{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:51:55Z","timestamp":1768690315932,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6812","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1038\/35046087","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:46:14Z","timestamp":1027673174000},"page":"593-596","source":"Crossref","is-referenced-by-count":287,"title":["Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast"],"prefix":"10.1038","volume":"408","author":[{"given":"Tomokazu","family":"Ohshiro","sequence":"first","affiliation":[]},{"given":"Takako","family":"Yagami","sequence":"additional","affiliation":[]},{"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Fumio","family":"Matsuzaki","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF35046087_CR1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/33854","volume":"392","author":"LY Jan","year":"1998","unstructured":"Jan, L. Y. & Jan, Y. N. Asymmetric cell division. Nature 392, 775\u2013778 (1998).","journal-title":"Nature"},{"key":"BF35046087_CR2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0959-4388(99)00052-5","volume":"10","author":"F Matsuzaki","year":"2000","unstructured":"Matsuzaki, F. Asymmetric division of Drosophila neural stem cells: a basis for neural diversity. Curr. Opin. Neurobiol. 10, 38\u201344 (2000).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BF35046087_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0092-8674(94)90112-0","volume":"76","author":"MS Rhyu","year":"1994","unstructured":"Rhyu, M. S., Jan, L. Y. & Jan, Y. N. Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76, 477\u2013491 (1994).","journal-title":"Cell"},{"key":"BF35046087_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/377627a0","volume":"377","author":"J Hirata","year":"1995","unstructured":"Hirata, J., Nakagoshi, H., Nabeshima, Y. & Matsuzaki, F. Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Nature 377, 627\u2013630 (1995).","journal-title":"Nature"},{"key":"BF35046087_CR5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/383050a0","volume":"383","author":"R Kraut","year":"1996","unstructured":"Kraut, R., Chia, W., Jan, L. Y., Jan, Y. N. & Knoblich, J. A. Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383, 50\u201355 (1996).","journal-title":"Nature"},{"key":"BF35046087_CR6","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/990128","volume":"402","author":"A Wodarz","year":"1999","unstructured":"Wodarz, A., Ramrath, A., Kuchinke, U. & Knust, E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402, 544\u2013547 (1999).","journal-title":"Nature"},{"key":"BF35046087_CR7","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/990135","volume":"402","author":"M Schober","year":"1999","unstructured":"Schober, M., Schaefer, M. & Knoblich, J. A. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402, 548\u2013551 (1999).","journal-title":"Nature"},{"key":"BF35046087_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0092-8674(00)80676-5","volume":"100","author":"F Yu","year":"2000","unstructured":"Yu, F., Morin, X., Cai, Y., Yang, X. & Chia, W. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in Inscuteable apical localization. Cell 100, 399\u2013409 (2000).","journal-title":"Cell"},{"key":"BF35046087_CR9","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1126\/science.96525","volume":"200","author":"E Gateff","year":"1978","unstructured":"Gateff, E. Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 200, 1448\u20131459 (1978).","journal-title":"Science"},{"key":"BF35046087_CR10","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0092-8674(81)90009-X","volume":"66","author":"DF Woods","year":"1991","unstructured":"Woods, D. F. & Bryant, P. J. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66, 451\u2013464 (1991).","journal-title":"Cell"},{"key":"BF35046087_CR11","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/37641","volume":"390","author":"H Ikeshima-Kataoka","year":"1997","unstructured":"Ikeshima-Kataoka, H., Skeath, J. B., Nabeshima, Y., Doe, C. Q. & Matsuzaki, F. Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions. Nature 390, 625\u2013629 (1997).","journal-title":"Nature"},{"key":"BF35046087_CR12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0092-8674(00)80505-X","volume":"90","author":"CP Shen","year":"1997","unstructured":"Shen, C. P., Jan, L. Y. & Jan, Y. N. Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell 90, 449\u2013458 (1997).","journal-title":"Cell"},{"key":"BF35046087_CR13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0092-8674(00)81753-5","volume":"90","author":"B Lu","year":"1998","unstructured":"Lu, B., Rothenberg, M., Jan, L. Y. & Jan, Y. N. Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors. Cell 90, 225\u2013235 (1998).","journal-title":"Cell"},{"key":"BF35046087_CR14","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/j.1460-2075.1985.tb03816.x","volume":"4","author":"BM Mechler","year":"1985","unstructured":"Mechler, B. M., McGinnis, W. & Gehring, W. J. Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J. 4, 1551\u20131557 (1985).","journal-title":"EMBO J."},{"key":"BF35046087_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0092-8674(87)90217-0","volume":"50","author":"L Jacob","year":"1987","unstructured":"Jacob, L., Opper, M., Metzroth, B., Phannavong, B. & Mechler, B. M. Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain. Cell 50, 215\u2013225 (1987).","journal-title":"Cell"},{"key":"BF35046087_CR16","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1242\/dev.122.7.2283","volume":"122","author":"P Manfruelli","year":"1996","unstructured":"Manfruelli, P., Arquier, N., Hanratty, W. P. & Semeriva, M. The tumor suppressor gene, lethal(2)giant larvae (l(2)gl), is required for cell shape change of epithelial cells during Drosophila development. Development 122, 2283\u20132294 (1996).","journal-title":"Development"},{"key":"BF35046087_CR17","first-page":"207","volume":"43","author":"C De Lorenzo","year":"1999","unstructured":"De Lorenzo, C., Strand, D. & Mechler, B. M. Requirement of Drosophila l(2)gl function for survival of the germline cells and organization of the follicle cells in a columnar epithelium during oogenesis. Int. J. Dev. Biol. 43, 207\u2013217 (1999).","journal-title":"Int. J. Dev. Biol."},{"key":"BF35046087_CR18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1242\/dev.117.1.359","volume":"117","author":"IA Dawson","year":"1993","unstructured":"Dawson, I. A., Roth, S., Akam, M. & Artavanis-Tsakonas, S. Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos. Development 117, 359\u2013376 (1993).","journal-title":"Development"},{"key":"BF35046087_CR19","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1083\/jcb.127.5.1361","volume":"127","author":"D Strand","year":"1994","unstructured":"Strand, D. et al. The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain. J. Cell Biol. 127, 1361\u20131373 (1994).","journal-title":"J. Cell Biol."},{"key":"BF35046087_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1101\/gad.7.1.29","volume":"7","author":"PE Young","year":"1993","unstructured":"Young, P. E., Richman, A. M., Ketchum, A. S. & Kiehart, D. P. Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function. Genes Dev. 7, 29\u201341 (1993).","journal-title":"Genes Dev."},{"key":"BF35046087_CR21","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/genetics\/149.4.1717","volume":"149","author":"M Kagami","year":"1998","unstructured":"Kagami, M., Toh-e, A. & Matsui, Y. Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function. Genetics 149, 1717\u20131727 (1998).","journal-title":"Genetics"},{"key":"BF35046087_CR22","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S1097-2765(00)80218-X","volume":"4","author":"B Lu","year":"1999","unstructured":"Lu, B., Ackerman, L., Jan, L. Y. & Jan, Y. N. Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division. Mol. Cell 4, 883\u2013891 (1999).","journal-title":"Mol. Cell"},{"key":"BF35046087_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1083\/jcb.131.1.179","volume":"131","author":"LP Cramar","year":"1995","unstructured":"Cramar, L. P. & Mitchison, T. J. Myosin is involved in postmitotic cell spreading. J. Cell Biol. 131, 179\u2013189 (1995).","journal-title":"J. Cell Biol."},{"key":"BF35046087_CR24","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/dev.124.22.4435","volume":"124","author":"S Wang","year":"1997","unstructured":"Wang, S., Younger-Shepherd, S., Jan, L. Y. & Jan, Y. N. Only a subset of the binary cell fate decisions mediated by Numb\/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless. Development 124, 4435\u20134446 (1997).","journal-title":"Development"},{"key":"BF35046087_CR25","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1242\/dev.126.16.3573","volume":"126","author":"M Gho","year":"1999","unstructured":"Gho, M., Bellaiche, Y. & Schweisguth, F. Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell. Development 126, 3573\u20133584 (1999).","journal-title":"Development"},{"key":"BF35046087_CR26","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1083\/jcb.134.6.1469","volume":"134","author":"DF Woods","year":"1996","unstructured":"Woods, D. F., Hough, C., Peel, D., Callaini, G. & Bryant, P. J. Dlg protein is required for junction structure, cell polarity and proliferation control in Drosophila epithelia. J. Cell Biol. 134, 1469\u20131482 (1996).","journal-title":"J. Cell Biol."},{"key":"BF35046087_CR27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1126\/science.289.5476.113","volume":"289","author":"D Bilder","year":"2000","unstructured":"Bilder, D., Li, M. & Perrimon, N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289, 113\u2013116 (2000).","journal-title":"Science"},{"key":"BF35046087_CR28","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1242\/dev.122.6.1673","volume":"122","author":"M Gho","year":"1996","unstructured":"Gho, M., Lecourtois, M., Geraud, G., Posakony, J. W. & Schweisguth, F. Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling. Development 122, 1673\u20131682 (1996).","journal-title":"Development"},{"key":"BF35046087_CR29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/genetics\/131.3.643","volume":"131","author":"TB Chou","year":"1992","unstructured":"Chou, T. B. & Perrimon, N. Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila. Genetics 131, 643\u2013653 (1992).","journal-title":"Genetics"},{"key":"BF35046087_CR30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401\u2013415 (1993).","journal-title":"Development"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35046087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35046087","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35046087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:16:07Z","timestamp":1684289767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35046087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":30,"journal-issue":{"issue":"6812","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["BF35046087"],"URL":"https:\/\/doi.org\/10.1038\/35046087","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}