{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:05:58Z","timestamp":1791273958280,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6860","license":[{"start":{"date-parts":[[2001,11,8]],"date-time":"2001-11-08T00:00:00Z","timestamp":1005177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,11,8]],"date-time":"2001-11-08T00:00:00Z","timestamp":1005177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,11,8]]},"DOI":"10.1038\/35102582","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:32:48Z","timestamp":1027672368000},"page":"209-212","source":"Crossref","is-referenced-by-count":627,"title":["An anorexic lipid mediator regulated by feeding"],"prefix":"10.1038","volume":"414","author":[{"given":"F.","family":"Rodr\u00edguez de Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Escuredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Murillo-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"LoVerme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gaetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kathuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Piomelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF35102582_CR1","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/372686a0","volume":"372","author":"V Di Marzo","year":"1994","unstructured":"Di Marzo, V. et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372, 686\u2013691 (1994).","journal-title":"Nature"},{"key":"BF35102582_CR2","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1006\/nbdi.1998.0221","volume":"5","author":"D Piomelli","year":"1998","unstructured":"Piomelli, D., Beltramo, M., Giuffrida, A. & Stella, N. Endogenous cannabinoid signaling. Neurobiol. Dis. 5, 462\u2013473 (1998).","journal-title":"Neurobiol. Dis."},{"key":"BF35102582_CR3","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0021-9258(18)97531-9","volume":"240","author":"NR Bachur","year":"1965","unstructured":"Bachur, N. R., Masek, K., Melmon, K. L. & Udenfriend, S. Fatty acid amides of ethanolamine in mammalian tissues. J. Biol. Chem. 240, 1019\u20131024 (1965).","journal-title":"J. Biol. Chem."},{"key":"BF35102582_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0009-3084(96)02554-6","volume":"80","author":"HH Schmid","year":"1996","unstructured":"Schmid, H. H., Schmid, P. C. & Natarajan, V. The N-acylation-phosphodiesterase pathway and cell signalling. Chem. Phys. Lipids 80, 133\u2013142 (1996).","journal-title":"Chem. Phys. Lipids"},{"key":"BF35102582_CR5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0009-3084(00)00198-5","volume":"108","author":"KD Chapman","year":"2000","unstructured":"Chapman, K. D. Emerging physiological roles for N-acylphosphatidylethanolamine metabolism in plants: signal transduction and membrane protection. Chem. Phys. Lipids 108, 221\u2013229 (2000).","journal-title":"Chem. Phys. Lipids"},{"key":"BF35102582_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/7268","volume":"2","author":"A Giuffrida","year":"1999","unstructured":"Giuffrida, A. et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nature Neurosci. 2, 358\u2013363 (1999).","journal-title":"Nature Neurosci."},{"key":"BF35102582_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1042\/bj3460369","volume":"346","author":"EV Berdyshev","year":"2000","unstructured":"Berdyshev, E. V., Schmid, P. C., Dong, Z. & Schmid, H. H. Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells. Biochem. J. 346, 369\u2013374 (2000).","journal-title":"Biochem. J."},{"key":"BF35102582_CR8","doi-asserted-by":"publisher","first-page":"3934","DOI":"10.1523\/JNEUROSCI.16-12-03934.1996","volume":"16","author":"H Cadas","year":"1996","unstructured":"Cadas, H., Gaillet, S., Beltramo, M., Venance, L. & Piomelli, D. Biosynthesis of an endogenous\u00a0cannabinoid precursor in neurons and its control by calcium and cAMP. J. Neurosci. 16, 3934\u20133942 (1996).","journal-title":"J. Neurosci."},{"key":"BF35102582_CR9","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1523\/JNEUROSCI.17-04-01226.1997","volume":"17","author":"H Cadas","year":"1997","unstructured":"Cadas, H., di Tomaso, E. & Piomelli, D. Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J. Neurosci. 17, 1226\u20131242 (1997).","journal-title":"J. Neurosci."},{"key":"BF35102582_CR10","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1126\/science.277.5329.1094","volume":"277","author":"M Beltramo","year":"1997","unstructured":"Beltramo, M. et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277, 1094\u20131097 (1997).","journal-title":"Science"},{"key":"BF35102582_CR11","doi-asserted-by":"publisher","first-page":"14145","DOI":"10.1016\/S0021-9258(17)38695-7","volume":"260","author":"PC Schmid","year":"1985","unstructured":"Schmid, P. C., Zuzarte-Augustin, M. L. & Schmid, H. H. Properties of rat liver N-acylethanolamine amidohydrolase. J. Biol. Chem. 260, 14145\u201314149 (1985).","journal-title":"J. Biol. Chem."},{"key":"BF35102582_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/384083a0","volume":"384","author":"BF Cravatt","year":"1996","unstructured":"Cravatt, B. F. et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384, 83\u201387 (1996).","journal-title":"Nature"},{"key":"BF35102582_CR13","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"WA Devane","year":"1992","unstructured":"Devane, W. A. et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946\u20131949 (1992).","journal-title":"Science"},{"key":"BF35102582_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002130050953","volume":"143","author":"CM Williams","year":"1999","unstructured":"Williams, C. M. & Kirkham, T. C. Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology 143, 315\u2013317 (1999).","journal-title":"Psychopharmacology"},{"key":"BF35102582_CR15","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0024-3205(99)00283-0","volume":"65","author":"AD Khanolkar","year":"1999","unstructured":"Khanolkar, A. D. & Makriyannis, A. Structure\u2013activity relationships of anandamide, an endogenous cannabinoid ligand. Life Sci. 65, 607\u2013616 (1999).","journal-title":"Life Sci."},{"key":"BF35102582_CR16","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1517\/13543784.9.7.1553","volume":"9","author":"RG Pertwee","year":"2000","unstructured":"Pertwee, R. G. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. Exp. Opin. Invest. Drugs 9, 1553\u20131571 (2000).","journal-title":"Exp. Opin. Invest. Drugs"},{"key":"BF35102582_CR17","first-page":"G1056","volume":"275","author":"H Kaneko","year":"1998","unstructured":"Kaneko, H., Kaunitz, J. & Tache, Y. Vagal mechanisms underlying gastric protection induced by chemical activation of raphe pallidus in rats. Am. J. Physiol. 275, G1056\u2013G1062 (1998).","journal-title":"Am. J. Physiol."},{"key":"BF35102582_CR18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0167-0115(85)90204-6","volume":"11","author":"DB MacLean","year":"1985","unstructured":"MacLean, D. B. Abrogation of peripheral cholecystokinin-satiety in the capsaicin treated rat. Regul. Pept. 11, 321\u2013333 (1985).","journal-title":"Regul. Pept."},{"key":"BF35102582_CR19","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s002130050570","volume":"136","author":"MD Lee","year":"1998","unstructured":"Lee, M. D., Aloyo, V. J., Fluharty, S. J. & Simansky, K. J. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136, 304\u2013307 (1998).","journal-title":"Psychopharmacology"},{"key":"BF35102582_CR20","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/35007534","volume":"404","author":"MW Schwartz","year":"2000","unstructured":"Schwartz, M. W., Woods, S. C., Porte, D. J., Seeley, R. J. & Baskin, D. G. Central nervous system control of food intake. Nature 404, 661\u2013671 (2000).","journal-title":"Nature"},{"key":"BF35102582_CR21","first-page":"79","volume":"2","author":"T Curran","year":"1987","unstructured":"Curran, T., Gordon, M. B., Rubino, K. L. & Sambucetti, L. C. Isolation and characterization of the c-fos (rat) cDNA and analysis of post-translational modification in vitro. Oncogene 2, 79\u201384 (1987).","journal-title":"Oncogene"},{"key":"BF35102582_CR22","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1054\/npep.1999.0051","volume":"33","author":"RC Ritter","year":"1999","unstructured":"Ritter, R. C., Covasa, M. & Matson, C. A. Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight. Neuropeptides 33, 387\u2013399 (1999).","journal-title":"Neuropeptides"},{"key":"BF35102582_CR23","first-page":"113","volume-title":"Lipid Second Messengers","author":"A Giuffrida","year":"1998","unstructured":"Giuffrida, A. & Piomelli, D. in Lipid Second Messengers (eds Laychock, S. G. & Rubin, R. P.) 113\u2013133 (CRC, Boca Raton, 1998)."},{"key":"BF35102582_CR24","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1074\/jbc.270.11.6030","volume":"270","author":"F D\u00e9sarnaud","year":"1995","unstructured":"D\u00e9sarnaud, F., Cadas, H. & Piomelli, D. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. J. Biol. Chem. 270, 6030\u20136035 (1995).","journal-title":"J. Biol. Chem."},{"key":"BF35102582_CR25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1006\/abio.2000.4509","volume":"280","author":"A Giuffrida","year":"2000","unstructured":"Giuffrida, A., Rodr\u00edguez de Fonseca, F. & Piomelli, D. Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Anal. Biochem. 280, 87\u201393 (2000).","journal-title":"Anal. Biochem."},{"key":"BF35102582_CR26","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/00001756-199701200-00023","volume":"8","author":"M Navarro","year":"1997","unstructured":"Navarro, M. et al. Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat. Neuroreport 8, 491\u2013496 (1997).","journal-title":"Neuroreport"},{"key":"BF35102582_CR27","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1046\/j.1471-4159.1996.67051982.x","volume":"67","author":"M Navarro","year":"1996","unstructured":"Navarro, M. et al. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J. Neurochem. 67, 1982\u20131991 (1996).","journal-title":"J. Neurochem."},{"key":"BF35102582_CR28","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1073\/pnas.90.8.3329","volume":"90","author":"KM Guthrie","year":"1993","unstructured":"Guthrie, K. M., Anderson, A. J., Leon, M. & Gall, C. Odor-induced increases in c-fos mRNA expression reveal an anatomical \u201cunit\u201d for odor processing in olfactory bulb. Proc. Natl Acad. Sci. USA 90, 3329\u20133333 (1993).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35102582_CR29","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0169-328X(93)90073-X","volume":"17","author":"JC Lauterborn","year":"1993","unstructured":"Lauterborn, J. C., Isackson, P. J., Montalvo, R. & Gall, C. M. In situ hybridization localization of choline acetyltransferase mRNA in adult rat brain and spinal cord. Brain Res. Mol. Brain Res. 17, 59\u201369 (1993).","journal-title":"Brain Res. Mol. Brain Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/35102582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/35102582","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/35102582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T09:04:27Z","timestamp":1642583067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35102582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,8]]},"references-count":29,"journal-issue":{"issue":"6860","published-print":{"date-parts":[[2001,11,8]]}},"alternative-id":["BF35102582"],"URL":"https:\/\/doi.org\/10.1038\/35102582","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11,8]]}}}