{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:50:01Z","timestamp":1774673401931,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6824","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1038\/35065111","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:48:26Z","timestamp":1027673306000},"page":"101-105","source":"Crossref","is-referenced-by-count":721,"title":["Visualizing the generation of memory CD4 T cells in the whole body"],"prefix":"10.1038","volume":"410","author":[{"given":"R. Lee","family":"Reinhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Khoruts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Merica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Traci","family":"Zell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc K.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF35065111_CR1","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1002\/eji.1830230834","volume":"23","author":"D Kyburz","year":"1993","unstructured":"Kyburz, D. et al. T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur. J. Immunol. 23, 1956\u20131962 (1993).","journal-title":"Eur. J. Immunol."},{"key":"BF35065111_CR2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/1074-7613(94)90084-1","volume":"1","author":"ER Kearney","year":"1994","unstructured":"Kearney, E. R., Pape, K. A., Loh, D. Y. & Jenkins, M. K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327\u2013339 (1994).","journal-title":"Immunity"},{"key":"BF35065111_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1126\/science.7535476","volume":"268","author":"MG McHeyzer-Williams","year":"1995","unstructured":"McHeyzer-Williams, M. G. & Davis, M. M. Antigen-specific development of primary and memory T cells in vivo. Science 268, 106\u2013111 (1995).","journal-title":"Science"},{"key":"BF35065111_CR4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","volume":"8","author":"K Murali-Krishna","year":"1998","unstructured":"Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177\u2013187 (1998).","journal-title":"Immunity"},{"key":"BF35065111_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.272.5258.54","volume":"272","author":"R Ahmed","year":"1996","unstructured":"Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54\u201360 (1996).","journal-title":"Science"},{"key":"BF35065111_CR6","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1146\/annurev.immunol.16.1.201","volume":"16","author":"RW Dutton","year":"1998","unstructured":"Dutton, R. W., Bradley, L. M. & Swain, S. L. T cell memory. Annu. Rev. Immunol. 16, 201\u2013223 (1998).","journal-title":"Annu. Rev. Immunol."},{"key":"BF35065111_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0952-7915(93)90063-X","volume":"5","author":"CR Mackay","year":"1993","unstructured":"Mackay, C. R. Homing of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5, 423\u2013427 (1993).","journal-title":"Curr. Opin. Immunol."},{"key":"BF35065111_CR8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1126\/science.272.5258.60","volume":"272","author":"EC Butcher","year":"1996","unstructured":"Butcher, E. C. & Picker, L. J. Lymphocyte homing and homeostasis. Science 272, 60\u201366 (1996).","journal-title":"Science"},{"key":"BF35065111_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1600-065X.1997.tb00959.x","volume":"156","author":"KA Pape","year":"1997","unstructured":"Pape, K. A. et al. Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cells for the study of T-cell activation in vivo. Immunol. Rev. 156, 67\u201378 (1997).","journal-title":"Immunol. Rev."},{"key":"BF35065111_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","volume":"76","author":"MJ Barnden","year":"1998","unstructured":"Barnden, M. J., Allison, J., Heath, W. R. & Carbone, F. R. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell. Biol. 76, 34\u201340 (1998).","journal-title":"Immunol. Cell. Biol."},{"key":"BF35065111_CR11","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/1911169a0","volume":"191","author":"DW Dresser","year":"1962","unstructured":"Dresser, D. W. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Nature 191, 1169\u20131171 (1962).","journal-title":"Nature"},{"key":"BF35065111_CR12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1126\/science.171.3973.813","volume":"171","author":"JM Chiller","year":"1971","unstructured":"Chiller, J. M., Habicht, G. S. & Weigle, W. O. Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science 171, 813\u2013815 (1971).","journal-title":"Science"},{"key":"BF35065111_CR13","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1084\/jem.137.3.740","volume":"137","author":"JM Chiller","year":"1973","unstructured":"Chiller, J. M. & Weigle, W. O. Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J. Exp. Med. 137, 740\u2013750 (1973).","journal-title":"J. Exp. Med."},{"key":"BF35065111_CR14","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/312555a0","volume":"312","author":"PJ Southern","year":"1984","unstructured":"Southern, P. J., Blount, P. & Oldstone, M. B. Analysis of persistent virus infections by in situ hybridization to whole-mouse sections. Nature 312, 555\u2013558. (1984).","journal-title":"Nature"},{"key":"BF35065111_CR15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4049\/jimmunol.159.2.591","volume":"159","author":"KA Pape","year":"1997","unstructured":"Pape, K. A., Khoruts, A., Mondino, A. & Jenkins, M. K. Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells. J. Immunol. 159, 591\u2013598 (1997).","journal-title":"J. Immunol."},{"key":"BF35065111_CR16","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1126\/science.2125367","volume":"250","author":"KM Murphy","year":"1990","unstructured":"Murphy, K. M., Heimberger, A. B. & Loh, D. Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250, 1720\u20131723 (1990).","journal-title":"Science"},{"key":"BF35065111_CR17","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.4049\/jimmunol.160.10.4719","volume":"160","author":"KA Pape","year":"1998","unstructured":"Pape, K. A., Merica, R., Mondino, A., Khoruts, A. & Jenkins, M. K. Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance. J. Immunol. 160, 4719\u20134729 (1998).","journal-title":"J. Immunol."},{"key":"BF35065111_CR18","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0952-7915(96)80118-X","volume":"8","author":"LM Bradley","year":"1996","unstructured":"Bradley, L. M. & Watson, S. R. Lymphocyte migration into tissue: the paradigm derived from CD4 subsets. Curr. Opin. Immunol. 8, 312\u2013320 (1996).","journal-title":"Curr. Opin. Immunol."},{"key":"BF35065111_CR19","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1126\/science.282.5392.1338","volume":"282","author":"J Alferink","year":"1998","unstructured":"Alferink, J. et al. Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking. Science 282, 1338\u20131341 (1998).","journal-title":"Science"},{"key":"BF35065111_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/348163a0","volume":"348","author":"EB Bell","year":"1990","unstructured":"Bell, E. B. & Sparshott, S. M. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 348, 163\u2013166 (1990).","journal-title":"Nature"},{"key":"BF35065111_CR21","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/0167-5699(96)80545-7","volume":"17","author":"J Westermann","year":"1996","unstructured":"Westermann, J. & Pabst, R. How organ-specific is the migration of \u2018na\u0131\u00a8ve\u2019 and \u2018memory\u2019 T cells? Immunol. Today 17, 278\u2013282 (1996).","journal-title":"Immunol. Today"},{"key":"BF35065111_CR22","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/1074-7613(95)90050-0","volume":"2","author":"AT Vella","year":"1995","unstructured":"Vella, A. T., McCormack, J. E., Linsley, P. S., Kappler, J. W. & Marrack, P. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2, 261\u2013270 (1995).","journal-title":"Immunity"},{"key":"BF35065111_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1084\/jem.187.2.225","volume":"187","author":"A Khoruts","year":"1998","unstructured":"Khoruts, A., Mondino, A., Pape, K. A., Reiner, S. L. & Jenkins, M. K. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187, 225\u2013236 (1998).","journal-title":"J. Exp. Med."},{"key":"BF35065111_CR24","doi-asserted-by":"publisher","first-page":"10814","DOI":"10.1073\/pnas.95.18.10814","volume":"95","author":"SK Kim","year":"1998","unstructured":"Kim, S. K. et al. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc. Natl Acad. Sci. USA 95, 10814\u201310819 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35065111_CR25","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.4049\/jimmunol.163.8.4125","volume":"163","author":"SK Kim","year":"1999","unstructured":"Kim, S. K., Schluns, K. S. & Lefrancois, L. Induction and visualization of mucosal memory CD8 T cells following systemic virus infection. J. Immunol. 163, 4125\u20134132 (1999).","journal-title":"J. Immunol."},{"key":"BF35065111_CR26","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/44385","volume":"401","author":"F Sallusto","year":"1999","unstructured":"Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708\u2013712 (1999).","journal-title":"Nature"},{"key":"BF35065111_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1084\/jem.157.4.1149","volume":"157","author":"K Haskins","year":"1983","unstructured":"Haskins, K. et al. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157, 1149\u20131169 (1983).","journal-title":"J. Exp. Med."},{"key":"BF35065111_CR28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0022-1759(94)90236-4","volume":"171","author":"AB Lyons","year":"1994","unstructured":"Lyons, A. B. & Parish, C. R. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171, 131\u2013137 (1994).","journal-title":"J. Immunol. Methods"},{"key":"BF35065111_CR29","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.4049\/jimmunol.164.9.4551","volume":"164","author":"R Merica","year":"2000","unstructured":"Merica, R., Khoruts, A., Pape, K. A., Reinhardt, R. L. & Jenkins, M. K. Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. J. Immunol. 164, 4551\u20134557 (2000).","journal-title":"J. Immunol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35065111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35065111","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/35065111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/35065111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:51:21Z","timestamp":1684288281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35065111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":29,"journal-issue":{"issue":"6824","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["BF35065111"],"URL":"https:\/\/doi.org\/10.1038\/35065111","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]}}}