{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:42:44Z","timestamp":1777963364545,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6812","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2000,11]]},"DOI":"10.1038\/35046102","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:46:14Z","timestamp":1027673174000},"page":"600-605","source":"Crossref","is-referenced-by-count":1163,"title":["T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-\u03b3"],"prefix":"10.1038","volume":"408","author":[{"given":"Hiroshi","family":"Takayanagi","sequence":"first","affiliation":[]},{"given":"Kouetsu","family":"Ogasawara","sequence":"additional","affiliation":[]},{"given":"Shigeaki","family":"Hida","sequence":"additional","affiliation":[]},{"given":"Tomoki","family":"Chiba","sequence":"additional","affiliation":[]},{"given":"Shigeo","family":"Murata","sequence":"additional","affiliation":[]},{"given":"Kojiro","family":"Sato","sequence":"additional","affiliation":[]},{"given":"Akinori","family":"Takaoka","sequence":"additional","affiliation":[]},{"given":"Taeko","family":"Yokochi","sequence":"additional","affiliation":[]},{"given":"Hiromi","family":"Oda","sequence":"additional","affiliation":[]},{"given":"Keiji","family":"Tanaka","sequence":"additional","affiliation":[]},{"given":"Kozo","family":"Nakamura","sequence":"additional","affiliation":[]},{"given":"Tadatsugu","family":"Taniguchi","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF35046102_CR1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/S0301-472X(99)00061-2","volume":"27","author":"GD Roodman","year":"1999","unstructured":"Roodman, G. D. Cell biology of the osteoclast. Exp. Hematol. 27, 1229\u20131241 (1999).","journal-title":"Exp. Hematol."},{"key":"BF35046102_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","volume":"20","author":"T Suda","year":"1999","unstructured":"Suda, T. et al. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20, 345\u2013357 (1999).","journal-title":"Endocr. Rev."},{"key":"BF35046102_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"YY Kong","year":"1999","unstructured":"Kong, Y. Y. et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315\u2013323 (1999).","journal-title":"Nature"},{"key":"BF35046102_CR4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/35005552","volume":"402","author":"YY Kong","year":"1999","unstructured":"Kong, Y. Y. et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402, 304\u2013309 (1999).","journal-title":"Nature"},{"key":"BF35046102_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1172\/JCI6093","volume":"104","author":"H Takayanagi","year":"1999","unstructured":"Takayanagi, H. et al. Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. J. Clin. Invest. 104, 137\u2013146 (1999).","journal-title":"J. Clin. Invest."},{"key":"BF35046102_CR6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1006\/bbrc.1999.1623","volume":"265","author":"NJ Horwood","year":"1999","unstructured":"Horwood, N. J. et al. Activated T lymphocytes support osteoclast formation in vitro. Biochem. Biophys. Res. Commun. 265, 144\u2013150 (1999).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF35046102_CR7","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.4049\/jimmunol.137.11.3544","volume":"137","author":"N Takahashi","year":"1986","unstructured":"Takahashi, N., Mundy, G. R. & Roodman, G. D. Recombinant human interferon-\u03b3 inhibits formation of human osteoclast-like cells. J. Immunol. 137, 3544\u20133549 (1986).","journal-title":"J. Immunol."},{"key":"BF35046102_CR8","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1084\/jem.185.6.1005","volume":"185","author":"N Udagawa","year":"1997","unstructured":"Udagawa, N. et al. Interleukin-18 (interferon-\u03b3-inducing factor) is produced by osteoblasts and acts via granulocyte\/macrophage colony-stimulating factor and not via interferon-\u03b3 to inhibit osteoclast formation. J. Exp. Med. 185, 1005\u20131012 (1997).","journal-title":"J. Exp. Med."},{"key":"BF35046102_CR9","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/j.1600-0765.1996.tb00510.x","volume":"31","author":"T Ukai","year":"1996","unstructured":"Ukai, T., Hara, Y. & Kato, I. Effects of T cell adoptive transfer into nude mice on alveolar bone resorption induced by endotoxin. J. Periodontal. Res. 31, 414\u2013422 (1996).","journal-title":"J. Periodontal. Res."},{"key":"BF35046102_CR10","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1128\/IAI.67.8.4231-4236.1999","volume":"67","author":"CY Chiang","year":"1999","unstructured":"Chiang, C. Y., Kyritsis, G., Graves, D. T. & Amar, S. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect. Immun. 67, 4231\u20134236 (1999).","journal-title":"Infect. Immun."},{"key":"BF35046102_CR11","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1126\/science.8456301","volume":"259","author":"S Huang","year":"1993","unstructured":"Huang, S. et al. Immune response in mice that lack the interferon-\u03b3 receptor. Science 259, 1742\u20131745 (1993).","journal-title":"Science"},{"key":"BF35046102_CR12","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.4049\/jimmunol.158.11.5501","volume":"158","author":"B Manoury-Schwartz","year":"1997","unstructured":"Manoury-Schwartz, B. et al. High susceptibility to collagen-induced arthritis in mice lacking IFN-\u03b3 receptors. J. Immunol. 158, 5501\u20135506 (1997).","journal-title":"J. Immunol."},{"key":"BF35046102_CR13","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.158.11.5507","volume":"158","author":"K Vermeire","year":"1997","unstructured":"Vermeire, K. et al. Accelerated collagen-induced arthritis in IFN-\u03b3 receptor-deficient mice. J. Immunol. 158, 5507\u20135513 (1997).","journal-title":"J. Immunol."},{"key":"BF35046102_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","volume":"67","author":"GR Stark","year":"1998","unstructured":"Stark, G. R., Kerr, I. M., Williams, B. R., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227\u2013264 (1998).","journal-title":"Annu. Rev. Biochem."