{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:05:16Z","timestamp":1761987916443},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2000,5,10]],"date-time":"2000-05-10T00:00:00Z","timestamp":957916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1038\/35014028","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:46:14Z","timestamp":1027673174000},"page":"339-345","source":"Crossref","is-referenced-by-count":77,"title":["Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents"],"prefix":"10.1038","volume":"2","author":[{"given":"Weiming","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme C. M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"lan G.","family":"Charles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,5,10]]},"reference":[{"key":"BFncb0600_339_CR1","first-page":"109","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada, S., Palmer, R. M. & Higgs, E. A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43, 109\u2013142 (1991).","journal-title":"Pharmacol. Rev."},{"key":"BFncb0600_339_CR2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1042\/bj2980249","volume":"298","author":"RG Knowles","year":"1994","unstructured":"Knowles, R. G. & Moncada, S. Nitric oxide synthases in mammals. Biochem. J. 298, 249\u2013258 (1994).","journal-title":"Biochem. J."},{"key":"BFncb0600_339_CR3","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/bjc.1994.409","volume":"70","author":"DC Jenkins","year":"1994","unstructured":"Jenkins, D. C. et al. Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation. Brit. J. Cancer 70, 847\u2013849 (1994).","journal-title":"Brit. J. Cancer"},{"key":"BFncb0600_339_CR4","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1073\/pnas.91.21.10089","volume":"91","author":"K Asano","year":"1994","unstructured":"Asano, K. et al. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl Acad. Sci. USA 91, 10089\u201310093 (1994).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0600_339_CR5","first-page":"334","volume":"58","author":"S Ambs","year":"1998","unstructured":"Ambs, S. et al. Frequent nitric oxide synthase-2 expression in human adenomas: implication for tumour angiogenesis and colon cancer progression. Cancer Res. 58, 334\u2013341 (1998).","journal-title":"Cancer Res."},{"key":"BFncb0600_339_CR6","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0006-2952(98)00187-7","volume":"56","author":"LL Thomsen","year":"1998","unstructured":"Thomsen, L. L., Sargent, J. M., Williamson, C. J. & Elgie, A. W. Nitric oxide synthase activity in fresh cells from ovarian tumour tissue: relationship of enzyme activity with clinical parameters of patients with ovarian cancer. Biochem. Pharmacol. 56, 1365\u20131370 (1998).","journal-title":"Biochem. Pharmacol."},{"key":"BFncb0600_339_CR7","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1182\/blood.V92.3.1031","volume":"92","author":"H Zhao","year":"1998","unstructured":"Zhao, H. et al. B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity. Blood 92, 1031\u20131043 (1998).","journal-title":"Blood"},{"key":"BFncb0600_339_CR8","doi-asserted-by":"publisher","first-page":"4392","DOI":"10.1073\/pnas.92.10.4392","volume":"92","author":"DC Jenkins","year":"1995","unstructured":"Jenkins, D. C. et al. Roles of nitric oxide in tumour growth. Proc. Natl Acad. Sci. USA 92, 4392\u20134396 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0600_339_CR9","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1073\/pnas.93.6.2442","volume":"93","author":"K Forrester","year":"1996","unstructured":"Forrester, K. et al. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc. Natl Acad. Sci. USA 93, 2442\u20132447 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0600_339_CR10","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/3957","volume":"4","author":"S Ambs","year":"1998","unstructured":"Ambs, S. et al. p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells. Nature Med. 4, 1371\u20131376 (1998).","journal-title":"Nature Med."},{"key":"BFncb0600_339_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0027-5107(99)00006-8","volume":"424","author":"S Burney","year":"1999","unstructured":"Burney, S., Caulfield, J. L., Niles, J. C., Wishnok, J. S., & Tannenbaum, S. R. The chemistry of DNA damage from nitric oxide and peroxynitrite. Mutat. Res. 424, 37\u201349 (1999).","journal-title":"Mutat. Res."},{"key":"BFncb0600_339_CR12","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1101\/gad.13.8.916","volume":"13","author":"GCM Smith","year":"1999","unstructured":"Smith, G. C. M. & Jackson, S. P. The DNA-dependent protein kinase. Genes Dev. 13, 916\u2013934 (1999).","journal-title":"Genes Dev."},{"key":"BFncb0600_339_CR13","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1073\/pnas.93.8.3346","volume":"93","author":"D No","year":"1996","unstructured":"No, D., Yao, T. P. & Evans, R. M. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl Acad. Sci. USA 93, 3346\u20133351 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0600_339_CR14","doi-asserted-by":"publisher","first-page":"11419","DOI":"10.1073\/pnas.90.23.11419","volume":"90","author":"IG Charles","year":"1993","unstructured":"Charles, I. G. et al. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Natl Acad. Sci. USA 90, 11419\u201311423 (1993).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0600_339_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0014-5793(91)81123-P","volume":"291","author":"M Salter","year":"1991","unstructured":"Salter, M., Knowles, R. G. & Moncada, S. Widespread tissue distribution, species distribution and changes in activity of Ca(2+)-dependent and Ca(2+)-independent nitric oxide synthases. FEBS Lett. 291, 145\u2013149 (1991).","journal-title":"FEBS Lett."