{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:33:44Z","timestamp":1773405224063,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6395","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1992,10]]},"DOI":"10.1038\/359500a0","type":"journal-article","created":{"date-parts":[[2003,6,12]],"date-time":"2003-06-12T23:34:24Z","timestamp":1055460864000},"page":"500-505","source":"Crossref","is-referenced-by-count":351,"title":["Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic"],"prefix":"10.1038","volume":"359","author":[{"given":"Jean-Luc","family":"Galzi","sequence":"first","affiliation":[]},{"given":"Anne","family":"Devillers-Thiery","sequence":"additional","affiliation":[]},{"given":"Nicolas","family":"Hussy","sequence":"additional","affiliation":[]},{"given":"Sonia","family":"Bertrand","sequence":"additional","affiliation":[]},{"given":"Jean-Pierre","family":"Changeux","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Bertrand","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF359500a0_CR1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0896-6273(90)90077-S","volume":"5","author":"H Betz","year":"1990","unstructured":"Betz, H. Neuron 5, 383\u2013392 (1990).","journal-title":"Neuron"},{"key":"BF359500a0_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1146\/annurev.pa.31.040191.000345","volume":"31","author":"JL Galzi","year":"1991","unstructured":"Galzi, J. L., Revah, F., Bessis, A. & Changeux, J. P. A. Rev. Pharmac. Tox. 31, 37\u201372 (1991).","journal-title":"A. Rev. Pharmac. Tox."},{"key":"BF359500a0_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1101\/SQB.1990.055.01.006","volume":"55","author":"PH Seeburg","year":"1991","unstructured":"Seeburg, P. H. et al. Cold Spring Harb. Symp. Quant. Biol. 55, 29\u201340 (1991).","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"BF359500a0_CR4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1126\/science.1718042","volume":"254","author":"AV Maricq","year":"1991","unstructured":"Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M. & Julius, D. Science 254, 432\u2013437 (1991).","journal-title":"Science"},{"key":"BF359500a0_CR5","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1073\/pnas.83.8.2719","volume":"83","author":"J Giraudat","year":"1986","unstructured":"Giraudat, J., Dennis, M., Heidmann, T., Chang, J. Y. & Changeux, J. P. Proc. natn. Acad. Sci. U.S.A. 83, 2719\u20132723 (1986).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359500a0_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0014-5793(86)80881-X","volume":"205","author":"F Hucho","year":"1986","unstructured":"Hucho, F., Oberth\u00fcr, W. & Lottspeich, F. FEBS Lett. 205, 137\u2013142 (1986).","journal-title":"FEBS Lett."},{"key":"BF359500a0_CR7","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1073\/pnas.87.12.4675","volume":"87","author":"F Revah","year":"1990","unstructured":"Revah, F. et al. Proc. natn. Acad. Sci. U.S.A. 87, 4675\u20134679 (1990).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359500a0_CR8","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/324670a0","volume":"324","author":"K Imoto","year":"1986","unstructured":"Imoto, K. et al. Nature 324, 670\u2013674 (1986).","journal-title":"Nature"},{"key":"BF359500a0_CR9","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/335645a0","volume":"335","author":"K Imoto","year":"1988","unstructured":"Imoto, K. et al. Nature 335, 645\u2013648 (1988).","journal-title":"Nature"},{"key":"BF359500a0_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1432-1033.1979.tb12894.x","volume":"94","author":"T Heidmann","year":"1979","unstructured":"Heidmann, T. & Changeux, J. P. Eur. J. Biochem. 94, 281\u2013296 (1979).","journal-title":"Eur. J. Biochem."