{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:17:45Z","timestamp":1791065865342,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6788","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1038\/35015579","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:45:49Z","timestamp":1027673149000},"page":"797-800","source":"Crossref","is-referenced-by-count":203,"title":["Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia"],"prefix":"10.1038","volume":"405","author":[{"given":"N. M.","family":"Page","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lomthaisong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. T.","family":"Gladwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Butlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. T.","family":"Manyonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35015579_CR1","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/0006-291X(83)90813-6","volume":"114","author":"K Kangawa","year":"1983","unstructured":"Kangawa, K., Minamino, N., Fukuda, A. & Matsuo, H. Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord.  Biochem. Biophys. Res. Commun. 114, 533\u2013 540 (1983).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF35015579_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1113\/jphysiol.1931.sp002763","volume":"72","author":"US von Euler","year":"1931","unstructured":"von Euler, U. S. & Gaddum, J. H. An unidentified depressor substance in certain tissue extracts. J. Physiol.  72, 74\u201387 (1931).","journal-title":"J. Physiol."},{"key":"BF35015579_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2183\/pjab.59.101","volume":"59","author":"S Kimura","year":"1983","unstructured":"Kimura, S., Okada, K., Sugita, Y., Kanazawa, I. & Munekata, E. Novel peptides neuropeptides, neurokinin \u03b1 and \u03b2, isolated from porcine spinal cord. Proc. Japan Acad. B  59, 101\u2013104 (1983).","journal-title":"Proc. Japan Acad. B"},{"key":"BF35015579_CR4","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1139\/y97-069","volume":"75","author":"J Longmore","year":"1997","unstructured":"Longmore, J., Hill, R. G. & Hargreaves, R. J. Neurokinin-receptor antagonists: pharmacological tools and therapeutic drugs. Canadian J. Physio. & Pharmacol.  75, 612\u2013621 ( 1997).","journal-title":"Canadian J. Physio. & Pharmacol."},{"key":"BF35015579_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0014-2999(87)90363-3","volume":"134","author":"D Mastrangelo","year":"1987","unstructured":"Mastrangelo, D.  et al. The rat isolated portal vein: a preparation sensitive to neurokinins, particularly neurokinin B. Eur. J. Pharmacol. 134, 321\u2013326 (1987).","journal-title":"Eur. J. Pharmacol."},{"key":"BF35015579_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0014-2999(91)90860-S","volume":"204","author":"P D'Orleans-Juste","year":"1991","unstructured":"D'Orleans-Juste, P., Claing, A., Telemaque, S., Warner, T. D. & Regoli, D. Neurokinins produce selective venoconstriction via NK-3 receptors in the rat mesenteric vascular bed. Eur. J. Pharmacol. 204, 329\u2013334 (1991).","journal-title":"Eur. J. Pharmacol."},{"key":"BF35015579_CR7","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1152\/ajpregu.1998.275.5.R1683","volume":"44","author":"GW Thompson","year":"1998","unstructured":"Thompson, G. W., Hoover, D. B., Ardell, J. L. & Armour, J. A. Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2 and NK3 receptors. Am. J. Physiol.-Regul. Integrative Comp. Physiol. 44, 1683\u20131689 ( 1998).","journal-title":"Am. J. Physiol.-Regul. Integrative Comp. Physiol."},{"key":"BF35015579_CR8","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/0306-4522(92)90285-A","volume":"48","author":"SM Moussaoui","year":"1992","unstructured":"Moussaoui, S. M.  et al. Distribution of neurokinin B in rat spinal cord and peripheral tissues: comparison with neurokinin A and substance P and effects of neonatal capsaican treatment. Neuroscience 48, 969 \u2013978 (1992).","journal-title":"Neuroscience"},{"key":"BF35015579_CR9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/jcbfm.1991.105","volume":"11","author":"I Jansen","year":"1991","unstructured":"Jansen, I., Alafaci, C., McCulloch, J., Uddman, R. & Edvinsson, L. Tachykinins (substance P, neurokinin A, neuropeptide K, and neurokinin B) in the cerebral circulation: vasomotor responses in vitro and in situ. J. Cereb. Blood Flow Metab. 11, 567\u2013575 ( 1991).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"BF35015579_CR10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0002-9378(91)90265-S","volume":"165","author":"H Baumann","year":"1991","unstructured":"Baumann, H. & Huch, R. Maternal hemodynamics in pregnancy. Am. J. Obstet. Gynecol. 165, 237\u2013 238 (1991).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BF35015579_CR11","first-page":"1809","volume":"151","author":"KH Lim","year":"1997","unstructured":"Lim, K. H.  et al. Human cytotrophoblast differentiation\/invasion is abnormal in pre-eclampsia. Am. J. Pathol. 151, 1809 \u20131818 (1997).","journal-title":"Am. J. Pathol."},{"key":"BF35015579_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1530\/ror.0.0010107","volume":"1","author":"F Lyall","year":"1996","unstructured":"Lyall, F. & Greer, I. A. The vascular endothelium in normal pregnancy and pre-eclampsia. Rev. Reprod. 1, 107\u2013116 (1996).","journal-title":"Rev. Reprod."},{"key":"BF35015579_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/107155769900600103","volume":"6","author":"R Hayman","year":"1999","unstructured":"Hayman, R., Brockelsby, J., Kenny, L. & Baker, P. Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J. Soc. Gynecol. Investig. 6, 3\u201310 (1999).","journal-title":"J. Soc. Gynecol. Investig."},{"key":"BF35015579_CR14","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1210\/jcem-64-5-1054","volume":"64","author":"A Campbell","year":"1987","unstructured":"Campbell, A.  et al. Plasma corticotrophin-releasing hormone concentrations during pregnancy and parturition. J. Clin. Endocrinol. Metab.  