{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:42:06Z","timestamp":1779345726506,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6374","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1992,5]]},"DOI":"10.1038\/357169a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:29:14Z","timestamp":1055460554000},"page":"169-172","source":"Crossref","is-referenced-by-count":277,"title":["Protein-DNA interactions at a yeast replication origin"],"prefix":"10.1038","volume":"357","author":[{"given":"John F. X.","family":"Diffley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie H.","family":"Cocker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF357169a0_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/0168-9525(90)90305-P","volume":"6","author":"JFX Diffley","year":"1990","unstructured":"Diffley, J. F. X. & Stillman, B. Trends Genet. 6, 426\u2013432 (1990).","journal-title":"Trends Genet."},{"key":"BF357169a0_CR2","unstructured":"Campbell, J. L. & Newlon, C. S. in The Molecular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis and Energetics (Cold Spring Harbor Laboratory Press, New York, in the press)."},{"key":"BF357169a0_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1146\/annurev.cb.07.110191.002111","volume":"7","author":"WL Fangman","year":"1991","unstructured":"Fangman, W. L. & Brewer, B. J. A. Rev. Cell Biol. 7, 375\u2013402 (1991).","journal-title":"A. Rev. Cell Biol."},{"key":"BF357169a0_CR4","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1128\/MCB.4.11.2455","volume":"4","author":"SE Celniker","year":"1984","unstructured":"Celniker, S. E., Sweder, K., Srienc, F., Bailey, J. E. & Campbell, J. L. Molec. cell. Biol. 4, 2455\u20132466 (1984).","journal-title":"Molec. cell. Biol."},{"key":"BF357169a0_CR5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1126\/science.1536007","volume":"255","author":"Y Marahrens","year":"1992","unstructured":"Marahrens, Y. & Stillman, B. Science 255, 817\u2013823 (1992).","journal-title":"Science"},{"key":"BF357169a0_CR6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1128\/MCB.8.1.210","volume":"8","author":"AR Buchman","year":"1988","unstructured":"Buchman, A. R., Kimmerly, W. J., Rine, J. & Kornberg, R. D. Molec. cell. Biol. 8, 210\u2013225 (1988).","journal-title":"Molec. cell. Biol."},{"key":"BF357169a0_CR7","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1073\/pnas.85.7.2120","volume":"85","author":"JFX Diffley","year":"1988","unstructured":"Diffley, J. F. X. & Stillman, B. Proc. natn. Acad. Sci. U.S.A. 85, 2120\u20132124 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF357169a0_CR8","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/j.1460-2075.1987.tb04776.x","volume":"6","author":"D Shore","year":"1987","unstructured":"Shore, D., Stillman, D. J., Brand, A. H. & Nasmyth, K. A. EMBO J. 6, 461\u2013467 (1987).","journal-title":"EMBO J."},{"key":"BF357169a0_CR9","doi-asserted-by":"crossref","first-page":"17270","DOI":"10.1016\/S0021-9258(19)77831-4","volume":"263","author":"KS Sweder","year":"1988","unstructured":"Sweder, K. S., Rhode, P. R. & Campbell, J. L. J. biol. Chem. 263, 17270\u201317277 (1988).","journal-title":"J. biol. Chem."},{"key":"BF357169a0_CR10","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/0092-8674(91)90319-T","volume":"64","author":"JF-X Hofmann","year":"1991","unstructured":"Hofmann, J. F.-X. & Gasser, S. M. Cell 64, 951\u2013960 (1991).","journal-title":"Cell"},{"key":"BF357169a0_CR11","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/j.1460-2075.1991.tb08032.x","volume":"10","author":"AM Schmidt","year":"1991","unstructured":"Schmidt, A. M., Herterich, S. U. & Krauss, G. EMBO J. 10, 981\u2013985 (1991).","journal-title":"EMBO J."},{"key":"BF357169a0_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0378-1119(90)90415-N","volume":"95","author":"K Kuno","year":"1990","unstructured":"Kuno, K., Murakami, S. & Kuno, S. Gene 95, 73\u201377 (1990).","journal-title":"Gene"},{"key":"BF357169a0_CR13","doi-asserted-by":"publisher","first-page":"7864","DOI":"10.1073\/pnas.88.17.7864","volume":"88","author":"JFX Diffley","year":"1991","unstructured":"Diffley, J. F. X. & Stillman, B. Proc. natn. Acad. Sci. U.S.A. 88, 7864\u20137868 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF357169a0_CR14","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/357128a0","volume":"357","author":"SP Bell","year":"1992","unstructured":"Bell, S. P. & Stillman, B. Nature 357, 128\u2013134 (1992).","journal-title":"Nature"},{"key":"BF357169a0_CR15","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/0076-6879(91)94042-B","volume":"194","author":"JM Huibregtse","year":"1991","unstructured":"Huibregtse, J. M. & Engelke, D. R. Meth. Enzym. 194, 550\u2013562 (1991).","journal-title":"Meth. Enzym."},{"key":"BF357169a0_CR16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/0022-2836(84)90046-9","volume":"177","author":"F Thoma","year":"1984","unstructured":"Thoma, F., Bergman, L. W. & Simpson, R. T. J. molec. Biol. 177, 715\u2013733 (1984).","journal-title":"J. molec. Biol."