{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:44:01Z","timestamp":1791067441196,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6792","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1038\/35018111","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:45:49Z","timestamp":1027658749000},"page":"199-203","source":"Crossref","is-referenced-by-count":353,"title":["Genetic ablation of parathyroid glands reveals another source of parathyroid hormone"],"prefix":"10.1038","volume":"406","author":[{"given":"Thomas","family":"G\u00fcnther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Priemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"Rueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Moseley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. John","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Karsenty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35018111_CR1","first-page":"52","volume-title":"Metabolic Bone Disease and Clinically Related Disorders: Parathyroid Hormone and Parathyroid Hormone-Related Peptide in Calcium Homeostasis, Bone Metabolism and Bone Development: The Proteins, their Genes, and Receptors","author":"JT Potts","year":"1998","unstructured":"Potts, J. T. & J\u00fcppner, H. in Metabolic Bone Disease and Clinically Related Disorders: Parathyroid Hormone and Parathyroid Hormone-Related Peptide in Calcium Homeostasis, Bone Metabolism and Bone Development: The Proteins, their Genes, and Receptors (eds Avioli, L. V. & Krane, S. M.) 52\u201394 (Academic, San Diego, 1998)."},{"key":"BF35018111_CR2","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0092-8674(95)90281-3","volume":"82","author":"T Hosoya","year":"1995","unstructured":"Hosoya, T., Takizawa, K., Nitta, K. & Hotta, Y. Glial cells missing: A binary switch between neuronal and glial determination in Drosophila . Cell 82, 1025\u20131036 (1995).","journal-title":"Cell"},{"key":"BF35018111_CR3","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/0092-8674(95)90280-5","volume":"82","author":"BW Jones","year":"1995","unstructured":"Jones, B. W., Fetter, R. D., Tear, G. & Goodman, C. S. Glial cells missing: A genetic switch that controls glial versus neuronal fate. Cell 82, 1013\u20131023 ( 1995).","journal-title":"Cell"},{"key":"BF35018111_CR4","doi-asserted-by":"publisher","first-page":"14912","DOI":"10.1073\/pnas.93.25.14912","volume":"93","author":"Y Akiyama","year":"1996","unstructured":"Akiyama, Y., Hosoya, T., Poole, A. & Hotta, Y. The gcm-motif: A novel DNA-binding motif conserved in Drosophila and mammals. Proc. Natl Acad. Sci. USA 93, 14912\u2013 14916 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35018111_CR5","doi-asserted-by":"publisher","first-page":"12364","DOI":"10.1073\/pnas.95.21.12364","volume":"95","author":"J Kim","year":"1998","unstructured":"Kim, J. et al. Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing. Proc. Natl Acad. Sci. USA 95, 12364\u201312369 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35018111_CR6","first-page":"342","volume-title":"Mineral Metabolism: Dynamics in Function of Calcium","author":"F Bronner","year":"1964","unstructured":"Bronner, F. in Mineral Metabolism: Dynamics in Function of Calcium (eds Comar, L. C. & Bronner, F.) 342\u2013447 (Academic, New York, 1964)."},{"key":"BF35018111_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/156719a0","volume":"156","author":"AT Cowie","year":"1945","unstructured":"Cowie, A. T. & Folley, S. J. Parathyroidectomy and lactation in the rat. Nature 156, 19\u2013 720 (1945).","journal-title":"Nature"},{"key":"BF35018111_CR8","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1053\/ajkd.1998.v32.pm9808140","volume":"32","author":"AS Dusso","year":"1998","unstructured":"Dusso, A. S. & Brown, A. J. Mechanism of vitamin D action and its regulation. Am. J. Kidney Dis. 32, (Suppl. 2) S13\u201324 (1998).","journal-title":"Am. J. Kidney Dis."},{"key":"BF35018111_CR9","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1210\/endo-16-5-547","volume":"16","author":"H Selye","year":"1932","unstructured":"Selye, H. On the stimulation of new bone-formation with parathyroid extract and irradiated ergosterol. Endocrinology 16, 547\u2013 558 (1932).","journal-title":"Endocrinology"},{"key":"BF35018111_CR10","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0140-6736(70)91271-7","volume":"1","author":"DN Kalu","year":"1970","unstructured":"Kalu, D. N., Doyle, F. H., Pennock, J. & Foster, G. V. Parathyroid hormone and experimental osteosclerosis. Lancet 1, 1363\u20131366 (1970).","journal-title":"Lancet"},{"key":"BF35018111_CR11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0021-9258(18)84324-1","volume":"72","author":"FS Hammett","year":"1927","unstructured":"Hammett, F. S. Studies of the thyroid apparatus. J. Biol. Chem. 72 , 505\u2013525 (1927).","journal-title":"J. Biol. Chem."},{"key":"BF35018111_CR12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/(SICI)1096-8628(19970822)71:3<283::AID-AJMG7>3.0.CO;2-V","volume":"71","author":"A Loshkajian","year":"1997","unstructured":"Loshkajian, A. et al. Familial Blomstrand chondrodysplasia with advanced skeletal maturation: further delineation. Am. J. Med. Genet. 71, 283\u2013288 (1997).","journal-title":"Am. J. Med. Genet."},{"key":"BF35018111_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1172\/JCI2918","volume":"102","author":"AS Jobert","year":"1998","unstructured":"Jobert, A. S. et al. Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J. Clin. Invest. 