{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:04:08Z","timestamp":1772759048988,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"6822","license":[{"start":{"date-parts":[[2001,2,15]],"date-time":"2001-02-15T00:00:00Z","timestamp":982195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,2,15]],"date-time":"2001-02-15T00:00:00Z","timestamp":982195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,2,15]]},"DOI":"10.1038\/35057006","type":"journal-article","created":{"date-parts":[[2002,9,13]],"date-time":"2002-09-13T18:01:34Z","timestamp":1031940094000},"page":"829-831","source":"Crossref","is-referenced-by-count":74,"title":["Keeping time with the human genome"],"prefix":"10.1038","volume":"409","author":[{"given":"Jonathan D.","family":"Clayton","sequence":"first","affiliation":[]},{"given":"Charalambos P.","family":"Kyriacou","sequence":"additional","affiliation":[]},{"given":"Steven M.","family":"Reppert","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF35057006_CR1","volume-title":"Suprachiasmatic Nucleus: The Mind's Clock","author":"DC Klein","year":"1991","unstructured":"Klein, D. C., Moore, R. Y. & Reppert, S. M. (eds) Suprachiasmatic Nucleus: The Mind's Clock (Oxford Univ. Press, New York, 1991)."},{"key":"BF35057006_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/074873000129001459","volume":"15","author":"SM Reppert","year":"2000","unstructured":"Reppert, S. M. & Weaver, D. R. Comparing clockworks: mouse versus fly. J. Biol. Rhythms 15, 357\u2013364 (2000).","journal-title":"J. Biol. Rhythms"},{"key":"BF35057006_CR3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1126\/science.288.5465.451","volume":"288","author":"MW Young","year":"2000","unstructured":"Young, M. W. Circadian rhythms. Marking time for a kingdom. Science 288, 451\u2013453 (2000).","journal-title":"Science"},{"key":"BF35057006_CR4","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1126\/science.288.5468.1013","volume":"288","author":"LP Shearman","year":"2000","unstructured":"Shearman, L. P. et al. Interacting molecular loops in the mammalian circadian clock. Science 288, 1013\u20131019 (2000).","journal-title":"Science"},{"key":"BF35057006_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0092-8674(00)80566-8","volume":"96","author":"JC Dunlap","year":"1999","unstructured":"Dunlap, J. C. Molecular bases for circadian clocks. Cell 96, 271\u2013290 (1999).","journal-title":"Cell"},{"key":"BF35057006_CR6","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1073\/pnas.95.10.5474","volume":"95","author":"JB Hogenesch","year":"1998","unstructured":"Hogenesch, J. B., Gu, Y. Z., Jain, S. & Bradfield, C. A. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl Acad. Sci. USA 95, 5474\u20135479 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35057006_CR7","doi-asserted-by":"publisher","first-page":"RC83","DOI":"10.1523\/JNEUROSCI.20-13-j0002.2000","volume":"20","author":"JB Hogenesch","year":"2000","unstructured":"Hogenesch, J. B. et al. The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. J. Neurosci. 20, RC83 (2000).","journal-title":"J. Neurosci."},{"key":"BF35057006_CR8","doi-asserted-by":"publisher","first-page":"36847","DOI":"10.1074\/jbc.C000629200","volume":"275","author":"K Maemura","year":"2000","unstructured":"Maemura, K. et al. CLIF, a novel cycle like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J. Biol. Chem. 275, 36847\u201336851 (2000).","journal-title":"J. Biol. Chem."},{"key":"BF35057006_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1126\/science.288.5465.483","volume":"288","author":"PL Lowrey","year":"2000","unstructured":"Lowrey, P. L. et al. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 288, 483\u2013491 (2000).","journal-title":"Science"},{"key":"BF35057006_CR10","doi-asserted-by":"publisher","first-page":"4888","DOI":"10.1128\/MCB.20.13.4888-4899.2000","volume":"10","author":"E Vielhaber","year":"2000","unstructured":"Vielhaber, E., Eide, E., Rivers, A., Gao, Z. H. & Virshup, D. M. Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase 1\u03b5. Mol. Cell. Biol. 10, 4888\u20134899 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BF35057006_CR11","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/77653","volume":"3","author":"AL Gotter","year":"2000","unstructured":"Gotter, A. L. et al. A time-less function for mouse Timeless. Nature Neurosci. 3, 755\u2013756 (2000).","journal-title":"Nature Neurosci."},{"key":"BF35057006_CR12","doi-asserted-by":"publisher","first-page":"R513","DOI":"10.1016\/S0960-9822(00)00594-7","volume":"10","author":"C Benna","year":"2000","unstructured":"Benna, C. et al. A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim. Curr. Biol. 10, R513 (2000).","journal-title":"Curr. Biol."},{"key":"BF35057006_CR13","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1126\/science.286.5442.1141","volume":"286","author":"M Jeon","year":"1999","unstructured":"Jeon, M., Gardner, H. F., Miller, E. A., Deshler, J. & Rougvie, A. E. Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins. Science 286, 1141\u20131146 (1999).","journal-title":"Science"},{"key":"BF35057006_CR14","doi-asserted-by":"crossref","unstructured":"Toh, K. L. et al. An hPer2 phosphorylation site mutation in familial advanced sleep-phase syndrome. Science, 11 January 2001 (10.1126\/science.1057499).","DOI":"10.1126\/science.1057499"},{"key":"BF35057006_CR15","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1093\/sleep\/21.6.569","volume":"21","author":"D Katzenberg","year":"1998","unstructured":"Katzenberg, D. et al. A CLOCK polymorphism associated with human diurnal preference. Sleep 21, 569\u2013576 (1998).","journal-title":"Sleep"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/35057006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/35057006","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/35057006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/35057006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T05:16:37Z","timestamp":1643692597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35057006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,15]]},"references-count":15,"journal-issue":{"issue":"6822","published-print":{"date-parts":[[2001,2,15]]}},"alternative-id":["BF35057006"],"URL":"https:\/\/doi.org\/10.1038\/35057006","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,15]]}}}