{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:04:45Z","timestamp":1791907485227,"version":"4.3.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6807","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1038\/35039519","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:46:14Z","timestamp":1027658774000},"page":"1011-1015","source":"Crossref","is-referenced-by-count":904,"title":["Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice"],"prefix":"10.1038","volume":"407","author":[{"given":"Debra A.","family":"Cockayne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara G.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika B.","family":"Malmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Berson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kassotakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hedley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm G.","family":"Lachnit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Burnstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P. D. W.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35039519_CR1","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/oxfordjournals.bja.a013473","volume":"84","author":"G Burnstock","year":"2000","unstructured":"Burnstock, G. P2X receptors in sensory neurons. Br. J. Anaesth. 84 , 476\u2013488 (2000).","journal-title":"Br. J. Anaesth."},{"key":"BF35039519_CR2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/377428a0","volume":"377","author":"CC Chen","year":"1995","unstructured":"Chen, C. C.  et al. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377, 428\u2013431 (1995).","journal-title":"Nature"},{"key":"BF35039519_CR3","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/377432a0","volume":"377","author":"C Lewis","year":"1995","unstructured":"Lewis, C. et al. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons.  Nature 377, 432\u2013435 ( 1995).","journal-title":"Nature"},{"key":"BF35039519_CR4","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1006\/mcne.1998.0719","volume":"12","author":"EJ Bradbury","year":"1998","unstructured":"Bradbury, E. J., Burnstock, G. & McMahon, S. B. The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor. Mol. Cell. Neurosci. 12, 256\u2013 268 (1998).","journal-title":"Mol. Cell. Neurosci."},{"key":"BF35039519_CR5","first-page":"413","volume":"50","author":"V Ralevic","year":"1998","unstructured":"Ralevic, V. & Burnstock, G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50, 413\u2013 492 (1998).","journal-title":"Pharmacol. Rev."},{"key":"BF35039519_CR6","first-page":"63","volume-title":"Proceedings of the 9th World Congress on Pain","author":"G Burnstock","year":"2000","unstructured":"Burnstock, G., McMahon, S. B., Humphrey, P. P. A. & Hamilton, S. G. in Proceedings of the 9th World Congress on Pain (eds Devor, M., Rowbotham, M. & Wiesenfeld-Hallin, Z.) 63\u201376 (IASP Press, Seattle, 2000)."},{"key":"BF35039519_CR7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.1469-7793.1997.503bb.x","volume":"505","author":"DR Ferguson","year":"1999","unstructured":"Ferguson, D. R., Kennedy, I. & Burton, T. J. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes\u2014a possible sensory mechanism? J. Physiol. (Lond.) 505, 503\u2013 511 (1999).","journal-title":"J. Physiol. (Lond.)"},{"key":"BF35039519_CR8","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1038\/sj.bjp.0702960","volume":"128","author":"M Tsuda","year":"1999","unstructured":"Tsuda, M., Ueno, S. & Inoue, K. Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.  Br. J. Pharmacol. 128, 1497\u20131504 (1999).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR9","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1046\/j.1464-410x.1999.00310.x","volume":"84","author":"S Namasivayam","year":"1999","unstructured":"Namasivayam, S., Eardley, I. & Morrison, J. F. B. Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. Br. J. Urol. Int.  84, 854\u2013860 ( 1999).","journal-title":"Br. J. Urol. Int."},{"key":"BF35039519_CR10","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1046\/j.1460-9568.1998.00355.x","volume":"10","author":"L Vulchanova","year":"1998","unstructured":"Vulchanova, L.  et al. P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur. J. Neurosci. 10, 3470\u20133478 (1998).","journal-title":"Eur. J. Neurosci."},{"key":"BF35039519_CR11","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/j.1476-5381.1996.tb15491.x","volume":"118","author":"SJ Robertson","year":"1996","unstructured":"Robertson, S. J., Rae, M. G., Rowan, E. G. & Kennedy, C. Characterization of a P2X-purinoceptor in cultured neurones of the rat dorsal root ganglia. Br. J. Pharmacol. 118, 951\u2013 956 (1996).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/sj.bjp.0701803","volume":"124","author":"MG Rae","year":"1998","unstructured":"Rae, M. G., Rowan, E. G. & Kennedy, C. Pharmacological properties of P2X3-receptors present in neurones of the rat dorsal root ganglia. Br. J. Pharmacol.  124, 176\u2013180 ( 1998).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR13","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1152\/jn.1999.82.3.1590","volume":"82","author":"EC Burgard","year":"1999","unstructured":"Burgard, E. C.  et al. P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J.\u00a0Neurophysiol. 82, 1590\u2013 1598 (1999).","journal-title":"J.\u00a0Neurophysiol."