},{"key":"BF357169a0_CR17","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1128\/MCB.5.11.3124","volume":"5","author":"CM Long","year":"1985","unstructured":"Long, C. M. Brajkovich, C. M. & Scott, J. F. Molec. cell. Biol. 5, 3124\u20133130 (1985).","journal-title":"Molec. cell. Biol."},{"key":"BF357169a0_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0022-2836(86)90291-3","volume":"190","author":"F Thoma","year":"1986","unstructured":"Thoma, F. J. molec. Biol. 190, 177\u2013190 (1986).","journal-title":"J. molec. Biol."},{"key":"BF357169a0_CR19","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1021\/bi00411a011","volume":"27","author":"D Lohr","year":"1988","unstructured":"Lohr, D. & Torchia, T. Biochemistry 27, 3961\u20133965 (1988).","journal-title":"Biochemistry"},{"key":"BF357169a0_CR20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/343387a0","volume":"343","author":"RT Simpson","year":"1990","unstructured":"Simpson, R. T. Nature 343, 387\u2013389 (1990).","journal-title":"Nature"},{"key":"BF357169a0_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-3490-6","volume-title":"Chromatin","author":"KE van Holde","year":"1989","unstructured":"van Holde, K. E. Chromatin (Springer, New York, 1989)."},{"key":"BF357169a0_CR22","doi-asserted-by":"publisher","first-page":"9097","DOI":"10.1021\/bi00491a001","volume":"29","author":"DS Sigman","year":"1990","unstructured":"Sigman, D. S. Biochemistry 29, 9097\u20139105 (1990).","journal-title":"Biochemistry"},{"key":"BF357169a0_CR23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0092-8674(85)90021-2","volume":"43","author":"M Sawodogo","year":"1985","unstructured":"Sawodogo, M. & Roeder, R. G. Cell 43, 165\u2013175 (1985).","journal-title":"Cell"},{"key":"BF357169a0_CR24","doi-asserted-by":"publisher","first-page":"7509","DOI":"10.1073\/pnas.88.17.7509","volume":"88","author":"S Buratowski","year":"1991","unstructured":"Buratowski, S., Sopta, M., Greenblatt, J. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 88, 7509\u20137513 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF357169a0_CR25","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1126\/science.1310361","volume":"255","author":"W Wang","year":"1992","unstructured":"Wang, W., Carey, M. & Gralla, J. D. Science 255, 450\u2013453 (1992).","journal-title":"Science"},{"key":"BF357169a0_CR26","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0092-8674(88)80031-X","volume":"52","author":"M Schnos","year":"1988","unstructured":"Schnos, M., Zahn, K., Inman, R. B. & Blattner, F. R. Cell 52, 385\u2013395 (1988).","journal-title":"Cell"},{"key":"BF357169a0_CR27","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/0092-8674(88)90412-6","volume":"52","author":"D Bramhill","year":"1988","unstructured":"Bramhill, D. & Kornberg, A. Cell 52, 743\u2013755 (1988).","journal-title":"Cell"},{"key":"BF357169a0_CR28","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1002\/j.1460-2075.1988.tb03182.x","volume":"7","author":"JA Borowiec","year":"1988","unstructured":"Borowiec, J. A. & Hurwitz, J. EMBO J. 7, 3149\u20133158 (1988).","journal-title":"EMBO J."},{"key":"BF357169a0_CR29","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/0092-8674(84)90374-X","volume":"37","author":"T Kataoka","year":"1984","unstructured":"Kataoka, T. et al. Cell 37, 437\u2013445 (1984).","journal-title":"Cell"},{"key":"BF357169a0_CR30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/350247a0","volume":"350","author":"NF Lowndes","year":"1991","unstructured":"Lowndes, N. F., Johnson, A. L. & Johnston, L. H. Nature 350, 247\u2013250 (1991).","journal-title":"Nature"},{"key":"BF357169a0_CR31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/282039a0","volume":"282","author":"DT Stinchcomb","year":"1979","unstructured":"Stinchcomb, D. T., Struhl, K. & Davis, R. W. Nature 282, 39\u201343 (1979).","journal-title":"Nature"},{"key":"BF357169a0_CR32","volume-title":"Methods in Yeast Genetics","author":"MD Rose","year":"1989","unstructured":"Rose, M. D., Winston, F. & Hieter, P. Methods in Yeast Genetics (Cold Spring Harbor Laboratory Press, New York, 1989)."},{"key":"BF357169a0_CR33","volume-title":"Molecular Cloning: a Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning: a Laboratory Manual (Cold Spring Harbor Laboratory Press, New York, 1989)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/357169a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/357169a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/357169a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:08:00Z","timestamp":1684289280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/357169a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":33,"journal-issue":{"issue":"6374","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["BF357169a0"],"URL":"https:\/\/doi.org\/10.1038\/357169a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}