},{"key":"BF35046102_CR15","first-page":"M9","volume":"1333","author":"T Taniguchi","year":"1997","unstructured":"Taniguchi, T., Lamphier, M. S. & Tanaka, N. IRF-1: the transcription factor linking the interferon response and oncogenesis. Biochim. Biophys. Acta 1333, M9\u2013M17 (1997).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF35046102_CR16","doi-asserted-by":"publisher","first-page":"28355","DOI":"10.1074\/jbc.273.43.28355","volume":"273","author":"BR Wong","year":"1998","unstructured":"Wong, B. R. et al. The TRAF family of signal transducers mediates NF-\u03baB activation by the TRANCE receptor. J. Biol. Chem. 273, 28355\u201328359 (1998).","journal-title":"J. Biol. Chem."},{"key":"BF35046102_CR17","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","volume":"13","author":"MA Lomaga","year":"1999","unstructured":"Lomaga, M. A. et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40 and LPS signaling. Genes Dev. 13, 1015\u20131024 (1999).","journal-title":"Genes Dev."},{"key":"BF35046102_CR18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1046\/j.1365-2443.1999.00265.x","volume":"4","author":"A Naito","year":"1999","unstructured":"Naito, A. et al. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4, 353\u2013362 (1999).","journal-title":"Genes Cells"},{"key":"BF35046102_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0092-8674(00)80929-0","volume":"92","author":"W Baumeister","year":"1998","unstructured":"Baumeister, W., Walz, J., Zuhl, F. & Seemuller, E. The proteasome: paradigm of a self-compartmentalizing protease. Cell 92, 367\u2013380 (1998).","journal-title":"Cell"},{"key":"BF35046102_CR20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1600-065X.1998.tb01195.x","volume":"163","author":"K Tanaka","year":"1998","unstructured":"Tanaka, K. & Kasahara, M. The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-\u03b3-inducible proteasome activator PA28. Immunol. Rev. 163, 161\u2013176 (1998).","journal-title":"Immunol. Rev."},{"key":"BF35046102_CR21","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1126\/science.286.5447.2162","volume":"286","author":"T Preckel","year":"1999","unstructured":"Preckel, T. et al. Impaired immunoproteasome assembly and immune responses in PA28-\/- mice. Science 286, 2162\u20132165 (1999).","journal-title":"Science"},{"key":"BF35046102_CR22","doi-asserted-by":"publisher","first-page":"14336","DOI":"10.1074\/jbc.275.19.14336","volume":"275","author":"N Tanahashi","year":"2000","unstructured":"Tanahashi, N. et al. Hybrid proteasomes. Induction by interferon-\u03b3 and contribution to ATP-dependent proteolysis. J. Biol. Chem. 275, 14336\u201314345 (2000).","journal-title":"J. Biol. Chem."},{"key":"BF35046102_CR23","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/art.1780330602","volume":"33","author":"GS Firestein","year":"1990","unstructured":"Firestein, G. S. & Zvaifler, N. J. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 33, 768\u2013773 (1990).","journal-title":"Arthritis Rheum."},{"key":"BF35046102_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0925-4439(96)00079-8","volume":"1360","author":"RW Kinne","year":"1997","unstructured":"Kinne, R. W., Palombo-Kinne, E. & Emmrich, F. T-cells in the pathogenesis of rheumatoid arthritis: villains or accomplices? Biochim. Biophys. Acta 1360, 109\u2013141 (1997).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF35046102_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/1529-0131(200002)43:2<259::AID-ANR4>3.0.CO;2-W","volume":"43","author":"H Takayanagi","year":"2000","unstructured":"Takayanagi, H. et al. Involvement of receptor activator of nuclear factor \u03baB ligand\/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum. 43, 259\u2013269 (2000).","journal-title":"Arthritis Rheum."},{"key":"BF35046102_CR26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P","volume":"43","author":"EM Gravallese","year":"2000","unstructured":"Gravallese, E. M. et al. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 43, 250\u2013258 (2000).","journal-title":"Arthritis Rheum."},{"key":"BF35046102_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0065-2776(08)60428-9","volume":"62","author":"A Billiau","year":"1996","unstructured":"Billiau, A. Interferon-\u03b3: biology and role in pathogenesis. Adv. Immunol. 62, 61\u2013130 (1996).","journal-title":"Adv. Immunol."},{"key":"BF35046102_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0092-8674(05)80086-8","volume":"75","author":"T Matsuyama","year":"1993","unstructured":"Matsuyama, T. et al. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75, 83\u201397 (1993).","journal-title":"Cell"},{"key":"BF35046102_CR29","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0092-8674(00)81288-X","volume":"84","author":"MA Meraz","year":"1996","unstructured":"Meraz, M. A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431\u2013442 (1996).","journal-title":"Cell"},{"key":"BF35046102_CR30","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","volume":"95","author":"H Yasuda","year":"1998","unstructured":"Yasuda, H. et al. Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL. Proc. Natl Acad. Sci. USA 95, 3597\u20133602 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35046102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35046102","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35046102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:16:08Z","timestamp":1684289768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35046102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":30,"journal-issue":{"issue":"6812","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["BF35046102"],"URL":"https:\/\/doi.org\/10.1038\/35046102","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]}}}