{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:33:20Z","timestamp":1791286400765,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6841","license":[{"start":{"date-parts":[[2001,6,28]],"date-time":"2001-06-28T00:00:00Z","timestamp":993686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,6,28]],"date-time":"2001-06-28T00:00:00Z","timestamp":993686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,6,28]]},"DOI":"10.1038\/35082583","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:50:09Z","timestamp":1027673409000},"page":"1058-1064","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":376,"title":["Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction"],"prefix":"10.1038","volume":"411","author":[{"given":"Adrian F.","family":"Ochsenbein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Sierro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Pericin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Karrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Hemmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,6,28]]},"reference":[{"key":"BF35082583_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/0952-7915(92)90034-C","volume":"4","author":"LJ Old","year":"1992","unstructured":"Old, L. J. Tumour immunology: the first century. Curr. Opin. Immunol. 4, 603\u2013607 (1992).","journal-title":"Curr. Opin. Immunol."},{"key":"BF35082583_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev.iy.12.040194.002005","volume":"12","author":"T Boon","year":"1994","unstructured":"Boon, T., Cerottini, J. C., van-den-Eynde, B., van-der-Bruggen, P. & Van-Pel, A. Tumour antigens recogniced by T lymphocytes. Annu. Rev. Immunol. 12, 337\u2013365 (1994).","journal-title":"Annu. Rev. Immunol."},{"key":"BF35082583_CR3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1056\/NEJM200002243420801","volume":"342","author":"S Braun","year":"2000","unstructured":"Braun, S. et al. Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II or III breast cancer. N. Engl. J. Med. 342, 525\u2013533 (2000).","journal-title":"N. Engl. J. Med."},{"key":"BF35082583_CR4","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S0092-8674(05)80055-8","volume":"71","author":"RH Schwartz","year":"1992","unstructured":"Schwartz, R. H. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7\/BB1 in interleukin-2 production and immunotherapy. Cell 71, 1065\u20131068 (1992).","journal-title":"Cell"},{"key":"BF35082583_CR5","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1126\/science.7678351","volume":"259","author":"SE Townsend","year":"1993","unstructured":"Townsend, S. E. & Allison, J. P. Tumour rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 259, 368\u2013370 (1993).","journal-title":"Science"},{"key":"BF35082583_CR6","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/S0092-8674(05)80059-5","volume":"71","author":"L Chen","year":"1992","unstructured":"Chen, L. et al. Costimulation of antitumour immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71, 1093\u20131102 (1992).","journal-title":"Cell"},{"key":"BF35082583_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1600-065X.1995.tb00079.x","volume":"145","author":"KE Hellstrom","year":"1995","unstructured":"Hellstrom, K. E., Hellstrom, I. & Chen, L. Can co-stimulated tumour immunity be therapeutically efficacious? Immunol. Rev. 145, 123\u2013145 (1995).","journal-title":"Immunol. Rev."},{"key":"BF35082583_CR8","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","volume":"12","author":"P Matzinger","year":"1994","unstructured":"Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev Immunol. 12, 991\u20131045 (1994).","journal-title":"Annu. Rev Immunol."},{"key":"BF35082583_CR9","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1126\/science.7761853","volume":"268","author":"TM K\u00fcndig","year":"1995","unstructured":"K\u00fcndig, T. M. et al. Fibroblasts as efficient antigen-presenting cells in lymphoid organs. Science 268, 1343\u20131347 (1995).","journal-title":"Science"},{"key":"BF35082583_CR10","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1073\/pnas.96.5.2233","volume":"96","author":"AF Ochsenbein","year":"1999","unstructured":"Ochsenbein, A. F. et al. Immune surveillance against a peripheral solid tumour fails because of immunological ignorance. Proc. Natl Acad. Sci. USA 96, 2233\u20132238 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35082583_CR11","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1093\/clinids\/3.6.1221","volume":"3","author":"H Hahn","year":"1981","unstructured":"Hahn, H. & Kaufmann, S. H. E. Role of cell mediated immunity in bacterial infections. Rev. Infect. Dis. 3, 1221\u20131250 (1981).","journal-title":"Rev. Infect. Dis."},{"key":"BF35082583_CR12","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S0167-5699(98)01301-2","volume":"19","author":"FR Carbone","year":"1998","unstructured":"Carbone, F. R., Kurts, C., Bennet, S. R. M., Miller, J. F. A. P. & Heath, W. R. Cross-presentation: a general mechanism for CTL immunity and tolerance. Immunol. Today 19, 368\u2013373 (1998).","journal-title":"Immunol. Today"},{"key":"BF35082583_CR13","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1126\/science.7513904","volume":"264","author":"AY Huang","year":"1994","unstructured":"Huang, A. Y. et al. Role of bone marrow-derived cells in presenting MHC class I-restricted tumour antigens. Science 264, 961\u2013965 (1994).","journal-title":"Science"},{"key":"BF35082583_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2776(08)60785-3","volume":"73","author":"JW Yewdell","year":"1999","unstructured":"Yewdell, J. W., Norbury, C. C. & Bennink, J. R. Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumours, transplants, and vaccines. Adv. Immunol. 73, 1\u201377 (1999).","journal-title":"Adv. Immunol."},{"key":"BF35082583_CR15","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/82751","volume":"1","author":"P Jeannin","year":"2000","unstructured":"Jeannin, P. OmpA targets dendritc cells, induces their maturation and delivers antigen into the MHC class I presentation pathway. Nature Immunol. 1, 502\u2013509 (2000).","journal-title":"Nature Immunol."