{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:10:39Z","timestamp":1791220239205,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6805","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1038\/35037509","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:46:14Z","timestamp":1027673174000},"page":"703-710","source":"Crossref","is-referenced-by-count":539,"title":["Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA"],"prefix":"10.1038","volume":"407","author":[{"given":"Galina","family":"Obmolova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changill","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35037509_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev.bi.65.070196.000533","volume":"65","author":"P Modrich","year":"1996","unstructured":"Modrich, P. & Lahue, R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65, 101\u2013133 ( 1996).","journal-title":"Annu. Rev. Biochem."},{"key":"BF35037509_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1432-1033.1996.0297z.x","volume":"238","author":"A Umar","year":"1996","unstructured":"Umar, A. & Kunkel, T. A. DNA-replication fidelity, mismatch repair and genome instability in cancer cells. Eur. J. Biochem. 238, 297\u2013307 ( 1996).","journal-title":"Eur. J. Biochem."},{"key":"BF35037509_CR3","unstructured":"Human Genome Mutation Database [online] (cited 25 March 2000) \u3008http:\/\/www.uwcm.ac.uk\/uwcm\/mg\/ns\/1\/203983.html\u3009 (1997)."},{"key":"BF35037509_CR4","unstructured":"HNPCC Mutation Database [online] (cited 25 March 2000) \u3008http:\/\/www.nfdht.nl\/database\/msh2.htm\u3009 ( 1997)."},{"key":"BF35037509_CR5","doi-asserted-by":"publisher","first-page":"6870","DOI":"10.1073\/pnas.95.12.6870","volume":"95","author":"JG Herman","year":"1998","unstructured":"Herman, J. G. et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl Acad. Sci. USA 95, 6870\u20136875 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35037509_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0092-8674(00)80717-5","volume":"97","author":"C Ban","year":"1999","unstructured":"Ban, C., Junop, M. & Yang, W. Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell 97, 85\u201397 (1999).","journal-title":"Cell"},{"key":"BF35037509_CR7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0921-8777(98)00056-1","volume":"409","author":"J Jiricny","year":"1998","unstructured":"Jiricny, J. Eukaryotic mismatch repair: an update. Mutat. Res. 409, 107\u2013121 (1998).","journal-title":"Mutat. Res."},{"key":"BF35037509_CR8","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1093\/emboj\/16.14.4467","volume":"14","author":"DJ Allen","year":"1997","unstructured":"Allen, D. J. et al. MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J. 14, 4467\u2013 4476 (1997).","journal-title":"EMBO J."},{"key":"BF35037509_CR9","doi-asserted-by":"publisher","first-page":"23673","DOI":"10.1074\/jbc.274.33.23673","volume":"274","author":"I Biswas","year":"1999","unstructured":"Biswas, I. et al. Oligomerization of a MutS mismatch repair protein from Thermus aquaticus. JBC 274, 23673\u2013 23678 (1999).","journal-title":"JBC"},{"key":"BF35037509_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1146\/annurev.genet.33.1.533","volume":"33","author":"AB Buermeyer","year":"1999","unstructured":"Buermeyer, A. B., Desch\u00eanes, S. M., Baker, S. M. & Liskay, R. M. Mammalian DNA mismatch repair. Annu. Rev. Genet. 33 , 533\u2013564 (1999).","journal-title":"Annu. Rev. Genet."},{"key":"BF35037509_CR11","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1093\/nar\/26.18.4291","volume":"26","author":"JA Eisen","year":"1998","unstructured":"Eisen, J. A. A phylogenomic study of the MutS family of proteins. Nucleic Acids Res. 26, 4291\u20134300 ( 1998).","journal-title":"Nucleic Acids Res."},{"key":"BF35037509_CR12","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0966-842X(96)81514-9","volume":"4","author":"I Matic","year":"1996","unstructured":"Matic, I., Taddei, F. & Radman, M. Genetic barriers among bacteria. Trends Microbiol. 4, 69\u201372 (1996 ).","journal-title":"Trends Microbiol."