{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:12:58Z","timestamp":1791342778661,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6832","license":[{"start":{"date-parts":[[2001,4,26]],"date-time":"2001-04-26T00:00:00Z","timestamp":988243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,4,26]],"date-time":"2001-04-26T00:00:00Z","timestamp":988243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,4,26]]},"DOI":"10.1038\/35074129","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:43:34Z","timestamp":1027673014000},"page":"1111-1116","source":"Crossref","is-referenced-by-count":1043,"title":["Somatic activation of the K-ras oncogene causes early onset lung cancer in mice"],"prefix":"10.1038","volume":"410","author":[{"given":"Leisa","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Greenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick T.","family":"Bronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Tuveson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Jacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35074129_CR1","first-page":"4682","volume":"49","author":"JL Bos","year":"1989","unstructured":"Bos, J. L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682\u20134689 (1989); erratum Cancer Res 50, 1352 (1990).","journal-title":"Cancer Res."},{"key":"BF35074129_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BF00690419","volume":"13","author":"R Khosravi-Far","year":"1994","unstructured":"Khosravi-Far, R. & Der, C. J. The Ras signal transduction pathway. Cancer Met. Rev. 13, 67\u201389 (1994).","journal-title":"Cancer Met. Rev."},{"key":"BF35074129_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/327293a0","volume":"327","author":"JL Bos","year":"1987","unstructured":"Bos, J. L. et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 327, 293\u2013297 (1987).","journal-title":"Nature"},{"key":"BF35074129_CR4","first-page":"1444","volume":"55","author":"NE Mills","year":"1995","unstructured":"Mills, N. E., Fishman, C. L., Rom, W. N., Dubin, N. & Jacobson, D. R. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res. 55, 1444\u20131447 (1995).","journal-title":"Cancer Res."},{"key":"BF35074129_CR5","first-page":"1556","volume":"54","author":"NS Pellegata","year":"1994","unstructured":"Pellegata, N. S. et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res. 54, 1556\u20131560 (1994).","journal-title":"Cancer Res."},{"key":"BF35074129_CR6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1056\/NEJM198809013190901","volume":"319","author":"B Vogelstein","year":"1988","unstructured":"Vogelstein, B. et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319, 525\u2013532 (1988).","journal-title":"N. Engl. J. Med."},{"key":"BF35074129_CR7","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1126\/science.1957168","volume":"254","author":"JM Adams","year":"1991","unstructured":"Adams, J. M. & Cory, S. Transgenic models of tumor development. Science 254, 1161\u20131167 (1991).","journal-title":"Science"},{"key":"BF35074129_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/350243a0","volume":"350","author":"P Hasty","year":"1991","unstructured":"Hasty, P., Ramirez-Solis, R., Krumlauf, R. & Bradley, A. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350, 243\u2013246 (1991); erratum Nature 53, 94 (1991).","journal-title":"Nature"},{"key":"BF35074129_CR9","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1101\/gad.11.19.2468","volume":"11","author":"L Johnson","year":"1997","unstructured":"Johnson, L. et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468\u20132481 (1997); erratum Genes Dev. 11, 3277 (1997).","journal-title":"Genes Dev."},{"key":"BF35074129_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1073\/pnas.85.1.189","volume":"85","author":"PK Seperack","year":"1988","unstructured":"Seperack, P. K., Strobel, M. C., Corrow, D. J., Jenkins, N. A. & Copeland, N. G. Somatic and germ-line reverse mutation rates of the retrovirus-induced dilute coat-color mutation of DBA mice. Proc. Natl Acad. Sci. USA 85, 189\u2013192 (1988).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35074129_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/01902149709046046","volume":"23","author":"EV Thrane","year":"1997","unstructured":"Thrane, E. V. et al. Differential distribution and increased levels of ras proteins during lung development. Exp. Lung Res. 23, 35\u201349 (1997).","journal-title":"Exp. Lung Res."},{"key":"BF35074129_CR12","first-page":"363","volume":"114","author":"K Nakanishi","year":"1990","unstructured":"Nakanishi, K. Alveolar epithelial hyperplasia and adenocarcinoma of the lung. Arch. Pathol. Lab. Med. 114, 363\u2013368 (1990).","journal-title":"Arch. Pathol. Lab. Med."},{"key":"BF35074129_CR13","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1093\/ajcp\/111.5.610","volume":"111","author":"H Kitamura","year":"1999","unstructured":"Kitamura, H., Kameda, Y., Ito, T. & Hayashi, H. Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma. Am. J. Clin. Pathol. 111, 610\u2013622 (1999).","journal-title":"Am. J. Clin. Pathol."},{"key":"BF35074129_CR14","first-page":"61","volume":"13","author":"RI Linnoila","year":"1992","unstructured":"Linnoila, R. I., Mulshine, J. L., Steinberg, S. M. & Gazdar, A. F. Expression of surfactant-associated protein in non-small-cell lung cancer: a discriminant between biologic subsets. J. Natl Cancer Inst. Monogr. 13, 61\u201366 (1992).","journal-title":"J. Natl Cancer Inst. Monogr."