{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:31:48Z","timestamp":1769146308223,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6393","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1992,9]]},"DOI":"10.1038\/359288a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:48:09Z","timestamp":1055461689000},"page":"288-294","source":"Crossref","is-referenced-by-count":973,"title":["Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis"],"prefix":"10.1038","volume":"359","author":[{"given":"Eva Y.-H. P.","family":"Lee","sequence":"first","affiliation":[]},{"given":"Chi-Yao","family":"Chang","sequence":"additional","affiliation":[]},{"given":"Nanpin","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Yi-Chun J.","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Chen-Ching","family":"Lai","sequence":"additional","affiliation":[]},{"given":"Karl","family":"Herrup","sequence":"additional","affiliation":[]},{"given":"Wen-Hwa","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Allan","family":"Bradley","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF359288a0_CR1","first-page":"15","volume":"25","author":"AG Knudson","year":"1989","unstructured":"Knudson, A. G. Birth Defects 25, 15\u201327 (1989).","journal-title":"Birth Defects"},{"key":"BF359288a0_CR2","first-page":"159","volume-title":"Tumour Suppressor Genes and Oncogenes","author":"W-H Lee","year":"1990","unstructured":"Lee, W.-H. in Tumour Suppressor Genes and Oncogenes (eds Knudson, A. G., Stanbridge, E. J., Sugimura, T., Terada, M. & Watanabe, S.) 159\u2013170 (Taylor and Francis, London and Bristol, 1990)."},{"key":"BF359288a0_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00295569","volume":"52","author":"F Vogel","year":"1979","unstructured":"Vogel, F. Hum. Genet. 52, 1\u201354 (1979).","journal-title":"Hum. Genet."},{"key":"BF359288a0_CR4","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1073\/pnas.68.4.820","volume":"68","author":"AG Knudson","year":"1971","unstructured":"Knudson, A. G. Proc. natn. Acad. Sci. U.S.A. 68, 820\u2013823 (1971).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359288a0_CR5","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/305779a0","volume":"305","author":"WK Cavenee","year":"1983","unstructured":"Cavenee, W. K. et al. Nature 305, 779\u2013784 (1983).","journal-title":"Nature"},{"key":"BF359288a0_CR6","doi-asserted-by":"publisher","first-page":"7391","DOI":"10.1073\/pnas.83.19.7391","volume":"83","author":"TP Dryja","year":"1986","unstructured":"Dryja, T. P., Rapaport, J. M., Joyce, J. M. & Petersen, R. A. Proc. natn. Acad. Sci. U.S.A. 83, 7391\u20137394 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359288a0_CR7","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/323643a0","volume":"323","author":"SH Friend","year":"1986","unstructured":"Friend, S. H. et al. Nature 323, 643\u2013646 (1986).","journal-title":"Nature"},{"key":"BF359288a0_CR8","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1126\/science.2885916","volume":"236","author":"YKT Fung","year":"1987","unstructured":"Fung, Y. K. T. et al. Science 236, 1657\u20131661 (1987).","journal-title":"Science"},{"key":"BF359288a0_CR9","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1126\/science.3823889","volume":"235","author":"W-H Lee","year":"1987","unstructured":"Lee, W.-H. et al. Science 235, 1394\u20131399 (1987).","journal-title":"Science"},{"key":"BF359288a0_CR10","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/S0161-6420(84)34127-6","volume":"91","author":"DH Abramson","year":"1984","unstructured":"Abramson, D. H., Ellsworth, R. M., Kitchin, D. & Tung, G. Ophthalmology 91, 1351\u20131355 (1984).","journal-title":"Ophthalmology"},{"key":"BF359288a0_CR11","doi-asserted-by":"publisher","first-page":"9059","DOI":"10.1073\/pnas.84.24.9059","volume":"84","author":"SH Friend","year":"1987","unstructured":"Friend, S. H. et al. Proc. natn. Acad. Sci. USA. 84, 9059\u20139063 (1987).","journal-title":"Proc. natn. Acad. Sci. USA."},{"key":"BF359288a0_CR12","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/329642a0","volume":"329","author":"W-H Lee","year":"1987","unstructured":"Lee, W.-H. et al. Nature 329, 642\u2013645 (1987).","journal-title":"Nature"},{"key":"BF359288a0_CR13","first-page":"221","volume-title":"Molecular Biology of the Retina: Basic and Clinically Relevant Studies","author":"EY-HP Lee","year":"1991","unstructured":"Lee, E. Y.-H. P., Huang, S., Shew, J.-Y., Donoso, L. A. & Lee, W.-H. in Molecular Biology of the Retina: Basic and Clinically Relevant Studies (eds Faber, D. B. & Chader, G. J.) 221\u2013240 (Wiley-Liss, New York, 1991)."},{"key":"BF359288a0_CR14","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.2300823","volume":"247","author":"R Bookstein","year":"1990","unstructured":"Bookstein, R., Shew, J.-Y., Chen, P.-L., Scully, P. & Lee, W.