},{"key":"BF359500a0_CR11","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1021\/bi00257a032","volume":"21","author":"R Neubig","year":"1982","unstructured":"Neubig, R., Boyd, N. & Cohen, J. B. Biochemistry 21, 3460\u20133467 (1982).","journal-title":"Biochemistry"},{"key":"BF359500a0_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1113\/jphysiol.1957.sp005838","volume":"138","author":"B Katz","year":"1957","unstructured":"Katz, B. & Thesleff, S. J. Physiol., Lond. 138, 63\u201380 (1957).","journal-title":"J. Physiol., Lond."},{"key":"BF359500a0_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/286071a0","volume":"286","author":"B Sakmann","year":"1980","unstructured":"Sakmann, B., Patlak, J. & Neher, E. Nature 286, 71\u201373 (1980).","journal-title":"Nature"},{"key":"BF359500a0_CR14","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/0896-6273(90)90344-F","volume":"5","author":"S Couturier","year":"1990","unstructured":"Couturier, S. et al. Neuron 5, 847\u2013856 (1990).","journal-title":"Neuron"},{"key":"BF359500a0_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0896-6273(90)90031-A","volume":"5","author":"R Schoepfer","year":"1990","unstructured":"Schoepfer, R., Conroy, W. G., Whithing, P., Gore, M. & Lindstrom, J. Neuron 5, 35\u201348 (1990).","journal-title":"Neuron"},{"key":"BF359500a0_CR16","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/353846a0","volume":"353","author":"F Revah","year":"1991","unstructured":"Revah, F. et al. Nature 353, 846\u2013849 (1991).","journal-title":"Nature"},{"key":"BF359500a0_CR17","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1073\/pnas.89.4.1261","volume":"89","author":"D Bertrand","year":"1992","unstructured":"Bertrand, D. et al. Proc. natn. Acad. Sci. U.S.A. 89, 1261\u20131265 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359500a0_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1113\/jphysiol.1987.sp016493","volume":"385","author":"J Bormann","year":"1987","unstructured":"Bormann, J., Hammill, O. P. & Sakmann, B. J. Physiol., Lond. 385, 243\u2013286 (1987).","journal-title":"J. Physiol., Lond."},{"key":"BF359500a0_CR19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0896-6273(90)90445-L","volume":"4","author":"P Charnet","year":"1990","unstructured":"Charnet, P. et al. Neuron 4, 87\u201395 (1990).","journal-title":"Neuron"},{"key":"BF359500a0_CR20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0014-5793(91)81068-J","volume":"289","author":"K Imoto","year":"1991","unstructured":"Imoto, K. et al. FEBS Lett. 289, 193\u2013200 (1991)","journal-title":"FEBS Lett."},{"key":"BF359500a0_CR21","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1126\/science.2462281","volume":"242","author":"RJ Leonard","year":"1988","unstructured":"Leonard, R. J., Labarca, C. G., Charnet, P., Davidson, N. & Lester, H. A. Science 242, 1578\u20131581 (1988).","journal-title":"Science"},{"key":"BF359500a0_CR22","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1021\/bi00383a003","volume":"26","author":"J Giraudat","year":"1987","unstructured":"Giraudat, J. et al. Biochemistry 26, 2410\u20132418 (1987).","journal-title":"Biochemistry"},{"key":"BF359500a0_CR23","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/0005-2736(91)90350-H","volume":"1063","author":"D Langosch","year":"1991","unstructured":"Langosch, D., Hartung, K., Grell, E., Bamberg, E. & Betz, H. Biochim. biophys. Acta 1063, 36\u201344 (1991).","journal-title":"Biochim. biophys. Acta"},{"key":"BF359500a0_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/328215a0","volume":"328","author":"G Grenningloh","year":"1987","unstructured":"Grenningloh, G. et al. Nature 328, 215\u2013220 (1987).","journal-title":"Nature"},{"key":"BF359500a0_CR25","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1126\/science.1709304","volume":"252","author":"M