},{"key":"BF35037509_CR13","doi-asserted-by":"publisher","first-page":"14186","DOI":"10.1073\/pnas.96.25.14186","volume":"96","author":"T Nakagawa","year":"1999","unstructured":"Nakagawa, T., Datta, A. & Kolodner, R. Multiple functions of MutS- and MutL-related heterocomplexes. Proc. Natl Acad. Sci. USA 96, 14186\u2013 14188 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35037509_CR14","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0092-8674(00)80490-0","volume":"91","author":"S Gradia","year":"1997","unstructured":"Gradia, S., Acharya, S. & Fishel, R. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell 91, 995 \u20131005 (1997).","journal-title":"Cell"},{"key":"BF35037509_CR15","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1128\/MCB.17.5.2436","volume":"17","author":"E Alani","year":"1997","unstructured":"Alani, E., Sokolsky, T., Studamire, B., Miret, J. J. & Lahue, R. S. Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition. Mol. Cell. Biol. 17, 2436\u20132447 (1997).","journal-title":"Mol. Cell. Biol."},{"key":"BF35037509_CR16","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1021\/bi992286u","volume":"39","author":"KP Bjornson","year":"2000","unstructured":"Bjornson, K. P., Allen, D. J. & Modrich, P. Modulation of MutS ATP hydrolysis by DNA cofactors. Biochemistry 39, 3176\u2013 3183 (2000).","journal-title":"Biochemistry"},{"key":"BF35037509_CR17","doi-asserted-by":"publisher","first-page":"5057","DOI":"10.1073\/pnas.83.14.5057","volume":"83","author":"SS Su","year":"1986","unstructured":"Su, S. S. & Modrich, P. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc. Natl Acad. Sci. USA 83, 5057\u20135061 ( 1986).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35037509_CR18","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1002\/j.1460-2075.1991.tb07815.x","volume":"10","author":"LT Haber","year":"1991","unstructured":"Haber, L. T. & Walker, G. C. Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. EMBO J. 10, 2707\u20132715 ( 1991).","journal-title":"EMBO J."},{"key":"BF35037509_CR19","doi-asserted-by":"publisher","first-page":"5040","DOI":"10.1074\/jbc.271.9.5040","volume":"271","author":"I Biswas","year":"1996","unstructured":"Biswas, I. & Hsieh, P. Identification and characterization of a thermostable MutS homolog from Thermus aquaticus. J. Biol. Chem. 271, 5040\u20135048 (1996).","journal-title":"J. Biol. Chem."},{"key":"BF35037509_CR20","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1002\/j.1460-2075.1990.tb08287.x","volume":"9","author":"WA Hendrickson","year":"1990","unstructured":"Hendrickson, W. A., Horton, J. R. & LeMaster, D. M. Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure. EMBO J. 9, 1665\u20131672 (1990).","journal-title":"EMBO J."},{"key":"BF35037509_CR21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0969-2126(01)00142-3","volume":"3","author":"W Yang","year":"1995","unstructured":"Yang, W. & Steitz, T. A. Recombining the structures of HIV integrase, RuvC and RNase H. Structure 3, 131\u2013134 (1995).","journal-title":"Structure"},{"key":"BF35037509_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0022-2836(05)80243-8","volume":"213","author":"AE Gorbalenya","year":"1990","unstructured":"Gorbalenya, A. E. & Koonin, E. V. Superfamily of UvrA-related NTP-binding proteins implication for rational classfication of recombination \/repair systems. J. Mol. Biol. 213 , 583\u2013591 (1990).","journal-title":"J. Mol. Biol."},{"key":"BF35037509_CR23","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/25393","volume":"396","author":"L-W Hung","year":"1998","unstructured":"Hung, L. -W. et al. Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 396, 703\u2013707 (1998).","journal-title":"Nature"},{"key":"BF35037509_CR24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0959-440X(96)80099-6","volume":"6","author":"JM Berger","year":"1996","unstructured":"Berger, J. M. & Wang, J. C. Recent developments in DNA topoisomerase II structure and mechanism. Curr. Opin. Struct. Biol. 6, 84\u201390 (1996).","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BF35037509_CR25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/genetics\/115.4.605","volume":"115","author":"M Jones","year":"1987","unstructured":"Jones, M., Wagner, R. & Radman, M. Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence. Genetics 115 , 605\u2013610 (1987).","journal-title":"Genetics"},{"key":"BF35037509_CR26","doi-asserted-by":"publisher","first-page":"23811","DOI":"10.1074\/jbc.272.38.23811","volume":"272","author":"VA Malkov","year":"1997","unstructured":"Malkov, V. A., Biswas, I., Camerini-Otero, R. D. & Hsieh, P. Photocross-linking of the NH2-terminal region of Taq MutS protein to the major groove of a heteroduplex DNA. J. Biol. Chem. 272, 23811\u201323817 (1997).","journal-title":"J. Biol. Chem."},{"key":"BF35037509_CR27","doi-asserted-by":"publisher","first-page":"23811","DOI":"10.1074\/jbc.272.38.23811","volume":"272","author":"I Biswas","year":"1997","unstructured":"Biswas, I. & Hsieh, P. Interaction of MutS protein with the major and minor grooves of a heteroduplex DNA. J. Biol. Chem. 272, 23811\u201323817 (1997).","journal-title":"J. Biol. Chem."},{"key":"BF35037509_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0027-5107(99)00195-5","volume":"447","author":"SR Bajski","year":"2000","unstructured":"Bajski, S. R., Jackson, B. A. & Barton, J. K. DNA repair: models for damage and mismatch recognition. Mutat. Res. 447, 49\u201372 (2000).","journal-title":"Mutat. Res."},{"key":"BF35037509_CR29","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/21460","volume":"399","author":"UM Ohndorf","year":"1999","unstructured":"Ohndorf, U. M., Rould, M. A., He, Q., Pabo, C. O. & Lippard, S. J. Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Nature 399, 708\u2013712 (1999).","journal-title":"Nature"},{"key":"BF35037509_CR30","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1093\/nar\/26.8.1906","volume":"26","author":"RE Dickerson","year":"1998","unstructured":"Dickerson, R. E. DNA bending: the prevalence of kinkiness and the virtues of normality. Nucleic Acids Res. 26, 1906\u20131926 (1998).","journal-title":"Nucleic Acids Res."},{"key":"BF35037509_CR31","doi-asserted-by":"publisher","first-page":"16115","DOI":"10.1074\/jbc.274.23.16115","volume":"274","author":"J Bowers","year":"1999","unstructured":"Bowers, J., Sokolsky, T., Quach, T. & Alani, E. A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition. J. Biol. Chem. 274, 16115\u201316125 (1999).","journal-title":"J. Biol. Chem."},{"key":"BF35037509_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/71684","volume":"24","author":"R Das Gupta","year":"2000","unstructured":"Das Gupta, R. & Kolodner, R. D. Novel dominant mutations in Saccharomyces cerevisiae MSH6. Nature Genet. 24 , 53\u201356 (2000).","journal-title":"Nature Genet."},{"key":"BF35037509_CR33","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1006\/jmbi.1999.2993","volume":"293","author":"IB Holland","year":"1999","unstructured":"Holland, I. B. & Blight, M. A. ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans. J. Mol. Biol. 293, 381\u2013399 (1999).","journal-title":"J. Mol. Biol."},{"key":"BF35037509_CR34","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0092-8674(00)80890-9","volume":"101","author":"KP Hopfner","year":"2000","unstructured":"Hopfner, K. P. et al. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101, 789\u2013800 (2000).","journal-title":"Cell"},{"key":"BF35037509_CR35","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/genetics\/153.3.1271","volume":"153","author":"J Zalevsky","year":"1999","unstructured":"Zalevsky, J., MacQueen, A. J., Duffy, J. B., Kemphues, K. J. & Villeneuve, A. M. Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast. Genetics 153, 1271\u20131283 (1999).","journal-title":"Genetics"},{"key":"BF35037509_CR36","doi-asserted-by":"publisher","first-page":"7558","DOI":"10.1128\/MCB.19.11.7558","volume":"19","author":"B Studamire","year":"1999","unstructured":"Studamire, B., Price, G., Sugawara, N., Haber, J. E. & Alani, E. Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. Mol. Cell. Biol. 19, 7558\u20137567 ( 1999).","journal-title":"Mol. Cell. Biol."},{"key":"BF35037509_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1097-2765(00)80316-0","volume":"3","author":"S Gradia","year":"1999","unstructured":"Gradia, S. et al. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatch DNA. Mol. Cell 3, 255\u2013 261 (1999).","journal-title":"Mol. Cell"},{"key":"BF35037509_CR38","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0021-9258(19)85043-3","volume":"264","author":"M Grilley","year":"1989","unstructured":"Grilley, M., Welsh, K. M., Su, S. -S. & Modrich, P. Isolation and characterization of the Escherichia coli mutL gene product. J. Biol. Chem. 264, 1000\u2013 1004 (1989).","journal-title":"J. Biol. Chem."