-H. Science 247, 712\u2013715 (1990).","journal-title":"Science"},{"key":"BF359288a0_CR15","first-page":"1968","volume":"52","author":"DW Goodrich","year":"1992","unstructured":"Goodrich, D. W., Chen, Y.-M., Scully, P. & Lee, W.-H. Cancer Res. 52, 1968\u20131973 (1992).","journal-title":"Cancer Res."},{"key":"BF359288a0_CR16","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1126\/science.3201247","volume":"242","author":"H-JS Huang","year":"1988","unstructured":"Huang, H.-J. S. et al. Science 242, 1563\u20131566 (1988).","journal-title":"Science"},{"key":"BF359288a0_CR17","first-page":"247","volume":"1","author":"J Sumegi","year":"1990","unstructured":"Sumegi, J., Uzvolgyi, E. & Klein, G. Cell Growth Differ. 1, 247\u2013250 (1990).","journal-title":"Cell Growth Differ."},{"key":"BF359288a0_CR18","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1073\/pnas.88.12.5257","volume":"88","author":"R Takahashi","year":"1991","unstructured":"Takahashi, R. et al. Proc. natn. Acad Sci. U.S.A. 88, 5257\u20135261 (1991).","journal-title":"Proc. natn. Acad Sci. U.S.A."},{"key":"BF359288a0_CR19","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1002\/j.1460-2075.1991.tb05006.x","volume":"10","author":"JA Lees","year":"1991","unstructured":"Lees, J. A., Buchkovich, K. J., Marshak, D. R., Anderson, C. W. & Harlow, E. EMBO J. 10, 4279\u20134289 (1991).","journal-title":"EMBO J."},{"key":"BF359288a0_CR20","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/j.1460-2075.1991.tb08018.x","volume":"10","author":"BT-Y Lin","year":"1991","unstructured":"Lin, B. T.-Y., Gruenwald, S., Morla, A. O., Lee, W.-H. & Wang, J. Y. J. EMBO J. 10, 857\u2013864 (1991).","journal-title":"EMBO J."},{"key":"BF359288a0_CR21","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/0092-8674(89)90508-4","volume":"58","author":"K Buchkovich","year":"1989","unstructured":"Buchkovich, K., Duffy, L. A. & Harlow, E. Cell 58, 1097\u20131105 (1989).","journal-title":"Cell"},{"key":"BF359288a0_CR22","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/0092-8674(89)90517-5","volume":"58","author":"P-L Chen","year":"1989","unstructured":"Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y.-J. & Lee, W.-H. Cell 58, 1193\u20131198 (1989).","journal-title":"Cell"},{"key":"BF359288a0_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/0092-8674(90)90590-B","volume":"60","author":"JW Ludlow","year":"1990","unstructured":"Ludlow, J. W., Shon, J., Pipas, J. M., Livingston, D. M. & DeCaprio, J. A. Cell 60, 387\u2013396 (1990).","journal-title":"Cell"},{"key":"BF359288a0_CR24","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1126\/science.2588006","volume":"246","author":"K Mihara","year":"1989","unstructured":"Mihara, K. et al. Science 246, 1300\u20131303 (1989).","journal-title":"Science"},{"key":"BF359288a0_CR25","first-page":"807","volume":"4","author":"H-J Xu","year":"1989","unstructured":"Xu, H.-J., Hu, S.-X., Hashimoto, T., Takahashi, R. & Benedict, W. F. Oncogene 4, 807\u2013812 (1989).","journal-title":"Oncogene"},{"key":"BF359288a0_CR26","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0092-8674(91)90181-W","volume":"67","author":"DW Goodrich","year":"1991","unstructured":"Goodrich, D. W., Wang, N. P., Qian, Y., Lee, E. Y.-H. P. & Lee, W.-H. Cell 67, 293\u2013302 (1991).","journal-title":"Cell"},{"key":"BF359288a0_CR27","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0092-8674(88)90559-4","volume":"54","author":"JA DeCaprio","year":"1988","unstructured":"DeCaprio, J. A. et al. Cell 54, 275\u2013283 (1988).","journal-title":"Cell"},{"key":"BF359288a0_CR28","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1126\/science.2537532","volume":"243","author":"N Dyson","year":"1989","unstructured":"Dyson, N., Howley, P. M., Munger, K. & Harlow, E. Science 243, 934\u2013937 (1989).","journal-title":"Science"},{"key":"BF359288a0_CR29","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/334124a0","volume":"334","author":"P Whyte","year":"1988","unstructured":"Whyte, P. et al. Nature 334, 124\u2013129 (1988).","journal-title":"Nature"},{"key":"BF359288a0_CR30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/352541a0","volume":"352","author":"AK Rustgi","year":"1991","unstructured":"Rustgi, A. K., Dyson, N. & Bernards, R. Nature 352, 541\u2013544 (1991).","journal-title":"Nature"},{"key":"BF359288a0_CR31","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/0092-8674(91)90558-G","volume":"65","author":"S Bagchi","year":"1991","unstructured":"Bagchi, S., Weinmann, R. & Raychaudhuri, P. Cell 65, 1063\u20131072 (1991).","journal-title":"Cell"},{"key":"BF359288a0_CR32","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/351494a0","volume":"351","author":"LR Bandara","year":"1991","unstructured":"Bandara, L. R. & La Thangue, N. B. Nature 351, 494\u2013497 (1991).","journal-title":"Nature"},{"key":"BF359288a0_CR33","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/0092-8674(91)90557-F","volume":"65","author":"SP Chellappan","year":"1991","unstructured":"Chellappan, S. P., Hiebert, S., Mudryji, M., Horowitz, J. M. & Nevins, J. R. Cell 65, 1053\u20131061 (1991).","journal-title":"Cell"},{"key":"BF359288a0_CR34","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/0092-8674(91)90559-H","volume":"65","author":"T Chittenden","year":"1991","unstructured":"Chittenden, T., Livingston, D. M. & W. G. Kaelin, J. Cell 65, 1073\u20131082 (1991).","journal-title":"Cell"},{"key":"BF359288a0_CR35","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/j.1460-2075.1990.tb08221.x","volume":"9","author":"Q Hu","year":"1990","unstructured":"Hu, Q., Dyson, N. & Harlow, E. EMBO J. 9, 1147\u20131155 (1990).","journal-title":"EMBO J."