Hollmann","year":"1991","unstructured":"Hollmann, M., Hartley, M. & Heinemann, S. Science 252, 851\u2013853 (1991).","journal-title":"Science"},{"key":"BF359500a0_CR26","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1126\/science.1710829","volume":"252","author":"TA Verdoorn","year":"1991","unstructured":"Verdoorn, T. A., Burnashev, N., Monyer, H., Seeburg, P. H. & Sakmann, B. Science 252, 1715\u20131718 (1991).","journal-title":"Science"},{"key":"BF359500a0_CR27","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/0006-291X(92)91843-F","volume":"182","author":"P Curutchet","year":"1992","unstructured":"Curutchet, P. et al. Biochem. biophys. Res. Commun. 182, 1089\u20131093 (1992).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF359500a0_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0896-6273(92)90115-T","volume":"8","author":"C Mulle","year":"1992","unstructured":"Mulle, C., Choquet, D., Korn, H. & Changeux, J. P. Neuron 8, 135\u2013143 (1992).","journal-title":"Neuron"},{"key":"BF359500a0_CR29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0896-6273(92)90114-S","volume":"8","author":"S Vernino","year":"1992","unstructured":"Vernino, S., Amador, M., Luetje, C. W., Patrick, J. & Dani, J. A. Neuron 8, 127\u2013134 (1992).","journal-title":"Neuron"},{"key":"BF359500a0_CR30","first-page":"217","volume":"16E","author":"S Vernino","year":"1992","unstructured":"Vernino, S., Amador, M. & Dani, J. A. J. Cell Biochem. 16E (suppl.) 217 (1992).","journal-title":"J. Cell Biochem."},{"key":"BF359500a0_CR31","first-page":"491","volume":"215","author":"R Miledi","year":"1982","unstructured":"Miledi, R. Proc. R. Soc. B215, 491\u2013497 (1982).","journal-title":"Proc. R. Soc."},{"key":"BF359500a0_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1113\/jphysiol.1984.sp015495","volume":"357","author":"R Miledi","year":"1984","unstructured":"Miledi, R. & Parker, I. J. Physiol., Lond. 357, 173\u2013183 (1984).","journal-title":"J. Physiol., Lond."},{"key":"BF359500a0_CR33","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1021\/bi00552a018","volume":"19","author":"RY Tsien","year":"1980","unstructured":"Tsien, R. Y. Biochemistry 19, 2396\u20132404 (1980).","journal-title":"Biochemistry"},{"key":"BF359500a0_CR34","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1021\/cr00005a008","volume":"91","author":"A Pullman","year":"1991","unstructured":"Pullman, A. Chem. Rev. 91, 793\u2013812 (1991).","journal-title":"Chem. Rev."},{"key":"BF359500a0_CR35","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/0896-6273(89)90235-3","volume":"3","author":"N Unwin","year":"1989","unstructured":"Unwin, N. Neuron 3, 665\u2013676 (1989).","journal-title":"Neuron"},{"key":"BF359500a0_CR36","unstructured":"Bertrand, D., Bertrand, S. & Ballivet, M. Neurosci. Lett. (in the press)."},{"key":"BF359500a0_CR37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1098\/rspb.1991.0053","volume":"244","author":"T Konno","year":"1991","unstructured":"Konno, T. et al. Proc. R. Soc. B244, 69\u201379 (1991).","journal-title":"Proc. R. Soc."},{"key":"BF359500a0_CR38","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/328221a0","volume":"328","author":"PR Schofield","year":"1987","unstructured":"Schofield, P. R. et al. Nature 328, 221\u2013227 (1987).","journal-title":"Nature"},{"key":"BF359500a0_CR39","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1152\/jn.1962.25.2.236","volume":"25","author":"L Tauc","year":"1962","unstructured":"Tauc, L. & Gershenfeld, H. M. J. Neurophysiol. 25, 236\u2013262 (1962).","journal-title":"J. Neurophysiol."},{"key":"BF359500a0_CR40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1113\/jphysiol.1972.sp009930","volume":"225","author":"J Kehoe","year":"1972","unstructured":"Kehoe, J. J. Physiol., Lond. 225, 85\u2013114 (1972).","journal-title":"J. Physiol., Lond."