{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:06:32Z","timestamp":1789949192712,"version":"4.0.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2000,9,29]],"date-time":"2000-09-29T00:00:00Z","timestamp":970185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1038\/35041020","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:47:57Z","timestamp":1027673277000},"page":"784-791","source":"Crossref","is-referenced-by-count":385,"title":["A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function"],"prefix":"10.1038","volume":"2","author":[{"given":"Nicole E.","family":"Faulkner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis L.","family":"Dujardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Yin","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Vallee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2000,9,29]]},"reference":[{"key":"BFncb1100_784_CR1","first-page":"2838","volume":"270","author":"WB Dobyns","year":"1993","unstructured":"Dobyns, W. B., Reiner, O., Carrozzo, R. & Ledbetter, D. H. Lissencephaly. A human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13. J. Am. Med. Soc. 270, 2838\u20132842 (1993).","journal-title":"J. Am. Med. Soc."},{"key":"BFncb1100_784_CR2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/364717a0","volume":"364","author":"O Reiner","year":"1993","unstructured":"Reiner, O. et al. Isolation of a Miller\u2013Dieker lissencephaly gene containing G protein \u03b2-subunit-like repeats. Nature 364, 717\u2013721 (1993).","journal-title":"Nature"},{"key":"BFncb1100_784_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/hmg\/6.2.157","volume":"6","author":"C Lo Nigro","year":"1997","unstructured":"Lo Nigro, C. et al. Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller\u2013Dieker syndrome. Hum. Mol. Genet. 6, 157\u2013164 (1997).","journal-title":"Hum. Mol. Genet."},{"key":"BFncb1100_784_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/hmg\/6.2.147","volume":"6","author":"SS Chong","year":"1997","unstructured":"Chong, S. S. et al. A revision of the lissencephaly and Miller\u2013Dieker syndrome critical regions in chromosome 17p13.3. Hum. Mol. Genet. 6, 147\u2013155 (1997).","journal-title":"Hum. Mol. Genet."},{"key":"BFncb1100_784_CR5","first-page":"1142","volume":"147","author":"M Mizuguchi","year":"1995","unstructured":"Mizuguchi, M., Takashima, S., Kakita, A., Yamada, M. & Ikeda, K. Lissencephaly gene product. Localization in the central nervous system and loss of immunoreactivity in Miller\u2013Dieker syndrome. Am. J. Pathol. 147, 1142\u20131151 (1995).","journal-title":"Am. J. Pathol."},{"key":"BFncb1100_784_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/1531-8249(199902)45:2<154::AID-ANA4>3.0.CO;2-P","volume":"45","author":"A Fogli","year":"1999","unstructured":"Fogli, A. et al. Intracellular levels of the LIS1 protein correlate with clinical and neuroradiological findings in patients with classical lissencephaly [see comments]. Ann. Neurol. 45, 154\u2013161 (1999).","journal-title":"Ann. Neurol."},{"key":"BFncb1100_784_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/1221","volume":"19","author":"S Hirotsune","year":"1998","unstructured":"Hirotsune, S. et al. Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nature Genet. 19, 333\u2013339 (1998).","journal-title":"Nature Genet."},{"key":"BFncb1100_784_CR8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/370216a0","volume":"370","author":"M Hattori","year":"1994","unstructured":"Hattori, M., Adachi, H., Tsujimoto, M., Arai, H. & Inoue, K. Miller\u2013Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor. Nature 370, 216\u2013218 (1994).","journal-title":"Nature"},{"key":"BFncb1100_784_CR9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1091\/mbc.6.3.297","volume":"6","author":"X Xiang","year":"1995","unstructured":"Xiang, X., Osmani, A. H., Osmani, S. A., Xin, M. & Morris, N. R. NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration. Mol. Biol. Cell 6, 297\u2013310 (1995).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb1100_784_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1083\/jcb.127.1.139","volume":"127","author":"M Plamann","year":"1994","unstructured":"Plamann, M., Minke, P. F., Tinsley, J. H. & Bruno, K. S. Cytoplasmic dynein and actin-related protein Arp1 are required for normal nuclear distribution in filamentous fungi. J. Cell Biol. 127, 139\u2013149 (1994).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR11","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1073\/pnas.91.6.2100","volume":"91","author":"X Xiang","year":"1994","unstructured":"Xiang, X., Beckwith, S. M. & Morris, N. R. Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans. Proc. Natl Acad. Sci. USA 91, 2100\u20132104 (1994).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1100_784_CR12","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1083\/jcb.148.6.1097","volume":"148","author":"NR Morris","year":"2000","unstructured":"Morris, N. R. Nuclear migration. From fungi to the mammalian brain. J. Cell Biol. 148, 1097\u20131101 (2000).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR13","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1091\/mbc.8.6.1035","volume":"8","author":"JR Geiser","year":"1997","unstructured":"Geiser, J. R. et al. Saccaromyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol. Biol. Cell 8, 1035\u20131050 (1997).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb1100_784_CR14","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/15680","volume":"1","author":"A Swan","year":"1999","unstructured":"Swan, A., Nguyen, T. & Suter, B. Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning. Nature Cell Biol. 1, 444\u2013449 (1999).","journal-title":"Nature Cell Biol."},{"key":"BFncb1100_784_CR15","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1242\/dev.126.20.4477","volume":"126","author":"Z Liu","year":"1999","unstructured":"Liu, Z., Xie, T. & Steward, R. Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation. Development 126, 4477\u20134488 (1999).","journal-title":"Development"},{"key":"BFncb1100_784_CR16","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1083\/jcb.132.4.617","volume":"132","author":"CJ Echeverri","year":"1996","unstructured":"Echeverri, C. J., Paschal, B. M., Vaughan, K. T. & Vallee, R. B. Molecular characterization of the 50kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132, 617\u2013633 (1996).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR17","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1083\/jcb.139.2.469","volume":"139","author":"JK Burkhardt","year":"1997","unstructured":"Burkhardt, J. K., Echeverri, C. J., Nilsson, T. & Vallee, R. B. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J. Cell Biol. 139, 469\u2013484 (1997).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR18","first-page":"425","volume":"59","author":"A Wolff","year":"1992","unstructured":"Wolff, A. et al. Distribution of glutamylated alpha and beta-tubulin in mouse tissues using a specific monoclonal antibody, GT335. Eur. J. Cell Biol. 59, 425\u2013432 (1992).","journal-title":"Eur. J. Cell Biol."},{"key":"BFncb1100_784_CR19","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1083\/jcb.143.6.1575","volume":"143","author":"Y Bobinnec","year":"1998","unstructured":"Bobinnec, Y. et al. Centriole disassembly in vivo and its effect on centrosome structure and function in vertebrate cells. J. Cell Biol. 143, 1575\u20131589 (1998).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR20","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1083\/jcb.138.3.629","volume":"138","author":"JL Carminati","year":"1997","unstructured":"Carminati, J. L. & Stearns, T. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. J. Cell Biol. 138, 629\u2013641 (1997).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR21","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/S0960-9822(98)70465-8","volume":"8","author":"AR Skop","year":"1998","unstructured":"Skop, A. R. & White, J. G. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos. Curr. Biol. 8, 1110\u20131116 (1998).","journal-title":"Curr. Biol."},{"key":"BFncb1100_784_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1083\/jcb.147.1.135","volume":"147","author":"P Gonczy","year":"1999","unstructured":"Gonczy, P., Pichler, S., Kirkham, M. & Hyman, A. A. Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. J. Cell Biol. 147, 135\u2013150 (1999).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR23","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0960-9822(98)70208-8","volume":"8","author":"S Busson","year":"1998","unstructured":"Busson, S., Dujardin, D., Moreau, A., Dompierre, J. & De Mey, J. R. Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells. Curr. Biol. 8, 541\u2013544 (1998).","journal-title":"Curr. Biol."},{"key":"BFncb1100_784_CR24","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1083\/jcb.126.6.1509","volume":"126","author":"S Reinsch","year":"1994","unstructured":"Reinsch, S. & Karsenti, E. Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J. Cell Biol. 126, 1509\u20131526 (1994).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR25","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/345266a0","volume":"345","author":"ER Steuer","year":"1990","unstructured":"Steuer, E. R., Wordeman, L., Schroer, T. A. & Sheetz, M. P. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature 345, 266\u2013268 (1990).","journal-title":"Nature"},{"key":"BFncb1100_784_CR26","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/345263a0","volume":"345","author":"CM Pfarr","year":"1990","unstructured":"Pfarr, C. M. et al. Cytoplasmic dynein is localized to kinetochores during mitosis. Nature 345, 263\u2013265 (1990).","journal-title":"Nature"},{"key":"BFncb1100_784_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1083\/jcb.110.1.81","volume":"110","author":"CL Rieder","year":"1990","unstructured":"Rieder, C. L. & Alexander, S. P. Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells. J. Cell Biol. 110, 81\u201395 (1990).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1083\/jcb.92.2.435","volume":"92","author":"RB Vallee","year":"1982","unstructured":"Vallee, R. B. A taxol dependent procedure for the purification of microtubules and MAPs. J. Cell Biol. 92, 435\u2013442 (1982).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR29","doi-asserted-by":"publisher","first-page":"6977","DOI":"10.1093\/emboj\/16.23.6977","volume":"16","author":"T Sapir","year":"1997","unstructured":"Sapir, T., Elbaun, M. & Reiner, O. Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. EMBO J. 16, 6977\u20136984 (1997).","journal-title":"EMBO J."},{"key":"BFncb1100_784_CR30","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0092-8674(92)90240-D","volume":"70","author":"P Pierre","year":"1992","unstructured":"Pierre, P., Scheel, J., Rickard, J. E. & Kreis, T. E. CLIP-170 links endocytic vesicles to microtubules. Cell 70, 887\u2013900 (1992).","journal-title":"Cell"},{"key":"BFncb1100_784_CR31","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1038\/sj.onc.1202247","volume":"17","author":"EE Morrison","year":"1998","unstructured":"Morrison, E. E., Wardleworth, B. N., Askham, J. M., Markham, A. F. & Meredith, D. M. EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. Oncogene 17, 3471\u20133477 (1998).","journal-title":"Oncogene"},{"key":"BFncb1100_784_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0092-8674(00)80656-X","volume":"96","author":"F Perez","year":"1999","unstructured":"Perez, F., Diamantopoulos, G. S., Stalder, R. & Kreis, T. E. CLIP-170 highlights growing microtubule ends in vivo. Cell 96, 517\u2013527 (1999).","journal-title":"Cell"},{"key":"BFncb1100_784_CR33","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0960-9822(00)00600-X","volume":"10","author":"Y Mimori-Kiyosue","year":"2000","unstructured":"Mimori-Kiyosue, Y., Shiina, N. & Tsukita, S. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr. Biol. 10, 865\u2013868 (2000).","journal-title":"Curr. Biol."},{"key":"BFncb1100_784_CR34","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1242\/jcs.112.10.1437","volume":"112","author":"KT Vaughan","year":"1999","unstructured":"Vaughan, K. T., Hughes, S. H., Echeverri, C. J., Faulkner, N. F. & Vallee, R. B. Co-localization of dynactin and cytoplasmic dynein with CLIP-170 at microtubule distal ends. J. Cell Sci. 112, 1437\u20131447 (1999).","journal-title":"J. Cell Sci."},{"key":"BFncb1100_784_CR35","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0960-9822(99)80190-0","volume":"9","author":"L Berrueta","year":"1999","unstructured":"Berrueta, L., Tirnauer, J. S., Schuyler, S. C., Pellman, D. & Bierer, B. E. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. Curr. Biol. 9, 425\u2013428 (1999).","journal-title":"Curr. Biol."},{"key":"BFncb1100_784_CR36","doi-asserted-by":"crossref","first-page":"15318","DOI":"10.1016\/S0021-9258(18)82472-3","volume":"268","author":"BM Paschal","year":"1993","unstructured":"Paschal, B. M. et al. Characterization of 50 kD polypeptide in cytoplasmic dynein preparations reveals a complex with p150Glued and a novel actin. J. Biol. Chem. 268, 15318\u201315323 (1993).","journal-title":"J. Biol. Chem."},{"key":"BFncb1100_784_CR37","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0092-8674(00)81365-3","volume":"87","author":"A Merdes","year":"1996","unstructured":"Merdes, A., Ramyar, K., Vechio, J. D. & Cleveland, D. W. