{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:37:11Z","timestamp":1776749831377,"version":"3.51.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6802","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1038\/35030160","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:46:14Z","timestamp":1027673174000},"page":"401-405","source":"Crossref","is-referenced-by-count":407,"title":["The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans"],"prefix":"10.1038","volume":"407","author":[{"given":"Zhaolan","family":"Zhou","sequence":"first","affiliation":[]},{"given":"Ming-juan","family":"Luo","sequence":"additional","affiliation":[]},{"given":"Katja","family":"Straesser","sequence":"additional","affiliation":[]},{"given":"Jun","family":"Katahira","sequence":"additional","affiliation":[]},{"given":"Ed","family":"Hurt","sequence":"additional","affiliation":[]},{"given":"Robin","family":"Reed","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF35030160_CR1","doi-asserted-by":"publisher","first-page":"14937","DOI":"10.1073\/pnas.96.26.14937","volume":"96","author":"M Luo","year":"1999","unstructured":"Luo, M. & Reed, R. Splicing is required for rapid and efficient mRNA export in metazoans. Proc. Natl Acad. Sci. USA 96, 14937\u201314942 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35030160_CR2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1093\/emboj\/19.3.410","volume":"19","author":"K Strasser","year":"2000","unstructured":"Strasser, K. & Hurt, E. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J. 19, 410\u2013420 ( 2000).","journal-title":"EMBO J."},{"key":"BF35030160_CR3","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1101\/gad.14.9.1098","volume":"14","author":"H Le Hir","year":"2000","unstructured":"Le Hir, H., Moore, M. J. & Maquat, L. E. Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev. 14, 1098\u20131108 ( 2000).","journal-title":"Genes Dev."},{"key":"BF35030160_CR4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S1097-2765(00)80318-4","volume":"5","author":"R Das","year":"2000","unstructured":"Das, R., Zhou, Z. & Reed, R. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol. Cell 5, 779\u2013787 (2000).","journal-title":"Mol. Cell"},{"key":"BF35030160_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0092-8674(90)90292-M","volume":"63","author":"J Hamm","year":"1990","unstructured":"Hamm, J. & Mattaj, I. W. Monomethylated cap structures facilitate RNA export from the nucleus. Cell 63, 109\u2013118 (1990).","journal-title":"Cell"},{"key":"BF35030160_CR6","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1017\/S1355838200000078","volume":"6","author":"F Stutz","year":"2000","unstructured":"Stutz, F. et al. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP\/Mex67p and participates in mRNA nuclear export. RNA 6, 638\u2013650 ( 2000).","journal-title":"RNA"},{"key":"BF35030160_CR7","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1093\/emboj\/16.11.3256","volume":"16","author":"A Segref","year":"1997","unstructured":"Segref, A. et al. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J. 16, 3256\u20133271 (1997).","journal-title":"EMBO J."},{"key":"BF35030160_CR8","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S1097-2765(00)80065-9","volume":"1","author":"P Gruter","year":"1998","unstructured":"Gruter, P. et al. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell. 1, 649 \u2013659 (1998).","journal-title":"Mol. Cell."},{"key":"BF35030160_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1128\/MCB.17.1.135","volume":"17","author":"RK Ernst","year":"1997","unstructured":"Ernst, R. K., Bray, M., Rekosh, D. & Hammarskjolk, M. L. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA. Mol. Cell Biol. 17, 135\u2013 144 (1997).","journal-title":"Mol. Cell Biol."},{"key":"BF35030160_CR10","doi-asserted-by":"publisher","first-page":"7500","DOI":"10.1093\/emboj\/16.24.7500","volume":"16","author":"AE Pasquinelli","year":"1997","unstructured":"Pasquinelli, A. E. et al. The constitutive transport element (CTE) of Mason\u2013Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J. 16, 7500\u20137510 ( 1997).","journal-title":"EMBO J."},{"key":"BF35030160_CR11","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0960-9822(06)00288-0","volume":"7","author":"C Saavedra","year":"1997","unstructured":"Saavedra, C., Felber, B. & Izaurralde, E. The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export. Curr. Biol. 7, 619\u2013628 ( 1997).","journal-title":"Curr. Biol."},{"key":"BF35030160_CR12","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1101\/gad.11.5.640","volume":"11","author":"L Bruhn","year":"1997","unstructured":"Bruhn, L., Munnerlyn, A. & Grosschedl, R. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev. 11, 640\u2013653 (1997).","journal-title":"Genes Dev."},{"key":"BF35030160_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0198-8859(98)00085-8","volume":"60","author":"I Wichmann","year":"1999","unstructured":"Wichmann, I., Garcia-Lozano, J. R., Respaldiza, N., Gonzalez-Escribano, M. F. & Nunez-Roldan, A. Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus. Hum. Immunol. 60, 57 \u201362 (1999).","journal-title":"Hum. Immunol."},{"key":"BF35030160_CR14","first-page":"527","volume":"3","author":"DS Portman","year":"1997","unstructured":"Portman, D. S., O'Connor, J. P. & Dreyfuss, G. YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity. RNA 3, 527\u2013537 ( 1997).","journal-title":"RNA"},{"key":"BF35030160_CR15","first-page":"663","volume":"1","author":"XD Fu","year":"1995","unstructured":"Fu, X. D. The superfamily of arginine\/serine-rich splicing factors. RNA 1, 663\u2013680 (1995).","journal-title":"RNA"},{"key":"BF35030160_CR16","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1128\/MCB.12.7.3165","volume":"12","author":"M Bennett","year":"1992","unstructured":"Bennett, M., Pinol-Roma, S., Staknis, D., Dreyfuss, G. & Reed, R. Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol. Cell. Biol. 12, 3165\u2013 3175 (1992).","journal-title":"Mol. Cell. Biol."},{"key":"BF35030160_CR17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.bi.62.070193.001445","volume":"62","author":"G Dreyfuss","year":"1993","unstructured":"Dreyfuss, G., Matunis, M. J., Pinol-Roma, S. & Burd, C. G. hnRNP proteins and the biogenesis of mRNA. Annu. Rev. Biochem. 62, 289\u2013321 ( 1993).","journal-title":"Annu. Rev. Biochem."},{"key":"BF35030160_CR18","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.4049\/jimmunol.143.8.2560","volume":"143","author":"WJ Habets","year":"1989","unstructured":"Habets, W. J., Hoet, M. H., De Jong, B. A., Van der Kemp, A. & Van Venrooij, W. J. Mapping of B cell epitopes on small nuclear ribonucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies. J. Immunol. 143, 2560\u20132566 (1989).","journal-title":"J. Immunol."},{"key":"BF35030160_CR19","doi-asserted-by":"publisher","first-page":"6756","DOI":"10.1128\/MCB.18.11.6756","volume":"18","author":"T Achsel","year":"1998","unstructured":"Achsel, T., Ahrens, K., Brahms, H., Teigelkamp, S. & Luhrmann, R. The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein. Mol. Cell. Biol. 18, 6756\u20136766 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BF35030160_CR20","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1093\/emboj\/16.13.4092","volume":"16","author":"P Fabrizio","year":"1997","unstructured":"Fabrizio, P., Laggerbauer, B., Lauber, J., Lane, W. S. & Luhrmann, R. An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J. 16, 4092\u2013 4106 (1997).","journal-title":"EMBO J."},{"key":"BF35030160_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0092-8674(00)80925-3","volume":"92","author":"JP Staley","year":"1998","unstructured":"Staley, J. P. & Guthrie, C. Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell 92, 315\u2013326 (1998).","journal-title":"Cell"},{"key":"BF35030160_CR22","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1101\/gad.13.9.1126","volume":"13","author":"Y Kang","year":"1999","unstructured":"Kang, Y. & Cullen, B. R. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev. 13, 1126\u2013 1139 (1999).","journal-title":"Genes Dev."},{"key":"BF35030160_CR23","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1093\/emboj\/18.9.2593","volume":"18","author":"J Katahira","year":"1999","unstructured":"Katahira, J. et al. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J. 18, 2593\u2013 2609 (1999).","journal-title":"EMBO J."},{"key":"BF35030160_CR24","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev.cb.09.110193.001405","volume":"9","author":"DL Spector","year":"1993","unstructured":"Spector, D. L. Macromolecular domains within the cell nucleus. Annu. Rev. Cell Biol. 9, 265\u2013315 ( 1993).","journal-title":"Annu. Rev. Cell Biol."},{"key":"BF35030160_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/343437a0","volume":"343","author":"XD Fu","year":"1990","unstructured":"Fu, X. D. & Maniatis, T. Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature 343, 437\u2013441 ( 1990).","journal-title":"Nature"},{"key":"BF35030160_CR26","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1126\/science.288.5470.1385","volume":"288","author":"JD Lewis","year":"2000","unstructured":"Lewis, J. D. & Tollervey, D. Like attracts like: getting RNA processing together in the nucleus. Science 288, 1385\u20131389 (2000).","journal-title":"Science"},{"key":"BF35030160_CR27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0092-8674(00)81666-9","volume":"99","author":"S Nakielny","year":"1999","unstructured":"Nakielny, S. & Dreyfuss, G. Transport of proteins and RNAs in and out of the nucleus. Cell 99, 677\u2013 690 (1999).","journal-title":"Cell"},{"key":"BF35030160_CR28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1101\/gad.2.2.215","volume":"2","author":"S Pinol-Roma","year":"1988","unstructured":"Pinol-Roma, S., Choi, Y. D., Matunis, M. J. & Dreyfuss, G. Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev. 2 , 215\u2013227 (1988); erratum Genes Dev. 2, 490 ( 1988).","journal-title":"Genes Dev."},{"key":"BF35030160_CR29","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/355730a0","volume":"355","author":"S Pinol-Roma","year":"1992","unstructured":"Pinol-Roma, S. & Dreyfuss, G. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355, 730\u2013732 ( 1992).","journal-title":"Nature"},{"key":"BF35030160_CR30","doi-asserted-by":"publisher","first-page":"8031","DOI":"10.1073\/pnas.87.20.8031","volume":"87","author":"R Reed","year":"1990","unstructured":"Reed, R. Protein composition of mammalian spliceosomes assembled in vitro. Proc. Natl Acad. Sci. USA 87, 8031\u2013 8035 (1990).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35030160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35030160","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35030160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:07:48Z","timestamp":1684289268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35030160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":30,"journal-issue":{"issue":"6802","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["BF35030160"],"URL":"https:\/\/doi.org\/10.1038\/35030160","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}