},{"key":"BF35037509_CR39","doi-asserted-by":"publisher","first-page":"9837","DOI":"10.1074\/jbc.273.16.9837","volume":"273","author":"Y Habraken","year":"1998","unstructured":"Habraken, Y., Sung, P., Prakash, L. & Prakash, S. ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes. J.\u00a0Biol. Chem. 273, 9837\u20139841 (1998).","journal-title":"J.\u00a0Biol. Chem."},{"key":"BF35037509_CR40","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1093\/emboj\/17.5.1526","volume":"17","author":"C Ban","year":"1998","unstructured":"Ban, C. & Yang, W. Structural basis for MutH activation in E. coli mismatch repair and relationship of MutH to restriction endonucleases. EMBO J. 17, 1526\u2013 1534 (1998).","journal-title":"EMBO J."},{"key":"BF35037509_CR41","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307\u2013326 ( 1997).","journal-title":"Methods Enzymol."},{"key":"BF35037509_CR42","unstructured":"Terwilliger, T. C. SOLVE: An automated structure solution for MAD and MIR. Edition 1.16 [online] \u3008http:\/\/www.solve.lanl.gov\u3009 (1997)."},{"key":"BF35037509_CR43","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"CCP4","year":"1994","unstructured":"CCP4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760\u2013763 (1994).","journal-title":"Acta Crystallogr. D"},{"key":"BF35037509_CR44","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"TA Jones","year":"1991","unstructured":"Jones, T. A., Zou, J. -Y. & Cowan, S. W. Improved methods for building models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110\u2013119 ( 1991).","journal-title":"Acta Crystallogr. A"},{"key":"BF35037509_CR45","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"AT Br\u00fcnger","year":"1998","unstructured":"Br\u00fcnger, A. T. et al. Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905\u2013921 (1998).","journal-title":"Acta Crystallogr. D"},{"key":"BF35037509_CR46","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/prot.340110407","volume":"11","author":"A Nicholls","year":"1991","unstructured":"Nicholls, A., Sharp, K. A. & Honig, B. Protein folding and association: insights from the interfacial and themodynamic properties of hydrocarbons. Proteins Struct. Funct. Genet. 11, 281\u2013296 ( 1991).","journal-title":"Proteins Struct. Funct. Genet."},{"key":"BF35037509_CR47","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0263-7855(87)80010-3","volume":"5","author":"M Carson","year":"1987","unstructured":"Carson, M. Ribbon models of macromolecules. J. Mol. Graphics 5 , 103\u2013106 (1987).","journal-title":"J. Mol. Graphics"},{"key":"BF35037509_CR48","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S0960-9822(99)80396-0","volume":"9","author":"K Drotschmann","year":"1999","unstructured":"Drotschmann, K., Clark, A. B. & Kunkel, T. A. Mutator phenotypes of common polymorphisms and missense mutations in MSH2. Curr. Biol. 9, 907\u2013 910 (1999).","journal-title":"Curr. Biol."},{"key":"BF35037509_CR49","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1073\/pnas.96.6.2970","volume":"96","author":"K Drotschmann","year":"1999","unstructured":"Drotschmann, K. et al. Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene. Proc. Natl Acad. Sci. USA 96, 2970\u20132975 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35037509_CR50","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1128\/jb.176.17.5393-5400.1994","volume":"176","author":"T-H Wu","year":"1994","unstructured":"Wu, T. -H. & Marinus, M. G. Dominant negative mutator mutations in the mutS gene of Escherichia coli. J. Bacteriol. 176, 5393\u20135400 ( 1994).","journal-title":"J. Bacteriol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35037509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35037509","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35037509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:10:06Z","timestamp":1684289406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35037509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":50,"journal-issue":{"issue":"6805","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["BF35037509"],"URL":"https:\/\/doi.org\/10.1038\/35037509","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}