{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:25:31Z","timestamp":1779344731610,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6863","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1038\/35107085","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:34:56Z","timestamp":1027658096000},"page":"550-554","source":"Crossref","is-referenced-by-count":541,"title":["Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression"],"prefix":"10.1038","volume":"414","author":[{"given":"Yuichi","family":"Makino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renhai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Bertilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Asman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Berkenstam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Poellinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF35107085_CR1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1152\/physrev.1996.76.3.839","volume":"76","author":"HF Bunn","year":"1996","unstructured":"Bunn, H. F. & Poyton, R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839\u2013885 (1996).","journal-title":"Physiol. Rev."},{"key":"BF35107085_CR2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/jeb.203.8.1253","volume":"203","author":"RH Wenger","year":"2000","unstructured":"Wenger, R. H. Mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 203, 1253\u20131263 (2000).","journal-title":"J. Exp. Biol."},{"key":"BF35107085_CR3","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1006\/jmbi.1994.1104","volume":"235","author":"A Krogh","year":"1994","unstructured":"Krogh, A., Brown, M., Mian, I. S., Sjolander, K. & Haussler, D. Hidden Markov models in computational biology. Applications to protein modeling. J. Mol. Biol. 235, 1501\u20131531 (1994).","journal-title":"J. Mol. Biol."},{"key":"BF35107085_CR4","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","volume":"92","author":"GL Wang","year":"1995","unstructured":"Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 5510\u20135514 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35107085_CR5","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1073\/pnas.94.9.4273","volume":"94","author":"M Ema","year":"1997","unstructured":"Ema, M. et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1\u03b1 regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl Acad. Sci. USA 94, 4273\u20134278 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35107085_CR6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1101\/gad.11.1.72","volume":"11","author":"H Tian","year":"1997","unstructured":"Tian, H., McKnight, S. L. & Russell, D. W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72\u201382 (1997).","journal-title":"Genes Dev."},{"key":"BF35107085_CR7","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1101\/gad.14.16.1983","volume":"14","author":"GL Semenza","year":"2000","unstructured":"Semenza, G. L. HIF-1 and human disease: one highly involved factor. Genes Dev. 14, 1983\u20131991 (2000).","journal-title":"Genes Dev."},{"key":"BF35107085_CR8","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.1074\/jbc.274.10.6519","volume":"274","author":"PJ Kallio","year":"1999","unstructured":"Kallio, P. J., Wilson, W. J., O'Brien, S., Makino, Y. & Poellinger, L. Regulation of the hypoxia-inducible transcription factor 1\u03b1 by the ubiquitin-proteasome pathway. J. Biol. Chem. 274, 6519\u20136525 (1999).","journal-title":"J. Biol. Chem."},{"key":"BF35107085_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"PH Maxwell","year":"1999","unstructured":"Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271\u2013275 (1999).","journal-title":"Nature"},{"key":"BF35107085_CR10","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1182\/blood.V92.7.2260","volume":"92","author":"MS Wiesener","year":"1998","unstructured":"Wiesener, M. S. et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1\u03b1. Blood 92, 2260\u20132268 (1998).","journal-title":"Blood"},{"key":"BF35107085_CR11","doi-asserted-by":"publisher","first-page":"21262","DOI":"10.1074\/jbc.271.35.21262","volume":"271","author":"H Li","year":"1996","unstructured":"Li, H., Ko, H. P. & Whitlock, J. P. Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1\u03b1. J. Biol. Chem. 271, 21262\u201321267 (1996).","journal-title":"J. Biol. Chem."},{"key":"BF35107085_CR12","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"JA Forsythe","year":"1996","unstructured":"Forsythe, J. A. et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16, 4604\u20134613 (1996).","journal-title":"Mol. Cell Biol."},{"key":"BF35107085_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/978-1-4684-6840-3_6","volume-title":"Inducible Gene Expression","author":"L Poellinger","year":"1995","unstructured":"Poellinger, L. in Inducible Gene Expression (ed. Baeuerle, P. A.) 177\u2013205 (Birkh\u00e4user, Boston, 1995)."},{"key":"BF35107085_CR14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1023\/A:1023291921695","volume":"18","author":"A Thakur","year":"1998","unstructured":"Thakur, A., Willcox, M. D. & Stapleton, F. The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: homeostatic mechanisms. J. Clin. Immunol. 18, 61\u201370 (1998).","journal-title":"J. Clin. Immunol."},{"key":"BF35107085_CR15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1076\/ceyr.18.3.186.5367","volume":"18","author":"RA Sack","year":"1999","unstructured":"Sack, R. A., Beaton, A. R. & Sathe, S. Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. Curr. Eye Res. 18, 186\u2013193 (1999).","journal-title":"Curr. Eye Res."},{"key":"BF35107085_CR16","doi-asserted-by":"publisher","first-page":"5221","DOI":"10.1128\/MCB.16.10.5221","volume":"16","author":"K Gradin","year":"1996","unstructured":"Gradin, K. et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol. Cell. Biol. 16, 5221\u20135231 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BF35107085_CR17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gad.14.1.34","volume":"14","author":"R Ravi","year":"2000","unstructured":"Ravi, R. et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1\u03b1. Genes Dev. 14, 34\u201344 (2000).","journal-title":"Genes Dev."},{"key":"BF35107085_CR18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1101\/gad.14.4.391","volume":"14","author":"W Zundel","year":"2000","unstructured":"Zundel, W. et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14, 391\u2013396 (2000).","journal-title":"Genes Dev."},{"key":"BF35107085_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/71527","volume":"6","author":"J Li","year":"2000","unstructured":"Li, J. et al. PR 39, a peptide regulator of angiogenesis. Nature Med. 6, 49\u201355 (2000).","journal-title":"Nature Med."},{"key":"BF35107085_CR20","first-page":"58","volume":"8","author":"JD Norton","year":"1998","unstructured":"Norton, J. D., Deed, R. W., Craggs, G. & Sablitzky, F. Id helix-loop-helix protein in cell growth and differentiation. Trends Cell Biol. 8, 58\u201365 (1998).","journal-title":"Trends Cell Biol."},{"key":"BF35107085_CR21","first-page":"114","volume":"3","author":"SR Eddy","year":"1995","unstructured":"Eddy, S. R. Multiple alignment using hidden Markov models. Ismb 3, 114\u2013120 (1995).","journal-title":"Ismb"},{"key":"BF35107085_CR22","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1093\/emboj\/19.16.4298","volume":"19","author":"K Tanimoto","year":"2000","unstructured":"Tanimoto, K., Makino, Y., Pereira, T. & Poellinger, L. Mechanism of regulation of the hypoxia-inducible factor-1\u03b1 by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19, 4298\u20134309 (2000).","journal-title":"EMBO J."},{"key":"BF35107085_CR23","doi-asserted-by":"publisher","first-page":"12208","DOI":"10.1073\/pnas.95.21.12208","volume":"95","author":"G Bertilsson","year":"1998","unstructured":"Bertilsson, G. et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl Acad. Sci. USA 95, 12208\u201312213 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF35107085_CR24","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1073\/pnas.96.10.5728","volume":"96","author":"R Cao","year":"1999","unstructured":"Cao, R. et al. Suppression of aniogenesis by a novel inhibitor, K1-5, generated by plasmin-mediated proteolysis. Proc. Natl Acad. Sci. USA 96, 5728\u20135733 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/35107085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35107085","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/35107085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T22:17:05Z","timestamp":1684275425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/35107085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":24,"journal-issue":{"issue":"6863","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["BF35107085"],"URL":"https:\/\/doi.org\/10.1038\/35107085","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1002978.30611","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}