{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:12:40Z","timestamp":1783498360919,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6423","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1993,4]]},"DOI":"10.1038\/362849a0","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T00:25:12Z","timestamp":1060647912000},"page":"849-852","source":"Crossref","is-referenced-by-count":1667,"title":["Thymocyte apoptosis induced by p53-dependent and independent pathways"],"prefix":"10.1038","volume":"362","author":[{"given":"A. R.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Purdie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Hooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Wyllie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF362849a0_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/B978-0-12-364932-4.50010-1","volume":"32","author":"MJ Arends","year":"1991","unstructured":"Arends, M. J. & Wyllie, A. H. Int. Rev. exp. Path. 32, 223\u2013254 (1991).","journal-title":"Int. Rev. exp. Path."},{"key":"BF362849a0_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/337181a0","volume":"337","author":"CA Smith","year":"1989","unstructured":"Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. & Owen, J. J. T. Nature 337, 181\u2013184 (1989).","journal-title":"Nature"},{"key":"BF362849a0_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/284555a0","volume":"284","author":"AH Wyllie","year":"1980","unstructured":"Wyllie, A. H. Nature 284, 555\u2013556 (1980).","journal-title":"Nature"},{"key":"BF362849a0_CR4","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.4049\/jimmunol.139.10.3199","volume":"139","author":"KS Sellins","year":"1987","unstructured":"Sellins, K. S. & Cohen, J. J. J. Immun. 139, 3199\u20133206 (1987).","journal-title":"J. Immun."},{"key":"BF362849a0_CR5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/0167-5699(90)90048-E","volume":"11","author":"DJ McConkey","year":"1990","unstructured":"McConkey, D. J., Orrenius, S. & Jondal, M. Immun, Today 11, 120\u2013121 (1990).","journal-title":"Immun, Today"},{"key":"BF362849a0_CR6","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1128\/MCB.13.1.711","volume":"13","author":"JJ Ryan","year":"1993","unstructured":"Ryan, J. J., Danish, R., Gottlieb, C. A. & Clarke, M. F. Molec. cell. Biol. 13, 711\u2013719 (1993).","journal-title":"Molec. cell. Biol."},{"key":"BF362849a0_CR7","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/352345a0","volume":"352","author":"E Yonish-Rouach","year":"1991","unstructured":"Yonish-Rouach, E. et al. Nature 352, 345\u2013347 (1991).","journal-title":"Nature"},{"key":"BF362849a0_CR8","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1073\/pnas.89.10.4495","volume":"89","author":"P Shaw","year":"1992","unstructured":"Shaw, P. et al. Proc. natn. Acad. Sci. U.S.A. 89, 4495\u20134499 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF362849a0_CR9","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/326292a0","volume":"326","author":"ML Hooper","year":"1987","unstructured":"Hooper, M. L., Hardy, K., Handyside, A., Hunter, S. & Monk, M. Nature 326, 292\u2013295 (1987).","journal-title":"Nature"},{"key":"BF362849a0_CR10","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/JVI.59.2.444-452.1986","volume":"59","author":"JW Yewdell","year":"1986","unstructured":"Yewdell, J. W., Gannon, J. V. & Lane, D. P. J. Virol. 59, 444\u2013452 (1986).","journal-title":"J. Virol."},{"key":"BF362849a0_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/359328a0","volume":"359","author":"AR Clarke","year":"1992","unstructured":"Clarke, A. R. et al. Nature 359, 328\u2013330 (1992).","journal-title":"Nature"},{"key":"BF362849a0_CR12","first-page":"1078","volume":"51","author":"PR Walker","year":"1991","unstructured":"Walker, P. R. et al. Cancer Res. 51, 1078\u20131085 (1991).","journal-title":"Cancer Res."},{"key":"BF362849a0_CR13","first-page":"199","volume":"42","author":"BD Zhivotovsky","year":"1982","unstructured":"Zhivotovsky, B. D., Seiliev, A. A. & Hanson, K. P. Int. J. Rad. Biol. 42, 199\u2013204 (1982).","journal-title":"Int. J. Rad. Biol."