},{"key":"BFncb0600_339_CR16","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0092-8674(95)90482-4","volume":"82","author":"KO Hartley","year":"1995","unstructured":"Hartley, K. O. et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849\u2013856 (1995).","journal-title":"Cell"},{"key":"BFncb0600_339_CR17","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.1002\/j.1460-2075.1996.tb00688.x","volume":"15","author":"Q Song","year":"1996","unstructured":"Song, Q. et al. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J. 15, 3238\u20133246 (1996).","journal-title":"EMBO J."},{"key":"BFncb0600_339_CR18","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1073\/pnas.92.1.320","volume":"92","author":"NJ Finnie","year":"1995","unstructured":"Finnie, N. J., Gottlieb, T. M., Blunt, T., Jeggo, P. A. & Jackson, S. P. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site specific recombination and DNA double strand break repair. Proc. Natl Acad. Sci. USA 92, 320\u2013324 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0600_339_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/geno.1997.5076","volume":"47","author":"MA Connelly","year":"1998","unstructured":"Connelly, M. A., Zhang, H., Kieleczawa, J. & Anderson, C. W. The promoters for human DNA-PKcs (PRKDC) and MCM 4: divergently transcribed genes located at chromosome 8 band q 11. Genomics 47, 71\u201383 (1998).","journal-title":"Genomics"},{"key":"BFncb0600_339_CR20","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/00005344-198401000-00018","volume":"6","author":"H Darius","year":"1984","unstructured":"Darius, H. et al. The effects of molsidomine and its metabolite SIN-1 on coronary vessel tone, platelet aggregation, and eicosanoid formation in vitro \u2014 inhibition of 12-HPETE biosynthesis. J. Cardiovasc. Pharmacol. 6, 115\u2013121 (1984).","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"BFncb0600_339_CR21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0092-8674(88)90144-4","volume":"55","author":"AJ Courey","year":"1988","unstructured":"Courey, A. J. & Tjian, R. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55, 887\u2013898 (1988).","journal-title":"Cell"},{"key":"BFncb0600_339_CR22","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1126\/science.7855602","volume":"267","author":"SP Lees-Miller","year":"1995","unstructured":"Lees-Miller, S. P. et al. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267, 1183\u20131185 (1995).","journal-title":"Science"},{"key":"BFncb0600_339_CR23","first-page":"2581","volume":"59","author":"RA Izzard","year":"1999","unstructured":"Izzard, R. A., Jackson, S. P. & Smith, G. C. Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res. 59, 2581\u20132586 (1999).","journal-title":"Cancer Res."},{"key":"BFncb0600_339_CR24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/095530098142031","volume":"73","author":"EC Woudstra","year":"1998","unstructured":"Woudstra, E. C., Driessen, C., Konings, A. W. & Kampinga, H. H. DNA damage induction and tumour cell radiosensitivity: PFGE and halo measurements. Int. J. Radiat. Biol. 73, 495\u2013502 (1998).","journal-title":"Int. J. Radiat. Biol."},{"key":"BFncb0600_339_CR25","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2307\/3578196","volume":"134","author":"MJ Allalunis-Turner","year":"1993","unstructured":"Allalunis-Turner, M. J. et al. Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. Radiat. Res. 134, 349\u2013354 (1993).","journal-title":"Radiat. Res."},{"key":"BFncb0600_339_CR26","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1093\/nar\/26.6.1382","volume":"26","author":"C Muller","year":"1998","unstructured":"Muller, C. et al. UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells. Nucleic Acids Res. 26, 1382\u20131389 (1998).","journal-title":"Nucleic Acids Res."},{"key":"BFncb0600_339_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0304-4165(98)00020-8","volume":"1381","author":"H Shen","year":"1998","unstructured":"Shen, H., Schultz, M., Kruh, G. D. & Tew, K. D. Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. Biochimica et Biophysica Acta 1381, 131\u2013138 (1998).","journal-title":"Biochimica et Biophysica Acta"},{"key":"BFncb0600_339_CR28","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1182\/blood.V92.7.2213","volume":"92","author":"C Muller","year":"1998","unstructured":"Muller, C., Christodoulopoulos, G., Salles, B. & Panasci, L. DNA-dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. Blood 92, 2213\u20132219 (1998).","journal-title":"Blood"},{"key":"BFncb0600_339_CR29","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1074\/jbc.274.10.6130","volume":"274","author":"CV Suschek","year":"1999","unstructured":"Suschek, C. V. et al. Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 upregulation. J. Biol. Chem. 274, 6130\u20136137 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFncb0600_339_CR30","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","volume":"11","author":"JD Dignam","year":"1983","unstructured":"Dignam, J. D., Lebovitz, R. M. & Roeder, R. G. Accurate transcription initiation by RNA polymerase-II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475\u20131489 (1983).","journal-title":"Nucleic Acids Res."},{"key":"BFncb0600_339_CR31","doi-asserted-by":"publisher","first-page":"7255","DOI":"10.1073\/pnas.87.18.7255","volume":"87","author":"MK Yagle","year":"1990","unstructured":"Yagle, M. K., Parruti, G., Xu, W., Ponder, B. & Solomon, E. Genetic and physical map of the von Recklinghausen neurofibromatosis (NF1) region on chromosome 17. Proc. Natl Acad. Sci. USA 87, 7255\u20137259 (1990).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb0600_339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb0600_339","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb0600_339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:06:18Z","timestamp":1684440378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb0600_339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5,10]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["BFncb0600_339"],"URL":"https:\/\/doi.org\/10.1038\/35014028","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5,10]]}}}