{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:11:15Z","timestamp":1779912675548,"version":"3.53.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6393","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1992,9]]},"DOI":"10.1038\/359325a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:48:09Z","timestamp":1055461689000},"page":"325-327","source":"Crossref","is-referenced-by-count":1400,"title":["Isolation and quantification of soluble Alzheimer's \u03b2-peptide from biological fluids"],"prefix":"10.1038","volume":"359","author":[{"given":"Peter","family":"Seubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Vigo-Pelfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Esch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Dovey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanto","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schiossmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Whaley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Swindlehurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McCormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wolfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Selkoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Lieberburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Schenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF359325a0_CR1","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","volume":"120","author":"GG Glenner","year":"1984","unstructured":"Glenner, G. G. & Wong, C. W. Biochem. biophys. Res. Commun. 120, 885\u2013890 (1984).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF359325a0_CR2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/325733a0","volume":"325","author":"J Kang","year":"1987","unstructured":"Kang, J. et al. Nature 325, 733\u2013736 (1987).","journal-title":"Nature"},{"key":"BF359325a0_CR3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/331525a0","volume":"331","author":"P Ponte","year":"1988","unstructured":"Ponte, P. et al. Nature 331, 525\u2013527 (1988).","journal-title":"Nature"},{"key":"BF359325a0_CR4","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/331528a0","volume":"331","author":"RE Tanzi","year":"1988","unstructured":"Tanzi, R. E. et al. Nature 331, 528\u2013530 (1988).","journal-title":"Nature"},{"key":"BF359325a0_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/331530a0","volume":"331","author":"N Kitaguchi","year":"1988","unstructured":"Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S. & Ito, H. Nature 331, 530\u2013532 (1988).","journal-title":"Nature"},{"key":"BF359325a0_CR6","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/341226a0","volume":"341","author":"CL Joachim","year":"1989","unstructured":"Joachim, C. L., Mori, H. & Selkoe, D. J. Nature 341, 226\u2013230 (1989).","journal-title":"Nature"},{"key":"BF359325a0_CR7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1126\/science.1738846","volume":"255","author":"S Estus","year":"1992","unstructured":"Estus, S. et al. Science 255, 726\u2013728 (1992).","journal-title":"Science"},{"key":"BF359325a0_CR8","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1126\/science.1738847","volume":"255","author":"T Golde","year":"1992","unstructured":"Golde, T. et al. Science 255, 728\u2013730 (1992).","journal-title":"Science"},{"key":"BF359325a0_CR9","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1073\/pnas.89.4.1345","volume":"89","author":"A Tamaoka","year":"1992","unstructured":"Tamaoka, A. et al. Proc. natn. Acad. Sci. U.S.A. 89, 1345\u20131347 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359325a0_CR10","doi-asserted-by":"publisher","first-page":"8910","DOI":"10.1073\/pnas.88.20.8910","volume":"88","author":"C Nordstedt","year":"1991","unstructured":"Nordstedt, C. et al. Proc. natn. Acad. Sci. U.S.A. 88, 8910\u20138914 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359325a0_CR11","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.1073\/pnas.87.15.6003","volume":"87","author":"JD Buxbaum","year":"1990","unstructured":"Buxbaum, J. D. et al. Proc. natn. Acad. Sci. U.S.A. 87, 6003\u20136006 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359325a0_CR12","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1126\/science.2111583","volume":"248","author":"FS Esch","year":"1990","unstructured":"Esch, F. S. et al. Science 248, 1122\u20131124 (1990).","journal-title":"Science"},{"key":"BF359325a0_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/0304-3940(91)90775-O","volume":"128","author":"JP Anderson","year":"1991","unstructured":"Anderson, J. P. et al. Neurosci. Lett. 128, 126\u2013128 (1991).","journal-title":"Neurosci. Lett."