp":1684440268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb0500_302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4,7]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["BFncb0500_302"],"URL":"https:\/\/doi.org\/10.1038\/35010579","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4,7]]}}}