{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:16Z","timestamp":1791355936087,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6844","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,7]]},"DOI":"10.1038\/35085588","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:32:48Z","timestamp":1027672368000},"page":"341-346","source":"Crossref","is-referenced-by-count":901,"title":["Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas"],"prefix":"10.1038","volume":"412","author":[{"given":"Laura","family":"Pasqualucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Neumeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gouri","family":"Nanjangud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S. K.","family":"Chaganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"K\u00fcppers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35085588_CR1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/25292","volume":"396","author":"C Lengauer","year":"1998","unstructured":"Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643\u2013649 (1998).","journal-title":"Nature"},{"key":"BF35085588_CR2","first-page":"2215","volume-title":"Cancer. Principles and Practice of Oncology","author":"R Dalla-Favera","year":"2001","unstructured":"Dalla-Favera, R. & Gaidano, G. in Cancer. Principles and Practice of Oncology (ed. DeVita, V. T. Jr, Hellman S. & Rosenberg, S. A.) 2215\u20132235 (Lippincott Williams & Wilkins, Philadelphia, 2001)."},{"key":"BF35085588_CR3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-065X.1998.tb01447.x","volume":"162","author":"U Klein","year":"1998","unstructured":"Klein, U. et al. Somatic hypermutation in normal and transformed human B cells. Immunol. Rev. 162, 261\u2013280 (1998).","journal-title":"Immunol. Rev."},{"key":"BF35085588_CR4","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1073\/pnas.95.5.2463","volume":"95","author":"T Goossens","year":"1998","unstructured":"Goossens, T., Klein, U. & K\u00fcppers, R. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl Acad. Sci. USA 95, 2463\u20132468 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35085588_CR5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/35041599","volume":"408","author":"FN Papavasiliou","year":"2000","unstructured":"Papavasiliou, F. N. & Schatz, D. G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 408, 216\u2013221 (2000).","journal-title":"Nature"},{"key":"BF35085588_CR6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1074-7613(00)00059-5","volume":"13","author":"L Bross","year":"2000","unstructured":"Bross, L. et al. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity 13, 589\u2013597 (2000).","journal-title":"Immunity"},{"key":"BF35085588_CR7","doi-asserted-by":"crossref","first-page":"11816","DOI":"10.1073\/pnas.95.20.11816","volume":"95","author":"L Pasqualucci","year":"1998","unstructured":"Pasqualucci, L. et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl Acad. Sci. USA 95, 11816\u201311821 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35085588_CR8","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1126\/science.280.5370.1750","volume":"280","author":"HM Shen","year":"1998","unstructured":"Shen, H. M., Peters, A., Baron, B., Zhu, X. & Storb, U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280, 1750\u20131752 (1998).","journal-title":"Science"},{"key":"BF35085588_CR9","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1084\/jem.192.12.1833","volume":"192","author":"M M\u00fcschen","year":"2000","unstructured":"M\u00fcschen, M. et al. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J. Exp. Med. 192, 1833\u20131840 (2000).","journal-title":"J. Exp. Med."},{"key":"BF35085588_CR10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-065X.1998.tb01424.x","volume":"162","author":"U Storb","year":"1998","unstructured":"Storb, U. et al. Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol. Rev. 162, 153\u2013160 (1998).","journal-title":"Immunol. Rev."},{"key":"BF35085588_CR11","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1073\/pnas.92.26.12520","volume":"92","author":"A Migliazza","year":"1995","unstructured":"Migliazza, A. et al. Frequent somatic hypermutation of the 5\u2032 noncoding region of the BCL6 gene in B-cell lymphoma. Proc. Natl Acad. Sci. USA 92, 12520\u201312524 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35085588_CR12","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/306760a0","volume":"306","author":"TH Rabbitts","year":"1983","unstructured":"Rabbitts, T. H., Hamlyn, P. H. & Baer, R. Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 306, 760\u2013765 (1983).","journal-title":"Nature"},{"key":"BF35085588_CR13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0092-8674(84)90309-X","volume":"37","author":"HT Cuypers","year":"1984","unstructured":"Cuypers, H. T. et al. Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell 37, 141\u2013150 (1984).","journal-title":"Cell"},{"key":"BF35085588_CR14","first-page":"2335","volume":"60","author":"H Akasaka","year":"2000","unstructured":"Akasaka, H. et al. Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays. Cancer Res. 60, 2335\u20132341 (2000).","journal-title":"Cancer Res."},{"key":"BF35085588_CR15","doi-asserted-by":"crossref","first-page":"14018","DOI":"10.1016\/S0021-9258(18)92804-8","volume":"266","author":"D Hoover","year":"1991","unstructured":"Hoover, D., Friedmann, M., Reeves, R. & Magnuson, N. S. Recombinant human pim-1 protein exhibits serine\/threonine kinase activity. J. Biol. Chem. 266, 14018\u201314023 (1991).","journal-title":"J. Biol. Chem."