},{"key":"BF359325a0_CR14","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/359322a0","volume":"359","author":"C Haass","year":"1992","unstructured":"Haass, C. et al. Nature 359, 322\u2013325 (1992).","journal-title":"Nature"},{"key":"BF359325a0_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/00005072-199201000-00009","volume":"51","author":"BT Hyman","year":"1992","unstructured":"Hyman, B. T. et al. J. Neuropath. exp. Neurol. 51, 76\u201383 (1992).","journal-title":"J. Neuropath. exp. Neurol."},{"key":"BF359325a0_CR16","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/0006-8993(88)90673-7","volume":"474","author":"CL Joachin","year":"1988","unstructured":"Joachin, C. L. et al. Brain Res. 474, 100\u2013111 (1988).","journal-title":"Brain Res."},{"key":"BF359325a0_CR17","doi-asserted-by":"crossref","first-page":"17082","DOI":"10.1016\/S0021-9258(18)41896-0","volume":"267","author":"H Mori","year":"1992","unstructured":"Mori, H. et al. J. biol. Chem. 267, 17082\u201317086 (1992).","journal-title":"J. biol. Chem."},{"key":"BF359325a0_CR18","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/j.1471-4159.1988.tb01087.x","volume":"51","author":"F Prelli","year":"1988","unstructured":"Prelli, F. et al. J. Neurochem. 51, 648\u2013651 (1988).","journal-title":"J. Neurochem."},{"key":"BF359325a0_CR19","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1021\/bi00139a028","volume":"31","author":"MG Zagorski","year":"1992","unstructured":"Zagorski, M. G. & Barrow, C. J. Biochemistry 31, 5621\u20135631 (1992).","journal-title":"Biochemistry"},{"key":"BF359325a0_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0022-2836(91)90881-6","volume":"218","author":"C Hilbich","year":"1991","unstructured":"Hilbich, C. et al. J. molec. Biol. 218, 149\u2013163 (1991).","journal-title":"J. molec. Biol."},{"key":"BF359325a0_CR21","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"A Goate","year":"1991","unstructured":"Goate, A. et al. Nature 349, 704\u2013706 (1991).","journal-title":"Nature"},{"key":"BF359325a0_CR22","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/353844a0","volume":"353","author":"MC Chartier-Harlin","year":"1991","unstructured":"Chartier-Harlin, M. C. et al. Nature 353, 844\u2013846 (1991).","journal-title":"Nature"},{"key":"BF359325a0_CR23","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1126\/science.2111584","volume":"248","author":"E Levy","year":"1990","unstructured":"Levy, E. et al. Science 248, 1124\u20131126 (1990).","journal-title":"Science"},{"key":"BF359325a0_CR24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.1925564","volume":"254","author":"J Murrell","year":"1991","unstructured":"Murrell, J., Farlow, M., Ghetti, B. & Benson, M. D. Science 254, 97\u201399 (1991).","journal-title":"Science"},{"key":"BF359325a0_CR25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/256495a0","volume":"256","author":"G K\u00f6hler","year":"1975","unstructured":"K\u00f6hler, G. & Milstein, C. Nature 256, 495\u2013497 (1975).","journal-title":"Nature"},{"key":"BF359325a0_CR26","volume-title":"Methods in Cellular Immunology","author":"VT Oi","year":"1990","unstructured":"Oi, V. T. et al. Methods in Cellular Immunology Ch. 17 (Freeman, San Francisco, 1990)."},{"key":"BF359325a0_CR27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0022-1759(77)90167-3","volume":"18","author":"RW Wang","year":"1984","unstructured":"Wang, R. W. et al. J. Immun. Meth. 18, 157\u2013164 (1984).","journal-title":"J. Immun. Meth."},{"key":"BF359325a0_CR28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0169-328X(91)90088-F","volume":"10","author":"EM Johnstone","year":"1991","unstructured":"Johnstone, E. M. et al. Molec. Brain Res. 10, 299\u2013305 (1991).","journal-title":"Molec. Brain Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/359325a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/359325a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/359325a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:17:59Z","timestamp":1684289879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/359325a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":28,"journal-issue":{"issue":"6393","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["BF359325a0"],"URL":"https:\/\/doi.org\/10.1038\/359325a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}