},{"key":"BF35082583_CR16","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1084\/jem.143.5.1283","volume":"143","author":"MJ Bevan","year":"1976","unstructured":"Bevan, M. J. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143, 1283\u20131288 (1976).","journal-title":"J. Exp. Med."},{"key":"BF35082583_CR17","first-page":"3782","volume":"56","author":"REM Toes","year":"1996","unstructured":"Toes, R. E. M. et al. Protective antitumour immunity induced by immunization with completely allogenic tumour cells. Cancer Res. 56, 3782\u20133787 (1996).","journal-title":"Cancer Res."},{"key":"BF35082583_CR18","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1084\/jem.191.3.541","volume":"191","author":"Z Lu","year":"2000","unstructured":"Lu, Z. et al. CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes. J. Exp. Med. 191, 541\u2013550 (2000).","journal-title":"J. Exp. Med."},{"key":"BF35082583_CR19","first-page":"3909","volume":"58","author":"IF Hermans","year":"1998","unstructured":"Hermans, I. F., Daish, A., Yang, J., Ritchie, D. S. & Ronchese, F. Antigen expressed on tumour cells fails to elicit an immune response, even in the presence of increased numbers of tumour-specific cytotoxic T lymphocyte precursors. Cancer Res. 58, 3909\u20133917 (1998).","journal-title":"Cancer Res."},{"key":"BF35082583_CR20","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.4049\/jimmunol.161.5.2187","volume":"161","author":"A Prevost-Blondel","year":"1998","unstructured":"Prevost-Blondel, A. et al. Tumour-infiltrating lymphocytes exhibiting high ex vivo cytolytic activity fail to prevent murine melanoma tumour growth in vivo. J. Immunol. 161, 2187\u20132194 (1998).","journal-title":"J. Immunol."},{"key":"BF35082583_CR21","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1073\/pnas.95.3.1178","volume":"95","author":"K Staveley-O'Carrol","year":"1998","unstructured":"Staveley-O'Carrol, K. et al. Induction of antigen-specific T cell anergy: an early event in the course of tumour progression. Proc. Natl Acad. Sci. USA 95, 1178\u20131183 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35082583_CR22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/cimm.1994.1281","volume":"158","author":"SU Oehen","year":"1994","unstructured":"Oehen, S. U. et al. Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels. Cell Immunol. 158, 342\u2013352 (1994).","journal-title":"Cell Immunol."},{"key":"BF35082583_CR23","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O","volume":"28","author":"A Oxenius","year":"1998","unstructured":"Oxenius, A., Bachmann, M. F., Zinkernagel, R. M. & Hengartner, H. Virus-specific MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune response after viral infection. Eur. J. Immunol. 28, 390\u2013400 (1998).","journal-title":"Eur. J. Immunol."},{"key":"BF35082583_CR24","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1126\/science.7688139","volume":"261","author":"A Shahinian","year":"1993","unstructured":"Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609\u2013612 (1993).","journal-title":"Science"},{"key":"BF35082583_CR25","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1084\/jem.185.12.2157","volume":"185","author":"U Karrer","year":"1997","unstructured":"Karrer, U. et al. On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly\/aly) and spleenless (Hox11-\/-) mutant mice. J. Exp. Med. 185, 2157\u20132170 (1997).","journal-title":"J. Exp. Med."},{"key":"BF35082583_CR26","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1084\/jem.179.4.1205","volume":"179","author":"L Ramarathinam","year":"1994","unstructured":"Ramarathinam, L., Castle, M., Wu, Y. & Liu, Y. T cell costimulation by B7\/BB1 induces CD8 T cell-dependent tumour rejection: an important tole of B7\/BB1 in the induction, recruitment, and effector function of antitumour T cells. J. Exp. Med. 179, 1205\u20131214 (1994).","journal-title":"J. Exp. Med."},{"key":"BF35082583_CR27","first-page":"3376","volume":"58","author":"M Maric","year":"1998","unstructured":"Maric, M., Zheng, P., Sarma, S., Guo, Y. & Liu, Y. Maturation of cytotoxic T lymphocytes against a B7-transfected nonmetastatic tumour: a critical role for costimulation by B7 on both tumour and host antigen-presenting cells. Cancer Res. 58, 3376\u20133384 (1998).","journal-title":"Cancer Res."},{"key":"BF35082583_CR28","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1084\/jem.187.5.693","volume":"187","author":"F Ossendrop","year":"1998","unstructured":"Ossendrop, F., Mengede, E., Camps, M., Filius, R. & Melief, C. J. Specific T helper requirement for optimal induction of cytotoxic T lymphocytes against major histocomatibility complex class II negative tumours. J. Exp. Med. 187, 693\u2013702 (1998).","journal-title":"J. Exp. Med."},{"key":"BF35082583_CR29","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1073\/pnas.91.8.3137","volume":"91","author":"DM Harlan","year":"1994","unstructured":"Harlan, D. M. et al. Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc. Natl Acad. Sci. USA 91, 3137\u20133141 (1994).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35082583_CR30","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1084\/jem.182.5.1415","volume":"182","author":"TC Wu","year":"1995","unstructured":"Wu, T. C., Huang, A. Y. C., Jaffee, E. M., Levitsky, H. I. & Pardoll, D. M. A reassessment of the role of B7-1 expression in tumour rejection. J. Exp. Med. 182, 1415\u20131421 (1995).","journal-title":"J. Exp. Med."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/35082583.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/35082583","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/35082583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/35082583.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:20:53Z","timestamp":1684862453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35082583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,28]]},"references-count":30,"journal-issue":{"issue":"6841","published-print":{"date-parts":[[2001,6,28]]}},"alternative-id":["BF35082583"],"URL":"https:\/\/doi.org\/10.1038\/35082583","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,28]]},"assertion":[{"value":"20 November 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}