{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:51:18Z","timestamp":1781592678074,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6845","license":[{"start":{"date-parts":[[2001,7,26]],"date-time":"2001-07-26T00:00:00Z","timestamp":996105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,7,26]],"date-time":"2001-07-26T00:00:00Z","timestamp":996105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,7,26]]},"DOI":"10.1038\/35086581","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:32:48Z","timestamp":1027657968000},"page":"442-445","source":"Crossref","is-referenced-by-count":580,"title":["Natural conjugative plasmids induce bacterial biofilm development"],"prefix":"10.1038","volume":"412","author":[{"given":"Jean-Marc","family":"Ghigo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35086581_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0966-842X(00)01703-0","volume":"8","author":"I de la Cruz","year":"2000","unstructured":"de la Cruz, I. & Davies, I. Horizontal gene transfer and the origin of species: lessons from bacteria. Trends Microbiol. 8, 128\u2013133 (2000).","journal-title":"Trends Microbiol."},{"key":"BF35086581_CR2","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/158558a0","volume":"158","author":"J Lederberg","year":"1946","unstructured":"Lederberg, J. & Tatum, E. L. Gene recombination in Escherichia coli. Nature 158, 558 (1946)..","journal-title":"Nature"},{"key":"BF35086581_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/35012500","volume":"405","author":"H Ochman","year":"2000","unstructured":"Ochman, H., Lawrence, J. G. & Groisman, E. A. Lateral gene transfer and the nature of bacterial innovation. Nature 405, 299\u2013304 (2000).","journal-title":"Nature"},{"key":"BF35086581_CR4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1146\/annurev.mi.49.100195.003431","volume":"49","author":"JW Costerton","year":"1995","unstructured":"Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R. & Lappin-Scott, H. M. Microbial biofilms. Annu. Rev. Microbiol. 49, 711\u2013745 (1995).","journal-title":"Annu. Rev. Microbiol."},{"key":"BF35086581_CR5","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1128\/AEM.65.8.3710-3713.1999","volume":"65","author":"M Hausner","year":"1999","unstructured":"Hausner, M. & Wuertz, S. High rates of conjugation in bacterial biofilms as determined by quantitative in situ analysis. Appl. Environ. Microbiol. 65, 3710\u20133713 (1999).","journal-title":"Appl. Environ. Microbiol."},{"key":"BF35086581_CR6","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1128\/AEM.64.6.2247-2255.1998","volume":"64","author":"BB Christensen","year":"1998","unstructured":"Christensen, B. B. et al. Establishment of new genetic traits in a microbial biofilm community. Appl.\u00a0Environ. Microbiol. 64, 2247\u20132255 (1998).","journal-title":"Appl.\u00a0Environ. Microbiol."},{"key":"BF35086581_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1046\/j.1365-2958.1998.01062.x","volume":"30","author":"GA O'Toole","year":"1998","unstructured":"O'Toole, G. A. & Kolter, R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol. Microbiol. 30, 295\u2013304 (1998).","journal-title":"Mol. Microbiol."},{"key":"BF35086581_CR8","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/S1369-5274(99)00028-4","volume":"2","author":"LA Pratt","year":"1999","unstructured":"Pratt, L. A. & Kolter, R. Genetic analyses of bacterial biofilm formation. Curr. Opin. Microbiol. 2, 598\u2013603 (1999).","journal-title":"Curr. Opin. Microbiol."},{"key":"BF35086581_CR9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1128\/mr.58.2.162-210.1994","volume":"58","author":"LS Frost","year":"1994","unstructured":"Frost, L. S., Ippen-Ihler, K. & Skurray, R. A. Analysis of the sequence and gene products of the transfer region of the F sex factor. Microbiol. Rev. 58, 162\u2013210 (1994).","journal-title":"Microbiol. Rev."