},{"key":"BF362849a0_CR14","first-page":"5304","volume":"51","author":"MB Kastan","year":"1991","unstructured":"Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R. W. Cancer Res. 51, 5304\u20135311 (1991).","journal-title":"Cancer Res."},{"key":"BF362849a0_CR15","doi-asserted-by":"publisher","first-page":"7491","DOI":"10.1073\/pnas.89.16.7491","volume":"89","author":"SJ Kuerbitz","year":"1992","unstructured":"Kuerbitz, S. J., Plunkett, B. S., Walsh, M. V. & Kastan, M. B. Proc. natn. Acad. Sci. U.S.A. 89, 7491\u20137495 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF362849a0_CR16","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/0014-4827(92)90190-J","volume":"200","author":"C Roy","year":"1992","unstructured":"Roy, C. et al. Expl. Cell Res. 200, 416\u2013424 (1992).","journal-title":"Expl. Cell Res."},{"key":"BF362849a0_CR17","first-page":"6280","volume":"51","author":"R Bertrand","year":"1991","unstructured":"Bertrand, R. Sarang, M. Jenkin, J., Kerrigan, D. & Pommier, Y. Cancer Res. 51, 6280\u20136285 (1991).","journal-title":"Cancer Res."},{"key":"BF362849a0_CR18","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/359554a0","volume":"359","author":"A Fanidi","year":"1992","unstructured":"Fanidi, A., Harrington, E. A. & Evan, G. I. Nature 359, 554\u2013556 (1992).","journal-title":"Nature"},{"key":"BF362849a0_CR19","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.4049\/jimmunol.147.12.4286","volume":"147","author":"R Iseki","year":"1991","unstructured":"Iseki, R., Mukai, M. & Iwata, M. J. Immun. 147, 4286\u20134292 (1991).","journal-title":"J. Immun."},{"key":"BF362849a0_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/path.1711420112","volume":"142","author":"AH Wyllie","year":"1984","unstructured":"Wyllie, A. H., Morris, R. G., Smith, A. L. & Dunlop, D. J. J. Path 142, 67\u201378 (1984).","journal-title":"J. Path"},{"key":"BF362849a0_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/0092-8674(92)90593-2","volume":"71","author":"MB Kastan","year":"1992","unstructured":"Kastan, M. B. et al. Cell 71, 587\u2013597 (1992).","journal-title":"Cell"},{"key":"BF362849a0_CR22","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1002\/j.1460-2075.1984.tb02110.x","volume":"3","author":"B Bienz","year":"1984","unstructured":"Bienz, B., Zakut-Houri, R., Givol, D. & Oren, M. EMBO J. 3, 2179\u20132183 (1984).","journal-title":"EMBO J."},{"key":"BF362849a0_CR23","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1093\/nar\/19.20.5755","volume":"19","author":"MW McBurney","year":"1991","unstructured":"McBurney, M. W. et al. Nucleic Acids Res. 19, 5755\u20135761 (1991).","journal-title":"Nucleic Acids Res."},{"key":"BF362849a0_CR24","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.1073\/pnas.76.8.3755","volume":"76","author":"F Colbere-Garapin","year":"1979","unstructured":"Colbere-Garapin, F., Chousterman, S., Horodniceanu, F., Kourilisky, P. & Garapin, A.-X. Proc. natn. Acad. Sci. U.S.A. 76, 3755\u20133759 (1979).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF362849a0_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0378-1119(91)90161-4","volume":"105","author":"N van der Lugt","year":"1991","unstructured":"van der Lugt, N., Robanus Maandag, E., te Riele, H., Laird, P. W. & Berns, A. Gene 105, 263\u2013267 (1991).","journal-title":"Gene"},{"key":"BF362849a0_CR26","doi-asserted-by":"publisher","first-page":"6895","DOI":"10.1093\/nar\/11.19.6895","volume":"11","author":"KR Kaster","year":"1983","unstructured":"Kaster, K. R., Burgett, S. G., Rao, R. N. & Ignolia, T. D. Nucleic Acids Res. 11, 6895\u20136911 (1983).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/362849a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/362849a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/362849a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:26:55Z","timestamp":1684290415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/362849a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":26,"journal-issue":{"issue":"6423","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["BF362849a0"],"URL":"https:\/\/doi.org\/10.1038\/362849a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}