},{"key":"BF359288a0_CR36","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/j.1460-2075.1990.tb08306.x","volume":"9","author":"S Huang","year":"1990","unstructured":"Huang, S., Wang, N.-P., Tseng, B. Y., Lee, W.-H. & Lee, E. Y.-H. P. EMBO J. 9, 1815\u20131822 (1990).","journal-title":"EMBO J."},{"key":"BF359288a0_CR37","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1128\/MCB.10.7.3761","volume":"10","author":"WG Kaelin Jr","year":"1990","unstructured":"Kaelin, W. G. Jr, Ewen, M. E. & Livingston, D. M. Molec. cell. Biol. 10, 3761\u20133769 (1990).","journal-title":"Molec. cell. Biol."},{"key":"BF359288a0_CR38","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1073\/pnas.87.1.6","volume":"87","author":"J-Y Shew","year":"1990","unstructured":"Shew, J.-Y. et al. Proc. natn. Acad. Sci. U.S.A. 87, 6\u201310 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359288a0_CR39","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/336348a0","volume":"336","author":"SL Mansour","year":"1988","unstructured":"Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348\u2013352 (1988).","journal-title":"Nature"},{"key":"BF359288a0_CR40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0378-1119(87)90214-9","volume":"60","author":"CN Adra","year":"1987","unstructured":"Adra, C. N., Boer, P. H. & McBurney, M. W. Gene 60, 65\u201374 (1987).","journal-title":"Gene"},{"key":"BF359288a0_CR41","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0092-8674(87)90646-5","volume":"51","author":"KR Thomas","year":"1987","unstructured":"Thomas, K. R. & Capecchi, M. R. Cell 51, 503\u2013512 (1987).","journal-title":"Cell"},{"key":"BF359288a0_CR42","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/0092-8674(90)90385-R","volume":"62","author":"AP McMahon","year":"1990","unstructured":"McMahon, A. P. & Bradley, A. Cell 62, 1073\u20131085 (1990).","journal-title":"Cell"},{"key":"BF359288a0_CR43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/359295a0","volume":"359","author":"T Jacks","year":"1992","unstructured":"Jacks, T. et al. Nature 359, 295\u2013300 (1992).","journal-title":"Nature"},{"key":"BF359288a0_CR44","doi-asserted-by":"publisher","first-page":"6474","DOI":"10.1073\/pnas.86.17.6474","volume":"86","author":"R Bernards","year":"1989","unstructured":"Bernards, R. et al. Proc. natn. Acad. Sci. U.S.A. 86, 6474\u20136478 (1989).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359288a0_CR45","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/359328a0","volume":"359","author":"AR Clarke","year":"1992","unstructured":"Clarke, A. R. et al. Nature 359, 328\u2013330 (1992).","journal-title":"Nature"},{"key":"BF359288a0_CR46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1365-2141.1970.tb01443.x","volume":"18","author":"MAS Moore","year":"1970","unstructured":"Moore, M. A. S. & Metcalf, D. Br. J. Haemat 18, 279\u2013296 (1970).","journal-title":"Br. J. Haemat"},{"key":"BF359288a0_CR47","unstructured":"Turner, D. L. & Cepko, C. L. 328, 131\u2013136 (1988)."},{"key":"BF359288a0_CR48","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","volume":"64","author":"P Soriano","year":"1991","unstructured":"Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Cell 64, 693\u2013702 (1991).","journal-title":"Cell"},{"key":"BF359288a0_CR49","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, M. M. Analyt. Biochem. 72, 248\u2013254 (1976).","journal-title":"Analyt. Biochem."},{"key":"BF359288a0_CR50","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/350160a0","volume":"350","author":"S Huang","year":"1991","unstructured":"Huang, S., Lee, W.-H. & Lee, E. Y.-H. P. Nature 350, 160\u2013162 (1991).","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/359288a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/359288a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/359288a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:17:51Z","timestamp":1684289871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/359288a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":50,"journal-issue":{"issue":"6393","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["BF359288a0"],"URL":"https:\/\/doi.org\/10.1038\/359288a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}