},{"key":"BF35086581_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/0014-5793(87)80324-1","volume":"223","author":"G Ried","year":"1987","unstructured":"Ried, G. & Henning, U. A unique amino acid substitution in the outer membrane protein OmpA causes conjugation deficiency in Escherichia coli K-12. FEBS Lett. 223, 387\u2013390 (1987).","journal-title":"FEBS Lett."},{"key":"BF35086581_CR11","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/genetics\/113.3.483","volume":"113","author":"PD Lundquist","year":"1986","unstructured":"Lundquist, P. D. & Levin, B. R. Transitory derepression and the maintenance of conjugative plasmids. Genetics 113, 483\u2013497 (1986).","journal-title":"Genetics"},{"key":"BF35086581_CR12","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1128\/JB.182.10.2675-2679.2000","volume":"182","author":"P Watnick","year":"2000","unstructured":"Watnick, P. & Kolter, R. Biofilm, city of microbes. J. Bacteriol. 182, 2675\u20132679 (2000).","journal-title":"J. Bacteriol."},{"key":"BF35086581_CR13","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1093\/genetics\/155.4.1505","volume":"155","author":"CT Bergstrom","year":"2000","unstructured":"Bergstrom, C. T., Lipsitch, M. & Levin, B. R. Natural selection, infectious transfer and the existence conditions for bacterial plasmids. Genetics 155, 1505\u20131519 (2000).","journal-title":"Genetics"},{"key":"BF35086581_CR14","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","volume":"284","author":"JW Costerton","year":"1999","unstructured":"Costerton, J. W., Stewart, P. S. & Greenberg, E. P. Bacterial biofilms: a common cause of persistent infections. Science 284, 1318\u20131322 (1999).","journal-title":"Science"},{"key":"BF35086581_CR15","doi-asserted-by":"publisher","first-page":"E97","DOI":"10.1093\/nar\/28.22.e97","volume":"28","author":"MK Chaveroche","year":"2000","unstructured":"Chaveroche, M. K., Ghigo, J. M. & d\u2019Enfert, C. A rapid method for efficient gene replacement in the filamentous fungus aspergillus nidulans. Nucleic Acids Res. 28, E97 (2000).","journal-title":"Nucleic Acids Res."},{"key":"BF35086581_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1128\/mr.52.3.375-395.1988","volume":"52","author":"M Couturier","year":"1988","unstructured":"Couturier, M., Bex, F., Bergquist, P. L. & Maas, W. K. Identification and classification of bacterial plasmids. Microbiol. Rev. 52, 375\u2013395 (1988).","journal-title":"Microbiol. Rev."},{"key":"BF35086581_CR17","first-page":"601","volume-title":"DNA Insertion Elements, Plasmids and Episomes","author":"AI Bukhari","year":"1977","unstructured":"Bukhari, A. I., Shapiro, J. A. & Adhya, S. L. (eds) DNA Insertion Elements, Plasmids and Episomes 601\u2013656 (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1977)."},{"key":"BF35086581_CR18","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1128\/jb.143.3.1466-1470.1980","volume":"143","author":"DE Bradley","year":"1980","unstructured":"Bradley, D. E., Taylor, D. E. & Cohen, D. R. Specification of surface mating systems among conjugative drug resistance plasmids in Escherichia coli K-12. J. Bacteriol. 143, 1466\u20131460 (1980).","journal-title":"J. Bacteriol."},{"key":"BF35086581_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-1-4757-9357-4_7","volume-title":"Bacterial conjugation","author":"LS Frost","year":"1993","unstructured":"Frost, L. S. in Bacterial conjugation (ed. Clewel, D. B.) 189\u2013221 (Plenum, New York, 1993)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/35086581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/35086581","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/35086581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T22:05:01Z","timestamp":1684274701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35086581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,26]]},"references-count":19,"journal-issue":{"issue":"6845","published-print":{"date-parts":[[2001,7,26]]}},"alternative-id":["BF35086581"],"URL":"https:\/\/doi.org\/10.1038\/35086581","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1000084.3352","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,26]]}}}