},{"key":"BF35085588_CR16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1074-7613(00)80145-4","volume":"11","author":"T Shirogane","year":"1999","unstructured":"Shirogane, T. et al. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 11, 709\u2013719 (1999).","journal-title":"Immunity"},{"key":"BF35085588_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MCB.19.1.1","volume":"19","author":"CV Dang","year":"1999","unstructured":"Dang, C. V. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 19, 1\u201311 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BF35085588_CR18","first-page":"265","volume":"194","author":"M Raffeld","year":"1995","unstructured":"Raffeld, M. et al. Clustered mutations in the transcriptional activation domain of Myc in 8q24 translocated lymphomas and their functional consequences. Curr. Top. Microbiol. Immunol. 194, 265\u2013272 (1995).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BF35085588_CR19","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1126\/science.3685977","volume":"238","author":"E Cesarman","year":"1987","unstructured":"Cesarman, E., Dalla-Favera, R., Bentley, D. & Groudine, M. Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma. Science 238, 1272\u20131275 (1987).","journal-title":"Science"},{"key":"BF35085588_CR20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.8146655","volume":"264","author":"W Gu","year":"1994","unstructured":"Gu, W., Bhatia, K., Magrath, I. T., Dang, C. V. & Dalla-Favera, R. Binding and suppression of the Myc transcriptional activation domain by p107. Science 264, 251\u2013254 (1994).","journal-title":"Science"},{"key":"BF35085588_CR21","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1038\/sj.onc.1203521","volume":"19","author":"C Preudhomme","year":"2000","unstructured":"Preudhomme, C. et al. Nonrandom 4p13 rearrangements of the RhoH\/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Oncogene 19, 2023\u20132032 (2000).","journal-title":"Oncogene"},{"key":"BF35085588_CR22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/smim.1998.0115","volume":"10","author":"AM Morrison","year":"1998","unstructured":"Morrison, A. M., Nutt, S. L., Thevenin, C., Rolink, A. & Busslinger, M. Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation. Semin. Immunol. 10, 133\u2013142 (1998).","journal-title":"Semin. Immunol."},{"key":"BF35085588_CR23","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/intimm\/12.7.1085","volume":"12","author":"HM Shen","year":"2000","unstructured":"Shen, H. M., Michael, N., Kim, N. & Storb, U. The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. Int. Immunol. 12, 1085\u20131093 (2000).","journal-title":"Int. Immunol."},{"key":"BF35085588_CR24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1084\/jem.191.2.395","volume":"191","author":"B Jungnickel","year":"2000","unstructured":"Jungnickel, B. et al. Clonal deleterious mutations in the I\u03baB\u03b1 gene in the malignant cells in Hodgkin's lymphoma. J. Exp. Med. 191, 395\u2013402 (2000).","journal-title":"J. Exp. Med."},{"key":"BF35085588_CR25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-065X.1998.tb01434.x","volume":"162","author":"MS Neuberger","year":"1998","unstructured":"Neuberger, M. S. et al. Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunol. Rev. 162, 107\u2013116 (1998).","journal-title":"Immunol. Rev."},{"key":"BF35085588_CR26","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.4049\/jimmunol.162.6.3437","volume":"162","author":"H Zan","year":"1999","unstructured":"Zan, H. et al. Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation. J.\u00a0Immunol. 162, 3437\u20133447 (1999).","journal-title":"J.\u00a0Immunol."},{"key":"BF35085588_CR27","first-page":"975","volume":"89","author":"B Gamberi","year":"1997","unstructured":"Gamberi, B. et al. Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas. Blood 89, 975\u2013979 (1997).","journal-title":"Blood"},{"key":"BF35085588_CR28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","volume":"102","author":"M Muramatsu","year":"2000","unstructured":"Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553\u2013563 (2000).","journal-title":"Cell"},{"key":"BF35085588_CR29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/(SICI)1098-2264(199906)25:2<123::AID-GCC8>3.0.CO;2-4","volume":"25","author":"JC Cigudosa","year":"1999","unstructured":"Cigudosa, J. C. et al. Cytogenetic analysis of 363 consecutively ascertained diffuse large B-cell lymphomas. Genes Chromosom. Cancer 25, 123\u2013133 (1999).","journal-title":"Genes Chromosom. Cancer"},{"key":"BF35085588_CR30","first-page":"5644","volume":"60","author":"L Pasqualucci","year":"2000","unstructured":"Pasqualucci, L., Neri, A., Baldini, L., Dalla-Favera, R. & Migliazza, A. BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. Cancer Res. 60, 5644\u20135648 (2000).","journal-title":"Cancer Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35085588.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35085588","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/35085588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/35085588.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:04:17Z","timestamp":1684289057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35085588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":30,"journal-issue":{"issue":"6844","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["BF35085588"],"URL":"https:\/\/doi.org\/10.1038\/35085588","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}