64, 1054\u20131059 (1987).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF35015579_CR15","first-page":"P257","volume":"156","author":"NM Page","year":"1998","unstructured":"Page, N. M., Manyonda, I., Butlin, D. J., Bicknell, A. B. & Lowry, P. J. Identification of novel differentially expressed secretory proteins from the human placenta. J. Endocr.  156 (Suppl.), P257 (1998).","journal-title":"J. Endocr."},{"key":"BF35015579_CR16","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/ng0893-332","volume":"4","author":"MS Boguski","year":"1993","unstructured":"Boguski, M. S., Lowe, T. M. & Tolstoshev, C. M. dbEST\u2014database for \u201cexpressed sequence tags\u201d. Nature Genet. 4, 332\u2013 333 (1993).","journal-title":"Nature Genet."},{"key":"BF35015579_CR17","unstructured":"Adams, M. D.  et al. Initial assessment of human gene diversity and expression patterns based upon 83-million nucleotides of cDNA sequence. Nature  377, Genome Directory 3S (1995)."},{"key":"BF35015579_CR18","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/BF00260610","volume":"340","author":"R Couture","year":"1989","unstructured":"Couture, R., Laneuville, O., Guimond, C., Drapeau, G. & Regoli, D. Characterization of the peripheral actions of neurokinins and neurokinin receptor selective agonists on the rat cardiovascular system. Naunyn Schmied. Arch. Pharmacol.  340, 547\u2013557 (1989).","journal-title":"Naunyn Schmied. Arch. Pharmacol."},{"key":"BF35015579_CR19","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/sj.bjp.0701435","volume":"122","author":"E Cellier","year":"1997","unstructured":"Cellier, E., Barbot, L., Regoli, D. & Couture, R. Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat. Br. J. Pharmacol.  122, 643\u2013654 ( 1997).","journal-title":"Br. J. Pharmacol."},{"key":"BF35015579_CR20","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/j.1476-5381.1996.tb15511.x","volume":"118","author":"A Roccon","year":"1996","unstructured":"Roccon, A., Marchionni, D. & Nisato, D. Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig.  Brit. J. Pharmacol. 118, 1095\u20131102 (1996).","journal-title":"Brit. J. Pharmacol."},{"key":"BF35015579_CR21","first-page":"F48","volume":"46","author":"KP Conrad","year":"1999","unstructured":"Conrad, K. P., Kerchner, L. J. & Mosher, M. D. Plasma and 24h NOx and cGMP during normal pregnancy and preeclampsia in women on a reduced NOx diet. Am. J. Physiol.  46, F48\u2013F57 ( 1999).","journal-title":"Am. J. Physiol."},{"key":"BF35015579_CR22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0162-3109(96)00035-5","volume":"33","author":"A Gecse","year":"1996","unstructured":"Gecse, A., Kis, B., Mezei, Z. & Telegdy, G. The effect of bradykinin and substance P on the arachidonate cascade of platelets.  Immunopharmacology 33, 167\u2013170 (1996).","journal-title":"Immunopharmacology"},{"key":"BF35015579_CR23","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/0006-291X(89)92630-2","volume":"161","author":"A Perianin","year":"1989","unstructured":"Perianin, A., Snyderman, R. & Malfroy, B. Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. Biochem. Biophys. Res. Commun. 161, 520\u2013524 (1989)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF35015579_CR24","first-page":"73","volume":"80","author":"M Perretti","year":"1993","unstructured":"Perretti, M., Ahluwalia, A., Flower, R J. & Manzini, S. Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors. Immunology 80, 73\u201377 (1993).","journal-title":"Immunology"},{"key":"BF35015579_CR25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0014-2999(96)00725-X","volume":"317","author":"M Kobari","year":"1996","unstructured":"Kobari, M.  et al. Intravascular substance P dilates cerebral parenchymal vessels through a specific tachykinin NK1 receptor in cats. Eur. J. Pharmacol.  317, 269\u2013274 ( 1996).","journal-title":"Eur. J. Pharmacol."},{"key":"BF35015579_CR26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S0006-8993(99)01386-4","volume":"830","author":"T Shimizu","year":"1999","unstructured":"Shimizu, T.  et al. Occurrence and distribution of substance P receptors in the cerebral blood vessels of the rat. Brain Res. 830, 372\u2013378 (1999).","journal-title":"Brain Res."},{"key":"BF35015579_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0143-4179(94)90059-0","volume":"27","author":"JM Stables","year":"1994","unstructured":"Stables, J. M.  et al. GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors. Neuropeptides 27, 333\u2013341 (1994).","journal-title":"Neuropeptides"},{"key":"BF35015579_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1677\/jme.0.0240053","volume":"24","author":"SM Baigent","year":"2000","unstructured":"Baigent, S. M. & Lowry, P. J. Urocortin is the principal ligand for the corticotrophin-releasing factor binding protein in the ovine brain with no evidence for a sauvagine-like peptide.  J. Mol. Endocrinol. 24, 53\u201363 (2000).","journal-title":"J. Mol. Endocrinol."},{"key":"BF35015579_CR29","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/283295a0","volume":"283","author":"V Clement-Jones","year":"1980","unstructured":"Clement-Jones, V., Lowry, P. J., Rees, L. H. & Besser, G. M. Met-enkephalin circulates in human plasma. Nature 283 , 295\u2013297 (1980).","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35015579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35015579","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35015579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:59:13Z","timestamp":1684288753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35015579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":29,"journal-issue":{"issue":"6788","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["BF35015579"],"URL":"https:\/\/doi.org\/10.1038\/35015579","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}