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 87, 447\u2013458 (1996).","journal-title":"Cell"},{"key":"BFncb1100_784_CR38","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1126\/science.271.5255.1539","volume":"271","author":"RB Vallee","year":"1996","unstructured":"Vallee, R. B. & Sheetz, M. P. Targeting of motor proteins. Science 271, 1539\u20131544 (1996).","journal-title":"Science"},{"key":"BFncb1100_784_CR39","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1083\/jcb.142.3.763","volume":"142","author":"DA Starr","year":"1998","unstructured":"Starr, D. A., Williams, B. C., Hays, T. S. & Goldberg, M. L. ZW10 helps recruit dynactin and dynein to the kinetochore. J. Cell Biol. 142, 763\u2013774 (1998).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR40","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/31014","volume":"393","author":"L Muhua","year":"1998","unstructured":"Muhua, L., Adames, N. R., Murphy, M. D., Shields, C. R. & Cooper, J. A. A cytokinesis checkpoint requiring the yeast homologue of an APC- binding protein. Nature 393, 487\u2013491 (1998).","journal-title":"Nature"},{"key":"BFncb1100_784_CR41","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1091\/mbc.11.5.1765","volume":"11","author":"CB O'Connell","year":"2000","unstructured":"O'Connell, C. B. & Wang, Y. Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol. Biol. Cell 11, 1765\u20131774 (2000).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb1100_784_CR42","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1083\/jcb.140.6.1417","volume":"140","author":"EH Hinchcliffe","year":"1998","unstructured":"Hinchcliffe, E. H., Cassels, G. O., Rieder, C. L. & Sluder, G. The coordination of centrosome reproduction with nuclear events of the cell cycle in the sea urchin zygote. J. Cell Biol. 140, 1417\u20131426 (1998).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR43","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1083\/jcb.118.4.759","volume":"118","author":"BC Williams","year":"1992","unstructured":"Williams, B. C., Karr, T. L., Montgomery, J. M. & Goldberg, M. L. The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset. J. Cell Biol. 118, 759\u2013773 (1992).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0167-4889(00)00011-2","volume":"1496","author":"RB Vallee","year":"2000","unstructured":"Vallee, R. B., Faulkner, N. E. & Tai, C. The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. Biochim. Biophys. Acta 1496, 89\u201398 (2000).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncb1100_784_CR45","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/0092-8674(95)90035-7","volume":"82","author":"A Chenn","year":"1995","unstructured":"Chenn, A. & McConnell, S. K. Cleavage orientation and the asymmetric inheritance of notch1 immunoreactivity in mammalian neurogenesis. Cell 82, 631\u2013641 (1995).","journal-title":"Cell"},{"key":"BFncb1100_784_CR46","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1126\/science.1925583","volume":"254","author":"SK McConnell","year":"1991","unstructured":"McConnell, S. K. & Kaznowski, C. E. Cell cycle dependence of laminar determination in developing neocortex. Science 254, 282\u2013285 (1991).","journal-title":"Science"},{"key":"BFncb1100_784_CR47","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1083\/jcb.131.6.1507","volume":"131","author":"KT Vaughan","year":"1995","unstructured":"Vaughan, K. T. & Vallee, R. B. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. J. Cell Biol. 131, 1507\u20131516 (1995).","journal-title":"J. Cell Biol."},{"key":"BFncb1100_784_CR48","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/S0960-9822(00)80122-0","volume":"9","author":"JA Garces","year":"1999","unstructured":"Garces, J. A., Clark, I. B., Meyer, D. I. & Vallee, R. B. Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeleton. Curr. Biol. 9, 1497\u20131500 (1999).","journal-title":"Curr. Biol."},{"key":"BFncb1100_784_CR49","volume-title":"Developmental Biology","author":"S Gilbert","year":"1994","unstructured":"Gilbert, S. Developmental Biology, (Sinauer, Sunderland, Massachusetts, 1994)."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1100_784.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1100_784","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1100_784.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:22:30Z","timestamp":1684437750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1100_784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,29]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["BFncb1100_784"],"URL":"https:\/\/doi.org\/10.1038\/35041020","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,29]]}}}