{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:52:59Z","timestamp":1779342779333,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6381","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1992,7]]},"DOI":"10.1038\/358070a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T00:00:04Z","timestamp":1060646404000},"page":"70-73","source":"Crossref","is-referenced-by-count":477,"title":["Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase"],"prefix":"10.1038","volume":"358","author":[{"given":"Calvin J.","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongkyeong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Michael","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Blenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald R.","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF358070a0_CR1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1126\/science.1715094","volume":"253","author":"J Heitman","year":"1991","unstructured":"Heitman, J., Movva, N. R. & Hall, M. N. Science 253, 905\u2013909 (1991).","journal-title":"Science"},{"key":"BF358070a0_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0167-5699(05)80040-4","volume":"5","author":"RE Morris","year":"1991","unstructured":"Morris, R. E. Immun. Today 5, 137\u2013140 (1991).","journal-title":"Immun. Today"},{"key":"BF358070a0_CR3","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.144.4.1418","volume":"144","author":"FJ Dumont","year":"1990","unstructured":"Dumont F. J. et al. J. Immun. 144, 1418\u20131424 (1990).","journal-title":"J. Immun."},{"key":"BF358070a0_CR4","doi-asserted-by":"publisher","first-page":"9231","DOI":"10.1073\/pnas.87.23.9231","volume":"87","author":"BE Bierer","year":"1990","unstructured":"Bierer, B. E. et al. Proc. natn. Acad. Sci. U.S.A. 87, 9231\u20139235 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF358070a0_CR5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4049\/jimmunol.144.1.251","volume":"144","author":"FJ Dumont","year":"1990","unstructured":"Dumont, F. J., Staruch, M. J., Koprak, S. L., Melino, M. R. & Sigal, N. H. J. Immun 144, 251\u2013258 (1990).","journal-title":"J. Immun"},{"key":"BF358070a0_CR6","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1126\/science.1702904","volume":"251","author":"SL Schreiber","year":"1991","unstructured":"Schreiber, S. L. Science 251, 283\u2013287 (1991).","journal-title":"Science"},{"key":"BF358070a0_CR7","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1016\/S0021-9258(18)38072-4","volume":"266","author":"RL Erikson","year":"1992","unstructured":"Erikson, R. L. J. biol. Chem. 266, 6007\u20136010 (1992).","journal-title":"J. biol. Chem."},{"key":"BF358070a0_CR8","first-page":"1","volume":"3","author":"J Blenis","year":"1991","unstructured":"Blenis, J. Cancer Cells 3, 1\u20134 (1991).","journal-title":"Cancer Cells"},{"key":"BF358070a0_CR9","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/341755a0","volume":"341","author":"JJ Siekierka","year":"1989","unstructured":"Siekierka, J. J., Hung, S. H. Y., Poe, M., Lin, C. S. & Sigal, N. H. Nature 341, 755\u2013757 (1989).","journal-title":"Nature"},{"key":"BF358070a0_CR10","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/341758a0","volume":"341","author":"MW Harding","year":"1989","unstructured":"Harding, M. W., Galat, A., Uehling, D. E. & Schreiber, S. L. Nature 341, 758\u2013760 (1989).","journal-title":"Nature"},{"key":"BF358070a0_CR11","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/346671a0","volume":"346","author":"RF Standaert","year":"1990","unstructured":"Standaert, R. F., Galat, A., Verdine, G. L. & Schreiber, S. L. Nature 346, 671\u2013674 (1990).","journal-title":"Nature"},{"key":"BF358070a0_CR12","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1002\/j.1460-2075.1991.tb04881.x","volume":"10","author":"T Miyazaki","year":"1991","unstructured":"Miyazaki, T., Maruyama, M., Yamada, G., Hatakeyama, M. & Taniguchi, T. EMBO J. 10, 3191\u20133197 (1991).","journal-title":"EMBO J."},{"key":"BF358070a0_CR13","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1128\/MCB.11.4.1868","volume":"11","author":"J Chung","year":"1991","unstructured":"Chung, J. Chen, R.-H. & Blenis, J. Molec. cell Biol. 11, 1868\u20131874 (1991).","journal-title":"Molec. cell Biol."},{"key":"BF358070a0_CR14","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1128\/MCB.11.4.1861","volume":"11","author":"R-H Chen","year":"1991","unstructured":"Chen, R.-H., Chung, J. & Blenis, J. Molec. cell. Biol. 11, 1861\u20131867 (1991).","journal-title":"Molec. cell. Biol."},{"key":"BF358070a0_CR15","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1126\/science.6427923","volume":"224","author":"DA Cantrell","year":"1984","unstructured":"Cantrell, D. A. & Smith, K. A. Science 224, 1312\u20131316 (1984).","journal-title":"Science"},{"key":"BF358070a0_CR16","doi-asserted-by":"publisher","first-page":"5968","DOI":"10.1073\/pnas.83.16.5968","volume":"83","author":"SL Pelech","year":"1986","unstructured":"Pelech, S. L., Olwin, B. B. & Krebs, E. G. Proc. natn. Acad. Sci. U.S.A. 83, 5968\u20135972 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF358070a0_CR17","doi-asserted-by":"publisher","first-page":"7944","DOI":"10.1073\/pnas.87.20.7944","volume":"87","author":"DJ Price","year":"1990","unstructured":"Price, D. J., Gunsalus, J. R. & Avruch, J. Proc. natn. Acad. Sci. U.S.A. 87, 7944\u20137948 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF358070a0_CR18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/0167-5699(92)90111-J","volume":"13","author":"SL Schreiber","year":"1992","unstructured":"Schreiber, S. L. & Crabtree, G. R. Immun. Today 13, 136\u2013142 (1992).","journal-title":"Immun. Today"},{"key":"BF358070a0_CR19","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","volume":"66","author":"J Liu","year":"1991","unstructured":"Liu, J. et al. Cell 66, 807\u2013815 (1991).","journal-title":"Cell"},{"key":"BF358070a0_CR20","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/0092-8674(91)90123-G","volume":"66","author":"J Friedman","year":"1991","unstructured":"Friedman, J. & Weissman, I. Cell 66, 799\u2013806 (1991).","journal-title":"Cell"},{"key":"BF358070a0_CR21","doi-asserted-by":"publisher","first-page":"8550","DOI":"10.1073\/pnas.87.21.8550","volume":"87","author":"P Banerjee","year":"1990","unstructured":"Banerjee, P. et al. Proc. natn. Acad. Sci. U.S.A. 87, 8550\u20138554 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF358070a0_CR22","doi-asserted-by":"publisher","first-page":"7365","DOI":"10.1073\/pnas.87.19.7365","volume":"87","author":"SC Kozma","year":"1990","unstructured":"Kozma, S. C. et al. Proc. natn. Acad. Sci. U.S.A. 87, 7365\u20137369 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF358070a0_CR23","unstructured":"Chung, J., Kuo, C. J., Crabtree, G. R. & Blenis, J. Cell (in the press)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/358070a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/358070a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/358070a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:12:07Z","timestamp":1684289527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/358070a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":23,"journal-issue":{"issue":"6381","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["BF358070a0"],"URL":"https:\/\/doi.org\/10.1038\/358070a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}