},{"key":"BF35039519_CR14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/sj.bjp.0702319","volume":"126","author":"S Ueno","year":"1999","unstructured":"Ueno, S., Tsuda, M., Iwanaga, T. & Inoue, K. Cell type-specific ATP-activated responses in rat dorsal root ganglion neurons. Br. J. Pharmacol. 126, 429\u2013436 (1999).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1046\/j.1460-9568.1999.00426.x","volume":"11","author":"BD Grubb","year":"1999","unstructured":"Grubb, B. D. & Evans, R. J. Characterization of cultured dorsal root ganglion neuron P2X receptors. Eur. J. Neurosci.  11, 149\u2013154 (1999).","journal-title":"Eur. J. Neurosci."},{"key":"BF35039519_CR16","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1469-7793.1998.411bn.x","volume":"509","author":"S Thomas","year":"1998","unstructured":"Thomas, S., Virginio, C., North, R. A. & Surprenant, A. The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones. J. Physiol. (Lond.)  509, 411\u2013417 (1998).","journal-title":"J. Physiol. (Lond.)"},{"key":"BF35039519_CR17","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/sj.bjp.0702258","volume":"126","author":"SG Hamilton","year":"1999","unstructured":"Hamilton, S. G., Wade, A. & McMahon, S. B. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat.  Br. J. Pharmacol. 126, 326\u2013332 (1999).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0304-3959(77)90066-5","volume":"3","author":"T Bleehan","year":"1977","unstructured":"Bleehan, T. & Keele, C. A. Observations on the algogenic actions of adenosine compounds on the human skin blister base preparation.  Pain 3, 367\u2013377 ( 1977).","journal-title":"Pain"},{"key":"BF35039519_CR19","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1093\/brain\/123.6.1238","volume":"123","author":"SG Hamilton","year":"2000","unstructured":"Hamilton, S. G., Warburton, J., Bhattacharjee, A., Ward, J. & McMahon, S. B. ATP in human skin elicits a dose related pain response which is potentiated under conditions of hyperalgesia. Brain 123, 1238\u20131246 (2000).","journal-title":"Brain"},{"key":"BF35039519_CR20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/sj.bjp.0701371","volume":"122","author":"PA Bland-Ward","year":"1997","unstructured":"Bland-Ward, P. A. & Humphrey, P. P. A. Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br. J. Pharmacol. 122, 365\u2013371 (1997).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR21","first-page":"245","volume-title":"Progress in Brain Research","author":"SB McMahon","year":"1986","unstructured":"McMahon, S. B. in Progress in Brain Research Vol. 67 (eds Cervero, F. & Morrison, J. F. B.) 245\u2013255 (Elsevier, Amsterdam, 1986)."},{"key":"BF35039519_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0166-4328(97)00185-X","volume":"92","author":"WC de Groat","year":"1998","unstructured":"de Groat, W. C.  et al. Developmental and injury induced plasticity in the micturition reflex pathway. Behav. Brain Res. 92, 127 \u2013140 (1998).","journal-title":"Behav. Brain Res."},{"key":"BF35039519_CR23","first-page":"339","volume":"18","author":"S Elneil","year":"1999","unstructured":"Elneil, S., Skepper, J. N., Kidd, E. J., Williamson, J. G. & Ferguson, D. R. The distribution of P2X 1 and P2X3 receptors in the rat and human urinary bladder. Neurourol. Urodyn. 18, 339\u2013 340 (1999).","journal-title":"Neurourol. Urodyn."},{"key":"BF35039519_CR24","volume-title":"The Bladder","author":"JM Fitzgerald","year":"1995","unstructured":"Fitzgerald, J. M. & Krane, R. J. The Bladder (Churchill Livingstone; Edinburgh, London, Melbourne, New York and Tokyo; 1995)."},{"key":"BF35039519_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1046\/j.1469-7580.1999.19430335.x","volume":"194","author":"G Burnstock","year":"1999","unstructured":"Burnstock, G. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J. Anat. 194 , 335\u2013342 (1999).","journal-title":"J. Anat."},{"key":"BF35039519_CR26","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/sj.bjp.0702118","volume":"125","author":"Y Zhong","year":"1998","unstructured":"Zhong, Y., Dunn, P. M., Xiang, Z., Bo, X. & Burnstock, G. Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br. J. Pharmacol.  125, 771\u2013781 (1998).","journal-title":"Br. J. Pharmacol."},{"key":"BF35039519_CR27","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1016\/S0022-5347(01)65552-6","volume":"156","author":"O Ishizuka","year":"1996","unstructured":"Ishizuka, O., Mattiasson, A. & Andersson, K.-E. Role of spinal and peripheral alpha2 adrenoceptors in micturition in normal conscious rats. J. Urol. 156 , 1853\u20131857 (1996).","journal-title":"J. Urol."},{"key":"BF35039519_CR28","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0306-4522(96)00575-1","volume":"78","author":"N Dmitrieva","year":"1997","unstructured":"Dmitrieva, N., Shelton, D., Rice, A. S. & McMahon, S. B. The role of nerve growth factor in a model of visceral inflammation. Neuroscience  78, 449\u2013459 ( 1997).","journal-title":"Neuroscience"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35039519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35039519","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35039519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T22:12:09Z","timestamp":1684275129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35039519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":28,"journal-issue":{"issue":"6807","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["BF35039519"],"URL":"https:\/\/doi.org\/10.1038\/35039519","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}