},{"key":"BF359500a0_CR41","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/978-1-4615-7858-1_20","volume-title":"Single\u2013channel Recording","author":"P Ascher","year":"1983","unstructured":"Ascher, P. & Ekulkar, S. in Single\u2013channel Recording (eds Sakmann, B. & Neher, E.) 401\u2013406 (Plenum, New York, London, 1983)."},{"key":"BF359500a0_CR42","first-page":"226","volume-title":"J. Cell. Biochem.","author":"JP Arena","year":"1992","unstructured":"Arena, J. P., Liu, K. K., Paress, P. S. & Cully, D. F. J. Cell. Biochem. 16E (suppl.) 226 (1992)."},{"key":"BF359500a0_CR43","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0304-4157(90)90009-2","volume":"1031","author":"F Franciolini","year":"1990","unstructured":"Franciolini, F. & Petris, A. Biochim. biophys. Acta 1031, 247\u2013259 (1990).","journal-title":"Biochim. biophys. Acta"},{"key":"BF359500a0_CR44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0896-6273(91)90119-K","volume":"6","author":"DC Lo","year":"1991","unstructured":"Lo, D. C., Pinkham, J. L. & Stevens C. F. Neuron 6, 31\u201340 (1991).","journal-title":"Neuron"},{"key":"BF359500a0_CR45","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1083\/jcb.107.3.1123","volume":"107","author":"N Unwin","year":"1988","unstructured":"Unwin, N., Toyoshima, C. & Kubalek, E. J. Cell Biol. 107, 1123\u20131138 (1988).","journal-title":"J. Cell Biol."},{"key":"BF359500a0_CR46","doi-asserted-by":"publisher","first-page":"5051","DOI":"10.1073\/pnas.88.11.5051","volume":"88","author":"JL Galzi","year":"1991","unstructured":"Galzi, J. L. et al. Proc. natn. Acad. Sci. U.S.A. 88, 5051\u20135055 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF359500a0_CR47","first-page":"71","volume-title":"The Harvey Lectures","author":"A Karlin","year":"1991","unstructured":"Karlin, A. The Harvey Lectures, Series 85 71\u2013107 (Wiley-Liss, New York, 1991)."},{"key":"BF359500a0_CR48","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1113\/jphysiol.1991.sp018382","volume":"432","author":"CF Newland","year":"1991","unstructured":"Newland, C. F., Colquhoun, D. & Cull-Candy, S. J. Physiol., Lond. 432, 203\u2013233 (1991).","journal-title":"J. Physiol., Lond."},{"key":"BF359500a0_CR49","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/0896-6273(90)90149-A","volume":"4","author":"G Grenningloh","year":"1990","unstructured":"Grenningloh, G. et al. Neuron 4, 963\u2013970 (1990).","journal-title":"Neuron"},{"key":"BF359500a0_CR50","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1469-185X.1951.tb01204.x","volume":"26","author":"AL Hodgkin","year":"1951","unstructured":"Hodgkin, A. L. Biol. Rev. 26, 339\u2013409 (1951).","journal-title":"Biol. Rev."},{"key":"BF359500a0_CR51","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/B978-0-12-185257-3.50017-3","volume":"4","author":"D Bertrand","year":"1991","unstructured":"Bertrand, D., Cooper, E., Valera, S., Rungger, D. & Ballivet, M. Methods in Neuroscience Vol. 4 (ed. Conn. P. M.) 174\u2013193 (Academic, San Diego, 1991).","journal-title":"Methods in Neuroscience"},{"key":"BF359500a0_CR52","unstructured":"Devillers-Thi\u00e9ry, A., Galzi, J. L., Bertrand, S., Changeux, J. P. & Bertrand, D. Neuroreport (in the press)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/359500a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/359500a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/359500a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:19:37Z","timestamp":1684289977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/359500a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":52,"journal-issue":{"issue":"6395","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["BF359500a0"],"URL":"https:\/\/doi.org\/10.1038\/359500a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}