},{"key":"BF35074129_CR15","first-page":"1564","volume":"51","author":"TP Pretlow","year":"1991","unstructured":"Pretlow, T. P. et al. Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res. 51, 1564\u20131567 (1991).","journal-title":"Cancer Res."},{"key":"BF35074129_CR16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0165-1110(88)90004-8","volume":"195","author":"JL Bos","year":"1988","unstructured":"Bos, J. L. The ras gene family and human carcinogenesis. Mutat. Res. 195, 255\u2013271 (1988).","journal-title":"Mutat. Res."},{"key":"BF35074129_CR17","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1126\/science.8502998","volume":"260","author":"RE Finney","year":"1993","unstructured":"Finney, R. E. & Bishop, J. M. Predisposition to neoplastic transformation caused by gene replacement of H-ras1. Science 260, 1524\u20131527 (1993).","journal-title":"Science"},{"key":"BF35074129_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0092-8674(90)90523-H","volume":"61","author":"R Bremner","year":"1990","unstructured":"Bremner, R. & Balmain, A. Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61, 407\u2013417 (1990).","journal-title":"Cell"},{"key":"BF35074129_CR19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1126\/science.3941898","volume":"231","author":"J Yokota","year":"1986","unstructured":"Yokota, J., Tsunetsugu-Yokota, Y., Battifora, H., Le Fevre, C. & Cline, M. J. Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation. Science 231, 261\u2013265 (1986).","journal-title":"Science"},{"key":"BF35074129_CR20","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1126\/science.278.5342.1481","volume":"278","author":"RF Bonner","year":"1997","unstructured":"Bonner, R. F. et al. Laser capture microdissection: molecular analysis of tissue. Science 278, 1481\u20131483 (1997).","journal-title":"Science"},{"key":"BF35074129_CR21","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1200\/JCO.1998.16.3.1207","volume":"16","author":"R Salgia","year":"1998","unstructured":"Salgia, R. & Skarin, A. T. Molecular abnormalities in lung cancer. J. Clin. Oncol. 16, 1207\u20131217 (1998).","journal-title":"J. Clin. Oncol."},{"key":"BF35074129_CR22","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","volume":"88","author":"M Serrano","year":"1997","unstructured":"Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature\u00a0cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593\u2013602 (1997).","journal-title":"Cell"},{"key":"BF35074129_CR23","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/0092-8674(94)90132-5","volume":"77","author":"N Tanaka","year":"1994","unstructured":"Tanaka, N. et al. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77, 829\u2013839 (1994).","journal-title":"Cell"},{"key":"BF35074129_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","volume":"4","author":"T Jacks","year":"1994","unstructured":"Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1\u20137 (1994).","journal-title":"Curr. Biol."},{"key":"BF35074129_CR25","doi-asserted-by":"publisher","first-page":"5318","DOI":"10.1038\/sj.onc.1203107","volume":"18","author":"DA Tuveson","year":"1999","unstructured":"Tuveson, D. A. & Jacks, T. Modeling human lung cancer in mice: similarities and shortcomings. Oncogene 18, 5318\u20135324 (1999).","journal-title":"Oncogene"},{"key":"BF35074129_CR26","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1002\/1097-0142(19950315)75:6+<1527::AID-CNCR2820751524>3.0.CO;2-Y","volume":"75","author":"N Yamashita","year":"1995","unstructured":"Yamashita, N., Minamoto, T., Ochiai, A., Onda, M. & Esumi, H. Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression? Cancer 75, 1527\u20131533 (1995).","journal-title":"Cancer"},{"key":"BF35074129_CR27","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1126\/science.2296722","volume":"247","author":"AR Moser","year":"1990","unstructured":"Moser, A. R., Pitot, H. C. & Dove, W. F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322\u2013324 (1990).","journal-title":"Science"},{"key":"BF35074129_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0092-8674(94)90308-5","volume":"77","author":"JB Gibbs","year":"1994","unstructured":"Gibbs, J. B., Oliff, A. & Kohl, N. E. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell 77, 175\u2013178 (1994).","journal-title":"Cell"},{"key":"BF35074129_CR29","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/00001622-199711000-00011","volume":"9","author":"S Sebti","year":"1997","unstructured":"Sebti, S. & Hamilton, A. D. Inhibitors of prenyl transferases. Curr. Opin. Oncol. 9, 557\u2013561 (1997).","journal-title":"Curr. Opin. Oncol."},{"key":"BF35074129_CR30","first-page":"229","volume":"12","author":"EC Lerner","year":"1997","unstructured":"Lerner, E. C., Hamilton, A. D. & Sebti, S. M. Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design. Anticancer Drug Des. 12, 229\u2013238 (1997).","journal-title":"Anticancer Drug Des."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35074129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35074129","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35074129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:57:56Z","timestamp":1684288676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35074129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,26]]},"references-count":30,"journal-issue":{"issue":"6832","published-print":{"date-parts":[[2001,4,26]]}},"alternative-id":["BF35074129"],"URL":"https:\/\/doi.org\/10.1038\/35074129","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,26]]}}}