102, 34\u201340 (1998).","journal-title":"J. Clin. Invest."},{"key":"BF35018111_CR14","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1126\/science.273.5275.663","volume":"273","author":"B Lanske","year":"1996","unstructured":"Lanske, B. et al. PTH\/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273, 663\u2013 666 (1996).","journal-title":"Science"},{"key":"BF35018111_CR15","doi-asserted-by":"publisher","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","volume":"94","author":"YC Li","year":"1997","unstructured":"Li, Y. C. et al. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl Acad. Sci. USA 94, 9831\u20139835 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35018111_CR16","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1126\/science.3616618","volume":"237","author":"LJ Suva","year":"1987","unstructured":"Suva, L. J. et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia. Science 237, 893\u2013 896 (1987).","journal-title":"Science"},{"key":"BF35018111_CR17","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1210\/endo-127-5-2517","volume":"127","author":"RA Fraser","year":"1990","unstructured":"Fraser, R. A., Kronenberg, H. M., Pang, P. K. & Harvey, S. Parathyroid hormone messenger ribonucleic acid in the rat hypothalamus. Endocrinology 127, 2517\u20132522 (1990).","journal-title":"Endocrinology"},{"key":"BF35018111_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/350473a0","volume":"350","author":"O Chisaka","year":"1991","unstructured":"Chisaka, O. & Capecchi, M. R. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1. 5. Nature 350, 473\u2013479 (1991).","journal-title":"Nature"},{"key":"BF35018111_CR19","unstructured":"Kovacs, C. S., Manley, N. R & Kronenberg, H. M. Hoxa3 knockout mice are hypocalcemic and have reduced placental calcium transfer. 80th meeting of the Endocrine Society , 91 (Endocrine Society Press, Bethesda, Maryland, 1998)."},{"key":"BF35018111_CR20","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1073\/pnas.82.12.4270","volume":"82","author":"J Silver","year":"1985","unstructured":"Silver, J., Russel, J. & Sherwood, L. M. Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc. Natl Acad. Sci. USA 82, 4270 \u20134273 (1985).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35018111_CR21","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1210\/endo-125-1-275","volume":"125","author":"T Naveh-Many","year":"1989","unstructured":"Naveh-Many, T., Friedlaender, M. M., Mayer, H. & Silver, J. Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of 1,25-Dihydroxyvitamin D. Endocrinology 125, 275\u2013 280 (1989).","journal-title":"Endocrinology"},{"key":"BF35018111_CR22","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1172\/JCI108276","volume":"57","author":"C Amiel","year":"1976","unstructured":"Amiel, C., Kuntziger, H., Couette, S., Coureau, C. & Bergounioux, N. Evidence for a parathyroid hormone-independent calcium modulation of phosphate transport along the nephron. J. Clin. Invest. 57, 256\u2013263 (1976).","journal-title":"J. Clin. Invest."},{"key":"BF35018111_CR23","first-page":"389","volume-title":"Reproductive Endocrinology: The Menopause and Perimenopausal Period","author":"RB Jaffe","year":"1991","unstructured":"Jaffe, R. B. in Reproductive Endocrinology: The Menopause and Perimenopausal Period (eds Samuel, S., Yen, C. & Jaffe, R. B.) 389\u2013408 (W. B. Saunders Company, Philadelphia, 1991)."},{"key":"BF35018111_CR24","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0896-6273(00)80988-5","volume":"20","author":"Q Ma","year":"1998","unstructured":"Ma, Q., Chen, Z., del Barco Barrantes, I., de la Pompa, J. L. & Anderson, D. J. Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20, 469\u2013 482 (1998).","journal-title":"Neuron"},{"key":"BF35018111_CR25","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1210\/jcem-73-6-1309","volume":"73","author":"V Grill","year":"1991","unstructured":"Grill, V. et al. Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J. Clin. Endocrinol. Metab. 73, 1309\u20131315 (1991).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BF35018111_CR26","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1006\/dbio.1995.1248","volume":"170","author":"A Neub\u00fcser","year":"1995","unstructured":"Neub\u00fcser, A., Koseki, H. & Balling, R. Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev. Biol. 170, 701\u2013716 (1995).","journal-title":"Dev. Biol."},{"key":"BF35018111_CR27","first-page":"555","volume":"10","author":"RL Emanuel","year":"1996","unstructured":"Emanuel, R. L. et al. Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Mol. Endocrinol. 10, 555\u2013565 (1996).","journal-title":"Mol. Endocrinol."},{"key":"BF35018111_CR28","doi-asserted-by":"crossref","unstructured":"Ducy, P. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197\u2013207 (2000).","DOI":"10.1016\/S0092-8674(00)81558-5"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35018111","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35018111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35018111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T22:01:36Z","timestamp":1684274496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35018111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":28,"journal-issue":{"issue":"6792","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["BF35018111"],"URL":"https:\/\/doi.org\/10.1038\/35018111","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}